Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT

Cancer Letters

Volumn 256, Issue 2, 2007, Pages 229-237

  Yde, Christina Westmose ^a   Frogne, Thomas ^b   Lykkesfeldt, Anne E ^b   Fichtner, Iduna ^c   Issinger, Olaf Georg ^a   Stenvang, Jan ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Antiestrogen resistance; Apoptosis; Bcl 2; Breast cancer; CK2; DMAT

Indexed keywords

2 DIMETHYLAMINO 4,5,6,7 TETRA BROMOBENZIMIDAZOLE; ANTIESTROGEN; BENZIMIDAZOLE DERIVATIVE; CASEIN KINASE II; CASPASE; FULVESTRANT; PROTEIN BCL 2; PROTEIN SERINE THREONINE KINASE INHIBITOR; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER RESISTANCE; CELL DEATH; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; FEMALE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZIMIDAZOLES; BREAST NEOPLASMS; CASEIN KINASE II; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; FEMALE; HUMANS; POLYUNSATURATED ALKAMIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; TAMOXIFEN; TIME FACTORS; TRANSFECTION;

EID: 34548668897     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.06.010     Document Type: Article

References (35)

1. Münstermann U., Fritz G., Seitz G., Lu Y.P., Schneider H.R., and Issinger O.G. Casein kinase II is elevated in solid human tumours and rapidly proliferating non-neoplastic tissue. Eur. J. Biochem. 189 (1990) 251-257
2. Ahmed K., Davis A.T., Wang H., Faust R.A., Yu S., and Tawfic S. Significance of protein kinase CK2 nuclear signaling in neoplasia. J. Cell. Biochem. Suppl. 35 (2000) 130-135
3. Landesman-Bollag E., Romieu-Mourez R., Song D.H., Sonenshein G.E., Cardiff R.D., and Seldin D.C. Protein kinase CK2 in mammary gland tumorigenesis. Oncogene 20 (2001) 3247-3257
4. Guerra B., Boldyreff B., Sarno S., Cesaro L., Issinger O.G., and Pinna L.A. CK2: a protein kinase in need of control. Pharmacol. Ther. 82 (1999) 303-313
5. Lykkesfeldt A.E., Larsen S.S., and Briand P. Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatment. Int. J. Cancer 61 (1995) 529-534
6. Lykkesfeldt A.E., and Briand P. Indirect mechanism of oestradiol stimulation of cell proliferation of human breast cancer cell lines. Br. J. Cancer 53 (1986) 29-35
7. Lykkesfeldt A.E., Madsen M.W., and Briand P. Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1. Cancer Res. 54 (1994) 1587-1595
8. Naundorf H., Fichtner I., Buttner B., and Frege J. Establishment and characterization of a new human oestradiol- and progesterone-receptor-positive mammary carcinoma serially transplantable in nude mice. J. Cancer Res. Clin. Oncol. 119 (1992) 35-40
9. Naundorf H., Becker M., Lykkesfeldt A.E., Elbe B., Neumann C., Buttner B., and Fichtner I. Development and characterization of a tamoxifen-resistant breast carcinoma xenograft. Br. J. Cancer 82 (2000) 1844-1850
10. Garcia-Calvo M., Peterson E.P., Leiting B., Ruel R., Nicholson D.W., and Thornberry N.A. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J. Biol. Chem. 273 (1998) 32608-32613
11. Lademann U., Cain K., Gyrd-Hansen M., Brown D., Peters D., and Jäättelä M. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. Mol. Cell. Biol. 23 (2003) 7829-7837
12. Lundholt B.K., Briand P., and Lykkesfeldt A.E. Growth inhibition and growth stimulation by estradiol of estrogen receptor transfected human breast epithelial cell lines involve different pathways. Breast Cancer Res. Treat. 67 (2001) 199-214
13. Yde C.W., and Issinger O.G. Enhancing cisplatin sensitivity in MCF-7 human breast cancer cells by down-regulation of Bcl-2 and cyclin D1. Int. J. Oncol. 29 (2006) 1397-1404
14. Zhu W., Cowie A., Wasfy G.W., Penn L.Z., Leber B., and Andrews D.W. Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J. 15 (1996) 4130-4141
15. Kanda T., Sullivan K.F., and Wahl G.M. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr. Biol. 8 (1998) 377-385
16. Yde C.W., Gyrd-Hansen M., Lykkesfeldt A.E., Issinger O.G., and Stenvang J. Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death. Mol. Cancer Ther. 6 (2007) 1869-1876
17. Seldin D.C., Landesman-Bollag E., Farago M., Currier N., Lou D., and Dominguez I. CK2 as a positive regulator of Wnt signalling and tumourigenesis. Mol. Cell. Biochem. 274 (2005) 63-67
18. Zhang T., Otevrel T., Gao Z., Gao Z., Ehrlich S.M., Fields J.Z., and Boman B.M. Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res. 61 (2001) 8664-8667
19. Tapia J.C., Torres V.A., Rodriguez D.A., Leyton L., and Quest A.F. Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription. Proc. Natl. Acad. Sci. USA 103 (2006) 15079-15084
20. Arnold S.F., Obourn J.D., Jaffe H., and Notides A.C. Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor. Mol. Endocrinol. 8 (1994) 1208-1214
21. Lin R., Beauparlant P., Makris C., Meloche S., and Hiscott J. Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol. Cell. Biol. 16 (1996) 1401-1409
22. O'Brien K.A., Lemke S.J., Cocke K.S., Rao R.N., and Beckmann R.P. Casein kinase 2 binds to and phosphorylates BRCA1. Biochem. Biophys. Res. Commun. 260 (1999) 658-664
23. Meek D.W., Simon S., Kikkawa U., and Eckhart W. The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II. EMBO J. 9 (1990) 3253-3260
24. Hjerrild M., Milne D., Dumaz N., Hay T., Issinger O.G., and Meek D. Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells. Biochem. J. 355 (2001) 347-356
25. Torres J., and Pulido R. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem. 276 (2001) 993-998
26. Guerra B. Protein kinase CK2 subunits are positive regulators of AKT kinase. Int. J. Oncol. 28 (2006) 685-693
27. Di Maira G., Salvi M., Arrigoni G., Marin O., Sarno S., Brustolon F., Pinna L.A., and Ruzzene M. Protein kinase CK2 phosphorylates and upregulates Akt/PKB. Cell Death Differ. 12 (2005) 668-677
28. Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L., and Lykkesfeldt A.E. Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth. Endocr. Relat. Cancer 12 (2005) 599-614
29. Guerra B., and Issinger O.G. Protein kinase CK2 and its role in cellular proliferation, development and pathology. Electrophoresis 20 (1999) 391-408
30. Ahmed K., Gerber D.A., and Cochet C. Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol. 12 (2002) 226-230
31. D. Behrens, A.E. Lykkesfeldt, I. Fichtner, The mTOR pathway inhibitor RAD001 (everolimus) is highly efficacious in tamoxifen-sensitive and -resistant breast cancer xenografts, Targeted Oncology. Available online 30 June 2007.
32. Slaton J.W., Unger G.M., Sloper D.T., Davis A.T., and Ahmed K. Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model. Mol. Cancer Res. 2 (2004) 712-721
33. Seeber S., Issinger O.G., Holm T., Kristensen L.P., and Guerra B. Validation of protein kinase CK2 as oncological target. Apoptosis 10 (2005) 875-885
34. Izeradjene K., Douglas L., Delaney A., and Houghton J.A. Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells. Clin. Cancer Res. 10 (2004) 6650-6660
35. Yamane K., and Kinsella T.J. CK2 inhibits apoptosis and changes its cellular localization following ionizing radiation. Cancer Res. 65 (2005) 4362-4367