Synergistic interaction between dexamethasone and tramadol in a murine model of acute visceral pain

Fundamental and Clinical Pharmacology

Volumn 21, Issue 5, 2007, Pages 515-520

  Dürsteler, Christian ^a   Miranda, Hugo F ^b   Poveda, Raquel ^c   Mases, Anna ^a   Planas, Eulalia ^c   Puig, Margarita M ^a,d  

^a HOSPITAL DEL MAR   (Spain)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSITY OF BARCELONA   (Spain)

^d Del Mar University   (Spain)

Author keywords

Drug interactions; Glucocorticoids; Isobolograms; Opioid analgesics

Indexed keywords

ACETIC ACID; ANTIEMETIC AGENT; DEXAMETHASONE; GLUCOCORTICOID; TRAMADOL;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; EXPERIMENTAL MOUSE; FEMALE; MOUSE; NONHUMAN; POSTOPERATIVE PAIN; PRIORITY JOURNAL; VISCERAL PAIN; WRITHING TEST;

ANALGESICS, OPIOID; ANIMALS; ANTIEMETICS; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; GLUCOCORTICOIDS; HUMANS; MICE; MODELS, BIOLOGICAL; PAIN; PAIN MEASUREMENT; TRAMADOL;

EID: 34548655474     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2007.00511.x     Document Type: Article

References (41)

1. Falkenstein E., Tillmann H.C., Christ M. et al. Multiple actions of steroid hormones-a focus on rapid, nongenomic effects. Pharmacol. Rev. (2000) 52 513 556.
2. Schleimer R.P. An overview of glucocorticoid anti-inflammatory actions. Eur. J. Clin. Pharmacol. (1993) 45 (Suppl. 1) S3 S7.
3. Ferreira S.H., Cunha F.Q., Lorenzetti B.B. et al. Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone. Br. J. Pharmacol. (1997) 121 883 888.
4. Henzi I., Walder B., Tramer M.R. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth. Analg. (2000) 90 186 194.
5. Holte K., Kehlet H. Perioperative single-dose glucocorticoid administration: pathophysiologic effects and clinical implications. J. Am. Coll. Surg. (2002) 195 694 712.
6. Romundstad L., Breivik H., Niemi G. et al. Methylprednisolone intravenously 1 day after surgery has sustained analgesic and opioid-sparing effects. Acta. Anaesthesiol. Scand. (2004) 48 1223 1231.
7. Wang S., Lim G., Zeng Q. et al. Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats. J. Neurosci. (2004) 24 8595 8605.
8. Sorrentino R., Capasso A., d'Emmanuele di Villa Bianca R., Pinto A. Dexamethasone modulates hypotension induced by opioids in anaesthetised rats. Eur. J. Pharmacol. (2001) 430 79 85.
9. Broccardo M., Scaccianoce S., Del Bianco P. et al. Nociceptin/orphanin fq-induced delay in gastric emptying: role of central corticotropin-releasing factor and glucocorticoid receptors. Neurogastroenterol. Motil. (2005) 17 871 877.
10. Rouveix B. Opiates and immune function. Consequences on infectious diseases with special reference to aids. Therapie (1992) 47 503 512.
11. Choi S.B., Jang J.S., Park S. Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized rats. Brain Res. Bull. (2005) 67 77 86.
12. Capasso A., Casciano C., Loizzo A. Dexamethasone reduces morphine-induced straub reaction in mice. J. Pharm. Pharmacol. (2002) 54 983 987.
13. Kizilkaya M., Yildirim O.S., Ezirmik N. et al. Comparisons of analgesic effects of different doses of morphine and morphine plus methylprednisolone after knee surgery. Eur. J. Anaesthesiol. (2005) 22 603 608.
14. Capasso A., Di Giannuario A., Loizzo A. et al. Central interaction of dexamethasone and ru-38486 on morphine antinociception in mice. Life Sci. (1992) 51 139 143.
15. Williams K.S. Postoperative nausea and vomiting. Surg. Clin. North. Am. (2005) 85 1229 1241.
16. DeWitte J.L., Schoenmaekers B., Sessler D.I., Deloof T. The analgesic efficacy of tramadol is impaired by concurrent administration of ondansetron. Anesth. Analg. (2001) 92 1319 1321.
17. Arcioni R., della Rocca M., Romano S., et al. Ondansetron inhibits the analgesic effects of tramadol: a possible 5-ht(3) spinal receptor involvement in acute pain in humans. Anesth. Analg. (2002) 94 1553 1557.
18. Dursteler C., Mases A., Fernandez V., et al. Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice. Eur. J. Pain (2006) 10 629 638.
19. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain (1983) 16 109 110.
20. Poveda R., Planas E., Pol O. et al. Interaction between metamizol and tramadol in a model of acute visceral pain in rats. Eur. J. Pain (2003) 7 439 448.
21. Statile L., Puig M.M., Warner W., et al. Droperidol enhances fentanyl and sufentanil, but not morphine, analgesia. Gen. Pharmacol. (1988) 19 451 454.
22. Collier H.O., Dinneen L.C., Johnson C.A., Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br. J. Pharmacol. (1968) 32 295 310.
23. LeBars D., Gozariu M., Cadden S.W. Animal models of nociception. Pharmacol. Rev. (2001) 53 597 652.
24. Tallarida R.J. Drug synergism and dose-effect data analysis. Chapman & Hall CRC, Boca Raton, FL, 2000.
25. Bisgaard T., Klarskov B., Kehlet H., Rosenberg J. Preoperative dexamethasone improves surgical outcome after laparoscopic cholecystectomy: a randomized double-blind placebo-controlled trial. Ann. Surg. (2003) 238 651 660.
26. Nakamura H., Mizushima Y., Seto Y. et al. Dexamethasone fails to produce antipyretic and analgesic actions in experimental animals. Agents Actions (1985) 16 542 547.
27. Dionne R.A., Gordon S.M., Rowan J. et al. Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation. J. Oral Maxillofac. Surg. (2003) 61 997 1003.
28. Buttgereit F., Scheffold A. Rapid glucocorticoid effects on immune cells. Steroids (2002) 67 529 534.
29. Buttgereit F., Straub R.H., Wehling M., Burmester G.R. Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action. Arthritis. Rheum. (2004) 50 3408 3417.
30. Song I.H., Buttgereit F. Non-genomic glucocorticoid effects to provide the basis for new drug developments. Mol. Cell. Endocrinol. (2006) 246 142 146.
31. Orchinik M., Murray T.F., Moore F.L. A corticosteroid receptor in neuronal membranes. Science (1991) 252 1848 1851.
32. Chen F., Watson C.S., Gametchu B. Association of the glucocorticoid receptor alternatively-spliced transcript 1a with the presence of the high molecular weight membrane glucocorticoid receptor in mouse lymphoma cells. J. Cell Biochem. (1999) 74 430 446.
33. Gametchu B., Watson C.S., Wu S. Use of receptor antibodies to demonstrate membrane glucocorticoid receptor in cells from human leukemic patients. FASEB J. (1993) 7 1283 1292.
34. Sackey F.N., Watson C.S., Gametchu B. Cell cycle regulation of membrane glucocorticoid receptor in ccrf-cem human all cells: correlation to apoptosis. Am. J. Physiol. (1997) 273 E571 E583.
35. Bartholome B., Spies C.M., Gaber T. et al. Membrane glucocorticoid receptors (mgcr) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis. FASEB J. (2004) 18 70 80.
36. Goulding N.J. The molecular complexity of glucocorticoid actions in inflammation - a four-ring circus. Curr. Opin. Pharmacol. (2004) 4 629 636.
37. Urbach V., Walsh D.E., Mainprice B. et al. Rapid non-genomic inhibition of atp-induced cl- secretion by dexamethasone in human bronchial epithelium. J. Physiol. (2002) 545 869 878.
38. Croxtall J.D., Choudhury Q., Flower R.J. Inhibitory effect of peptides derived from the n-terminus of lipocortin 1 on arachidonic acid release and proliferation in the a549 cell line: Identification of e-q-e-y-v as a crucial component. Br. J. Pharmacol. (1998) 123 975 983.
39. Pieretti S., Capasso A., Di Giannuario A., et al. The interaction of peripherally and centrally administered dexamethasone and ru 38486 on morphine analgesia in mice. Gen. Pharmacol. (1991) 22 929 933.
40. Grond S., Sablotzki A. Clinical pharmacology of tramadol. Clin. Pharmacokinet. (2004) 43 879 923.
41. Miranda H.F., Sierralta F., Pinardi G. An isobolographic analysis of the adrenergic modulation of diclofenac antinociception. Anesth. Analg. (2001) 93 430 435.