Inhibitory effect of peptides derived from the N-terminus of lipocortin 1 on arachidonic acid release and proliferation in the A549 cell line: Identification of E-Q-E-Y-V as a crucial component

British Journal of Pharmacology

Volumn 123, Issue 5, 1998, Pages 975-983

  Croxtall, J D ^a   Choudhury, Q ^a   Flower, R J ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Annexins; Cell proliferation; cPLA2; Glucocorticoids; SH2 domains; Tyrosine kinase

Indexed keywords

ARACHIDONIC ACID; EPIDERMAL GROWTH FACTOR; LIPOCORTIN 1; LIPOSOME; PHOSPHATIDYLSERINE; THAPSIGARGIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANNEXIN A1; ARACHIDONIC ACID; CELL DIVISION; CELL LINE; ENZYME ACTIVATION; HUMANS; LIPOSOMES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHOSPHATIDYLSERINES; PHOSPHOLIPASES A; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0031907233     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701679     Document Type: Article

References (36)

1. BROWNING, J.L., WARD, M.P., WALLNER, B.P. & PEPINSKY, R.B. (1990). Studies on the structural properties of lipocortin-1 and the regulation of its synthesis by steroids. In Prog. Clin. Biol. Res. Cytokines and Lipocortins in Inflammation and Differentiation. ed. Melli, M. & Parente, L. pp. 27-45. New York: Wiley-Liss.
2. CAMUSSI, G., TETTA, C., BUSSOLINO, F. & BAGLIONI, C. (1990). Antiinflammatory peptides (antiflammins) inhibit synthesis of platelet-activating factor, neutrophil aggregation and chemotaxis, and intradermal inflammatory reactions. J. Exp. Med., 171, 913-927.
3. CAREY, F., FORDER, R., EDGE, M.D., GREENE, A.R., HORAN, M.A., STRIJBOS, P.J.L.M. & ROTHWELL, N.J. (1990). Lipocortin-1 modifies pyrogenic actions of cytokines in the rat. Am. J. Physiol., 259, 266-269.
4. CIRINO, G., CICALA, C., SORRENTINO, L., CILIBERTO, G., ARPAIA, G., PERRETTI, M. & FLOWER, R.J. (1993). Antiinflammatory actions of an N-terminal peptide from human lipocortin-1. Br. J. Pharmacol., 108, 573-574.
5. CIRINO, G., FLOWER, R,J., BROWNING, J.L., SINCLAIR, L.K. & PEPINSKY, R.B. (1987). Recombinant human lipocortin 1 inhibits thromboxane release from guinea-pig isolated perfused lung. Nature, 328, 270-272.
6. CIRINO, G., PEERS, S.H., FLOWER, R.J., BROWNING, J.L. & PEPINSKY, R.B. (1989). Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test. Proc. Natl. Acad. Sci. USA, 86, 3428-3432.
7. CROXTALL, J.D., CHOUDHURY, Q., NEWMAN, S. & FLOWER, R.J. (1996). Lipocortin 1 and the control of cPLA2 activity in A549 cells. Glucocorticoids block EGF stimulation of cPLA2 phosphorylation. Biochem. Pharmacol., 52, 351- 356.
8. CROXTALL, J.D., CHOUDHURY, Q., TOKUMOTO, H. & FLOWER, R.J. (1995). Lipocortin I and the control of arachidonic acid release in cell signalling. Biochem. Pharmacol., 50, 465-474.
9. CROXTALL, J.D. & FLOWER, R.J. (1994). Antisense oligonucleotides to human lipocortin-1 inhibit glucocorticoid-induced inhibition of A549 cell growth and eicosanoid release. Biochem. Pharmacol., 48, 1729-1734.
10. CROXTALL, J.D. & FLOWER, R.J. (1992). Lipocortin-1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell-line. Proc. Natl. Acad. Sci. USA, 89, 3571-3575.
11. CROXTALL, J.D., WAHEED, S., CHOUDHURY, Q., ANAND, R. & FLOWER, R.J. (1993). N-terminal peptide fragments of LC1 inhibit A549 cell growth and block EGF induced stimulation of proliferation. Int. J. Cancer, 54, 153-158.
12. CROXTALL, J.D., WU, H.-L., YANG, H.-S., SMITH, B., SUTTON, C., CHANG, B.-I., SHI, G.-Y. & FLOWER, R.J. (1997). Lipocortin 1 coassociates with cytokeratin 8 and 18 in A549 cells via the N-terminal domain. Biochim. Biophys. Acta. (in press).
13. DAVIDSON, J., FLOWER, R.J., MILTON, A.S., PEERS, S.H. & ROTONDO, D. (1991). Antipyretic actions of human recombinant lipocortin-1. Br. J. Pharmacol., 102, 7-9.
14. FLOWER, R.J. & ROTHWELL, N.J. (1994). Lipocortin-1: cellular mechanisms and clinical relevance. Trends Pharmacol. Sci., 15, 71-76.
15. GOLD, R., PEPINSKY, R.B., ZETTL, U.K., TOYKA, K.V. & HARTUNG. H.-P. (1996). Lipocortin 1 (annexin 1) suppresses activation of auto-immune T-cell lines in the Lewis rat. J. Neuroimmunol., 69, 157-164.
16. GOLDBERG, A.R., SLATE, D., TATTER, S.B. & RADZIEJEWSKI, C. (1980). Inhibition of tyrosine kinases in cultured cells. J. Cell. Biochem. Suppl., 10, 180.
17. GOULDING, N.J., L., PAN., K., WARDELL., V.C., GUYRE, & P.M., GUYRE. (1996). Evidence for specific annexin 1 - binding proteins on human monocytes. Biochem. J., 316, 593-597.
18. HIRATA, F., NOTSU, Y., MATSUDA, K., VASANTHAKUMAR, G., SCHIFFMAN, E., WONG, T.-W. & GOLDBERG, A.R. (1984). Inhibition of leukoeyte chemotaxis by Glu-Glu-Glu-Glu-Tyr-Pro-Met-Glu and Leu-Ile-Glu-Asp-Asn-Glu-Tyr Thr-Ala-Arg-Gln-Gly. Biochem. Biophys. Res. Commun., 118, 682-690.
19. HUANG, K.-S., MCGRAY, P., MATTALIANAO, J., BURNE, C., CHOW, E.P., SINCLAIR, L.K. & PEPINSKY, R.B. (1987). Purification and characterisation of proteolytic fragments of lipocortin 1 that inhibit phospholipasc A2. J. Biol. Chem., 262, 7639-7645.
20. LAEMMLI, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
21. PEPINSKY, R.B. (1991). Phosphorylation of lipocortin-1 by the epidermal growth factor receptor. Methods Enzymol., 198, 260-271.
22. PEPINSKY, R.B. & SINCLAIR, L.K. (1986). Epidermal growth factor-dependent phosphorylation of lipocortin. Nature, 321, 81-84.
23. PERRETTI, M. (1994). Lipocortin-derived peptides. Biochem. Pharmacol., 47, 931-938.
24. PERRETTI, M., AHLUWALIA, A. & HARRIS, J.G., GOULDING, N.J. & FLOWER, R.J., (1993). Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse: a qualitative comparison with an anti-CD11b monoclonal antibody. J. Immunol., 151, 4306-4314.
25. PERRETTI, M. & FLOWER, R.J. (1993). Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1. J.Immunol., 150, 992-999.
26. PIKE, L., MARQUARDT, H., TODAROS, G.J., GALLIS, B., CASNELLIE, J.E., BORNSTEIN, P. & KREBS, E. (1982). Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine containing peptide in a similar manner. J. Biol. Chem., 257, 14628-14631.
27. RAYNAL, P. & POLLARD, H.B. (1994). Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins. Biochim. Biophys. Acta. 1197, 63-93.
28. RELTON, J.K., STRIJBOS, P.J.L.M., O'SHAUGHNESSY, C.T., CAREY, F., FORDER, R.A., TILDERS, F.J.H. & ROTHWELL, N.J. (1991). Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain. J.Exp.Med., 174, 305-310.
29. SCHAUFFHAUSEN, B., BENJAMIN, T.L., PIKE, L., CASNELLIE, J. & KREBS, E. (1982). Antibody to the nonapeptide Glu-Glu-Glu-Tyr-Met-Pro-Met-Glu is specific for polyoma middleT antigen and inhibits in vitro kinase activity. J. Biol. Chem., 257, 12467-12470.
30. SEEMAN, J., K.WEBER & V.GERKE. (1996). Structural requirements for annexin 1 - S100C formation. Biochem. J., 319, 123-129.
31. SONGYANG, Z., CARRAWAY III, K.L., ECK, M.J., HARRISON, S.C., FELDMAN, R.A., MOHAMMADI, M., SCHLESSINGER, J., HUBBARD, S.R., SMITH, D.P., ENG, C., LORENZO, M.J., PONDER, B.A.J., MAYER, B.J. & CANTLEY, L.C. (1995). Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature, 373, 536-539.
32. TAYLOR, A.D., COWELL, A.M. & FLOWER, R.J. & BUCKINGHAM, J.C. (1993). Lipocortin 1 mediates an early inhibitory action of glucocorticoids on the secretion of ACTH by the rat anterior pituitary gland in vitro. Neuroendocrinology, 58, 430-439.
33. TAYLOR, A.D., FLOWER, R.J. & BUCKINGHAM, J.C. (1995). Dexamethasone inhibits the release of thyrotrophin (TSH) in vitro by a lipocortin 1 dependent mechanism. J. Endocrinol., 147, 533-544.
34. WEI, E.T. & KIANG, J.G. (1989). Peptides of the corticoliberin superfamily attenuate thermal and neurogenic inflammation in rat pawskin. Eur. J. Pharmacol., 168, 81-86.
35. WONG, T.-W. & GOLDBERG, A.R. (1981). Synthetic peptide fragments of src gene product inhibits the src protein kinase and crossreacts immunologically with avian one kinases and cellular phosphoproteins. Proc. Natl. Acad. Sci. USA, 78, 7412-7416.
36. WU, C.-C., CROXTALL, J.D., PERRETTI, M.P., BRYANT, C.E., THIEMMERMAN, C., FLOWER, R.J. & VANE, J.R. (1995). Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proc. Natl. Acad. Sci. USA, 92, 3473-3477.