A study of the PEMT gene in schizophrenia

Neuroscience Letters

Volumn 424, Issue 3, 2007, Pages 203-206

  Liu, Yang ^a,d   Zhang, Haiying ^a   Ju, Guizhi ^a   Zhang, Xuan ^a   Xu, Qi ^b   Liu, Shuzheng ^a   Yu, Yaqin ^a   Shi, Jieping ^a   Boyle, Susanne ^c   Wang, Zhenqi ^a   Shen, Yan ^b   Wei, Jun ^e  

^a JILIN UNIVERSITY   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^c ROBERT GORDON UNIVERSITY   (United Kingdom)

^d the PLA   (China)

^e UNIVERSITY OF THE HIGHLANDS AND ISLANDS   (United Kingdom)

Author keywords

Membrane phospholipids; PEMT; Schizophrenia; Single nucleotide polymorphisms (SNPs)

Indexed keywords

MEMBRANE PHOSPHOLIPID; NICOTINIC ACID; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; POLYUNSATURATED FATTY ACID;

ADULT; ALLELE; ARTICLE; CHINESE; DISEASE ASSOCIATION; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ANALYSIS; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHOSPHOLIPID METABOLISM; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CHI-SQUARE DISTRIBUTION; CHINA; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; SCHIZOPHRENIA;

EID: 34548644005     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.07.038     Document Type: Article

References (43)

1. Arvindakshan M., Sitasawad S., Debsikdar V., Ghate M., Evens D., Horrobin D.F., Bennett C., Ranjekar P.K., and Mahadik S.P. Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients. Biol. Psychiatry 53 (2003) 56-64
2. Cao Y., Traer E., Zimmerman G.A., McIntyre T.M., and Prescott S.M. Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4). Genomics 49 (1998) 327-330
3. Cao Y., Murphy K.J., McIntyre T.M., Zimmerman G.A., and Prescott S.M. Expression of fatty acid-CoA ligase 4 during development and in brain. FEBS Lett. 467 (2000) 263-267
4. Chowdari K.V., Brandstaetter B., Semwal P., Bhatia T., Deshpande S., Reddy R., Wood J., Weinberg C.R., Thelma B.K., and Nimgaonkar V.L. Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family-based samples. Psychiatr. Genet. 111 (2001) 207-212
5. Covault J., Pettinati H., Moak D., Mueller T., and Kranzler H.R. Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. Am. J. Med. Genet. 127B (2004) 42-47
6. Doris A.B., Wahle K., MacDonald A., Morris S., Coffey I., Muir W., and Blackwood D. Red cell membrane fatty acids, cytosolic phospholipase-A2 and schizophrenia. Schizophr. Res. 31 (1998) 185-196
7. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 25 (2003) 115-121
8. Emsley R., Oosthuizen P., and van Rensburg S.J. Clinical potential of omega-3 fatty acids in the treatment of schizophrenia. CNS Drugs 17 (2003) 1081-1091
9. Frieboes R.M., Moises H.W., Gattaz W.F., Yang L., Li T., Liu X., Vetter P., Macciardi F., Hwu H.G., and Henn F. Lack of association between schizophrenia and the phospholipase-A (2) genes cPLA2 and sPLA2. Am. J. Med. Genet. 105 (2001) 246-249
10. 31P magnetic resonance chemical shift imaging. Acta Psychiat. Scand. 86 (1992) 455-462
11. Glen A.I., Glen E.M., Horrobin D.F., Vaddadi K.S., Spellman M., Morse-Fisher N., Ellis K., and Skinner F.S. A red cell membrane abnormality in a subgroup of schizophrenic patients: evidence for two diseases. Schizophr. Res. 12 (1994) 53-61
12. Hitzemann R., Hirschowitz J., and Garver D. Membrane abnormalities in the psychoses and affective disorders. J. Psychiat. Res. 18 (1984) 319-326
13. Hudson C.J., Kennedy J.L., Gotowiec A., Lin A., King N., Gojtan K., Macciardi F., Skorecki K., Meltzer H.Y., Warsh J.J., and Horrobin D.F. Genetic vairiant near cytosolic phospholipase A2 associated with schizophrenia. Schizophr. Res. 21 (1996) 111-116
14. Junqueira R., Cordeiro Q., Meira-Lima I., Gattaz W.F., and Vallada H. Allelic association analysis of phospholipase A2 genes with schizophrenia. Psychiat. Genet. 14 (2004) 157-160
15. Keshavan M.S., Mallinger A., Pettegrew J.W., and Dippold C. Erythrocyte membrane phospholipids in psychotic patients. Psychiat. Res. 49 (1993) 89-95
16. Khan M.M., Evans D.R., Gunna V., Scheffer R.E., Parikh V.V., and Mahadik S.P. Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics. Schizophr. Res. 58 (2002) 1-10
17. Lin S.H., Liu C.M., Chang S.S., Hwu H.G., Liu S.K., Hwang T.J., Hsieh M.H., Guo S.C., and Chen W.J. Familial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relatives. Schizophr. Bull. 33 (2007) 174-182
18. Messamore E., Hoffman W.F., and Janowsky A. The niacin skin flush abnormality in schizophrenia: a quantitative dose-response study. Schizophr. Res. 62 (2003) 251-258
19. Pae C.U., Yu H.S., Lee K.U., Kim J.J., Lee C.U., Lee S.J., Jun T.Y., Lee C., and Paik I.H. BanI polymorphism of the cytosolic phospholipase A2 gene may confer susceptibility to the development of schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 28 (2004) 739-741
20. Peet M., Ramchand C.N., Lee J., Telang S.D., Vankar G.K., Shah S., and Wei J. Association of the Ban I dimorphic site at the human cytosolic phospholipase A2 gene with schizophrenia. Psychiatr. Genet. 8 (1998) 191-192
21. Peet M. Eicosapentaenoic acid in the treatment of schizophrenia and depression: rationale and preliminary double-blind clinical trial results. Prostaglandins Leukot. Essent. Fatty Acids 69 (2003) 477-485
22. Pettegrew J.W., Keshavan M.S., Panchalingam K., Strychor S., Kaplan D.B., Tretta M.G., and Allen M. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Arch. Gen. Psychiat. 48 (1991) 563-568
23. Potwarka J.J., Drost D.J., Williamson P.C., Carr T., Canaran G., Rylett W.J., and Neufeld R.W. A 1H-decoupled 31P chemical shift imaging study of medicated schizophrenic patients and healthy controls. Biol. Psychiatry 45 (1999) 687-693
24. Price S.A., Fox H., St Clair D., and Shaw D.J. Lack of association between schizophrenia and a polymorphism close to the cytosolic phospholipase A2 gene. Psychiat. Genet. 7 (1997) 111-114
25. Puri B.K., Hirsch S.R., Easton T., and Richardson A.J. A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 26 (2002) 49-52
26. Puri B.K., Easton T., Das I., Kidanes L., and Richardson A.J. The niacin skin flush test in schizophrenia: a replication study. Int. J. Clin. Pract. 55 (2001) 368-370
27. Ross B.M., Hughes B., Turenne S., Seeman M., and Warsh J.J. Reduced vasodilatory response to methylnicotinate in schizophrenia as assessed by laser Doppler flowmetry. Eur. Neuropsychopharmacol. 14 (2004) 191-197
28. Rybakowski J.K., Borkowska A., Czerski P.M., Dmitrzak-Weglarz M., and Hauser J. The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker. Neuropsychobiology 47 (2003) 115-119
29. Smesny S., Berger G., Rosburg T., Riemann S., Riehemann S., McGorry P., and Sauer H. Potential use of the topical niacin skin test in early psychosis-a combined approach using optical reflection spectroscopy and a descriptive rating scale. J. Psychiatr. Res. 37 (2003) 237-247
30. Stanley J.A., Williamson P.C., Drost D.J., Carr T.J., Rylett R.J., Morrison-Stewart S., and Thompson R.T. Membrane phospholipid metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study. Schizophr. Res. 13 (1994) 209-215
31. Stanley J.A., Williamson P.C., Drost D.J., Carr T.J., Rylett R.J., Malla A., and Thompson R.T. An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy. Arch. Gen. Psychiatry 52 (1995) 399-406
32. Sugden C. One-carbon metabolism in psychiatric illness. Nutr. Res. Rev. 19 (2006) 117-136
33. Tao R., Wei J., Guo Y., Yu Y., Xu Q., Shi J., Liu S., Ju G., Li Y., and Shen Y. The PLA2G4A gene and negative symptoms in a Chinese population. Schizophr. Res. 86 (2006) 326-328
34. Tao R., Yu Y.-Q., Zhang X.-J., Guo Y.-J., Shi J.-P., Zhang X., Xie L., Liu S., Ju G., Xu Q., Shen Y., and Wei J. Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia. Am. J. Med. Genet. 137B (2005) 56-58
35. Tavares H., Yacubian J., Talib L.L., Barbosa N.R., and Gattaz W.F. Increased phospholipase A2 activity in schizophrenia with absent response to niacin. Schizophr. Res. 61 (2003) 1-6
36. Tolbert L.C., Monti J.A., O'Shields H., Walter-Ryan W., Meadows D., and Smythies J.R. Defects in transmethylation and membrane lipids in schizophrenia. Psychopharmacol. Bull. 19 (1983) 594-599
37. Ward P.E., Sutherland J., Glen E.M., and Glen A.I. Niacin skin flush in schizophrenia: a preliminary report. Schizophr. Res. 29 (1998) 269-274
38. Wei J., and Hemmings G.P. A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia. Prostaglandins Leukot. Essent. Fatty Acids 70 (2005) 413-415
39. Wei J., and Hemmings G.P. A further study of a possible locus for schizophrenia on the X chromosome. Biochem. Biophys. Res. Commun. 344 (2006) 1241-1245
40. Wei J., and Hemmings G.P. A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. Prostaglandins Leukot. Essent. Fatty Acids 73 (2005) 441-445
41. Wei J., Lee K.-H., and Hemmings G.P. Is the cPLA2 gene associated with schizophrenia?. Mol. Psychiatry 3 (1998) 480-481
42. Yu Y.-Q., Tao R., Wei J., Xu Q., Liu S.Z., Ju G.Z., Shi J.P., Zhang X., Xie L., and Shen Y. No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population. Prostaglandins Leukot. Essent. Fatty Acids 71 (2004) 405-408
43. Yu Y.-Q., Tao R., Shi J.-P., Zhang X.-J., Kou C.-G., Guo Y.-J., Zhang X., Lin X., Liu S.-Z., Ju G.-Z., Xu Q., Shang H., Shen Y., and Wei J. A genetic study of two calcium-independnet cytosolic PLA2 genes in schizophrenia. Prostaglandins Leukot. Essent. Fatty Acids 73 (2005) 351-354