Red cell membrane fatty acids, cytosolic phospholipase-A2 and schizophrenia

Schizophrenia Research

Volumn 31, Issue 2-3, 1998, Pages 185-196

  Doris, Alan B ^a   Wahle, Klaus ^b   MacDonald, Alison ^b   Morris, Stewart ^c   Coffey, Ian ^d   Muir, Walter ^a,c   Blackwood, Douglas ^a,c  

^a ROYAL EDINBURGH HOSPITAL   (United Kingdom)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d ST JOHN'S HOSPITAL   (United Kingdom)

Author keywords

Association study; Chromosome 1; Cytosolic phospholipase A2; Dihomogamma linolenic acid; Phospholipids; Schizophrenia

Indexed keywords

DIHOMO GAMMA LINOLENIC ACID; FATTY ACID; PHOSPHOLIPASE A2;

ADULT; ARTICLE; CAPILLARY GAS CHROMATOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE MEMBRANE; FEMALE; GENE FREQUENCY; HUMAN; LIPID COMPOSITION; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SYMPTOM;

ADULT; ALLELES; CASE-CONTROL STUDIES; ERYTHROCYTE MEMBRANE; FATTY ACIDS; FEMALE; GENETIC MARKERS; HUMANS; MALE; MATCHED-PAIR ANALYSIS; MEMBRANE LIPIDS; MIDDLE AGED; PHOSPHOLIPASES A; POLYMORPHISM, GENETIC; SCHIZOPHRENIA;

EID: 17544384839     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(98)00016-4     Document Type: Article

References (44)

1. Abdulla, Y.H., Hamadah, K., 1975. Effect of ADP on PGE1 formation in blood platelets from patients with depression, mania and schizophrenia. Br. J. Psychiatry 127, 591-595.
2. Atkinson, P.M., Wheeler, M.C., Mendelsohn, D., Pienaar, N., Chetty, N., 1987. Effects of a 4 week freshwater fish (trout) diet on platelet aggregation, platelet fatty acids, serum lipids, and coagulation factors. Am. J. Hematol. 24, 143-149.
3. Bazire, S., 1996. Comparative information on psychotropic drugs. Psychotropic Drug Directory. Mark Allen Publishing, Salisbury, Wiltshire, pp. 72-85.
4. Brenner, R.R., 1982. Nutritional and hormonal factors influencing desaturation of essential fatty acids. Progr. Lipid Res. 20, 41-48.
5. Brown, A.J., Pang, E., Roberts, C.K.. 1991. Persistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n-3 polyunsaturated fatty acids: study design implications. Am. J. Clin. Nutr. 54, 668-673.
6. Copland, S.A., McHardy, K.C., Wahle, K.W.J., Hutcheon, A.W., 1992. Altered stearic to oleic acid ratio in malignancy. Eur. J. Cancer 28A, 1135-1137.
7. Dougherty, R.M., Galli, C., Ferro-Luzzi, A., Iacono, J.M., 1987. Lipid and phospholipid fatty acid composition of plasma, red blood cells and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland and the USA. Am. J. Clin. Nutr. 45, 443-455.
8. Ebmeier, K.P., Blackwood, D.H.R., Murray, C. et al.. 1993. Single-photon emission computed tomography with 99mTc-Exametazine in unmedicated schizophrenic patients. Biol. Psychiatry 33, 487-495.
9. Endicott, J., Spitzer, R.L., 1978. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch. Gen. Psychiatry 35, 837-844.
10. Fischer, S., Kissling, W., Kuss, H.-J., 1992. Schizophrenic patients treated with high dose phenothiazine or thioxanthine become deficient in polyunsaturated fatty acids in their thrombocytes. Biochem. Pharmacol. 44, 317-323.
11. Gattaz, W.F., Schmitt, A., Maras, A., 1995. Increased platelet phospholipase-A2 activity in schizophrenia. Schizophr. Res. 16, 1-6.
12. Glen, A.I.M., Glen, E.M.T., Horrobin, D.F., Vaddadi, K.S., Spellman, M., Morse-Fisher, N., Ellis, K., Skinner, F.S., 1994. A red cell membrane abnormality in a subgroup of schizophrenic patients: evidence for two diseases. Schizophr. Res. 12, 53-61.
13. Guy, W., 1976. ECDEU Assessment Manual for Psychopharmacology. National Institute for Mental Health, Rockville, MD, pp. 76-338.
14. He, L., Mansfield, D.C., Brown, A.F., Green, D.K., Morris, S.W., St. Clair, D.M., Muir, W.J., Maclean, A., Wright, A.F.. Blackwood, D.H., 1995. Automated linkage analysis in psychiatric disorders. Am. J. Med. Gen. (Neuropsych. Gen.) 60, 192-198.
15. Horrobin, D.F., Glen. A.I.M., Vaddadi, K., 1994. The membrane hypothesis of schizophrenia. Schizophr. Res. 13, 195-207.
16. Houtia, N.E., Maziere, J.C., Maziere, C., Auclair, M., 1988. Phenothiazines inhibit cholesteryl ester formation in J774 monocyte like cells. J. Clin. Chem. Clin. Biochem. 26, 673-678.
17. Hudson, C.J., Kennedy, J.L., Gotowiec, A., Lin, A., King, N., Gojtan, K.. Macciardi, F., Skorecki, K., Meltzer, H.Y., Warsh, J.J., Horrobin, D.F., 1996. Genetic variant near cytosolic phospholipase A2 associated with schizophrenia. Schizophr. Res. 21, 111-116.
18. Johnstone, E.C., Frith, C.D.. 1996. Validation of three dimensions of schizophrenic symptoms in a large unselected sample of patients. Psychol. Med. 26, 669-679.
19. Kaiya, H., Horrobin, D.F., Manku, M.S., Morse-Fisher, N., 1991. Essential and other fatty acids in plasma in schizophrenics and normal individuals from Japan. Biol. Psychiatry 30, 357-362.
20. Kay, S.R., Fiszbein, A., Opler, L.A., 1987. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr. Bull. 13 (2). 261-275.
21. Krawiecka, M., Goldberg. D., Vaughan, M., 1977. A standardised psychiatric assessment scale for rating chronic psychotic patients. Acta Psychiatr. Scand. 55, 299-308.
22. Liddle, P.F., 1987. The symptoms of chronic schizophrenia: a re-examination of the positive negative dichotomy. Br. J. Psychiatry 151, 145-151.
23. Liddle, P.F., Morris, D., 1991. Schizophrenic syndromes and frontal lobe performance. Br. J. Psychiatry 158, 340-345.
24. Liddle, P.F., Friston, K.J., Frith, C.D. et al., 1992. Patterns of cerebral bloodflow in schizophrenia. Br. J. Psychiatry 160, 179-186.
25. Mahadik, S.P., Mukherjee, S., Horrobin, D.F., Jenkins, K., Correnti, E.E., Scheffer, R.E., 1996. Plasma membrane phospholipid fatty acid composition of cultured skin fibroblasts from schizophrenic patients: comparison with bipolar patients and normal subjects. Psychiatry Res. 63, 133-142.
26. Mansfield, D.C. et al., 1994. Automation of genetic linkage analysis using fluorescent microsatellite markers. Genomics 24, 225-233.
27. Nunez, E.A., 1993. Fatty Acids and Cell Signalling, Prostaglandino, Leukotrienes, EFA's 48, 1-122.
28. O'Brien, J.S., Samson, E.L., 1965. Lipid composition of the normal human brain: gray matter, white matter and myelin. J. Lipid Res. 6, 537-544.
29. Overall, J.E., Gorham, D.R., 1962. A Brief Psychiatric Rating Scale. Psychol. Rep. 10, 799-812.
30. Peet, M., Laugharne, J.D.E., Horrobin. D.F.. Reynolds, G.P., 1994. Arachidonic acid, a common link in the biology of schizophrenia? Arch. Gen. Psychiatry 51. 665-666.
31. Pettegrew, J.W., Keshavan, M.S., Panchalingam, K., Strychor, S., Kaplan, D.B., Tretta, M.G.. Allen. M., 1991. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. Arch. Gen. Psychiatry 48, 563-568.
32. Reitz, C., 1993. Dietary fatty acids and alcohol: effects on cellular membranes. Alcohol and Alcoholism 28, 59-71.
33. Rotrosen, J., Wolkin, A., 1987. Phospholipid and prostaglandia hypotheses of schizophrenia. In: Meltzer, H.J., (Ed.) Psychopharmacology: the Third Generation of Progress. Raven Press, New York.
34. Sanders, T.A.B., Roshanai, F., 1983. The influence of different types of omega-3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. Clin. Sci. 63, 91-99.
35. Sham, P., Curtis, D., 1995. Monte Carlo tests for association between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 59, 323-336.
36. 31P-MR spectroscopy study. Schizophr. Res. 13, 209-215.
37. Svennerholm, L.. 1968. Distribution and fatty acid composition of phosphoglycerides in normal human brain. J. Lipid Res. 9, 570-579.
38. Vaddadi, K.S., Gilleard C.J., 1990. Essential fatty acids, tardive dyskinesia and schizophrenia. In: Horrobin, D.F. (Ed.), Omega-6 Essential Fatty Acids, Pathophysiology and Roles in Clinical Medicine. Alan R. Liss, New York. pp. 33-343.
39. Vaddadi, K.S.. Gilleard, C.J., Soosai. E., Polonowita, A.K., Gibson, R.A., Burrows, G.D., 1996. Schizophr. Res. 20, 287-294.
40. Wahle. K.W.J., McIntosh, G., Duncan, W.R.H., James, W.P.T., 1991. Concentrations of linoleic acid in adipose tissue differ with age in women but not men. Eur. J. Clin. Nutr. 45, 195-202.
41. Wood, C.B., Habib, N.A., Thompson, A. et al., 1985. Increase of oleic acid in erythrocytes associated with malignancy. Br. Med. J. 291, 163-165.
42. Yamamoto, N., Saitoh, M., Moriuchi, A., Nomura, M., Okuyama, H., 1987. Effect of dietary alphalinolenate/linoleate balance on brain lipid compositions and learning ability of rats. J. Lipid Res. 28, 144-151.
43. Yao. J.K., van Kammen, D.P., Welker, J.A., 1994a. Red blood cell dynamics in schizophrenia. II. Fatty acid composition. Schizophr. Res. 13, 217-226.
44. Yao, J.K., van Kammen. D.P., Gurklis, J., 1994b. Red blood cell membrane dynamics in schizophrenia. III. Correlation of fatty acid abnormalities with clinical measures. Schizophr. Res. 13. 227-232.