Biomedical interfaces: Titanium surface technology for implants and cell carriers

Nanomedicine

Volumn 1, Issue 4, 2006, Pages 449-463

  Schuier, Martin ^a   Trentin, Quito ^a   Textor, Marcus ^a   Tosatti, Samuele G P ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Bioligand; Biomimetic; Drug delivery; Implant; Nonfouling; Peptide; Polyethylene glycol; Surface (bio)chemistry; Surface modification; Surface topography; Titanium

Indexed keywords

BIOMIMETIC MATERIAL; NANOMATERIAL; TITANIUM;

BIOTECHNOLOGY; CELL TRANSPLANTATION; CHEMISTRY; CULTURE TECHNIQUE; INSTRUMENTATION; METHODOLOGY; NANOTECHNOLOGY; PROSTHESES AND ORTHOSES; PROSTHESIS; REVIEW; SURFACE PROPERTY; ULTRASTRUCTURE;

BIOMIMETIC MATERIALS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CELL TRANSPLANTATION; NANOSTRUCTURES; NANOTECHNOLOGY; PROSTHESES AND IMPLANTS; PROSTHESIS DESIGN; SURFACE PROPERTIES; TITANIUM;

EID: 34548639934     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/17435889.1.4.449     Document Type: Article

References (128)

1. Titanium in Medicine. Brunette DM, Tengvall P, Textor M, Thomsen P (Eds), Springer-Verlag, Berlin & Heidelberg, Germany (2001).
2. Titanium and Titanium Alloys: Fundamentals and Applications. Lcycns C, Peters M (Eds), Wiley-VCH, Weinheim, Germany (2003).
3. Textor M, Sittig C, Frauchiger V.M., Tosatti SGP, Brunette DM Properties and biological significance of natural oxide films on titanium and its alloys. In: Titanium in Medicine. Brunette DM, Tengvall P, Textor M, Thomsen P (Eds). Springer-Verlag: Berlin & Heidelberg, Germany 171-230(2001).
4. Jansen JA, Vonrecum AF, Vandcrwaerdcn J, Degroot K: Soft-tissue response to different types of sintered metal fiber-web materials. Biomaterials 13, 959-968 (1992).
5. Albrektsson T et al.: The interface zone of inorganic implants in vivo - titanium implants in bone. Ann. Biomed. Eng. 11, 1-27(1983).
6. Rossetti FF, Bally M, Michel R., Textor M, Reviakinc I: Interactions between titanium dioxide and phosphatidyl serine-containing liposomes: formation and patterning of supported phospholipid bilayers on the surface of a medically relevant material. Langmuir 21, 6443-6450 (2005).
7. Davies JE: Bone Engineering. Em Squared Inc., Toronto, Canada (1999).
8. Jaeger, NAF, Brunette DM. Production of microfabricated surfaces and their effects on cell behaviour. In: Titanium in Medicine. Brunette DM, Tengvall P, Textor M, Thomsen P (Eds). Springer-Verlag, Berlin & Heidelberg, Germany 343-374 (2001).
9. Brunette DM, Kenner GS, Gould TRL: Grooved titanium surfaces orient growth and migration of cells from human gingival expiants, J Dent. Res. 62, 1045-1048 (1983).
10. Sykaras N, Iacopino AM, Marker V.A., Triplet RG, Woody RD: Implant materials, designs, and surface topographies: their effect on osseointegration. A literature review. Int.). Oral Maxillofac. Implants 15, 675-690 (2000).
11. Wennerberg A, Albrektsson T, Andersson B: Design and surface characteristics of 13 commercially available oral implant systems. Int. J. Oral Maxillofac. Implants 8, 622-633 (1993).
12. Wieland M. Experimental determination and quantitative evaluation of the surface composition and topography of medical implant surfaces and their influence on osteoblastic cell-surface interactions. In: Departement of Materials. Swiss Federal Institute of Technology, Zürich, Switzerland (1999).
13. Wieland M, Textor M, Spencer N.D., Brunette DM Measurement and evaluation of the chemical composition and topography of titanium implant surface. In: Bone Engineering. Davies JE (Ed.). Em Squared Inc, Toronto, Canada (2000).
14. Wieland M, Chehroudi B, Textor M., Brunette DM: Use of Ti-coated replicas to investigate the effects on fibroblast shape of surfaces with varying roughness and constant chemical composition. J. Biomed. Mater. Res. 60, 434-444 (2002).
15. Wieland M, Textor M, Spencer N.D., Brunette DM: Wavelength-dependent roughness: a quantitative approach to characterizing the topography of rough titanium surfaces. Int.]. Oral Maxillofac. Implants 16, 163-181 (2001).
16. Chauvy PF, Hoffmann P, Landolt D: Applications of laser lithography on oxide film to titanium micromachining. Appl. Surf. Sci. 208, 165-170 (2003).
17. Chauvy PF, Hoffmann P, Landolt D: Electrochemical micromachining of titanium through a laser patterned oxide film. Electrochem. Solid State Lett. 4, C31-C34(2001).
18. Dunand DC: Processing of titanium foams. Adv. Eng. Mater. 6, 369-376 (2004).
19. Schuier M, Kunzler TP, Sprecher C.M., de Wild M, Tosatti S, Textor M: Innovative method for the production of similar TiOj-coated cpoxy replicas used in cell culture assays. Presented at: Biosurf VI, Tissue-Surface-Interaction. September 21-23, Lausanne Switzerland (2005).
20. Schuier M, Owen GR, Hamilton DW et al.: Biomimetic modification of titanium dental implant model surfaces using the RGDSP-peptide sequence: a cell morphology study. Biomaterials 27, 4003-4015(2006).
21. Kunzler TP, Sprecher CM, Schuier M, Drobek T., Spencer ND: Fabrication of material-independent morphology gradients for high-throughput applications. Appl. Surf Sci. (2006) (In press).
22. Ratner BD: A perspective on titanium biocompatibility. In: Titanium in Medicine. Brunette DM, Tengvall P, Textor M, Thomsen P (Eds). Springer-Verlag, Berlin & Heidelberg, Germany 1-12 (2001).
23. Porter JA, von Fraunhofer JA: Success or failure of dental implants? A literature review with treatment considerations. Gen. Dent. 53, 423-432 (2005).
24. WHO: Diet, nutrition and the prevention of chronic diseases: report of a joint WHO/FAO expert consultation. In: WHO Technical Report Series. 916. WHO, Geneva, Switzerland (2002).
25. Morra M: Biochemical modification of titanium surfaces: peptides and ECM proteins. Eur. Cell. Mater. 24, 1-15 (2006).
26. Liu Y, Li JP, Hunziker E.B., De Groot K: Incorporation of growth factors into medical devices via biomimecic coatings. Philos. Transac. A Math. Phys. Eng. Sci. 364, 233-248 (2006).
27. Yang YZ, Kim KH, Ong JL: Review on calcium phosphate coatings produced using a sputtering process - an alternative to plasma spraying. Biomaterials 26, 327-337 (2005).
28. Sun LM, Berndt CC, Gross K.A., Kucuk A: Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: a review. J. Biomed. Mater. Res. 58, 570-592 (2001).
29. Hoffman AS: Hydrogels for biomedical applications. In: Bioartificial Organs III: Tissue Sourcing, Immunoisolation, and Clinical Trials. Hunkeler D, Cherrington A, Prokop A, Rajotte R (Eds), New York Acad Sciences, NY, USA 62-73 (2001).
30. Hoffman AS: Hydrogels for biomedical applications. Adv. Drug Deliv. Rev. 54, 3-12 (2002).
31. Lausmaa J: Mechanical, thermal, chemical and electrochemical surface treatment of titanium. In: Titanium in Medicine. Brunette DM, Tengvall P, Textor M, Thomsen P (Eds). Springer-Verlag, Berlin & Heidelberg, Germany 231-266 (2001).
32. Piveteau LD: Sol-gel coatings on titanium. In: Titanium in Medicine. Brunette DM, Tengvall P, Textor M, Thomsen P (Eds). Springer-Verlag, Berlin & Heidelberg, Germany 267-282 (2001).
33. Thull R, Grant D: Physical and chemical vapor deposition and plasma-assisted techniques for coating titanium. In: Titanium in Medicine. Brunette DM, Tengvall P, Textor M, Thomsen P (Eds). Springer-Verlag, Berlin & Heidelberg, Germany 283-341 (2001).
34. Grüner H: Thermal spray coatings on titanium. In: Titanium in Medicine. Brunette DM, Tengvall P, Textor M, Thomsen P (Eds). Springer-Verlag, Berlin & Heidelberg, Germany 375-416 (2001).
35. Tengvall P: Proteins at titanium interfaces. In: Titanium in Medicine. Brunette DM, Tengvall P, Textor M, Thomsen P (Eds). Springer-Verlag, Berlin & Heidelberg, Germany 457-484 (2001).
36. Schwartz J, Avaltroni MJ, Danahy MP et al.: Cell attachment and spreading on metal implant materials. Mater. Sci. Eng. C Biomimetic Supramol. Sys. 23, 395-400 (2003).
37. Zwahlen M, Tosatti S, Textor M., Hahner G: Orientation in methyl- and hydroxyl-terminated self-assembled alkanephosphatc monolayers on titanium oxide surfaces investigated with soft x-ray absorption. Langmuir 18, 3957-3962 (2002).
38. Tosatti S, Michel R, Textor M., Spencer ND: Self-assembled monolayers of dodecyl and hydroxy-dodecyl phosphates on both smooth and rough titanium and titanium oxide surfaces. Langmuir 18, 3537-3548 (2002).
39. Michael KE, Vernekar VN, Keselowsky B.G., Meredith JC, Latour RA, Garcia AJ: Adsorption-induced conformational changes in fibronectin due to interactions with well-defined surface chemistries. Langmuir 19, 8033-8040 (2003).
40. Massaro C, Rotolo P, De Riccardis F et al.: Comparative investigation of the surface properties of commercial titanium dental implants. Part I: chemical composition. J. Mater. Sci. Mater. Med. 13, 535-548 (2002).
41. Nuzzo RG, Allara DL: Adsorption of bifunctional organic disulfides on gold surfaces. J. Am. Chem. Soc. 105, 4481-4483 (1983).
42. Maege I, Jaehne E, Henke A et al: Self-assembling adhesion promoters for corrosion resistant metal polymer interfaces. Prog. Organic Coat. 34, 1-12 (1998).
43. Maege I, Jaehne E, Henke A et al.: Ultrathin organic layers for corrosion protection. Macromol. Symp. 126, 7-24 (1998).
44. Brovelli D, Hahner G, Ruiz L et al.: Highly oriented, self-assembled alkanephosphatc monolayers on tantalum(V) oxide surfaces. Langmuir 15, 4324-4327(1999).
45. Hofer R, Textor M, Spencer ND: Alkyl phosphate monolayers, self-assembled from aqueous solution onto metal oxide surfaces. Langmuir 17, 4014-4020 (2001).
46. Gawalt ES, Avaltroni MJ, Koch N, Schwartz J: Self-assembly and bonding of alkanephosphonic acids on the native oxide surface of titanium. Langmuir 17, 5736-5738 (2001).
47. Silverman BM, Wieghaus KA, Schwartz J: Comparative properties of siloxane vs phosphonate monolayers on a key titanium alloy. Langmuir 21, 225-228 (2005).
48. Textor M, Tosatti S, Wieland M., Brunette DM: Use of molecular assembly techniques for tailoring the chemical properties on smooth and rough titanium surfaces. In: Bio-Implant Interface-Improving Biomaterials and Tissue Reaction. Ellingsen JE, Lyngstadaas SP (Eds). CRC Press, Boca Raton, FL, USA (2003).
49. Wilson CJ, Clegg RE, Leavesley D.I., Pearcy MJ: Mediation of biomaterial-cell interactions by adsorbed proteins: a review. Tissue Eng. 11, 1-18 (2005).
50. Ku Y, Chung CP, Jang JH: The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior. Biomaterials 26, 5153-5157 (2005).
51. Bierbaum S, Beutner R, Hanke T., Scharnweber D, Hempel U, Worch H: Modification of Ti6A14V surfaces using collagen I, III, and fibronectin. I. Biochemical and morphological characteristics of the adsorbed matrix. J. Biomed. Mater. Res. A 67A, 421-430 (2003).
52. Bierbaum S, Hempel U, Geissler U et al: Modification of Ti6A14V surfaces using collagen I, III, and fibronectin. II. Influence on osteoblast responses. J. Biomed. Mater. Res. A 67A, 431-438 (2003).
53. Becker D, Geissler U, Hempel U et al.: Proliferation and differentiation of rat calvarial osteoblasts on type I collagen-coated titanium alloy. J. Biomed. Mater. Res. 59, 516-527 (2002).
54. van den Dolder J, Bancroft GN, Sikavitsas VI, Spauwen PHM, Mikos AG, Jansen JA: Effect of fibronectin- and collagen I-coated titanium fiber mesh on proliferation and differentiation of osteogenic cells. Tissue Eng. 9, 505-515 (2003).
55. Slack SM, Horbett TA: The Vroman effect - a critical review. In: Proteins at Interfaces II. Horbett TA, Brash JL (Eds), American Chemical Soc, Washington, USA 112-128(1995).
56. Morra M, Cassinelli C, Cascardo G et al.: Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies. Biomaterials 24, 4639-4654 (2003).
57. Scharnweber D, Born R, Flade K., Roessler S, Stoelzel M, Worch H: Mineralization behaviour of collagen type I immobilized on different substrates. Biomaterials 25, 2371-2380 (2004).
58. Mrksich M, Whitesides GM: Using self-assembled monolayers to understand the interactions of man-made surfaces with proteins and cells. Annu. Rev. Biophys. Biomol. Struct. 25, 55-78 (1996).
59. Dettin M, Conconi MT, Gambaretto R et al.: Effect of synthetic peptides on osteoblast adhesion. Biomaterials 26, 4507-4515(2005).
60. Xiao SJ, Textor M, Spencer N.D., Sigrist H: Covalent attachment of cell-adhesive, (Arg-Gly-Asp)-containing peptides to titanium surfaces. Langmuir 14, 5507-5516(1998).
61. Pierschbacher MD, Ruoslahti E: Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309, 30-33 (1984).
62. Main AL, Harvey TS, Baron M, Boyd J., Campbell ID: The 3-dimensional structure of the 10th type-Iii module of fibronectin - an insight into RGD-mediated interactions. Cell 71, 671-678 (1992).
63. Ruoslahti E: RGD and other recognition sequences for integrins. Annu. Rev. Cell Dev. Biol. 12, 697-715 (1996).
64. Dee KC, Andersen TT, Bizios R: Design and function of novel osteoblast-adhesive peptides for chemical modification of biomaterials. J. Biomed. Mater. Res. 40, 371-377 (1998).
65. Rezania A, Healy KE: Biomimetic peptide surfaces that regulate adhesion, spreading, cytoskeletal organization, and mineralization of the matrix deposited by osteoblast-like cells. Biotechnol. Prog. 15, 19-32 (1999).
66. Kapyla J, Jaalinoja J, Tulla M et al.: The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix, J. Biol. Chem. 279, 51677-51687(2004).
67. Gunn JW, Turner SD, Mann BK: Adhesive and mechanical properties of hydrogels influence neurite extension. J. Biomed. Mater. Res. A 72A, 91-97 (2005).
68. Cheng S, Craig WS, Mullen D, Tschopp J F, Dixon D, Pierschbacher MD: Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin a(Iib)β (3) antagonists. J. Med. Chem. 37, 1-8 (1994).
69. Samanen J, Ali F, Romoff T et al: Development of a small Rgd peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro. J. Med. Chem. 34, 3114-3125(1991).
70. Schaffner P, Dard MM: Structure and function of RGD peptides involved in bone biology. Cell. Mol Life Sci. 60, 119-132 (2003).
71. Dalton BA, McFarland CD, Underwood P.A., Steele JG: Role of the heparin-binding domain of fibronectin in attachment and spreading of human bone-derived cells, J Cell Sci. 108, 2083-2092 (1995).
72. Woods A, Couchman JR, Johansson S, Hook M: Adhesion and cytoskeletal organization of fibroblasts in response to fibronectin fragments. EMBOJ. 5, 665-670 (1986).
73. Zreiqat H, Akin FA, Howlett CR et al.: Differentiation of human bone-derived cells grown on GRGDSP-peptide bound titanium surfaces. J. Biomed. Mater. Res. A 64A, 105-113(2003).
74. Porte-Durrieu M.C., Guillemot F, Pallu S et al: Cydo-(DfKRG) peptide grafting onto TÎ-6A1-4V: physical characterization and interest towards human osteoprogenitor cells adhesion. Biomaterials 25, 4837-4846 (2004).
75. Senyah N, Hildebrand G, Liefeith K: Comparison between RGD-peptide-modified titanium and borosilicare surfaces. Anal. BioanaL Chem. 383, 758-762 (2005).
76. Pallu S, Bourget C, Bareille R et al: The effect of cyclo-DfKRG peptide immobilization on titanium on the adhesion and differentiation of human osteoprogenitor cells. Biomaterials 26, 6932-6940 (2005).
77. De Giglio E., Sabbatini L, Colucci S., Zambonin G: Synthesis, analytical characterization, and osteoblast adhesion properties on RGD-grafted polypyrrole coatings on titanium substrates, J. Biomater. Sci. Pofym. Ed. 11, 1073-1083 (2000).
78. Morra M: On the molecular basis of fouling resistance, J. Biomater. Sci. Pofym. Ed. 11, 547-569 (2000).
79. Davis FF: Commentary - the origin of pegnology. Adv. Drug Deliv. Rev. 54, 457-458 (2002).
80. Pasche S, Textor M, Meagher L., Spencer ND, Griesser HJ: Relationship between interfacial forces measured by colloid-probe atomic force microscopy and protein resistance of poly(ethylene glycol)-grafted poly(L-lysine) adlayers on niobia surfaces. Langmuir 21, 6508-6520 (2005).
81. Woodle MC, Engbers CM, Zalipsky S: New amphipatic polymer lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes. Bioconjug. Chem. 5, 493-496(1994).
82. Golander CG, Jonsson S, Vladkova T., Stenius P, Eriksson JC: Preparation and protein adsorption properties of photopolymerized hydrophilic films containing N-vinylpyrroiidone (Nvp), acrylic-acid (Aa) or ethyleneoxide (Eo) units as studied by esca. Colloids Surf. 21, 149-165 (1986).
83. Morra M, Cassineli C: Non-fouling properties of polysaccharide-coated surfaces. J Biomater. Sci. Pofym. Ed. 10, 1107-1124(1999).
84. Yoshikawa C, Goto A, Tsujii Y et al.: Protein repellency of well-defined, concentrated poly(2-hydroxyethyl methacrylate) brushes by the size-exclusion effect. Macromolecules 39, 2284-2290 (2006).
85. Yang SY, Mendelsohn JD, Rubner MF: New class of ultrathin, highly cell-adhesion-resistant polyelectrolyte multilayers with micropatterning capabilities. Biomacromolecules 4, 987-994 (2003).
86. Chen SF, Liu LY, Hang SY: Strong resistance of oligo(phosphorylcholine) self-assembled monolayers to protein adsorption. Langmuir 22, 2418-2421 (2006).
87. Saeki S, Kuwahara N, Nakata M., Kaneko M: Upper and lower critical solution temperatures in poly (ethyleneglycol) solutions. Polymer 17, 685-689 (1976).
88. Dalsin JL, Lin LJ, Tosatti S, Voros J., Textor M, Messersmith PB: Protein resistance of titanium oxide surfaces modified by biologically inspired mPEG-DOPA. Langmuir 21, 640-646 (2005).
89. Barber TA, Golledge SL, Castner D.G., Healy KE: Peptide-modified p(AAm-co-EG/AAc) IPNs grafted to bulk titanium modulate osteoblast behavior in vitro. J. Biomed. Mater. Res. A 64A, 38-47 (2003).
90. Harbers GM, Healy KE: The effect of ligand type and density on osteoblast adhesion, proliferation, and matrix mineralization. J. Biomed. Mater. Res. A 75A, 855-869 (2005).
91. Harbers GA, Gamble LJ, Irwin E.F., Castner DG, Healy KE: Development and characterization of a high-throughput system for assessing cell-surface receptor-ligand engagement. Langmuir 21, 8374-8384 (2005).
92. Barber TA, Harbers GM, Park S, Gilbert M., Healy KE: Ligand density characterization of peptide-modified biomaterials. Biomaterials 26, 6897-6905 (2005).
93. Healy KE, Harbers GM, Barber T.A., Sumner DR: Osteoblast interactions with engineered surfaces. In: Bone Engineering. Davies JE (Ed.). EMSSquared Inc., Toronto, Canada 268-281 (2000).
94. Garcia AJ, Collard DM, Keselowsky BG et al: Engineering of integrin-specific biomimetic surfaces to control cell adhesion and function, in biomimetic materials and design. Dillow AK, Lowman AM (Eds). Dekker, NY, USA 29-53 (2002).
95. Kenausis GL, Voros J, Elbert DL et al.: Poly(L-lysine)-g-poly(ethylene glycol) layers on metal oxide surfaces: attachment mechanism and effects of polymer architecture on resistance to protein adsorption. J Phys. Chem. B 104, 3298-3309 (2000).
96. Huang NP, Michel R, Voros J et al: Poly(L-lysine)-£-poly(ethylene glycol) layers on metal oxide surfaces: surface-analytical characterization and resistance to serum and fibrinogen adsorption. Langmuir 17, 489-498(2001).
97. Tosatti S, De Paul SM, Askendal A et al: Peptide functionalized poly(L-lysine)-£-poly(ethylene glycol) on titanium: resistance to protein adsorption in full heparinized human blood plasma. Biomaterials 24, 4949-4958 (2003).
98. Tosatti S, Schwartz Z, Campbell C et al.: RGD-containing peptide GCRGYGRGDSPG reduces enhancement of osteoblast differentiation by polyO-lysine graft-poly(ethylene glycol) coated titanium surfaces, J Biomed. Mater. Res. 68A, 458-472 (2004).
99. VandeVondele S, Voros J, Hubbell JA: RGD-gafted poly-L-lysine-graft- (polyethylene glycol) copolymers block non-specific protein adsorption while promoting cell adhesion. Biotechnol. Bioeng. 82, 784-790 (2003).
100. Boyan BD, Dean DD, Lohmann C.H., Cochran DL, Sylvia VL, Schwartz Z. The titanium-bone cell interface in vitro: the role of the surface in promoting osteointegration. In: Titanium in Medicine. Brunette DM et al. (Eds). Springer-Verlag, Berlin & Heidelberg, Germany 561-586 (2001).
101. Schuier M, Tosatti S, Hamilton DW et al: A novel experimental setup for testing primary osteoblasts on non-fouling peptide-modified titanium surfaces. In: 19th European Conference On Biomaterials. Sorrento, Naples, Italy (2005).
102. Harris LG, Tosatti S, Wieland M., Textor M, Richards RG: Staphylococcus aureus adhesion to titanium oxide surfaces coated with non-functionalized and peptide-functionalizcd poly(L-lysine)-grafted-poly(ethylene glycol) copolymers. Biomaterials 25, 4135-4148 (2004).
103. Maddikeri RR, Tosatti S, Richards R.G., Harris LG: Bacterial adhesion to PLL-£-PEG modified surfaces. Presented at: Biosurf VI, Tissue-Surface-Interaction. September 21-23, Lausanne, Switzerland (2005).
104. Groll J, Fiedler J, Engelhard E et al: A novel star PEG-derived surface coating for specific cell adhesion. J Biomed. Mater. Res. A 74A, 607-617 (2005).
105. Allen TM, Cullis PR: Drug delivery systems: entering the mainstream. Science 303, 1818-1822(2004).
106. Langer R: Drug delivery and targeting. Nature 392, 5-10(1998).
107. Palmaz JC: Intravascular stents in the last and the next 10 years. J Endovasc. Ther. 11, 200-206(2004).
108. Serruys P, Rensing B: Handbook of Coronary Stents (4tb Edition). Serruys P, Kutryk M (Eds), Verlag Martin Dunitz, London, UK (2002).
109. Sanchez AR, Sheridan PJ, Kupp LI: Is platelet-rich plasma the perfect enhancement factor? A current review. Int. J. Oral Maxillofac. Implants 18, 93-103 (2003).
110. Puleo DA, Kissling RA, Sheu MS: A technique to immobilize bioactive proteins, including bone morphogenetic protein-4 (BMP-4), on titanium alloy. Biomaterials 23, 2079-2087 (2002).
111. Smith DJ, Chakravarthy D, Pulfer S et al: Nitric oxide-releasing polymers containing the [N(O)NOK-) group. J. Med. Chem. 39, 1148-1156(1996).
112. Frost MC, Reynolds MM, Meyerhoff ME: Polymers incorporating nitric oxide releasing/generating substances for improved biocompatibility of blood-contactincy medical devices. Biomaterials 26, 1685-1693 (2005).
113. Piotrowicz A, Shoichet MS: Nerve guidance channels as drug delivery vehicles. Biomaterials 27, 2018-2027 (2006).
114. Ehrbar M, Djonov VG, Schnell C et al.: Cell-demanded liberation of VEGF(121) from fibrin implants induces local and controlled blood vessel growth. Circ. Res. 94, 1124-1132(2004).
115. Holland TA, Tessmar, JKV, Tabata Y, Mikos AG: Transforming growth factor-β 1 release from oligo(poly(ethylene glycol) fumarate) hydrogels in conditions that model the cartilage wound healing environment. J. Control. Release 94, 101-114(2004).
116. Seol Y, Park Y, Lee S et al: Enhanced osteogenic promotion around dental implants with synthetic binding motif mimicking bone morphogenetic protein (BMP)-2. J. Biomed Mater. Res. A 77, 599-607 (2006).
117. Catauro M, Raucci MG, de Marco D, Ambrosio L: Release kinetics of ampicillin, characterization and bioactivity of Ti02/PCL hybrid materials synthesized by sol-gel processing. J. Biomed. Mater. Res. A 77, 340-350 (2006).
118. Rupp F, Scheideler L, Olshanska N., de Wild M, Wieland M, Geis-Gerstorfer J: Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J Biomed Mater. Res. A 76A, 323-334 (2006).
119. Buser D, Broggini N, Wieland M et al: Enhanced bone apposition to a chemically modified SLA titanium surface. J Dent. Res. 83, 529-533 (2004).
120. Ferguson SJ, Broggini N, Wieland M et al: Biomechanical evaluation of the interfacial strength of a chemically modified sandblasted and acid-etched titanium surface. J Biomed. Mater. Res. A 78A, 291-297 (2006).
121. Morra M, Cassinelli C, Meda L., Fini M, Giavaresi G, Giardino R: Surface analysis and effects on interfacial bone microhardness of collagen-coated titanium implants: a rabbit model. Int. J. Oral Maxillofac. Implants 20, 23-30 (2005).
122. Kroese-Deutman H.C., Van Den Dolder J, Spauwen PHM, Jansen JA: Influence of RGD-loaded titanium implants on bone formation in vivo. Tissue Eng. 11, 1867-1875 (2005).
123. Elmengaard B, Bechtold JE, Soballe K: in vivo study of the effect of RGD treatment on bone ongrowth on press-fit titanium alloy implants. Biomaterials 26, 3521-3526 (2005).
124. Bernhardt R, van den Dolder J, Bierbaum S et al.: Osteoconductive modifications of Ti-implants in a goat defect model: characterization of bone growth with SR mu CT and histology. Biomaterials 26, 3009-3019 (2005).
125. O'TooIe G.C., Salih E, Gallagher C., FitzPatrick D, O'Higgins N, O'Rourke SK: Bone sialoprotein-coated femoral implants are osteoinductive but mechanically compromised, J Orthop. Res. 22, 641-646 (2004).
126. Germanier Y, Tosatti S, Broggini N., Textor M, Buser D: Enhanced bone apposition around biofunctionalized sandblasted and acid-etched titanium implant surfaces - a histomorphomerric study in miniature pigs. Clin. Oral Implants Res. 17, 251-257 (2006).
127. Scacchi M, Merz BR, Schar AR: The development of the ITI® DENTAL IMPLANT SYSTEM: Part 2. 1998-2000: Steps into the next millennium. Clin. Oral Implants Res. 11, 22-32 (2000).
128. Zainuddin, Albinska J, Ulanski P, Rosiak JM: Radiation-induced degradation and crosslinking of poly(ethylene oxide) in solid state. J. Radioanalytical Nuclear Chem. 253, 339-344 (2002).