Release kinetics of ampicillin, characterization and bioactivity of TiO2/PCL hybrid materials synthesized by sol-gel processing

Journal of Biomedical Materials Research - Part A

Volumn 77, Issue 2, 2006, Pages 340-350

  Catauro, M ^a   Raucci, M G ^b   De Marco, D ^b   Ambrosio, L ^b  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Bioactivity; Organic inorganic hybrid; Sol gel

Indexed keywords

SODIUM AMPICILLIN; SYNTHETIC TREATMENT;

BIOACTIVITY; CONTROLLED DRUG DELIVERY; HYBRID MATERIALS; HYDROGEN BONDS; PLASMA (HUMAN); POLYCAPROLACTONE; SOL-GEL PROCESS; TITANIUM DIOXIDE;

ANTIBIOTICS;

AMPICILLIN; BIOMATERIAL; CARBOXYLIC ACID; CHLOROFORM; HYDROXYAPATITE; POLYCAPROLACTONE; POLYMER; TITANIUM BUTOXIDE; TITANIUM DERIVATIVE; TITANIUM DIOXIDE; UNCLASSIFIED DRUG; WATER; AQUAPLAST, CAPROLACTONE; DRUG CARRIER; POLYESTER; TITANIUM;

ARTICLE; ATOMIC FORCE MICROSCOPY; DRUG DELIVERY SYSTEM; DRUG RELEASE; GEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYBRID; HYDROGEN BOND; INFRARED SPECTROSCOPY; KINETICS; MEASUREMENT; MORPHOLOGY; POROSITY; SCANNING ELECTRON MICROSCOPE; SURFACE PROPERTY; SYNTHESIS; ULTRAVIOLET SPECTROSCOPY; CHEMICAL STRUCTURE; CHEMISTRY; EVALUATION; HUMAN; MATERIALS TESTING;

AMPICILLIN; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GELS; HUMANS; MATERIALS TESTING; MICROSCOPY, ATOMIC FORCE; MOLECULAR STRUCTURE; POLYESTERS; SURFACE PROPERTIES; TITANIUM;

EID: 33749064356     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.30617     Document Type: Article

References (48)

1. Granick S (editor). Polymers in confined environments. Advances in Polymer Science, 138, New York: Springer; 1998.
2. Zhu S, Liu Y, Rafailovich MH, Sokolov J, Gersappe D, Winsett DA, Ade H. Confinement-induced miscibility in polymer blends. Nature 1999;400:449.
3. Jones RL, Kumar SK, Ho DL, Briber RM, Russel TP. Chain conformation in ultrathin polymer films. Nature 1999;400:146.
4. Frank CW, Rao V, Dspotopoulou MM, Pease RFW, Hisberg WD, Miller RD, Rabolt JF. Structure in thin and ultrathin spin-cast polymer films. Science 1996;273:912-915.
5. Calvert P. When a thick film is thin. Nature 1996;384:311.
6. Hu HW, Granick S. Viscoelastic dynamics of confined polymer melts. Science 1992;258:1339-1342.
7. Alsten JV, Granick S. Molecular tribometry of ultrathin liquid films. Phys Rev Lett 1988;61:2570.
8. Ahrens H, Forster S, Helm CA. Charged polymer brushes: Counterion incorporation and scaling relations. Phys Rev Lett 1998;81:4172-4175.
9. Zheng X, Rafailovich MH, Sokolov J, Strzhemechny Y, Schwarz SA. Long-range effects on polymer diffusion induced by a bounding interface. Phys Rev Lett 1997;79:241-244.
10. Novak MB. Hybrid nanocomposite materials - between inorganic glasses and organic polymers. Advanced Mater 1993;5: 422-433.
11. Ellsworth MW, Novak BM. Mutually interpenetrating inorganic-organic networks. New routes into nonshrinking sol-gel composite materials. J Am Chem Soc 1991;113:2756-2758.
12. Novak BM, Davies C. "Inverse" organic-inorganic composite materials. 2. Free-radical routes into nonshrinking sol-gel composites. Macromolecules 1991;24:5481-5483.
13. Novak BM, Ellsworth MW. "Inverse" organic-inorganic composite materials: High glass content non-shrinking sol-gel composites. Mater Sci Eng A 1993;162:257-264.
14. Ellsworth MW, Novak BM. "Inverse" organic-inorganic composite materials. 3. High glass content "nonshrinking" sol-gel composites via poly(silicic acid esters). Chem Mater 1993;5: 839-844.
15. Loy BA, Shea KJ. Bridged polysilsesquioxanes. Highly porous hybrid organic-inorganic materials. Chem Rev 1995;95:1431-1442.
16. Schubert U, Husing N, Lorenz A. Hybrid inorganic-organic materials by sol-gel processing of organofunctional metal alkoxides. Chem Mater 1995;7:2010-2027.
17. Loy DA, Jamison GM, Augher BM, Myers SA, Assink RA, Shea KJ. Sol-gel synthesis of hybrid organic-inorganic materials. Hexylene. And phenylene-bridged polysiloxanes. Chem Mater 1996;8:656-663.
18. Jackson CL, Bauer BJ, Nakatani Al, Barnes JD. Synthesis of hybrid organic-inorganic materials from interpenetrating polymer network chemistry. Chem Mater 1996;8:727-733.
19. Mark JE, Lee CYC, Bianconi PA, (editors). Hybrid Organic-Inorganic composites. ACS Symposium Series 585. Washington DC: ACS; 1995.
20. Prakash SS, Brinker CJ, Hurd AJ, Rao SM. Silica aerogel films prepared at ambient pressure by using surface derivatization to induce reversible drying shrinkage. Nature 1995;21:439-443.
21. Naddad TS, Lichtenhan JD. Hybrid organic-inorganic thermoplastics: Styryl-based polyhedral oligomeric silsesquioxane polymers. Macromolecules 1996;29:7302-7304.
22. Landry CJT, Coltrain BK, Teegarden DM, Lond TE, Lond VK. Use of organic copolymers as compatibilizers for organic-inorganic composites. Macromulecules 1996;29:4712-4721.
23. Vaia RA, Vasudevan S, Kroviee W, Scanion LG, Ginnelis EP. New polymer electrolyte nanocomposites: Melt intercalation of poly(ethylene oxide) in mica-type silicates. Advanced Mater 1995;7:154-156.
24. Novak BM, Ellsworth M, Wallow T, Davies C. Simultaneous interpenetrating networks of inorganic glasses and organic polymers. New routes into nonshrinking sol-gel derived composites. Polymer Prepr 1990;31:698.
25. Huang HH, Orler B, Wilkes GH. Structure-property behavior of new hybrid materials incorporating oligomeric species into sol-gel glasses. 3. Effect of acid content, tetraethoxysilane content, and molecular weight of poly(dimethylsiloxane). Macromolecules 1987;20:1322-1330.
26. Brinker CJ, Scherer G. Sol-gel Science, The Physics and Chemistry of Sol-Gel Processing. New York: Academic Press; 1990.
27. Nakamura T, Shimizu Y, Matsui T, Okumura N, Hyon SH, Nishiya K. In: Planck H, Dauner M, Renardy M, editors. Degradation phenomena on polymeric biomaterials: proceedings of the 4th International ITV Conference on Biomaterials. Berlin: Springer; 1992. p 153.
28. David IA, Scherer GW. An organic/inorganic single-phase composite. Chem Mater 1995;7:1957.
29. Landry CJT, Coltrain BK, Wesson JA, Lipper JL. In situ polymerization of tetraethoxysilane in poly(methyl methacrylate): Morphology and dynamic mechanical properties. Polymer 1992;33:1486-1495.
30. Fitzgerald JJ, Landry CJT, Pochan JM. Dynamic studies of the molecular relaxations and interactions in microcomposites prepared by in-situ polymerization of silicon alkoxides. Macromolecules 1992; 25:3715-3722.
31. Wie Y, Bakthavatchalam R, Whitecar CK. Synthesis of new organic-inorganic hybrid glasses. Chem Mater 1990;2:337-339.
32. Saegusa T. Organic/inorganic polymer hybrids. Macromol Symp 1995;98:719.
33. Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontol 2000 1996;10:139-159.
34. Farag SA. Simultaneous liquid chromatographic analysis of the β-lactam antibiotics cefazolin, cefadroxil, cephalexin, ampicillin, and cephradine in solution. J AOAC Int 1998;81:381-385.
35. Somayasi BV, Jariwalau U, Jaya Chandran P, Vidyalakshimi K, Dudhami RV. Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery system. J Periodontol 1998;69:409-413.
36. Unsal E, Akkaya M, Walsh TF. Influence of a single application of subgingival chlorhexidine gel or tetracycline paste on the clinical parameters of adult periodontitis patients. J Clin Periodontol 1994;21:351-355.
37. Steinberg D, Friedman M, Soskolne A, Sela MN. A new degradable controlled release device for treatment of periodontal disease: in vitro release study. J Periodontol 1990;61:393-398.
38. 2 hybrid material. J Mater Sci 2003;38:3097-3102.
39. 2 hybrid material. J Mater Sci Med 2004;15:991-995.
40. Kokubo T. Proceedings of the XVI International Congress on Glass, Madrid, 1992. Boll Soc Esp Ceram Vid 1(31-C1), 119, 1999.
41. 5 glasses in a simulated body fluid. J Non-Cryst Solids 1992;143:84-92.
42. Hench LL, Clark DE. Physical chemistry of glass surfaces. J Non-Cryst Solids 1978;28:83-105.
43. Paul A. Chemistry of Glasses, 2nd ed. London: Chapman and Hall; 1990. p 184.
44. Wang DS, Pantano CG. Surface chemistry of multicomponent silicate gels. J Non-Cryst Solids 1992;147/148:115-122.
45. Thomas M. In: Ando DJ, editor. Ultraviolet and Visible Spectroscopy, 2nd ed. England: Wiley; 1996. p 16-30.
46. Sanchez C, Livage J, Henry M, Babonneau F. Chemical modification of alkoxide precursors. J Non-Cryst Solids 1988;100:65.
47. Radlein E, Frischot GH. Atomic force microscopi as a tool to correlate nanostructure to properties of glasses. J Non-Cryst Solids 1997;222:69-82.
48. Kim Y, Clark AE. Early stages of calcium-phosphate layer formation in bioglasses. J Non-Cryst Solids 1989;113:195-202.