Reduced histamine levels and H3 receptor antagonist-induced histamine release in the amygdala of Apoe-/- mice

Journal of Neurochemistry

Volumn 103, Issue 1, 2007, Pages 124-130

  Van Meer, Peter ^a   Pfankuch, Tim ^a   Raber, Jacob ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Amygdala; apoE; Histamine; Histamine H3 receptor; Mice

Indexed keywords

APOENZYME; HISTAMINE; HISTAMINE H3 RECEPTOR ANTAGONIST; THIOPERAMIDE;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; GENOTYPE; HISTAMINE RELEASE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC MEMBRANE; WILD TYPE;

MUS;

EID: 34548628948     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04705.x     Document Type: Article

References (32)

1. Acevedo S., Ohtsu H., Benice T., Rizk-Jackson A. Raber J. (2006) Age-dependent effects on measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc-/-) mice. Brain Res. 1071, 113 123.
2. Alguacil L. F. Perez-Garcia C. (2003) Histamine H3 receptor: a potential drug target for the treatment of central nervous system disorders. Current Drug Targets - CNS & Neurol. Disorders 2, 303 313.
3. Arrang J. M., Garbarg M. Schwartz J. C. (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 302, 832 837.
4. Bongers G., Leurs R., Robertson J. Raber J. (2004) Role of H3 receptor-mediated signaling in anxiety and cognition in wild-type and Apoe-/- mice. Neuropsychopharmacology 29, 441 449.
5. Brown R. E., Stevens D. R. Haas H. L. (2001) The physiology of brain histamine. Prog. Neurobiol. 63, 637 672.
6. Farrer L. A., Cupples L. A., Haines J. L., Hyman B., Kukull W. A., Mayeux R., Myers R. H., Pericak-Vance M. A., Risch N. van Duijn C. M. (1997) Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. J. Am. Med. Assoc. 278, 1349 1356.
7. Ferreti L., McCurry S. M., Logsdon R., Gibbons L. Teri L. (2001) Anxiety and Alzheimer's disease. J. Geriatr. Psychiatr. Neurol. 14, 52 58.
8. Haas H. L. Panula P. (2003) The role of histamine and the tubermamillary nucleus in the nervous system. Nature Rev. Neurosci. 4, 121 130.
9. Hill S. J., Ganellin C. R., Timmerman H., Schwartz J. C., Shankley N. P., Young J. M., Schunack W., Levi R. Haas H. L. (1997) International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacol. Rev. 49, 253 278.
10. Huang M., Pang X., Letourneau R., Boucher W. Theoharides T. (2002) Acute stress induces cardiac mast cell activation and histamine release, effects that are increased in Apolipoprotein E knockout mice. Cardiovascul. Res. 55, 150 160.
11. Igbavboa U., Hamilton J., Kim H., Sun G. Wood W. (2002) A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes. J. Neurochem. 80, 255 261.
12. Igbavboa U., Eckert G., Malo T. et al. (2005) Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and increasing age. J. Neurol. Sci. 229-230, 225 232.
13. Kukko-Lukjanow T.-. K., Soini S., Taira T., Michelsen K. A., Panula P. Holopainen I. E. (2006) Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system. J. Neurosci. 26, 1088 1097.
14. Leurs R., Blandina P., Tedford C. Timmerman H. (1998) Therapeutic potential of histamine H3 receptor agonists and antagonists. Trends Pharmacol. Sci. 19, 177 183.
15. Lomnitski L., Oron L., Sklan D. Michaelson D. (1999) Distinct alterations in phospholipid metabolism in brains of apolipoprotein E-deficient mice. J. Neurosci. Res. 58, 586 592.
16. Lovenberg T. W., Roland B. L., Wilson S. J., Jiang X., Pyati J., Huvar A., Jackson M. R. Erlander M. G. (1999) Cloning and functional expression of the human histamine H3 receptor. Mol. Pharmacol. 55, 1101 1107.
17. Mahley R. Huang Y. (1999) Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr. Opin. Lipidol. 10, 207 217.
18. Medhurst A. D., Atkins A. R., Beresford I. J. et al. (2007) GSK189254 - a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J. Pharmacol. Exp. Ther. 321, 1032 1045.
19. Miklos I. H. Kovacs K. J. (2003) Functional heterogeneity of the responses of histaminergic neuron subpopulation to various stress challenges. Eur. J. Neurosci. 18, 3069 3079.
20. Nakamura T., Itadani H., Hidaka Y., Ohta M. Tanaka K. (2000) Molecular cloning and characterization of a new human histamine receptor, HH4R. Biochem. Biophys. Res. Comm. 279, 615 620.
21. Ohtsu H., Tanaka S., Terui T. et al. (2001) Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett. 502, 53 56.
22. Okuizumi K., Onodera O., Tanaka H. et al. (1994) ApoE-Ó4 and early-onset Alzheimer's. Nature Genet. 7, 10 11.
23. Oroszi G., Enoch M., Chun J., Virkkunen M. Goldman D. (2005) Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations. Alcholism Clin. Exp. Res. 29, 303 309.
24. Piedrahita J. A., Zhang S. H., Hagaman J. R., Oliver P. M. Maeda N. (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl. Acad. Sci. USA 89, 4471 4475.
25. Plump A. S., Smith J. D., Hayek T., Aalto-Setealea K., Walsh A., Verstuyft J. G., Rubin E. M. Breslow J. L. (1992) Severe hypocholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71, 343 353.
26. Raber J. (2005) Histamine receptors as potential therapeutic targets to treat anxiety and depression. Drug Dev. Res. 65, 126 132.
27. Raber J., Mehta P., Kreifeldt M., Parsons L., Weiss F., Bloom F. Wilson M. (1997) Coloboma hyperactive mutant mice exhibit regional and transmitter-specific deficits in neurotransmission. J. Neurochem. 68, 176 186.
28. Raber J., Akana S. F., Bhatnagar S., Dallman M. F., Wong D. Mucke L. (2000) Hypothalamic-pituitary-adrenal function in Apoe-/- mice: Possible role in behavioral and metabolic alterations. J. Neurosci. 20, 2064 2071.
29. Saper C. German D. (1987) Hypothalamic pathology in Alzheimer's disease. Neurosci. Lett. 74, 364 370.
30. Silverman A., Sutherland A., Wilhelm M. Silver R. (2000) Mast cells migrate from blood to brain. J. Neurosci. 20, 401 408.
31. Simpson J., Yates C., Watts A. Fink G. (1988) Congo red birefringent structures in the hypothalamus in senile dementia of the Alzheimer type. Neuropathol. Appl. Neurobiol. 14, 381 393.
32. Yawata I., Tanaka K., Nakgawa Y., Murashima Y. L. Nakano K. (2004) Role of histaminergic neurons in development of epileptic seizures in EL mice. Mol. Brain Res. 132, 13 17.