Efficacy and safety of Allium sativum (garlic)

Focus on Alternative and Complementary Therapies

Volumn 12, Issue 3, 2007, Pages 162-166

  Izzo, Angelo A ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Adverse effects; Allium sativum; Garlic; Herb drug interaction; Herbal medicine; Phytopharmacovigilance

Indexed keywords

AJOENE; CHLORPROPAMIDE; CHOLESTEROL; FLUINDIONE; GARLET; GARLIC EXTRACT; GARLIC OIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PARACETAMOL; PLACEBO; RITONAVIR; SAQUINAVIR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; WARFARIN;

ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; BLEEDING; BLEEDING TENDENCY; BLOOD CLOTTING TIME; CANCER PREVENTION; CANCER RISK; CARDIOVASCULAR FUNCTION; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; COMMON COLD; CONTACT DERMATITIS; DERMATOMYCOSIS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DRUG POTENTIATION; DRUG SAFETY; DYSPEPSIA; EPIDURAL HEMATOMA; FIBRINOLYSIS; GARLIC; GASTROINTESTINAL SYMPTOM; GLYCEMIC CONTROL; HALITOSIS; HELICOBACTER INFECTION; HERBAL MEDICINE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INTERMITTENT CLAUDICATION; INTRAOCULAR PRESSURE; NAUSEA; NONHUMAN; PEMPHIGUS; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHOTOALLERGY; PREECLAMPSIA; RETROBULBAR HEMORRHAGE; RHEUMATOID ARTHRITIS; RISK REDUCTION; SIDE EFFECT; THROMBOCYTE AGGREGATION INHIBITION; THRUSH; TICK BITE; TRIACYLGLYCEROL BLOOD LEVEL; UNSTABLE ANGINA PECTORIS; URTICARIA;

EID: 34548612251     PISSN: 14653753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Capasso F, Gaginella TS, Grandolini G, Izzo AA. Phytotherapy. A Quick Reference to Herbal Medicine. Berlin: Springer-Verlag, 2003.
2. Ernst E, Pittler MH, Wider B, Boddy K. The Desktop Guide to Complementary and Alternative Medicine, Edinburgh: Mosby Elsevier, 2006.
3. Johns Cupp M. Toxicology and Clinical Pharmacology of Herbal Products. Totowa, NJ: Humana Press, 2000.
4. Schulz V, Hansel R, Blumenthal M, Tyler VE. Rational Phytotherapy. Berlin: Springer-Verlag, 2004.
5. Rotblatt M, Ziment I. Evidence-based Herbal Medicine. Philadelphia, PA: Hanley & Belfus Inc., 2002.
6. Rahman K, Lowe GM. Garlic and cardiovascular disease: a critical review. J Nutr 2006; 136: S736-40.
7. Ackermann RT, Mulrow CD, Ramirez G etal. Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med 2001; 161: 813-24.
8. Stevinson C, Pittler MH, Ernst E. Garlic for treating hypercholesterolemia. A meta-analysis of randomized clinical trials. Ann Intern Med 2000: 133: 420-9.
9. Alder R, Lookinland S, Berry JA et al. A systematic review of the effectiveness of garlic as an anti-hyperlipidemic agent. J Am Acad Nurse Pract 2003; 15: 120-9.
10. Silagy C, Neil A. Garlic as a lipid lowering agent - a meta-analysis. J R Coll Physicians Lond 1994; 28: 39-45.
11. Meher S, Duley L. Garlic for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 2006; 3: CD006065.
12. Budoff M. Aged garlic extract retards progression of coronary artery calcification. J Nutr 2006; 136: S741-4.
13. Koscielny J, Klussendorf D, Latza R et al. The anti-atherosclerotic effect of Allium sativum. Atherosclerosis 1999; 144: 237-49.
14. Breithaupt-Grogler K, Ling M, Boudoulas H et al. Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation 1997; 96:2649-55.
15. Bingham S, Riboli E. Diet and cancer - the European Prospective Investigation into Cancer and Nutrition. Nat Rev Cancer 2004; 4: 206-15.
16. Boon H, Wong J. Botanical medicine and cancer: a review of the safety and efficacy. Expert Opin Pharmacother 2004; 5: 2485-501.
17. Tanaka S, Haruma K, Kunihiro M et al. Effects of aged garlic extract (AGE) on colorectal adenomas: a double- blinded study. Hiroshima J Med Sci 2000; 53: 39-45.
18. Ishikawa. H, Saeki T, Otani T et al. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr 2006; 136: S816-20.
19. You WC, Brown LM, Zhang L et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006; 98: 974-83.
20. Ledezma E, Marcano K, Jorquera A et al. Efficacy of ajoene in the treatment of tinea pedis: a double-blind and comparative study with terbinafine. J Am Acad Dermatol 2000; 43: 829-32.
21. Sabitha P, Adhikari PM, Shenoy SM et al. Efficacy of garlic paste in oral candidiasis. Trop Doct 2005; 35: 99-100.
22. Aydin A, Ersoz G, Tekesin O et al. Garlic oil and Helicobacter pylori infection. Am J Gastroenterol 2000; 95: 563-4.
23. Stjernberg L, Berglund J. Garlic as a tick repellent. JAMA 2001; 285: 41-2.
24. Rajan TV, Hein M, Porte P et al. A double-blinded, placebo-controlled trial of garlic as a mosquito repellent: a preliminary study. Med Vet Entomol 2005; 19: 84-9.
25. Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther 2001; 18: 189-93.
26. Denisov LN, Andrianova IV, Timofeeva SS. Garlic effectiveness in rheumatoid arthritis. Ter Arkh 1999; 71: 55-8.
27. Beck E, Grunwald J. Allium sativum in der Stufentherapie der Hyperlipidaemie. Med Welt 1993; 44: 516-20.
28. Bojs G, Svensson A. Contact allergy to garlic used for wound healing. Contact Dermatitis 1988; 18: 179-81.
29. Burden AD, Wilkinson SM, Beck MH et al. Garlic-induced systemic contact dermatitis. Contact Dermatitis 1994; 30: 299-300.
30. Pires G, Pargana E, Loureiro V et al. Allergy to garlic. Allergy 2002; 57: 957-8.
31. Asero R, Mistrello G, Roncarolo D et al. A case of garlic allergy. J Allergy Clin Immunol 1998; 101: 427-8.
32. Perez-Pimiento AJ Moneo I, Santaolalla M et al. Anaphylactic reaction to young garlic. Allergy 1999; 54: 626-9.
33. Ruocco V, Brenner S, Lombardi ML. A case of diet-related pemphigus. Dermatology 1996; 192: 373-4.
34. Alvarez MS, Jacobs S, Jiang SB et al. Photocontact allergy to diallydisulfide. Am J Contact Dermat 2003; 14: 161-5.
35. Fernandez-Vozmediano JM, Armario-Hita JC, Manrique-Plaza A. Allergic contact dermatitis from diallyl disulfide. Contact Dermatitis 2000; 42: 108-9.
36. Hubbard VG, Goldsmith P. Garlic-fingered chefs. Contact Dermatitis 2005: 52: 165-6.
37. Seuri M, Taivanen A, Ruoppi P et al. Three cases of occupational asthma and rhinitis caused by garlic. Clin Exp Allergy 1993; 23: 1011-14.
38. Jappe U, Bonnekoh B, Hausen BM, Gollnick H. Garlic-related dermatoses: case report and review of the literature. Am J Contact Dermat 1999; 10: 37-9.
39. Moyle M, Frowen K, Nixon R. Use of gloves in protection from diallyl disulphide allergy. Australas J Dermatol 2004; 45: 223-35.
40. Rafaat M, Leung AK. Garlic burns. Pediatr Dermatol 2000; 17: 475-6.
41. McGovern TW, LaWarre S. Botanical briefs: garlic - Allium sativum. Cutis 2001; 67: 193-4.
42. Friedman T, Shalom A, Westreich M. Self-inflicted garlic burns: our experience and literature review. Int J Dermatol 2006; 45: 1161-3.
43. Dietz DM, Varcelotti JR, Stahlfeld KR. Garlic burns: a not-so-rare complication of a naturopathic remedy? Bums 2004: 30: 612-13.
44. Baruchin AM, Sagi A, Yoffe B et al. Garlic burns. Burns 2001; 27: 781-2.
45. Ang-Lee MK, Moss J, Yuan CS et al. Herbal medicines and perioperative care. JAMA 2001; 286: 208-16.
46. Rose KD, Croissant PD, Parliament CF et al. Spontaneous spinal epidural hematoma. with associated platelet dysfunction from excessive garlic ingestion: a case report. Neurosurgery 1990; 26: 880-2.
47. Burnham BE. Garlic as a possible risk for postoperative bleeding. Plast Reconstr Surg 1995; 95: 213.
48. German K, Kumar U, Blackford HN. Garlic and the risk of TURP bleeding. Br J Urol 1995; 76: 518.
49. Carden SM, Good WV, Carden PA et al. Garlic and the strabismus surgeon. Clin Experiment Ophthalmol 2002; 30: 303-4.
50. Ziaei S, Hantoshzadeh S, Rezasoltani P et al. The effect of garlic tablet on plasma lipids and platelet aggregation in nulliparous pregnants at high risk of preeclampsia. Eur J Obstet Gynecol Reprod Biol 2001; 99: 201-6.
51. Mennella JA, Johnson A, Beauchamp GK. Garlic ingestion by pregnant women alters the odor of amniotic fluid. Chem Senses 1995; 20: 207-9.
52. Mennella JA, Beauchamp GK. Maternal diet alters the sensory qualities of human milk and the nursling's behaviour. Pediatrics 1991; 88: 737-44.
53. Izzo AA. Herb-drug interactions: an overview of the clinical evidence. Fundam Clin Pharmacol 2005; 19: 1-16.
54. Sunter WH. Warfarin and garlic. Pharm J 1991; 246: 772.
55. Pathak A, Leger P, Bagheri H et al. Garlic interaction with fluindione: a case report. Therapie 2003; 58: 380-1.
56. Macan H, Uykimpang R, Alconcel M et al. Aged garlic extract may be safe for patients on warfarin therapy. J Nutr 2006; 136: S793-5.
57. Piscitelli SC, Burstein AH, Welden N et al. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis 2002; 34: 234-8.
58. Gallicano K, Foster B, Choudhri S. Effect of short-term administration of garlic supplements on single-dose ritonavir pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2003; 55: 199-202.
59. Markowitz JS, Devane CL, Chavin KD et al. Effects of garlic ( Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clin Pharmacol Ther 2003; 74; 170-7.
60. Gurley BJ, Gardner SF, Hubbard MA et al. Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs Aging 2005; 22: 525-39.
61. Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979; 1: 607.
62. Gwilt PR, Lear CL, Tempero MA et al. The effect of garlic extract on human metabolism of acetaminophen. Cancer Epidemiol Biomarkers Prev 1994; 3: 155-60.