Amide backbones with conformationally restricted furanose rings: highly improved affinity of the modified oligonucleotides for their rna complements

Angewandte Chemie - International Edition

Volumn 35, Issue 23-24, 1997, Pages 2790-2794

  De Mesmaeker, Alain ^a   Lesueur, Catherine ^a   Bévièrre, Marc Olivier ^a   Waldner, Adrian ^a   Fritsch, Valérie ^a   Wolf, Romain M ^a  

^a Central Research Laboratories   (Switzerland)

Author keywords

Amides; Antisense oligonucleotides; Deoxysugars; Molecular modeling; Nucleic acids

Indexed keywords

EID: 0030484689     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. a) J. Lebreton, A. De Mesmaeker, A. Waldner, V. Fritsch, R. M. Wolf, S. M. Freier, Tetrahedron Lett. 1993, 34, 6383
2. b) A. De Mesmaeker, A. Waldner, J. Lebreton, P. Hoffmann, V. Fritsch, R. M. Wolf, S. M. Freier, Angew. Chem. 1994, 106, 237;
3. Angew. Chem. Int. Ed. Engl. 1994, 33, 226
4. c) I. Idziak, G. Just, M. J. Damha, P. A. Giannaris, Tetrahedron Lett. 1993, 34, 5417