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Volumn 97, Issue 6, 2007, Pages 745-754

In vitro evaluation of cancer-specific NF-κB-CEA enhancer-promoter system for 5-fluorouracil prodrug gene therapy in colon cancer cell lines

Author keywords

CEA; Colorectal cancer; GDEPT; NF B; Thymidine phosphorylase

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; DOXIFLURIDINE; FLUOROURACIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; THYMIDINE PHOSPHORYLASE;

EID: 34548580291     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603930     Document Type: Article
Times cited : (15)

References (38)
  • 1
    • 0034186366 scopus 로고    scopus 로고
    • Prodrug activation enzymes in cancer gene therapy
    • Aghi M, Hochberg F, Breakefield XO (2000) Prodrug activation enzymes in cancer gene therapy. J Gene Med 2: 148-164
    • (2000) J Gene Med , vol.2 , pp. 148-164
    • Aghi, M.1    Hochberg, F.2    Breakefield, X.O.3
  • 2
    • 0020611791 scopus 로고
    • A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
    • Banerji J, Olson L, Schaffner W (1983) A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell 33: 729-740
    • (1983) Cell , vol.33 , pp. 729-740
    • Banerji, J.1    Olson, L.2    Schaffner, W.3
  • 3
    • 1642327569 scopus 로고    scopus 로고
    • Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan
    • Boyer J, McLean EG, Aroori S, Wilson P, McCulla A, Carey PD, Longley DB, Johnston PG (2004) Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. Clin Cancer Res 10: 2158-2167
    • (2004) Clin Cancer Res , vol.10 , pp. 2158-2167
    • Boyer, J.1    McLean, E.G.2    Aroori, S.3    Wilson, P.4    McCulla, A.5    Carey, P.D.6    Longley, D.B.7    Johnston, P.G.8
  • 4
    • 0029147795 scopus 로고
    • In vitro and in vivo footprint analysis of the promoter of carcinoembryonic antigen in colon carcinoma cells: Effects of interferon gamma treatment
    • Chen CJ, Li LJ, Maruya A, Shively JE (1995) In vitro and in vivo footprint analysis of the promoter of carcinoembryonic antigen in colon carcinoma cells: effects of interferon gamma treatment. Cancer Res 55: 3873-3882
    • (1995) Cancer Res , vol.55 , pp. 3873-3882
    • Chen, C.J.1    Li, L.J.2    Maruya, A.3    Shively, J.E.4
  • 5
    • 0035554258 scopus 로고    scopus 로고
    • Combination of thymidine phosphorylase gene transfer and deoxyinosine treatment greatly enhances 5-fluorouracil antitumor activity in vitro and in vivo
    • Ciccolini J, Cuq P, Evrard A, Giacometti S, Pelegrin A, Aubert C, Cano JP, Iliadis A (2001) Combination of thymidine phosphorylase gene transfer and deoxyinosine treatment greatly enhances 5-fluorouracil antitumor activity in vitro and in vivo. Mol Cancer Ther 1: 133-139
    • (2001) Mol Cancer Ther , vol.1 , pp. 133-139
    • Ciccolini, J.1    Cuq, P.2    Evrard, A.3    Giacometti, S.4    Pelegrin, A.5    Aubert, C.6    Cano, J.P.7    Iliadis, A.8
  • 6
    • 0021928806 scopus 로고
    • B lineage - specific interactions of an immunoglobulin enhancer with cellular factors in vivo
    • Ephrussi A, Church GM, Tonegawa S, Gilbert W (1985) B lineage - specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227: 134-140
    • (1985) Science , vol.227 , pp. 134-140
    • Ephrussi, A.1    Church, G.M.2    Tonegawa, S.3    Gilbert, W.4
  • 7
    • 0036740439 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of capecitabine in combination with epirubicin and cisplatin in patients with inoperable oesophago-gastric adenocarcinoma
    • Evans TR, Pentheroudakis G, Paul J, McInnes A, Blackie R, Raby N, Morrison R, Fullarton GM, Soukop M, McDonald AC (2002) A phase I and pharmacokinetic study of capecitabine in combination with epirubicin and cisplatin in patients with inoperable oesophago-gastric adenocarcinoma. Ann Oncol 13: 1469-1478
    • (2002) Ann Oncol , vol.13 , pp. 1469-1478
    • Evans, T.R.1    Pentheroudakis, G.2    Paul, J.3    McInnes, A.4    Blackie, R.5    Raby, N.6    Morrison, R.7    Fullarton, G.M.8    Soukop, M.9    McDonald, A.C.10
  • 8
    • 0344267645 scopus 로고    scopus 로고
    • Enhancement of 5-fluorouracil cytotoxicity by human thymidine-phosphorylase expression in cancer cells: In vitro and in vivo study
    • Evrard A, Cuq P, Robert B, Vian L, Pelegrin A, Cano JP (1999) Enhancement of 5-fluorouracil cytotoxicity by human thymidine-phosphorylase expression in cancer cells: in vitro and in vivo study. Int J Cancer 80: 465-470
    • (1999) Int J Cancer , vol.80 , pp. 465-470
    • Evrard, A.1    Cuq, P.2    Robert, B.3    Vian, L.4    Pelegrin, A.5    Cano, J.P.6
  • 9
    • 0033057177 scopus 로고    scopus 로고
    • The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues
    • Hammarstrom S (1999) The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 9: 67-81
    • (1999) Semin Cancer Biol , vol.9 , pp. 67-81
    • Hammarstrom, S.1
  • 10
    • 0028961480 scopus 로고
    • Transcriptional regulation of the carcinoembryonic antigen gene. Identification of regulatory elements and multiple nuclear factors
    • Hauck W, Stanners CP (1995) Transcriptional regulation of the carcinoembryonic antigen gene. Identification of regulatory elements and multiple nuclear factors. J Biol Chem 270: 3602-3610
    • (1995) J Biol Chem , vol.270 , pp. 3602-3610
    • Hauck, W.1    Stanners, C.P.2
  • 11
    • 0028108469 scopus 로고
    • Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
    • Huber BE, Austin EA, Richards CA, Davis ST, Good SS (1994) Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Natl Acad Sci USA 91: 8302-8306
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8302-8306
    • Huber, B.E.1    Austin, E.A.2    Richards, C.A.3    Davis, S.T.4    Good, S.S.5
  • 12
    • 0033595893 scopus 로고    scopus 로고
    • How NF-kappaB is activated: The role of the IkappaB kinase (IKK) complex
    • Karin M (1999) How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene 18: 6867-6874
    • (1999) Oncogene , vol.18 , pp. 6867-6874
    • Karin, M.1
  • 13
    • 0031056806 scopus 로고    scopus 로고
    • Enhancement of drug sensitivity and a bystander effect in PC-9 cells transfected with a platelet-derived endothelial cell growth factor thymidine phosphorylase cDNA
    • Kato Y, Matsukawa S, Muraoka R, Tanigawa N (1997) Enhancement of drug sensitivity and a bystander effect in PC-9 cells transfected with a platelet-derived endothelial cell growth factor thymidine phosphorylase cDNA. Br J Cancer 75: 506-511
    • (1997) Br J Cancer , vol.75 , pp. 506-511
    • Kato, Y.1    Matsukawa, S.2    Muraoka, R.3    Tanigawa, N.4
  • 16
    • 0033436285 scopus 로고    scopus 로고
    • Transcriptional analysis of human survivin gene expression
    • Li F, Altieri DC (1999) Transcriptional analysis of human survivin gene expression. Biochem J 344(Part 2): 305-311
    • (1999) Biochem J , vol.344 , Issue.PART 2 , pp. 305-311
    • Li, F.1    Altieri, D.C.2
  • 17
    • 0036057596 scopus 로고    scopus 로고
    • Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): A review
    • Malet-Martino M, Martino R (2002) Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review. Oncologist 7: 288-323
    • (2002) Oncologist , vol.7 , pp. 288-323
    • Malet-Martino, M.1    Martino, R.2
  • 19
    • 0023176085 scopus 로고
    • An inducible transcription factor activates expression of human immunodeficiency virus in T cells
    • Nabel G, Baltimore D (1987) An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326: 711-713
    • (1987) Nature , vol.326 , pp. 711-713
    • Nabel, G.1    Baltimore, D.2
  • 20
    • 0025343218 scopus 로고
    • Identification of a second inducible DNA-protein interaction in the kappa immunoglobulin enhancer
    • Nelms K, Hromas R, Van Ness B (1990) Identification of a second inducible DNA-protein interaction in the kappa immunoglobulin enhancer. Nucleic Acids Res 18: 1037-1043
    • (1990) Nucleic Acids Res , vol.18 , pp. 1037-1043
    • Nelms, K.1    Hromas, R.2    Van Ness, B.3
  • 22
    • 0029100420 scopus 로고
    • Increased sensitivity to the prodrug 5′-deoxy-5- fluorouridine and modulation of 5-fluoro-2′-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase
    • Patterson AV, Zhang H, Moghaddam A, Bicknell R, Talbot DC, Stratford IJ, Harris AL (1995) Increased sensitivity to the prodrug 5′-deoxy-5- fluorouridine and modulation of 5-fluoro-2′-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase. Br J Cancer 72: 669-675
    • (1995) Br J Cancer , vol.72 , pp. 669-675
    • Patterson, A.V.1    Zhang, H.2    Moghaddam, A.3    Bicknell, R.4    Talbot, D.C.5    Stratford, I.J.6    Harris, A.L.7
  • 23
    • 0027209915 scopus 로고
    • A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation
    • Perkins ND, Edwards NL, Duckett CS, Agranoff AB, Schmid RM, Nabel GJ (1993) A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation. EMBO J 12: 3551-3558
    • (1993) EMBO J , vol.12 , pp. 3551-3558
    • Perkins, N.D.1    Edwards, N.L.2    Duckett, C.S.3    Agranoff, A.B.4    Schmid, R.M.5    Nabel, G.J.6
  • 24
    • 1542724504 scopus 로고    scopus 로고
    • Novel fluoropyrimidines: Improving the efficacy and tolerability of cytotoxic therapy
    • Petty RD, Cassidy J (2004) Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy. Curr Cancer Drug Targets 4: 191-204
    • (2004) Curr Cancer Drug Targets , vol.4 , pp. 191-204
    • Petty, R.D.1    Cassidy, J.2
  • 25
    • 0024356008 scopus 로고
    • Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay
    • Plumb JA, Milroy R, Kaye SB (1989) Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res 49: 4435-4440
    • (1989) Cancer Res , vol.49 , pp. 4435-4440
    • Plumb, J.A.1    Milroy, R.2    Kaye, S.B.3
  • 26
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/nfkb genes and activity in human cancer
    • Rayet B, Gelinas C (1999) Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18: 6938-6947
    • (1999) Oncogene , vol.18 , pp. 6938-6947
    • Rayet, B.1    Gelinas, C.2
  • 27
    • 0028984807 scopus 로고
    • Transcriptional regulatory sequences of carcinoembryonic antigen: Identification and use with cytosine deaminase for tumor-specific gene therapy
    • Richards CA, Austin EA, Huber BE (1995a) Transcriptional regulatory sequences of carcinoembryonic antigen: identification and use with cytosine deaminase for tumor-specific gene therapy. Hum Gene Ther 6: 881-893
    • (1995) Hum Gene Ther , vol.6 , pp. 881-893
    • Richards, C.A.1    Austin, E.A.2    Huber, B.E.3
  • 28
    • 0028984807 scopus 로고
    • Transcriptional regulatory sequences of carcinoembryonic antigen: Identification and use with cytosine deaminase for tumor-specific gene therapy
    • Richards CA, Austin EA, Huber BE (1995b) Transcriptional regulatory sequences of carcinoembryonic antigen: identification and use with cytosine deaminase for tumor-specific gene therapy. Hum Gene Ther 6: 881-893
    • (1995) Hum Gene Ther , vol.6 , pp. 881-893
    • Richards, C.A.1    Austin, E.A.2    Huber, B.E.3
  • 30
    • 0021108999 scopus 로고
    • Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit
    • Sassone-Corsi P, Hen R, Borrelli E, Leff T, Chambon P (1983) Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit. Nucleic Acids Res 11: 8735-8745
    • (1983) Nucleic Acids Res , vol.11 , pp. 8735-8745
    • Sassone-Corsi, P.1    Hen, R.2    Borrelli, E.3    Leff, T.4    Chambon, P.5
  • 31
    • 0025353707 scopus 로고
    • Cloning of the complete gene for carcinoembryonic antigen: Analysis of its promoter indicates a region conveying cell type-specific expression
    • Schrewe H, Thompson J, Bona M, Hefta LJ, Maruya A, Hassauer M, Shively JE, von Kleist S, Zimmermann W (1990) Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression. Mol Cell Biol 10: 2738-2748
    • (1990) Mol Cell Biol , vol.10 , pp. 2738-2748
    • Schrewe, H.1    Thompson, J.2    Bona, M.3    Hefta, L.J.4    Maruya, A.5    Hassauer, M.6    Shively, J.E.7    von Kleist, S.8    Zimmermann, W.9
  • 32
    • 0021902411 scopus 로고
    • CEA-related antigens: Molecular biology and clinical significance
    • Shively JE, Beatty JD (1985) CEA-related antigens: molecular biology and clinical significance. Crit Rev Oncol Hematol 2: 355-399
    • (1985) Crit Rev Oncol Hematol , vol.2 , pp. 355-399
    • Shively, J.E.1    Beatty, J.D.2
  • 33
    • 0033082526 scopus 로고    scopus 로고
    • Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
    • Takakura M, Kyo S, Kanaya T, Hirano H, Takeda J, Yutsudo M, Inoue M (1999) Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 59: 551-557
    • (1999) Cancer Res , vol.59 , pp. 551-557
    • Takakura, M.1    Kyo, S.2    Kanaya, T.3    Hirano, H.4    Takeda, J.5    Yutsudo, M.6    Inoue, M.7
  • 34
    • 33746531095 scopus 로고    scopus 로고
    • Mechanism of action of a distal NF-kappaB-dependent enhancer
    • Teferedegne B, Green MR, Guo Z, Boss JM (2006) Mechanism of action of a distal NF-kappaB-dependent enhancer. Mol Cell Biol 26: 5759-5770
    • (2006) Mol Cell Biol , vol.26 , pp. 5759-5770
    • Teferedegne, B.1    Green, M.R.2    Guo, Z.3    Boss, J.M.4
  • 35
    • 0035881303 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the cre/loxP system in the orthotopic gastric carcinoma model
    • Ueda K, Iwahashi M, Nakamori M, Nakamura M, Matsuura I, Yamaue H, Tanimura H (2001) Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the cre/loxP system in the orthotopic gastric carcinoma model. Cancer Res 61: 6158-6162
    • (2001) Cancer Res , vol.61 , pp. 6158-6162
    • Ueda, K.1    Iwahashi, M.2    Nakamori, M.3    Nakamura, M.4    Matsuura, I.5    Yamaue, H.6    Tanimura, H.7
  • 36
    • 0037463238 scopus 로고    scopus 로고
    • Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells
    • Wang W, Cassidy J (2003) Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells. Br J Cancer 88: 624-629
    • (2003) Br J Cancer , vol.88 , pp. 624-629
    • Wang, W.1    Cassidy, J.2
  • 37
    • 0037457481 scopus 로고    scopus 로고
    • Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines
    • Wang W, McLeod HL, Cassidy J (2003) Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Int J Cancer 104: 504-511
    • (2003) Int J Cancer , vol.104 , pp. 504-511
    • Wang, W.1    McLeod, H.L.2    Cassidy, J.3
  • 38
    • 0025214992 scopus 로고
    • Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors
    • Yoshimura A, Kuwazuru Y, Furukawa T, Yoshida H, Yamada K, Akiyama S (1990) Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors. Biochim Biophys Acta 1034: 107-113
    • (1990) Biochim Biophys Acta , vol.1034 , pp. 107-113
    • Yoshimura, A.1    Kuwazuru, Y.2    Furukawa, T.3    Yoshida, H.4    Yamada, K.5    Akiyama, S.6


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