-
1
-
-
33745464490
-
Fluorinated Pyrimidines: A New Class of Tumour Inhibitory Compunds
-
Heidelberger, C.; Chandari, N. K.; Dannenberg, P. et al., Fluorinated Pyrimidines: A New Class of Tumour Inhibitory Compunds. Nature 1957, 199, 663.
-
(1957)
Nature
, vol.199
, pp. 663
-
-
Heidelberger, C.1
Chandari, N.K.2
Dannenberg, P.3
-
2
-
-
0000828960
-
Antimetabolites
-
Souhami R. L.; Tannock I., Hohenberger R.; Horiot J. C. Eds.; Oxford University Press: Oxford UK
-
Peters, G. J.; Jansen, G. Antimetabolites, In Oxford Textbook of Oncology; Souhami R. L; Tannock I., Hohenberger R.; Horiot J. C. Eds.; Oxford University Press: Oxford UK, 2002, pp663-715
-
(2002)
Oxford Textbook of Oncology
, pp. 663-715
-
-
Peters, G.J.1
Jansen, G.2
-
3
-
-
0032847412
-
Adjuvant therapy of Colon Cancer
-
Moore, H. C. F.; Haller, D. G. Adjuvant therapy of Colon Cancer. Semin. Oncol. 1999, 26(5), 545-555.
-
(1999)
Semin. Oncol.
, vol.26
, Issue.5
, pp. 545-555
-
-
Moore, H.C.F.1
Haller, D.G.2
-
4
-
-
1542669879
-
Colorectal Cancer
-
Souhami RL; Tannock I; Hohenberger R; Horiot JC Eds.; Oxford University Press; Oxford UK
-
Northover, J. M. A.; Arnott, S.; Jass, J. R.; Williams, N. S.; Colorectal Cancer. In Oxford Textbook of Oncology; Souhami RL; Tannock I; Hohenberger R; Horiot JC Eds.; Oxford University Press; Oxford UK, 2002, pp1545-1591.
-
(2002)
Oxford Textbook of Oncology
, pp. 1545-1591
-
-
Northover, J.M.A.1
Arnott, S.2
Jass, J.R.3
Williams, N.S.4
-
5
-
-
0024164649
-
5-Fluorouracil: Biochemistry and Pharmacology
-
Pinedo, H. M.; Peters, G. J. 5-Fluorouracil: Biochemistry and Pharmacology. J. Clin. Oncol. 1988, 6, 1653-1654.
-
(1988)
J. Clin. Oncol.
, vol.6
, pp. 1653-1654
-
-
Pinedo, H.M.1
Peters, G.J.2
-
6
-
-
0025991626
-
Biochemical Pharmacology and Analysis of Fluropyrimidines Alone and in Combination with Modulators
-
Weckbecker, G. Biochemical Pharmacology and Analysis of Fluropyrimidines Alone and in Combination with Modulators. Pharmacol. 1991, 50, 367-424.
-
(1991)
Pharmacol.
, vol.50
, pp. 367-424
-
-
Weckbecker, G.1
-
7
-
-
0020563004
-
Elucidation of Pathways of 5-Flourouracil Metabolism in Xenografts of Human Colorectal Adenocarcinoma
-
Houghton, J. A.; Houghton, P. J. Elucidation of Pathways of 5-Flourouracil Metabolism in Xenografts of Human Colorectal Adenocarcinoma. Eur. J. Can. Clin. Oncol. 1983, 19, 807-815.
-
(1983)
Eur. J. Can. Clin. Oncol.
, vol.19
, pp. 807-815
-
-
Houghton, J.A.1
Houghton, P.J.2
-
8
-
-
0022448330
-
Distribution and Inhibition of Dihydrouracil Dehydrogeenase Activities in Human Tissues Using 5-fluororuacil as a Substrate
-
Ho, D. H.; Townsend, L.; Luna, M. L.; Bodey, G. P. Distribution and Inhibition of Dihydrouracil Dehydrogeenase Activities in Human Tissues Using 5-fluororuacil as a Substrate. Anticancer Res. 1986, 6, 781-784.
-
(1986)
Anticancer Res.
, vol.6
, pp. 781-784
-
-
Ho, D.H.1
Townsend, L.2
Luna, M.L.3
Bodey, G.P.4
-
9
-
-
0025184886
-
Chromatographic Analysis of Anticancer Drugs
-
Tjaden, U. R.; De Bruijn, E. A. Chromatographic Analysis of Anticancer Drugs. J. Chrom. Biomed. Appl., 1990, 531, 235-294.
-
(1990)
J. Chrom. Biomed. Appl.
, vol.531
, pp. 235-294
-
-
Tjaden, U.R.1
De Bruijn, E.A.2
-
10
-
-
0025096726
-
Tumour Trapping of 5-fluorouracil: In vivo 19F-NMR Spectroscoptic Pharmacokinetics in Tumour Bearing Humans and Rabbits
-
Presant, C. A.; Wolf, W.; Albright, M. J.; Servis, K. L.; Ring, R., III; Atkinson, D.; Ong, R. L.; Wiseman, C.; King, M.; Blayney, D. Tumour Trapping of 5-fluorouracil: In vivo 19F-NMR Spectroscoptic Pharmacokinetics in Tumour Bearing Humans and Rabbits. Proc. Natl. Acad. Sci. USA. 1990, 87, 492-496.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 492-496
-
-
Presant, C.A.1
Wolf, W.2
Albright, M.J.3
Servis, K.L.4
Ring III, R.5
Atkinson, D.6
Ong, R.L.7
Wiseman, C.8
King, M.9
Blayney, D.10
-
11
-
-
0028231298
-
Association of Intratumoural Pharmacokinetics of Fluorouracil with Clinical Response
-
Presant, C. A. Association of Intratumoural Pharmacokinetics of Fluorouracil with Clinical Response. Lancet, 1994, 343, 1184-87.
-
(1994)
Lancet
, vol.343
, pp. 1184-1187
-
-
Presant, C.A.1
-
12
-
-
0024595925
-
Clinical Pharmacology of 5-Fluorouracil
-
Diasio, R. B.; Harris, B. E. Clinical Pharmacology of 5-Fluorouracil. Clin. Pharmacol. 1989, 6, 215-37.
-
(1989)
Clin. Pharmacol.
, vol.6
, pp. 215-237
-
-
Diasio, R.B.1
Harris, B.E.2
-
13
-
-
0030755985
-
Rapid, and Sensitive High Performance Liquid Chromatograpic Analysis of Halogenpyrimidines in Plasma
-
Gamelin, E.; Boisdron-Celle, M.; Turcant, A.; Allain, P.; Robert, J.; Rapid, and Sensitive High Performance Liquid Chromatograpic Analysis of Halogenpyrimidines in Plasma. J. Chrom. 1997, 695, 409-416.
-
(1997)
J. Chrom.
, vol.695
, pp. 409-416
-
-
Gamelin, E.1
Boisdron-Celle, M.2
Turcant, A.3
Allain, P.4
Robert, J.5
-
14
-
-
0031106817
-
Simultaneous determination of dihydrofluorouracil and 5-fluorouracil in plasma by high performance liquid chromatography
-
Ackland, S.P.; Garg, M.B.; Dunstan, R.H. Simultaneous determination of dihydrofluorouracil and 5-fluorouracil in plasma by high performance liquid chromatography. Anal. Biochem. 1997, 246, 79-85.
-
(1997)
Anal. Biochem.
, vol.246
, pp. 79-85
-
-
Ackland, S.P.1
Garg, M.B.2
Dunstan, R.H.3
-
15
-
-
0018870880
-
Combination Clinical Trials with Thymidine and Fluorouracil: A Phase I and Clinical Pharmacological Evaluation
-
Woodcock, T. M.; Martin, D. S.; Damin, L. A. M.; Kemneny, N. E.; Young, C. W. Combination Clinical Trials with Thymidine and Fluorouracil: A Phase I and Clinical Pharmacological Evaluation. Cancer 1980, 45, 1135-1143.
-
(1980)
Cancer
, vol.45
, pp. 1135-1143
-
-
Woodcock, T.M.1
Martin, D.S.2
Damin, L.A.M.3
Kemneny, N.E.4
Young, C.W.5
-
16
-
-
0024262909
-
Pharmacokinetics of 5-flourouracil Assessed with a Sensitive Mass Spectrometric Method in Patients during a Dose Escalation Schedule
-
Van Groeningen, C. J.; Pinedo, H. M.; Heddes, J. Pharmacokinetics of 5-flourouracil Assessed with a Sensitive Mass Spectrometric Method in Patients During a Dose Escalation Schedule. Cancer Res. 1988, 48, 6956-6961.
-
(1988)
Cancer Res.
, vol.48
, pp. 6956-6961
-
-
Van Groeningen, C.J.1
Pinedo, H.M.2
Heddes, J.3
-
17
-
-
0019537132
-
The Pharmacology of Fluoropyrimidines
-
Myers, C. E. The Pharmacology of Fluoropyrimidines. Pharmacol. Rev. 1981, 33, 1-15.
-
(1981)
Pharmacol. Rev.
, vol.33
, pp. 1-15
-
-
Myers, C.E.1
-
18
-
-
0001111461
-
Effect of Different Leucovorin Formulations on 5-fluorouracil Induced Thymidylate Synthase Inhibition in Colon Tumours and Normal Tissues from Patients in Relation to Response to 5-fluorouracil
-
Pfleiderer W.; Rokos H. (Ed.). Berlin. Blackwell Science
-
Peters, G. J.; Van der Wilt, C. L.; Van Groeningen, C. J. Effect of Different Leucovorin Formulations on 5-fluorouracil Induced Thymidylate Synthase Inhibition in Colon Tumours and Normal Tissues from Patients in Relation to Response to 5-fluorouracil. In Pfleiderer W.; Rokos H. (Ed.). Chemistry and Biology of Pteridins and Folates (Proceedings of the 11th International Symposium). Berlin. Blackwell Science, 1997, pp.145-150.
-
(1997)
Chemistry and Biology of Pteridins and Folates (Proceedings of the 11th International Symposium)
, pp. 145-150
-
-
Peters, G.J.1
Van Der Wilt, C.L.2
Van Groeningen, C.J.3
-
19
-
-
0029916516
-
Different Intravenous Administration Techniques for 5-flourouracil
-
Larsson, P-A.; Carlsson, G.; Gustavasson, B.; Graf, W.; Glimelius, B. Different Intravenous Administration Techniques for 5-flourouracil. Acta Oncol. 1996, 35,207-212.
-
(1996)
Acta Oncol.
, vol.35
, pp. 207-212
-
-
Larsson, P.-A.1
Carlsson, G.2
Gustavasson, B.3
Graf, W.4
Glimelius, B.5
-
20
-
-
0018936361
-
Non-linear Pharmacokinetic Models for 5-fluorouracil in Man
-
Collins, J. M.; Dedrick, R. L.; King, F. G.; Speyer, J. L.; Myers, C. E. Non-linear Pharmacokinetic Models for 5-fluorouracil in Man. Clin. Pharmacol. Ther. 1980, 28, 235-246.
-
(1980)
Clin. Pharmacol. Ther.
, vol.28
, pp. 235-246
-
-
Collins, J.M.1
Dedrick, R.L.2
King, F.G.3
Speyer, J.L.4
Myers, C.E.5
-
21
-
-
0023187085
-
Clinical Pharmacokinetics of 5-fluorouracil and its Metabolites in Plasma, Urine and Bile
-
Hedgie, G. D.; Sommadossi, J. D.; Cross, D. S.; Huster, W. J.; Diasio, R. D. Clinical Pharmacokinetics of 5-fluorouracil and its Metabolites in Plasma, Urine and Bile. Cancer Res. 1987, 46, 2203-2206.
-
(1987)
Cancer Res.
, vol.46
, pp. 2203-2206
-
-
Hedgie, G.D.1
Sommadossi, J.D.2
Cross, D.S.3
Huster, W.J.4
Diasio, R.D.5
-
22
-
-
0031973816
-
Characteristaion of Dyhydropyrimidine Dehyrogenase Acivity in Colorectal Tumours
-
Mcloed, H. J.; Sludden, J.; Murray, G. I.; Keenan, R. A; Davidson, A. I. ; Park, K.; Koruth, M.; Cassidy, J.; Characteristaion of Dyhydropyrimidine Dehyrogenase Acivity in Colorectal Tumours. Br. J. Cancer 1998, 77, 461-465.
-
(1998)
Br. J. Cancer
, vol.77
, pp. 461-465
-
-
Mcloed, H.J.1
Sludden, J.2
Murray, G.I.3
Keenan, R.A.4
Davidson, A.I.5
Park, K.6
Koruth, M.7
Cassidy, J.8
-
23
-
-
0021233990
-
New Approach to Metabolism of 5′deoxy-5-fluorouridine in Humans with Fluorine-19NMR
-
Malet-Martino, M. C.; Martino, R.; Lopez, A. New Approach to Metabolism of 5′deoxy-5-fluorouridine in Humans with Fluorine-19NMR. Cancer Chem. Pharmacol. 1984, 13, 31-35.
-
(1984)
Cancer Chem. Pharmacol.
, vol.13
, pp. 31-35
-
-
Malet-Martino, M.C.1
Martino, R.2
Lopez, A.3
-
24
-
-
0023902287
-
Familial Deficiency of Dihydropyrimidine Dehydrogenase: Biochemical Basis for Familial Pyrimidinemia and Severe 5-fluorouracil-Induced Toxicity
-
Diasio, R. B.; Beavers, T. L.; Carpenter, J. T. Familial Deficiency of Dihydropyrimidine Dehydrogenase: Biochemical Basis for Familial Pyrimidinemia and Severe 5-fluorouracil-Induced Toxicity. J. Clin. Invest. 1988, 81, 47-51.
-
(1988)
J. Clin. Invest.
, vol.81
, pp. 47-51
-
-
Diasio, R.B.1
Beavers, T.L.2
Carpenter, J.T.3
-
25
-
-
0031876466
-
Putative Role of Dihyropyrimidine Dehydrogenase in the Toxic Side Effect of 5-fluorouracil in Colorectal Cancer Patients
-
Katona, C.; Kralovanszky, J.; Rosta, A.; Pandi, E.; Fonyad, G.; Toth, K. ; Jeney, A. Putative Role of Dihyropyrimidine Dehydrogenase in the Toxic Side Effect of 5-fluorouracil in Colorectal Cancer Patients. Oncology, 1998, 55, 468-474.
-
(1998)
Oncology
, vol.55
, pp. 468-474
-
-
Katona, C.1
Kralovanszky, J.2
Rosta, A.3
Pandi, E.4
Fonyad, G.5
Toth, K.6
Jeney, A.7
-
26
-
-
0031696544
-
Clinical impact of Pharmacokinetically-guided Dose Adaption of 5-fluorouracil: Results from a Multicentric Randomized trial in patients with locally advanced head and neck carcinomas
-
Fety, R.; Rolland, F.; Barberi-Heyob, M.; Hardouin, A.; Campion, L. Clinical impact of Pharmacokinetically-guided Dose Adaption of 5-fluorouracil: Results from a Multicentric Randomized trial in patients with locally advanced head and neck carcinomas. Clin. Cancer Res. 1998, 4, 2039-2045.
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 2039-2045
-
-
Fety, R.1
Rolland, F.2
Barberi-Heyob, M.3
Hardouin, A.4
Campion, L.5
-
27
-
-
0345596364
-
Toxicity of Flourouracil in Patients with Advanced Colorectal Cancer: Effect of Administration Scheduleand Prognostic Factors
-
Meta-Analysis Group in Cancer. Toxicity of Flourouracil in Patients with Advanced Colorectal Cancer: Effect of Administration Scheduleand Prognostic Factors. J. Clin. Oncol. 1998, 16, 3534-3541.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 3534-3541
-
-
-
28
-
-
0344109583
-
Efficacy of intravenous Continous Infusion of Fluorouracil Compared with Bolus Administration in Advanced Colorectal Cancer
-
Meta-Analysis Group in Cancer. Efficacy of intravenous Continous Infusion of Fluorouracil Compared with Bolus Administration in Advanced Colorectal Cancer. J. Clin. Oncol. 1998, 16, 301-308.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 301-308
-
-
-
29
-
-
0033828356
-
Oral Fluorouropyrmidines in the Treatment of Colorectal Cancer
-
Bissett, D.; Ahmed, F.; Mcloed, H.; Cassidy, J. Oral Fluorouropyrmidines in the Treatment of Colorectal Cancer. Clin. Oncol., 2000, 12, 240-245.
-
(2000)
Clin. Oncol.
, vol.12
, pp. 240-245
-
-
Bissett, D.1
Ahmed, F.2
Mcloed, H.3
Cassidy, J.4
-
30
-
-
0022585663
-
Biochemical Modulation: Application of laboratory models to the clinic
-
Leyland-Jones, B.; O'Dwyer P. Biochemical Modulation: Application of laboratory models to the clinic. Cancer Treat. Rep. 1986, 70, 219-229.
-
(1986)
Cancer Treat. Rep.
, vol.70
, pp. 219-229
-
-
Leyland-Jones, B.1
O'Dwyer, P.2
-
31
-
-
0024413739
-
Fluorouracil and High Dose Leucovorin in Previously Treated Patients with Metastatic Breast Cancer
-
Swain, S. M.; Lippmann, M. E.; Egan, E. F.; Drake, F. G.; Steinberg, S. M.; Allegra, C. J.; Fluorouracil and High Dose Leucovorin in Previously Treated Patients with Metastatic Breast Cancer. J. Clin. Oncol. 1989, 7, 890-899.
-
(1989)
J. Clin. Oncol.
, vol.7
, pp. 890-899
-
-
Swain, S.M.1
Lippmann, M.E.2
Egan, E.F.3
Drake, F.G.4
Steinberg, S.M.5
Allegra, C.J.6
-
32
-
-
33947093786
-
Effect of 5,10-Methylenetetrahydrofolate on the Dissociation of 5-Flouro-2-deoxyuridylate from Thymidyate Synthetase: Evidence for an Ordered Mechanism
-
Daneberg P. V.; Daneberg K. D. Effect of 5,10-Methylenetetrahydrofolate on the Dissociation of 5-Flouro-2-deoxyuridylate from Thymidyate Synthetase: Evidence for an Ordered Mechanism. Biochem. 1978, 17, 4018-4024.
-
(1978)
Biochem.
, vol.17
, pp. 4018-4024
-
-
Daneberg, P.V.1
Daneberg, K.D.2
-
33
-
-
0027395111
-
Effect of Folate Diastereoisomers on the Binding of 5-fluroro-2-deoxyuridine-5-monophosphate to Thymydylate Synthetase
-
Van der Wilt, C. L.; Pinedo, H. M.; De Jong, M.; Peters, G. J. Effect of Folate Diastereoisomers on the Binding of 5-fluroro-2-deoxyuridine-5-monophosphate to Thymydylate Synthetase. Biochem. Pharmaco. 1993, 45, 1177-1199.
-
(1993)
Biochem. Pharmaco.
, vol.45
, pp. 1177-1199
-
-
Van Der Wilt, C.L.1
Pinedo, H.M.2
De Jong, M.3
Peters, G.J.4
-
34
-
-
0031938504
-
Rationale for treatment design: Biochemical modulation of 5-fluorouracil by leucovorin
-
Rustum, Y. F.; Cao, S.; Zhang, Z. Rationale for treatment design: biochemical modulation of 5-fluorouracil by leucovorin. Cancer 1998, 4, 12-18.
-
(1998)
Cancer
, vol.4
, pp. 12-18
-
-
Rustum, Y.F.1
Cao, S.2
Zhang, Z.3
-
35
-
-
0022626114
-
Binding of 5-fluorodeoxyuridylate to Thymidylate Synthase in Human Colon Adenocarcinoma Xenographs
-
Houghton, J. A.; Torrance, P. M.; Radparvar, S.; Williams, L. G.; Houghton, P. J. Binding of 5-fluorodeoxyuridylate to Thymidylate Synthase in Human Colon Adenocarcinoma Xenographs. Eur. J. Cancer Clin. Oncol. 1986, 22, 505-510.
-
(1986)
Eur. J. Cancer Clin. Oncol.
, vol.22
, pp. 505-510
-
-
Houghton, J.A.1
Torrance, P.M.2
Radparvar, S.3
Williams, L.G.4
Houghton, P.J.5
-
36
-
-
0023111335
-
Thymidylate Synthase Overproduction Gene Amplification in a Colon Tumour Resistant to Fluoropyrimidine cChemotherapy
-
Clark, J. L.; Berger, S. H.; Mittelman, A.; Berger, F. G. Thymidylate Synthase Overproduction Gene Amplification in a Colon Tumour Resistant to Fluoropyrimidine cChemotherapy. Cancer Treat. Rep. 1989, 71, 261-265.
-
(1989)
Cancer Treat. Rep.
, vol.71
, pp. 261-265
-
-
Clark, J.L.1
Berger, S.H.2
Mittelman, A.3
Berger, F.G.4
-
37
-
-
0018578292
-
Effect of 5-fluorouracil on RNA Metabolism in Novikoff Hepatoma cells
-
Cory, J. G.; Breland, J. C.; Carter, G. L. Effect of 5-fluorouracil on RNA Metabolism in Novikoff Hepatoma cells. Cancer Res. 1979, 39, 4905-4913.
-
(1979)
Cancer Res.
, vol.39
, pp. 4905-4913
-
-
Cory, J.G.1
Breland, J.C.2
Carter, G.L.3
-
38
-
-
0022492228
-
5-fluorouracil Augmentation of Dihydrofolate Reductase Gene Transcripts Containing Intervening Sequences in Methotrexate Resistant KB cells
-
Will, C. L.; Dolnick, B. J. 5-fluorouracil Augmentation of Dihydrofolate Reductase Gene Transcripts Containing Intervening Sequences in Methotrexate Resistant KB cells. Mol. Pharmacol. 1996, 29, 643-648.
-
(1996)
Mol. Pharmacol.
, vol.29
, pp. 643-648
-
-
Will, C.L.1
Dolnick, B.J.2
-
39
-
-
1542669884
-
Improving the Anti-Tumour Efficacy of 5-fluorouracil by Increasing its Incorporation into RNA by Metabolic Modulation
-
Spiegelman, S.; Sawyer, R.; Nayak, R.; Ritzi, E.; Stolfi, R.; Martin, D. S. Improving the Anti-Tumour Efficacy of 5-fluorouracil by Increasing its Incorporation into RNA by Metabolic Modulation. Proc. Natl. Acad. Sci. (USA). 1980, 389, 4966-4970.
-
(1980)
Proc. Natl. Acad. Sci. (USA)
, vol.389
, pp. 4966-4970
-
-
Spiegelman, S.1
Sawyer, R.2
Nayak, R.3
Ritzi, E.4
Stolfi, R.5
Martin, D.S.6
-
40
-
-
0018744377
-
Mechanism of Induction of the Gastrointestinal Toxicity in the Mouse by 5-fluorouracil, 5-fluororidine and 5-Fluoro-2′-deoxyuridine
-
Houghton, J. A.; Houghton, P. J.; Wooten, R. S. Mechanism of Induction of the Gastrointestinal Toxicity in the Mouse by 5-fluorouracil, 5-fluororidine and 5-Fluoro-2′-deoxyuridine. Cancer Res. 1979, 39, 2406-2413.
-
(1979)
Cancer Res.
, vol.39
, pp. 2406-2413
-
-
Houghton, J.A.1
Houghton, P.J.2
Wooten, R.S.3
-
41
-
-
0018888653
-
The Effect of 5-fluorouracil on the Synthesis and Methylation of Low Molecular Weight RNA in L1210 cells
-
Glazer, R. I.; Hartman, K. D. A. The Effect of 5-fluorouracil on the Synthesis and Methylation of Low Molecular Weight RNA in L1210 cells. Mol. Pharmacol. 1980, 17, 245-249.
-
(1980)
Mol. Pharmacol.
, vol.17
, pp. 245-249
-
-
Glazer, R.I.1
Hartman, K.D.A.2
-
42
-
-
1542564875
-
Nucleotide and Nucleobase Transport Systems of Mammalian Cells
-
Griffith, D. A.; Jarvis, S. M. Nucleotide and Nucleobase Transport Systems of Mammalian Cells. Biochimica. Biophysica. Acta. 1963, 73, 160-162.
-
(1963)
Biochimica. Biophysica. Acta
, vol.73
, pp. 160-162
-
-
Griffith, D.A.1
Jarvis, S.M.2
-
43
-
-
0033385164
-
The use of Thymidylate Synthetase Inhibitors in the Treatment of advanced Colorectal Cancer: Current Status
-
Papamichael, D. The use of Thymidylate Synthetase Inhibitors in the Treatment of advanced Colorectal Cancer: Current Status. Oncologist 1999, 4, 478-487.
-
(1999)
Oncologist
, vol.4
, pp. 478-487
-
-
Papamichael, D.1
-
44
-
-
0028223117
-
Induction of Resistance to Flurodeoxyuridine Cytotoxicity and DNA Damage in Human Tumour Cells by Expression of Escercichia coli
-
Canman, C. E.; Randany, E. H.; Parsels, L. A.; Davis, M. A.; Lawrence, T. S.; Maybaum, J. Induction of Resistance to Flurodeoxyuridine Cytotoxicity and DNA Damage in Human Tumour Cells by Expression of Escercichia coli. Cancer Res. 1994, 344, 2296-2298.
-
(1994)
Cancer Res.
, vol.344
, pp. 2296-2298
-
-
Canman, C.E.1
Randany, E.H.2
Parsels, L.A.3
Davis, M.A.4
Lawrence, T.S.5
Maybaum, J.6
-
45
-
-
0021363705
-
Incorporation of 5-fluorouracil into Murine Bone Marrow DNA in vivo
-
Sawyer, R. C.; Stolfi, R. I.; Martin, D. S.; Spiegelman, S. Incorporation of 5-fluorouracil into Murine Bone Marrow DNA in vivo. Cancer Res. 1984, 44, 1847-1851.
-
(1984)
Cancer Res.
, vol.44
, pp. 1847-1851
-
-
Sawyer, R.C.1
Stolfi, R.I.2
Martin, D.S.3
Spiegelman, S.4
-
46
-
-
1542564866
-
Locus of the Interaction among 5-fluorouracil, Leucovorin, and Interferon-alpha-2A in Colon Carcinoma Cells
-
Houghton, J. A.; Morton, C. L.; Adkins, D. A.; Rahman, A. Locus of the Interaction among 5-fluorouracil, Leucovorin, and Interferon-alpha-2A in Colon Carcinoma Cells. Eur. J. Cancer 1997, 33, 471-478.
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 471-478
-
-
Houghton, J.A.1
Morton, C.L.2
Adkins, D.A.3
Rahman, A.4
-
47
-
-
1542669878
-
Accumulation of DNA Strand Breaks during Thymineless Death in Thymidylate Negative Mutants of Mouse FM3A cells
-
Ayasawa, D.; Shimizu, K.; Koyama, H.; Takeish, K. Seno, T. Accumulation of DNA Strand Breaks during Thymineless Death in Thymidylate Negative Mutants of Mouse FM3A cells. J. Biol. Chem. 1988, 258, 122448-12454.
-
(1988)
J. Biol. Chem.
, vol.258
, pp. 122448-112454
-
-
Ayasawa, D.1
Shimizu, K.2
Koyama, H.3
Takeish, K.4
Seno, T.5
-
48
-
-
0035754080
-
To Cycle or Not to Cycle: A Critical Decision in Cancer
-
Malumbres, M.; Barbacid, M. To Cycle or Not to Cycle: A Critical Decision in Cancer. Nat. Rev. Cancer 2001, 1, 222-231.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
49
-
-
0000623426
-
Four Deaths and a Funeral: From Caspases to aAlternative Mechanisms
-
Leist, M.; Jaalletta, M. Four Deaths and a Funeral: From Caspases to aAlternative Mechanisms. Nat. Rev. Mol. Cell Biol. 2001, 2, 1-10.
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 1-10
-
-
Leist, M.1
Jaalletta, M.2
-
50
-
-
0032963179
-
Therapy for Early Stage Colorectal Cancer
-
Peeters, T.; Haller, D. Therapy for Early Stage Colorectal Cancer. Oncology, 1999, 13, 307-313.
-
(1999)
Oncology
, vol.13
, pp. 307-313
-
-
Peeters, T.1
Haller, D.2
-
51
-
-
1542775265
-
Challenging the Definition of 'best clinical practice': The Impact of New and Ongoing studies
-
Cunningham D.; Haller D.; Miles A.; (editors). London. Aesulapius Medical Press
-
Topham, C. A. Challenging the Definition of 'best clinical practice': The Impact of New and Ongoing studies. The Effective Management of Colorectal Cancer. Cunningham D.; Haller D.; Miles A.; (editors). London. Aesulapius Medical Press, 2000, pp17-36.
-
(2000)
The Effective Management of Colorectal Cancer
, pp. 17-36
-
-
Topham, C.A.1
-
52
-
-
0024539308
-
A Prospective Randomised Comparison of Continous Infusion Fluorouracil with a Conventional bolus Schedule in Metastatic Colorectal Cancer: A Mid-Atlantic Oncology Program Study
-
Lokich, J. J.; Ahlgren, J. D.; Gullo, J. J.; Phillips, J. A.; Fryer, J. G. A Prospective Randomised Comparison of Continous Infusion Fluorouracil with a Conventional bolus Schedule in Metastatic Colorectal Cancer: A Mid-Atlantic Oncology Program Study. J. Clin. Oncol. 1989, 7, 425-432.
-
(1989)
J. Clin. Oncol.
, vol.7
, pp. 425-432
-
-
Lokich, J.J.1
Ahlgren, J.D.2
Gullo, J.J.3
Phillips, J.A.4
Fryer, J.G.5
-
53
-
-
0026721532
-
Advanced Colorectal Cancer Meta-analysis Project Modulation of Fluorouracil by Leucovorin in Patients with Advanced Colorectal Cancer: Evidence in Terms of Response Rate
-
Advanced Colorectal Cancer Meta-analysis Project Modulation of Fluorouracil by Leucovorin in Patients with Advanced Colorectal Cancer: Evidence in Terms of Response Rate. J. Clin. Oncol. 1992, 10, 896-903.
-
(1992)
J. Clin. Oncol.
, vol.10
, pp. 896-903
-
-
-
54
-
-
0023515617
-
Two Randomised Phase II Trials of Intermittent Intravenous versus Subcutaneous Alpha-2 interferon alone (trial I) and in Combination with 5-fluorouracil (trial 2) in Advanced Colorectal Cancer
-
Clark, P.I.; Slevin, M.L.; Reznek, R.H.; Niederle, N.; Kurschel, E. Two Randomised Phase II Trials of Intermittent Intravenous versus Subcutaneous Alpha-2 interferon alone (trial I) and in Combination with 5-fluorouracil (trial 2) in Advanced Colorectal Cancer. Int. J. Colorectal Dis. 1987, 2, 26-29.
-
(1987)
Int. J. Colorectal Dis.
, vol.2
, pp. 26-29
-
-
Clark, P.I.1
Slevin, M.L.2
Reznek, R.H.3
Niederle, N.4
Kurschel, E.5
-
55
-
-
0344333428
-
Modulation of 5-fluorouracil with Methotrexate and low-dose N-(phosphonacetyl)-L-aspartate in Patients with Advanced Colorectal Cancer. Results of a Phase II study
-
Kohne, C. H.; Harstrick, A.; Hiddeman, W.; Goldman, I. J. Modulation of 5-fluorouracil with Methotrexate and low-dose N-(phosphonacetyl)-L-aspartate in Patients with Advanced Colorectal Cancer. Results of a Phase II study. Eur. J. Cancer 1997, 33, 1896-1899.
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 1896-1899
-
-
Kohne, C.H.1
Harstrick, A.2
Hiddeman, W.3
Goldman, I.J.4
-
56
-
-
0021637621
-
Sequential Methotrexate and 5-fluorouracil: Improved Response Rate in Metastatic Colorectal Cancer
-
Herrmann, S. R.; Spehn, J.; Beyer, J. H.; von Franque, U.; Schmieder, A. ; Holzmann, K. Sequential Methotrexate and 5-fluorouracil: Improved Response Rate in Metastatic Colorectal Cancer. J. Clin. Oncol. 1984, 2, 591-594.
-
(1984)
J. Clin. Oncol.
, vol.2
, pp. 591-594
-
-
Herrmann, S.R.1
Spehn, J.2
Beyer, J.H.3
Von Franque, U.4
Schmieder, A.5
Holzmann, K.6
-
57
-
-
0028219974
-
Meta-analysis of Randomised Trials Testing the Biochemical -Modulation of Fluorouracil by Methatrexate in Metastatic Colorectal Cancer
-
Advanced Colorectal Cancer Meta-Analysis Project. Meta-analysis of Randomised Trials Testing the Biochemical Modulation of Fluorouracil by Methatrexate in Metastatic Colorectal Cancer. J. Clin. Oncol. 1994, 12, 960-969.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 960-969
-
-
-
58
-
-
0024578676
-
Effect of Polyglutamylation of 5,10-methyltetrahydrofolate on the Binding of 5-fluoro-2′-deoxyuridylate to Thymidylate Synthase Purified from a Human Colon Adencarcinoma Xenograft
-
Radparvar, S.; Houghton, P. J.; Houghton, J. A. Effect of Polyglutamylation of 5,10-methyltetrahydrofolate on the Binding of 5-fluoro-2′-deoxyuridylate to Thymidylate Synthase Purified from a Human Colon Adencarcinoma Xenograft. Biochem. Pharmacol. 1989, 38, 335-342.
-
(1989)
Biochem. Pharmacol.
, vol.38
, pp. 335-342
-
-
Radparvar, S.1
Houghton, P.J.2
Houghton, J.A.3
-
59
-
-
0026721532
-
Modulation of Fluorouracil by Leucovorin in Patients with Advanced Colorectal Cancer; Evidence in Terms of Response Rate
-
Advanced Colorectal Cancer Meta-analysis Project. Modulation of Fluorouracil by Leucovorin in Patients with Advanced Colorectal Cancer; Evidence in Terms of Response Rate. J. Clin. Oncol. 1992, 10, 896-903.
-
(1992)
J. Clin. Oncol.
, vol.10
, pp. 896-903
-
-
-
60
-
-
0031019918
-
Randomised Trial Comparing Monthly Low Dose Leucovorin and Fluorouracil Bolus with Bimonthly High Dose Leucovorin and Fluorouracil plus Continuous Infusion for Advanced Colorectal Cancer: A French Intergroup Study
-
De Gramont, A.; Bosset, J. F.; Milan, C.; Rougier, P.; Bouche, O.; Etienne, P. L.; Morva F.; Louvet C. Randomised Trial Comparing Monthly Low Dose Leucovorin and Fluorouracil Bolus with Bimonthly High Dose Leucovorin and Fluorouracil plus Continuous Infusion for Advanced Colorectal Cancer: A French Intergroup Study. J. Clin. Oncol. 1997, 15, 808-815.
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 808-815
-
-
De Gramont, A.1
Bosset, J.F.2
Milan, C.3
Rougier, P.4
Bouche, O.5
Etienne, P.L.6
Morva, F.7
Louvet, C.8
-
61
-
-
0029644482
-
International Multicentre Pooled Analysis of Colon cancer Trials (IMPACT)
-
International Multicentre Pooled Analysis of Colon cancer Trials (IMPACT). Lancet 1995, 345, 939-945.
-
(1995)
Lancet
, vol.345
, pp. 939-945
-
-
-
62
-
-
0031982505
-
Prospectively Randomised Trial of Post-Operative Adjuvant Chemotherapy in Patients with High Risk Colon Cancer
-
O'Connell, M. J.; Laurie, J. A.; Kahn, M.; Fitzgibbons, R. J., Jr.; Erlichman, C.; Shepherd, L.; Moertel, C. G.; Kocha, W. I.; Pazdur, R.; Wieand, H. S.; Rubin, J.; Vukov, A. M.; Donohue, J. H.; Krook, J. E.; Figueredo, A. Prospectively Randomised Trial of Post-Operative Adjuvant Chemotherapy in Patients with High Risk Colon Cancer. J. Clin. Oncol. 1998, 16, 295-300.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 295-300
-
-
O'Connell, M.J.1
Laurie, J.A.2
Kahn, M.3
Fitzgibbons Jr., R.J.4
Erlichman, C.5
Shepherd, L.6
Moertel, C.G.7
Kocha, W.I.8
Pazdur, R.9
Wieand, H.S.10
Rubin, J.11
Vukov, A.M.12
Donohue, J.H.13
Krook, J.E.14
Figueredo, A.15
-
63
-
-
0032729240
-
Clinical Trial to Assess the Relative Efficacy of Fluorouracil and Leucovorin, Flurouracil and Levimasole in Patients with Duke's B and C Carcinoma of the Colon: Results from the National Surgical Adjuvant Breast and Bowel Project C-04
-
Wolmark, N.; Rockette, H.; Mamounas, E.; Jones, J.; Wieand, S.; Wickerham, D. L.; Bear, H. D.; Atkins, J. N.; Dimitrov, N. V.; Glass, A. G.; Fisher E.R.; Fisher B. Clinical Trial to Assess the Relative Efficacy of Fluorouracil and Leucovorin, Flurouracil and Levimasole in Patients with Duke's B and C Carcinoma of the Colon: Results from the National Surgical Adjuvant Breast and Bowel Project C-04. J. Clin. Oncol. 1999, 17, 3533-3539.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 3533-3539
-
-
Wolmark, N.1
Rockette, H.2
Mamounas, E.3
Jones, J.4
Wieand, S.5
Wickerham, D.L.6
Bear, H.D.7
Atkins, J.N.8
Dimitrov, N.V.9
Glass, A.G.10
Fisher, E.R.11
Fisher, B.12
-
64
-
-
0032950293
-
Efficacy of adjuvant 5-fluorouracil and leucovorin in B2 colon cancer
-
International Multicentre pooled Analysis of B2 Colon Cancer Trials Investigators. Efficacy of adjuvant 5-fluorouracil and leucovorin in B2 colon cancer. J. Clin. Oncol. 1999, 17, 1356-1363.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 1356-1363
-
-
-
65
-
-
1542775262
-
No Treatment for the over 65s? Agreeing a Definition of Fit and Unfit for Chemotherapy
-
Cunningham D.; Haller D.; Miles A.; (editors). London. Aesulapius Medical Press
-
Sumpter, K.; Hill M. No Treatment for the over 65s? Agreeing a Definition of Fit and Unfit for Chemotherapy. The Effective Management of Colorectal Cancer. Cunningham D.; Haller D.; Miles A.; (editors). London. Aesulapius Medical Press, 2000, pp75-86.
-
(2000)
The Effective Management of Colorectal Cancer
, pp. 75-86
-
-
Sumpter, K.1
Hill, M.2
-
66
-
-
0034611854
-
Comparison of Flurouracil with Additional Levimasole, Higher Dose Folinic Acid, or Both as Adjuvant Therapy for Colorectal Cancer: A Randomised Trial
-
QUASAR Collabourative Group. Comparison of Flurouracil with Additional Levimasole, Higher Dose Folinic Acid, or Both as Adjuvant Therapy for Colorectal Cancer: A Randomised Trial. Lancet 2000, 355, 1588-1595.
-
(2000)
Lancet
, vol.355
, pp. 1588-1595
-
-
-
67
-
-
0038575246
-
Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer
-
Saini, A.; Norman, A. R.; Cunningham, D.; Chau, I.; Hill, M.; Tait, D.; Hickish, T.; Iveson, T.; Lofts F. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer. Br. J. Cancer 2003, 88, 1859-1865.
-
(2003)
Br. J. Cancer
, vol.88
, pp. 1859-1865
-
-
Saini, A.1
Norman, A.R.2
Cunningham, D.3
Chau, I.4
Hill, M.5
Tait, D.6
Hickish, T.7
Iveson, T.8
Lofts, F.9
-
68
-
-
25744437741
-
Adjuvant Treatment of Dukes's C Colorectal Cancer with 6 cycles of Modified DeGramont 5-Fluorouracil/Folinic Acid Produces Disease Free and Overall Survival Comparible to 6 months of Treatment
-
Petty, R. D.; Samuel, L. M.; Cassidy, J. Adjuvant Treatment of Dukes's C Colorectal Cancer with 6 cycles of Modified DeGramont 5-Fluorouracil/Folinic Acid Produces Disease Free and Overall Survival Comparible to 6 months of Treatment. Br. J. Cancer 2002, 86, (Suppl. I), S52.
-
(2002)
Br. J. Cancer
, vol.86
, Issue.SUPPL. I
-
-
Petty, R.D.1
Samuel, L.M.2
Cassidy, J.3
-
69
-
-
0031017851
-
Patient Preferences for Oral Versus Intravenous Palliative Chemotherapy
-
Liu, G.; Franssen, E.; Fitch, M. I.; Warner, E. Patient Preferences for Oral Versus Intravenous Palliative Chemotherapy. J. Clin. Oncol. 1997, 15, 110-115.
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 110-115
-
-
Liu, G.1
Franssen, E.2
Fitch, M.I.3
Warner, E.4
-
70
-
-
0032874167
-
A Human Capecitabine Excretion Balance Pharmacokinetic Study after Administration of a Single Oral Dose of 14C-labelled Drug
-
Judson, R.; Beale, P. J. A Human Capecitabine Excretion Balance and Pharmacokinetic Study after Administration of a Single Oral Dose of 14C-labelled Drug. Invest. New Drug. 1999, 17, 49-56.
-
(1999)
Invest. New Drug
, vol.17
, pp. 49-56
-
-
Judson, R.1
Beale, P.J.2
-
71
-
-
0032127244
-
Design of a Novel Oral Fluoropyrimidine Carbamate, Capecitabine which generates 5-flurouracil Selectively in Tumours by Enzymes Concentrated in Human Liver and Cancer Tissue
-
Miwa, M.; Ura, M.; Nisida, M. Design of a Novel Oral Fluoropyrimidine Carbamate, Capecitabine which generates 5-flurouracil Selectively in Tumours by Enzymes Concentrated in Human Liver and Cancer Tissue. Eur. J. Cancer 1998, 34, 1274-1281.
-
(1998)
Eur. J. Cancer
, vol.34
, pp. 1274-1281
-
-
Miwa, M.1
Ura, M.2
Nisida, M.3
-
72
-
-
0034016415
-
Preferential Activation of Capecitabine in Tumour Following Oral Administration to Colorectal Cancer Patients
-
Schuller, J.; Cassidy, J. Preferential Activation of Capecitabine in Tumour Following Oral Administration to Colorectal Cancer Patients. Cancer Chem. Pharmacol. 2000, 45, 291-297.
-
(2000)
Cancer Chem. Pharmacol.
, vol.45
, pp. 291-297
-
-
Schuller, J.1
Cassidy, J.2
-
73
-
-
0034016343
-
Capecitabine, an Oral Fluropyrimodine Carbamate with Substantial Activity in Colorectal Cancer: Results of a Randomised Phase II Study
-
Van Cutsem, E.; Findlay, M.; Osterwalder, B.; Kocha, W.; Dalley, D.; Pazdur, R.; Cassidy, J.; Dirix, L.; Twelves, C.; Allman, D.; Seitz, J. F.; Scholmerich, J.; Burger, H. U.; Verweij J. Capecitabine, an Oral Fluropyrimodine Carbamate with Substantial Activity in Colorectal Cancer: Results of a Randomised Phase II Study. J. Clin. Oncol. 2000, 18, 1337-1345.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 1337-1345
-
-
Van Cutsem, E.1
Findlay, M.2
Osterwalder, B.3
Kocha, W.4
Dalley, D.5
Pazdur, R.6
Cassidy, J.7
Dirix, L.8
Twelves, C.9
Allman, D.10
Seitz, J.F.11
Scholmerich, J.12
Burger, H.U.13
Verweij, J.14
-
74
-
-
0034792770
-
Vision of the Future: Capecitabine
-
Twelves, C. Vision of the Future: Capecitabine. Oncologist 2001, 6(suppl 4), 35-39.
-
(2001)
Oncologist
, vol.6
, Issue.SUPPL. 4
, pp. 35-39
-
-
Twelves, C.1
-
75
-
-
0035871538
-
Comparison of Oral Capecitabine Versus Intravenous Fluorouracil Plus Leucovorin as First Line Treatment in 605 patients with Metastatic Colorectal Cancer; Results of a Randomised Phase III study
-
Hoff, P. M.; Ansari, R.; Batist, G. Comparison of Oral Capecitabine Versus Intravenous Fluorouracil Plus Leucovorin as First Line Treatment in 605 patients with Metastatic Colorectal Cancer; Results of a Randomised Phase III study. J. Clin. Oncol. 2001, 19, 2282-2292.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 2282-2292
-
-
Hoff, P.M.1
Ansari, R.2
Batist, G.3
-
76
-
-
0035503151
-
Oral Capecitabine Compared with Intravenous 5-Fluoruracil plus Leucovorin (Mayo Clinic regimen) in Patients with Metastatic Colorectal Cancer; Results of a Large Phase III study
-
Van Cutsem, E.; Twelves, C.; Cassidy, J.; Allman, D.; Bajetta, E.; Boyer, M.; Bugat, R.; Findlay, M.; Frings, S.; Jahn,; McKendrick, J.; Osterwalder, B. ; Perez-Manga, G.; Rosso, R.; Rougier, P.; Schmiegel, W. H. Oral Capecitabine Compared with Intravenous 5-Fluoruracil plus Leucovorin (Mayo Clinic regimen) in Patients with Metastatic Colorectal Cancer; Results of a Large Phase III study. J. Clin. Oncol. 2001, 19, 4097-4106.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 4097-4106
-
-
Van Cutsem, E.1
Twelves, C.2
Cassidy, J.3
Allman, D.4
Bajetta, E.5
Boyer, M.6
Bugat, R.7
Findlay, M.8
Frings, S.9
Jahn10
McKendrick, J.11
Osterwalder, B.12
Perez-Manga, G.13
Rosso, R.14
Rougier, P.15
Schmiegel, W.H.16
-
77
-
-
0002500431
-
Capecitabine as First line Treatment for Colorectal Cancer: Integrated Results from 1207 Patients from 2 Randomised Phase II studies. On behalf of the Capecitabine CRC study Group
-
Hoff, P. M. Capecitabine as First line Treatment for Colorectal Cancer: Integrated Results from 1207 Patients from 2 Randomised Phase II studies. On behalf of the Capecitabine CRC study Group. Annal. of Oncol. 2000, 11(suppl. 4), 60a.
-
(2000)
Annal. of Oncol.
, vol.11
, Issue.SUPPL. 4
-
-
Hoff, P.M.1
-
78
-
-
0034798771
-
The Evolution of Fluoropyrimidine Therapy: From Intravenous to Oral
-
Hoff, P. M.; Cassidy, J.; Schmoll, H.-J. The Evolution of Fluoropyrimidine Therapy: From Intravenous to Oral. Oncologist 2001, 6(suppl. 4), 3-11.
-
(2001)
Oncologist
, vol.6
, Issue.SUPPL. 4
, pp. 3-11
-
-
Hoff, P.M.1
Cassidy, J.2
Schmoll, H.-J.3
-
79
-
-
0003258995
-
Effective Dose Modification Scheme for the Management of Toxicities with Capecitabine Therapy; Data from Metastatic Colorectal Cancer Phase II Trials
-
Capecitabine CRC study Group
-
Cassidy, J.; Twelves, C. Effective Dose Modification Scheme for the Management of Toxicities with Capecitabine Therapy; Data from Metastatic Colorectal Cancer Phase II Trials. Capecitabine CRC study Group. Annal. Oncol. 2000, 11(suppl. 4), 62a.
-
(2000)
Annal. Oncol.
, vol.11
, Issue.SUPPL. 4
-
-
Cassidy, J.1
Twelves, C.2
-
80
-
-
1542460451
-
Metabolic Activation of R,S-I-(tetrahydro-2-furanyl)-5-Fluorouracil by Soluble Enzymes
-
El Sayed Y. M.; Sadee W. Metabolic Activation of R,S-I-(tetrahydro-2-furanyl)-5-Fluorouracil by Soluble Enzymes. Cancer Res. 1983, 43, 4309-4344.
-
(1983)
Cancer Res.
, vol.43
, pp. 4309-4344
-
-
El Sayed, Y.M.1
Sadee, W.2
-
81
-
-
0022398782
-
Effects of Uridine and Thymidine on the Degradation of 5-fluorouracil, Uracil and Thymine by rat liver Dihydropyrimidine Dehydrgenase
-
Tuchman, M.; Ramnaiarine, M. L.; O'Dea, R. F. Effects of Uridine and Thymidine on the Degradation of 5-fluorouracil, Uracil and Thymine by rat liver Dihydropyrimidine Dehydrgenase. Cancer Res. 1985, 45, 5553-5556.
-
(1985)
Cancer Res.
, vol.45
, pp. 5553-5556
-
-
Tuchman, M.1
Ramnaiarine, M.L.2
O'Dea, R.F.3
-
82
-
-
0019357727
-
General Pharmacological Properties of UFT, a New type of Anti-cancer Agent Consisting of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and Uracil.: Pharmacological Analysis of the Combined Effect of FT and Uracil
-
Yamamoto, J.; Toide, K.; Haruno, A.; Yoshimura, Y.; Unemi, N. General Pharmacological Properties of UFT, a New type of Anti-cancer Agent Consisting of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and Uracil.: Pharmacological Analysis of the Combined Effect of FT and Uracil. Arzneimittelforshrung, 1981, 31, 1268-1278.
-
(1981)
Arzneimittelforshrung
, vol.31
, pp. 1268-1278
-
-
Yamamoto, J.1
Toide, K.2
Haruno, A.3
Yoshimura, Y.4
Unemi, N.5
-
83
-
-
0028099423
-
Phase II Trial of Uracil plus Tegafur plus Oral Leucovorin: An Effective Oral Regimen in the Treatment of Metastaic Colorectal Carcinoma
-
Pazdur, R.; Lassere, Y.; Rhodes, V.; Ajani, A.; Sugarman, S. M.; Patt, Y. Z.; Jones, D. V., Jr.; Markowitz, A. B.; Abbruzzese, J. L. Phase II Trial of Uracil plus Tegafur plus Oral Leucovorin: An Effective Oral Regimen in the Treatment of Metastaic Colorectal Carcinoma. J. Clin. Oncol. 1994, 12, 2296-2300.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 2296-2300
-
-
Pazdur, R.1
Lassere, Y.2
Rhodes, V.3
Ajani, A.4
Sugarman, S.M.5
Patt, Y.Z.6
Jones Jr., D.V.7
Markowitz, A.B.8
Abbruzzese, J.L.9
-
84
-
-
0023726563
-
Report on the Nationwide Pooled Data and Cohort Investigation in UFT Phase II study
-
Ota, K.; Taguchi, T. Report on the Nationwide Pooled Data and Cohort Investigation in UFT Phase II study. Cancer Chem. Pharmacol. 1988, 22, 333-338.
-
(1988)
Cancer Chem. Pharmacol.
, vol.22
, pp. 333-338
-
-
Ota, K.1
Taguchi, T.2
-
85
-
-
0036727089
-
Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
-
Carmichael, J.; Popiela, T.; Radstone, D.; Falk, S.; Borner, M.; Oza, A. ; Skovsgaard, T.; Munier, S.; Martin, C. Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol, 2002, 20, 3617-3627.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3617-3627
-
-
Carmichael, J.1
Popiela, T.2
Radstone, D.3
Falk, S.4
Borner, M.5
Oza, A.6
Skovsgaard, T.7
Munier, S.8
Martin, C.9
-
86
-
-
0031060206
-
Phase II study of UFT plus leucovorin in colorectal cancer
-
Pazdur, R. Phase II study of UFT plus leucovorin in colorectal cancer. Oncology. 1997; 54 Suppl. 1:19-23.
-
(1997)
Oncology
, vol.54
, Issue.SUPPL.
, pp. 19-23
-
-
Pazdur, R.1
-
87
-
-
0032784111
-
Eniluracil Treatment Completely Inactivates DPD Activity in Colorectal Tumours
-
Ahmed, F. Y.; Johnston, S. J.; Cassidy, J.; O'Kelly, T.; Binnie, N.; Murray, G. I.; van Gennip, A. H.; Abeling, N. G. Eniluracil Treatment Completely Inactivates DPD Activity in Colorectal Tumours. J. Clin. Oncol. 1999, 17, 2439-2445.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 2439-2445
-
-
Ahmed, F.Y.1
Johnston, S.J.2
Cassidy, J.3
O'Kelly, T.4
Binnie, N.5
Murray, G.I.6
Van Gennip, A.H.7
Abeling, N.G.8
-
88
-
-
10544243363
-
A Pharmacokinetic, Oral Bioavailability and Safety of Fluorouracil in Patients Treated with 776C85, an Activator of DPD
-
Baker, S. D.; Khor, S. P.; Adjei, A. A.; Doucette, M.; Spector, T.; Donehower, R.C.; Grochow, L. B.; Sartorius, S. E.; Noe, D. A.; Hohneker, J., A. ; Rowinsky, E. K. A Pharmacokinetic, Oral Bioavailability and Safety of Fluorouracil in Patients Treated with 776C85, an Activator of DPD. J. Clin. Oncol. 1996, 14, 3085-96.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 3085-3096
-
-
Baker, S.D.1
Khor, S.P.2
Adjei, A.A.3
Doucette, M.4
Spector, T.5
Donehower, R.C.6
Grochow, L.B.7
Sartorius, S.E.8
Noe, D.A.9
Hohneker, J.A.10
Rowinsky, E.K.11
-
89
-
-
0031900670
-
Phase I Clinical and Pharmacologic Study of Eniluracil Plus Fluorouracil in Patients with Advanced Cancer
-
Schilsky, R. L.; Hohneker, J.; Ratain, M. J.; Janisch, L.; Smetzer, L.; Lucas, V. S.; Khor, S. P.; Diasio, R.; Von Hoff, D. D.; Burris, H. A. Phase I Clinical and Pharmacologic Study of Eniluracil Plus Fluorouracil in Patients with Advanced Cancer. J. Clin. Oncol. 1998, 16, 1450-1457.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 1450-1457
-
-
Schilsky, R.L.1
Hohneker, J.2
Ratain, M.J.3
Janisch, L.4
Smetzer, L.5
Lucas, V.S.6
Khor, S.P.7
Diasio, R.8
Von Hoff, D.D.9
Burris, H.A.10
-
90
-
-
0034034108
-
A Multicenter Phase II Study of a Five-Day Regimen of Oral 5-Fluorouracil Plus Eniluracil with or without Leucovorin in Patients with Metastatic Colorectal Cancer
-
Schilsky, R. L.; Bukowski, R.; Burris, H., III; Hochster, H.; O'Rourke, M.; Wall, J. G.; Mani, S.; Bonny, T.; Levin, J.; Hohneker, J. A Multicenter Phase II Study of a Five-Day Regimen of Oral 5-Fluorouracil Plus Eniluracil with or without Leucovorin In Patients with Metastatic Colorectal Cancer. Ann. Oncol. 2000, 11, 415-420.
-
(2000)
Ann. Oncol.
, vol.11
, pp. 415-420
-
-
Schilsky, R.L.1
Bukowski, R.2
Burris III, H.3
Hochster, H.4
O'Rourke, M.5
Wall, J.G.6
Mani, S.7
Bonny, T.8
Levin, J.9
Hohneker, J.10
-
91
-
-
0037087668
-
Randomized, open-label, phase III study of a 28-day oral regimen of eniluracil plus fluorouracil versus intravenous fluorouracil plus leucovorin as first-line therapy in patients with metastatic/advanced colorectal cancer
-
Schilsky, R. L.; Levin, J.; West, W. H.; Wong, A.; Colwell, B.; Thirlwell, M. P.; Ansari, R. H.; Bell, W. N.; White, R. L.; Yates, B. B.; McGuirt, P. V.; Pazdur, R. Randomized, open-label, phase III study of a 28-day oral regimen of eniluracil plus fluorouracil versus intravenous fluorouracil plus leucovorin as first-line therapy in patients with metastatic/advanced colorectal cancer. J. Clin. Oncol. 2002, 20, 1519-1526.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 1519-1526
-
-
Schilsky, R.L.1
Levin, J.2
West, W.H.3
Wong, A.4
Colwell, B.5
Thirlwell, M.P.6
Ansari, R.H.7
Bell, W.N.8
White, R.L.9
Yates, B.B.10
McGuirt, P.V.11
Pazdur, R.12
-
92
-
-
0036018890
-
Eastern Cooperative Oncology Group Phase III trial (E4296) of Oral 5-Fluorouracil and Eniluracil as a 28-Day Regimen in Metastatic Colorectal Cancer
-
Marsh, J. C.; Catalano, P.; Huang, J.; Graham, D. L.; Cornfeld, M. J.; O'Dwyer, P. J.; Benson, A. B., III. Eastern Cooperative Oncology Group Phase III trial (E4296) of Oral 5-Fluorouracil and Eniluracil as a 28-Day Regimen in Metastatic Colorectal Cancer. Clin Colorectal Cancer 2002, 2, 43-50
-
(2002)
Clin Colorectal Cancer
, vol.2
, pp. 43-50
-
-
Marsh, J.C.1
Catalano, P.2
Huang, J.3
Graham, D.L.4
Cornfeld, M.J.5
O'Dwyer, P.J.6
Benson III, A.B.7
-
94
-
-
0034657911
-
Fas-dependent and Fas-independent Mechanisms of Cell death following DNA damage in human colon carcinoma cells
-
Petak, I.; Tillman, D. M.; Harwood, F. G.; Mihalik, R.; Houghton, J. A. Fas-dependent and Fas-independent Mechanisms of Cell death following DNA damage in human colon carcinoma cells. Cancer Res. 2000, 60, 2643-2650.
-
(2000)
Cancer Res.
, vol.60
, pp. 2643-2650
-
-
Petak, I.1
Tillman, D.M.2
Harwood, F.G.3
Mihalik, R.4
Houghton, J.A.5
-
95
-
-
0033748796
-
p53 Dependence of fas Induction and Acute Apoptosis in Response to 5-fluorouracil-leucovorin in Human Colon Carcinoma cell lines
-
Petak, I.; Tillman, D. M.; Hougton, J. A. p53 Dependence of fas Induction and Acute Apoptosis in Response to 5-fluorouracil-leucovorin in Human Colon Carcinoma cell lines. Clin. Cancer Res. 2000, 6, 4432-4441.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 4432-4441
-
-
Petak, I.1
Tillman, D.M.2
Hougton, J.A.3
-
96
-
-
0030808385
-
Thymineless Death in Colon Carcinoma Cells is Mediated via Fas Signalling
-
Houghton, J. A.; Harwood, F. G.; Tillman, D. M. Thymineless Death in Colon Carcinoma Cells is Mediated via Fas Signalling. Proc. Natl. Acad. Sci USA 1987, 94, 8144-8149.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8144-8149
-
-
Houghton, J.A.1
Harwood, F.G.2
Tillman, D.M.3
-
97
-
-
0027145632
-
Molecular Cloning and Expression of the Fas Ligand, a Novel Member of the TNF family
-
Suda, T.; Takahashi, T.; Golstein, P.; Nagata, S. Molecular Cloning and Expression of the Fas Ligand, a Novel Member of the TNF family. Cell 1993, 75, 1169-1178.
-
(1993)
Cell
, vol.75
, pp. 1169-1178
-
-
Suda, T.1
Takahashi, T.2
Golstein, P.3
Nagata, S.4
-
98
-
-
0028246885
-
Expression of APO-I (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium
-
Moller, P.; Koretz, K.; Leithauser, F.; Bruderlein, S.; Henne, C.; Quentmeier, A.; Krammer, P. H. Expression of APO-I (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium Intl. J. Cancer 1994, 57, 371-377.
-
(1994)
Intl. J. Cancer
, vol.57
, pp. 371-377
-
-
Moller, P.1
Koretz, K.2
Leithauser, F.3
Bruderlein, S.4
Henne, C.5
Quentmeier, A.6
Krammer, P.H.7
-
99
-
-
0030892234
-
Apoptosis by Death factor
-
Nagata, S. Apoptosis by Death factor. Cell 1997, 88, 355-365.
-
(1997)
Cell
, vol.88
, pp. 355-365
-
-
Nagata, S.1
-
100
-
-
0032575714
-
Death Receptors: Signalling and Modulation
-
Askenazi, A.; Dixit, V. M. Death Receptors: Signalling and Modulation. Science 1998, 281, 1305-1308.
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Askenazi, A.1
Dixit, V.M.2
-
101
-
-
0031743648
-
p53 Activated the CD95 (APO-I/fas) Gene in Reponse to DNA Damage by Anticancer Agents
-
Muller, M.; Wilder, S.; Bannasch, D.; Israeli, D.; Lehlbach, K.; Li, W. M.; Friedman, S. L.; Galle, P. R.; Stremmel, R. W. Oren, M.; Krammer, P. H. p53 Activated the CD95 (APO-I/fas) Gene in Reponse to DNA Damage by Anticancer Agents. J. Exp. Med. 1998, 188, 2033-20445.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 2033-20445
-
-
Muller, M.1
Wilder, S.2
Bannasch, D.3
Israeli, D.4
Lehlbach, K.5
Li, W.M.6
Friedman, S.L.7
Galle, P.R.8
Stremmel, R.W.9
Oren, M.10
Krammer, P.H.11
-
102
-
-
0033118475
-
Apoptosis, p53 and Tumour cell Sensitivity to Anticancer Agents
-
Brown, J. M.; Wouters, B. G. Apoptosis, p53 and Tumour cell Sensitivity to Anticancer Agents. Cancer Research 1999, 59, 1391-1399.
-
(1999)
Cancer Research
, vol.59
, pp. 1391-1399
-
-
Brown, J.M.1
Wouters, B.G.2
-
103
-
-
0032891550
-
A Novel Adenoviral Vector Expressing Human fas/APO-I/CD95 Enhances p53 Mediated Apoptosis
-
Rakkar, A. N. S.; Katoyse, Y.; Kim, M.; Craig, C.; Ohiri, E.; Li, Z.; Cown, K. H.; Seth, P. A. A Novel Adenoviral Vector Expressing Human fas/APO-I/CD95 Enhances p53 Mediated Apoptosis. Cell Death Differen. 1999, 6, 326-333.
-
(1999)
Cell Death Differen.
, vol.6
, pp. 326-333
-
-
Rakkar, A.N.S.1
Katoyse, Y.2
Kim, M.3
Craig, C.4
Ohiri, E.5
Li, Z.6
Cown, K.H.7
Seth, P.A.8
-
104
-
-
0030916669
-
The Proto-oncogene Bcl-2 and its Role in Regulating Apoptosis
-
Kroemer, G. The Proto-oncogene Bcl-2 and its Role in Regulating Apoptosis. Nat. Med. 1997, 3, 614-617.
-
(1997)
Nat. Med.
, vol.3
, pp. 614-617
-
-
Kroemer, G.1
-
105
-
-
0027279128
-
Bcl-2 Modulation of Apoptosis Induced by Anticancer Drugs: Resistance to Thymidylate Stress is Independent of Classical Resistance Pathways
-
Fisher, T. C.; Milner, A. E.; Gregory, C. D.; Jackman, A. L. Bcl-2 Modulation of Apoptosis Induced by Anticancer Drugs: Resistance to Thymidylate Stress is Independent of Classical Resistance Pathways. Cancer Res. 1993, 53, 3321-3326.
-
(1993)
Cancer Res.
, vol.53
, pp. 3321-3326
-
-
Fisher, T.C.1
Milner, A.E.2
Gregory, C.D.3
Jackman, A.L.4
-
106
-
-
0030861571
-
Bcl-2 and Bax Function Independently to Regulate Cell Death
-
Knudson, C. M.; Korsmeyer S. J. Bcl-2 and Bax Function Independently to Regulate Cell Death. Nat. Gen. 1997, 16, 358-363.
-
(1997)
Nat. Gen.
, vol.16
, pp. 358-363
-
-
Knudson, C.M.1
Korsmeyer, S.J.2
-
107
-
-
0034088892
-
Molecular Downstream Events and Induction of Thymidylate Synthase in Mutant and Wild Type p53 Colon Cancer Cell Lines after Treatment with 5-Fluorouracil and the Thymidylate Synthase Inhibitor Raltitrexed
-
Peters, G. J.; Van Triest, H. H. J.; Backus, C. M.; Van der Wilt, C. L.; Pinedo, H. M. Molecular Downstream Events and Induction of Thymidylate Synthase in Mutant and Wild Type p53 Colon Cancer Cell Lines after Treatment with 5-Fluorouracil and the Thymidylate Synthase Inhibitor Raltitrexed. Eur. J. Cancer 2000, 36, 916-924.
-
(2000)
Eur. J. Cancer
, vol.36
, pp. 916-924
-
-
Peters, G.J.1
Van Triest, H.H.J.2
Backus, C.M.3
Van Der Wilt, C.L.4
Pinedo, H.M.5
-
108
-
-
0038002279
-
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
-
[107a] Ribic, C. M.; Sargent, D. J.; Moore, M. J.; Thibodeau, S. J.; French, A. J.; Goldberg, R. N.; Hamilton, S. R.; Laurent-Puig, P.; Gryfe, R.; Shepherd, L. E.; Tu, D.; Redston, M.; Gallinger S. Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer. N. Engl. J. Med. 2003, 349, 247-57.
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 247-257
-
-
Ribic, C.M.1
Sargent, D.J.2
Moore, M.J.3
Thibodeau, S.J.4
French, A.J.5
Goldberg, R.N.6
Hamilton, S.R.7
Laurent-Puig, P.8
Gryfe, R.9
Shepherd, L.E.10
Tu, D.11
Redston, M.12
Gallinger, S.13
-
109
-
-
0028896159
-
Bcl-2 and p53 Oncoprotein Expression during Colorectal Tumourigenesis
-
Sinicrope, F. A.; Ruan, S. B.; Cleary, K. R.; Stephens, L. C.; Lee, J. J.; Levin B. Bcl-2 and p53 Oncoprotein Expression during Colorectal Tumourigenesis. Cancer Res. 1995, 55, 237-241.
-
(1995)
Cancer Res.
, vol.55
, pp. 237-241
-
-
Sinicrope, F.A.1
Ruan, S.B.2
Cleary, K.R.3
Stephens, L.C.4
Lee, J.J.5
Levin, B.6
-
110
-
-
0033770113
-
Capecitabine; Preclinical Pharmacology Studies
-
Ishitsuka, H. Capecitabine; Preclinical Pharmacology Studies. Invest. New Drugs 2000, 18, 343-354.
-
(2000)
Invest. New Drugs
, vol.18
, pp. 343-354
-
-
Ishitsuka, H.1
-
111
-
-
0037096755
-
Superior Survival with Capecitabine Plus Docetaxel Combination Therapy in Anthracycline-Pretreated Patients with Advanced Breast Cancer: Phase III Trial Results
-
O'Shaughnessy, J.; Miles, D.; Vukelja, S.; Moiseyenko, V.; Ayoub, J. P.; Cervantes, G.; Fumoleau, P.; Jones, S.; Lui, W. Y.; Mauriac, L.; Twelves, C.; Van Hazel, G.; Verma, S.; Leonard, R. Superior Survival with Capecitabine Plus Docetaxel Combination Therapy in Anthracycline-Pretreated Patients with Advanced Breast Cancer: Phase III Trial Results. J. Clin. Oncol. 2002, 20, 2812-2823.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2812-2823
-
-
O'Shaughnessy, J.1
Miles, D.2
Vukelja, S.3
Moiseyenko, V.4
Ayoub, J.P.5
Cervantes, G.6
Fumoleau, P.7
Jones, S.8
Lui, W.Y.9
Mauriac, L.10
Twelves, C.11
Van Hazel, G.12
Verma, S.13
Leonard, R.14
-
112
-
-
0034902364
-
Schedule Dependency of Antitumor Activity in Combination Therapy with Capecitabine/5′-Deoxy-5-Fluorouridine and Docetaxel in Breast Cancer Models
-
Fujimoto-Ouchi, K.; Tanaka, Y.; Tominaga, T. Schedule Dependency of Antitumor Activity in Combination Therapy with Capecitabine/5′ -Deoxy-5-Fluorouridine and Docetaxel in Breast Cancer Models. Clin. Cancer Res. 2001, 7, 1079-1086.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1079-1086
-
-
Fujimoto-Ouchi, K.1
Tanaka, Y.2
Tominaga, T.3
-
113
-
-
0002858704
-
A Phase II Ttrial of Capecitabine in Relapsed Ovarian Cancer
-
Vasey, P. A.; McMahon, L. A Phase II Ttrial of Capecitabine in Relapsed Ovarian Cancer. Ann. Oncol. 2000, 11(supl 4), 84a.
-
(2000)
Ann. Oncol.
, vol.11
, Issue.SUPPL. 4
-
-
Vasey, P.A.1
McMahon, L.2
-
114
-
-
0036137690
-
Phase II Study of Oral Capecitabine in Patients with Advanced or Metastatic Pancreatic Cancer
-
Cartwright, T. H.; Cohn, A.; Varkey, J. A.; Chen, Y. M.; Szatrowski, T. P.; Cox, J. V.; Schulz, J. J. Phase II Study of Oral Capecitabine in Patients with Advanced or Metastatic Pancreatic Cancer. J. Clin. Oncol. 2002, 20, 60-164.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 60-164
-
-
Cartwright, T.H.1
Cohn, A.2
Varkey, J.A.3
Chen, Y.M.4
Szatrowski, T.P.5
Cox, J.V.6
Schulz, J.J.7
-
115
-
-
0037208590
-
Combining Capecitabine and Gemcitabine in Patients with Advanced Pancreatic Carcinoma: A Phase I/II Trial
-
Hess, V.; Salzberg, M.; Borner, M.; Morant, R.; Roth, A. D.; Ludwig, C.; Herrmann, R. Combining Capecitabine and Gemcitabine in Patients with Advanced Pancreatic Carcinoma: A Phase I/II Trial. J. Clin. Oncol. 2003, 21, 66-68.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 66-68
-
-
Hess, V.1
Salzberg, M.2
Borner, M.3
Morant, R.4
Roth, A.D.5
Ludwig, C.6
Herrmann, R.7
-
116
-
-
0043202995
-
A Phase II Study of Mitomycin C, Cisplatin and Protracted infusional 5-Flurorouracil (MCF) in Advanced Pancreatic Carcinoma: Efficacy and Low Toxcity
-
Petty, R. D.; Nicolson, M. C.; Skaria, S.; Sinclair, T. S.; Samuel, L. M. A Phase II Study of Mitomycin C, Cisplatin and Protracted infusional 5-Flurorouracil (MCF) in Advanced Pancreatic Carcinoma: Efficacy and Low Toxcity. Ann. Oncol. 2003, 14, 1100-1105.
-
(2003)
Ann. Oncol.
, vol.14
, pp. 1100-1105
-
-
Petty, R.D.1
Nicolson, M.C.2
Skaria, S.3
Sinclair, T.S.4
Samuel, L.M.5
-
117
-
-
0034712536
-
Irinotecan combined with Fluorouracil Compared with Fluorouracil Alone in the First Line Treatment of Metastatic Colorectal Cancer: A Multicentre Randomised Trial
-
Douillard, J. Y.; Cunningham, D.; Roth A. Irinotecan combined with Fluorouracil Compared with Fluorouracil Alone in the First Line Treatment of Metastatic Colorectal Cancer: A Multicentre Randomised Trial. Lancet 2000, 355, 1041-1047.
-
(2000)
Lancet
, vol.355
, pp. 1041-1047
-
-
Douillard, J.Y.1
Cunningham, D.2
Roth, A.3
-
118
-
-
0033989203
-
Phase III Multicentre Randomised Trial of Oxaliplatin Added to Chronomodulated 5-Fluorouracil-leucovorin as First line Treatment for Metastatic Colorectal Cancer Oxaliplatin
-
Giacchetti, S.; Perpoint, B.; Zidani R. et al., Phase III Multicentre Randomised Trial of Oxaliplatin Added to Chronomodulated 5-Fluorouracil-leucovorin as First line Treatment for Metastatic Colorectal Cancer Oxaliplatin. J. Clin. Oncol. 2000, 18, 136-147.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 136-147
-
-
Giacchetti, S.1
Perpoint, B.2
Zidani, R.3
-
119
-
-
0033874892
-
Leucovorin and Fluorouracil with or without Oxaliplatin as First Line Treatment in Advanced Colorectal Cancer
-
De Gramont, A.; Figer, A.; Seymour, M. Leucovorin and Fluorouracil with or without Oxaliplatin as First Line Treatment in Advanced Colorectal Cancer. J. Clin. Oncol. 2000, 18, 905-914.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 905-914
-
-
De Gramont, A.1
Figer, A.2
Seymour, M.3
-
120
-
-
0035018397
-
Five-Year Survival Following Hepatic Resection after Neoadjuvant Therapy for Nonresectable Colorectal [Liver] Metastases Ann
-
Adam, R.; Avisar, E.; Ariche, A.; Giachetti, A.; Azoulay, D.; Castaing D.; Kunstlinger F.; Levi F.; Bismuth F.Five-Year Survival Following Hepatic Resection After Neoadjuvant Therapy for Nonresectable Colorectal [Liver] Metastases Ann. Surg. Oncol. 2001, 8: 347-353.
-
(2001)
Surg. Oncol.
, vol.8
, pp. 347-353
-
-
Adam, R.1
Avisar, E.2
Ariche, A.3
Giachetti, A.4
Azoulay, D.5
Castaing, D.6
Kunstlinger, F.7
Levi, F.8
Bismuth, F.9
-
121
-
-
0029794696
-
Resection of Nonresectable Liver Metastases from Colorectal Cancer after Neoadjuvant Chemotherapy
-
Bismuth, H.; Adam, R.; Levi, F.; Giachetti, A. Resection of Nonresectable Liver Metastases from Colorectal Cancer after Neoadjuvant Chemotherapy. Ann. Surg. 1996, 224, 509-520.
-
(1996)
Ann. Surg.
, vol.224
, pp. 509-520
-
-
Bismuth, H.1
Adam, R.2
Levi, F.3
Giachetti, A.4
-
122
-
-
0033989203
-
Phase III Multicenter Randomized Trial of Oxaliplatin Added to Chronomodulated Fluorouracil-Leucovorin as First-Line Treatment of Metastatic Colorectal Cancer
-
Giacchetti, S.; Perpoint, B.;. Zidani, R.; Le Bail, N.; Faggiuolo, R.; Focan, C.; Chollet, P.; Llory, J.; Letourneau, Y.; Coudert, B.; Bertheaut-Cvitkovic, F.; Larregain-Fournier, D.; Le Rol, A.; Walter, S.; Ada, R.; Misset J.; Lévi F. Phase III Multicenter Randomized Trial of Oxaliplatin Added to Chronomodulated Fluorouracil-Leucovorin as First-Line Treatment of Metastatic Colorectal Cancer. J. Clin. Oncol. 2000, 18, 136-147.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 136-147
-
-
Giacchetti, S.1
Perpoint, B.2
Zidani, R.3
Le Bail, N.4
Faggiuolo, R.5
Focan, C.6
Chollet, P.7
Llory, J.8
Letourneau, Y.9
Coudert, B.10
Bertheaut-Cvitkovic, F.11
Larregain-Fournier, D.12
Le Rol, A.13
Walter, S.14
Ada, R.15
Misset, J.16
Lévi, F.17
-
123
-
-
0037837645
-
Randomized Multicenter Phase II Trial of Two Different Schedules of Capecitabine plus Oxaliplatin as First-line Treatment in Advanced Colorectal Cancer
-
Scheithauer, W.; Kornek, G. V. Raderer, M.; Schull, B.; Schmid, K.; Kovats, E.; Schneeweiss, B.; Lang, F.; Lenauer, A.; Depisch, D. Randomized Multicenter Phase II Trial of Two Different Schedules of Capecitabine plus Oxaliplatin as First-line Treatment in Advanced Colorectal Cancer. J. Clin. Oncol. 2003, 21(7), 1307-1312.
-
(2003)
J. Clin. Oncol.
, vol.21
, Issue.7
, pp. 1307-1312
-
-
Scheithauer, W.1
Kornek, G.V.2
Raderer, M.3
Schull, B.4
Schmid, K.5
Kovats, E.6
Schneeweiss, B.7
Lang, F.8
Lenauer, A.9
Depisch, D.10
-
124
-
-
0036545337
-
Capecitabine/irinotecan Combination Regimens in Colorectal Cancer
-
Kerr, D. J. Capecitabine/irinotecan Combination Regimens in Colorectal Cancer. Oncology 2002 16(4 Suppl 3),27-9.
-
(2002)
Oncology
, vol.16
, Issue.4 SUPPL. 3
, pp. 27-29
-
-
Kerr, D.J.1
-
125
-
-
0035987216
-
Capecitabine (Xeloda) in Combination with Oxaliplatin: A Phase I, Dose-escalation Study in Patients with Advanced or Metastatic Solid tumors
-
Diaz-Rubio, E.; Evans, T. R.; Tabemero, J.; Cassidy, J.; Sastre, J.; Eatock, M.; Bisset, D.; Regueiro, P.; Baselga, J. Capecitabine (Xeloda) in Combination with Oxaliplatin: a Phase I, Dose-escalation Study in Patients with Advanced or Metastatic Solid tumors. Ann. Oncol. 2002, 13(4):558-65.
-
(2002)
Ann. Oncol.
, vol.13
, Issue.4
, pp. 558-565
-
-
Diaz-Rubio, E.1
Evans, T.R.2
Tabemero, J.3
Cassidy, J.4
Sastre, J.5
Eatock, M.6
Bisset, D.7
Regueiro, P.8
Baselga, J.9
-
126
-
-
0034988840
-
Incorporating Genomics into the Cancer Clinical Trial Process
-
Paik, S. Incorporating Genomics into the Cancer Clinical Trial Process. Sem. Oncol. 2001, 28, 305-309.
-
(2001)
Sem. Oncol.
, vol.28
, pp. 305-309
-
-
Paik, S.1
-
127
-
-
0031926839
-
Effect of Preoperative chemotherapy on Outcome of Women with Operable Breast Cancer
-
Fisher, B.; Bryant, J.; Wolmark, N.; Mamounas, E.; Brown, A.; Fisher, E. R.; Wickerham, D. L.; Begovic, M.; DeCillis, A.; Robidoux, A.; Margolese, R. G. ; Cruz, A. B., Jr.; Hoehn, J. L.; Lees, A. W.; Dimitrov, N. V.; Bear, H. D. Effect of Preoperative chemotherapy on Outcome of Women with Operable Breast Cancer. J. Clin. Oncol. 1998, 16, 2672-2685.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 2672-2685
-
-
Fisher, B.1
Bryant, J.2
Wolmark, N.3
Mamounas, E.4
Brown, A.5
Fisher, E.R.6
Wickerham, D.L.7
Begovic, M.8
DeCillis, A.9
Robidoux, A.10
Margolese, R.G.11
Cruz Jr., A.B.12
Hoehn, J.L.13
Lees, A.W.14
Dimitrov, N.V.15
Bear, H.D.16
-
128
-
-
0026560328
-
Quantitation of Thymidylate Synthease, Dihydrofolate Reductase, DT-diaphorase Gene Expression in Human tumours using Polymerase Chain Reaction
-
Horikoshi, T.; Danenberg, K. D.; Stadbauer, T. H. Quantitation of Thymidylate Synthease, Dihydrofolate Reductase, DT-diaphorase Gene Expression in Human tumours using Polymerase Chain Reaction. Cancer Res. 1992, 51, 108-116.
-
(1992)
Cancer Res.
, vol.51
, pp. 108-116
-
-
Horikoshi, T.1
Danenberg, K.D.2
Stadbauer, T.H.3
-
129
-
-
0028151449
-
The role of Thymidylate Synthease Expression in Prognosis and Outcome of Adjuvant Chemotherapy in Patients with Rectal Cancer
-
Johnston, P., G.; Fisher, E. R.; Rockette, H. E.; Fisher, B.; Wolmark, N.; Drake, J. C. The role of Thymidylate Synthease Expression in Prognosis and Outcome of Adjuvant Chemotherapy in Patients with Rectal Cancer. J. Clin. Oncol. 1994, 12, 2640-2647.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 2640-2647
-
-
Johnston, P.G.1
Fisher, E.R.2
Rockette, H.E.3
Fisher, B.4
Wolmark, N.5
Drake, J.C.6
-
130
-
-
9044250848
-
Thymidylate Synthase mRNA Level in Adenocarcinoma of the Stomach: A Predictor for Primary Tumour Response and Overall Survival
-
Lenz, H. J.; Leichman, C. G.; Danenberg, K. D.; Danenberg, P. V.; Groshen, S.; Cohen, H.; Laine, L.; Crookes, P.; Silberman, H.; Baranda, J.; Garcia, Y.; Li, J.; Leichman, L. Thymidylate Synthase mRNA Level in Adenocarcinoma of the Stomach: A Predictor for Primary Tumour Response and Overall Survival. J. Clin. Oncol. 1996, 14, 176-182.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 176-182
-
-
Lenz, H.J.1
Leichman, C.G.2
Danenberg, K.D.3
Danenberg, P.V.4
Groshen, S.5
Cohen, H.6
Laine, L.7
Crookes, P.8
Silberman, H.9
Baranda, J.10
Garcia, Y.11
Li, J.12
Leichman, L.13
-
131
-
-
0031019404
-
Thymidylate Synthase Expression and Response to Neoadjuvant Chemotherapy in Patients with Advanced Head and Neck Cancer
-
Johnston, P. G.; Mick, R.; Recand, W. Thymidylate Synthase Expression and Response to Neoadjuvant Chemotherapy in Patients with Advanced Head and Neck Cancer. J. Natl. Cancer Inst. 1997, 89, 308-313.
-
(1997)
J. Natl. Cancer Inst.
, vol.89
, pp. 308-313
-
-
Johnston, P.G.1
Mick, R.2
Recand, W.3
-
132
-
-
12144289277
-
Prognostic Importance of Thymidylate Synthase Expression in Early Breast Cancer
-
Pestalozzi, B. C.; Peterson, H. F.; Gelber, R. D.; Goldhirsch, A.; Gusterson, B. A.; Trihia, H.; Lindtner, J.; Cortes-Funes, H.; Simmoncini, E.; Byrne, M. J.; Golouh, R.; Rudenstam, C. M.; Castiglione-Gertsch, M.; Allegra, C. J. Prognostic Importance of Thymidylate Synthase Expression in Early Breast Cancer. J. Clin. Oncol. 1997, 75, 903-907.
-
(1997)
J. Clin. Oncol.
, vol.75
, pp. 903-907
-
-
Pestalozzi, B.C.1
Peterson, H.F.2
Gelber, R.D.3
Goldhirsch, A.4
Gusterson, B.A.5
Trihia, H.6
Lindtner, J.7
Cortes-Funes, H.8
Simmoncini, E.9
Byrne, M.J.10
Golouh, R.11
Rudenstam, C.M.12
Castiglione-Gertsch, M.13
Allegra, C.J.14
-
133
-
-
0028982820
-
Response to Fluorouracil Therapy in Cancer Patients: The role of Tumoural Dihydropyrimidine Dehydrogenase
-
Etienne, M. C.; Cheradame, S.; Fischel, J. L.; Formento, P.; Dassonville, O.; Renee, N. Response to Fluorouracil Therapy in Cancer Patients: The role of Tumoural Dihydropyrimidine Dehydrogenase. J. Clin. Oncol. 1995, 13, 1663-1670.
-
(1995)
J. Clin. Oncol.
, vol.13
, pp. 1663-1670
-
-
Etienne, M.C.1
Cheradame, S.2
Fischel, J.L.3
Formento, P.4
Dassonville, O.5
Renee, N.6
-
134
-
-
0032945491
-
Dihydropyrimidine Dehydrogenase Activity and mRNA Level may be Correlated to to the Antitumour Effect of 5-fluorouracil on Human Tumour Xenografts in Nude Mice
-
Ishikawa, Y.; Kubota, T.; Otani, Y.; Watanabe, M.; Teramoto, T.; Kumai, K.; Takechi, T. Dihydropyrimidine Dehydrogenase Activity and mRNA Level may be Correlated to to the Antitumour Effect of 5-fluorouracil on Human Tumour Xenografts in Nude Mice. Clin. Cancer Res. 1999, 5, 883-889.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 883-889
-
-
Ishikawa, Y.1
Kubota, T.2
Otani, Y.3
Watanabe, M.4
Teramoto, T.5
Kumai, K.6
Takechi, T.7
-
135
-
-
0034048729
-
Colorectal Tumours Responding to 5-fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthease and Thymidine Phosphorylase
-
Salonga, D.; Danenberg, K. D.; Johnson, M.; Metzger, R.; Groshen, S.; Tsao-Wei, D. D.; Lenz, H. J.; Leichman, C. G.; Leichman, L.; Diasio, R. B.; Danenberg, P. V. Colorectal Tumours Responding to 5-fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthease and Thymidine Phosphorylase. Clin. Cancer Res. 2000, 6, 1322-1327.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 1322-1327
-
-
Salonga, D.1
Danenberg, K.D.2
Johnson, M.3
Metzger, R.4
Groshen, S.5
Tsao-Wei, D.D.6
Lenz, H.J.7
Leichman, C.G.8
Leichman, L.9
Diasio, R.B.10
Danenberg, P.V.11
-
136
-
-
1542669882
-
The Pharmacology of Anti-cancer Drugs
-
Souhami R.L.; Tannock I; Hoheriberger R.; Horiot J.C. Eds.; Oxford University Press
-
Newell, D. R.; McLeod, H.L.; Schullens H. N.; The Pharmacology of Anti-cancer Drugs. In Oxford Textbook of Oncology; Souhami R. L; Tannock I; Hoheriberger R.; Horiot J.C. Eds.; Oxford University Press 2002, pp623-638.
-
(2002)
Oxford Textbook of Oncology
, pp. 623-638
-
-
Newell, D.R.1
McLeod, H.L.2
Schullens, H.N.3
-
137
-
-
0029852580
-
Use of a cDNA Microarray to Analyse Gene Expression Patterns in Human Cancer
-
DeRisi, U. J.; Penland, L.; Brown, P. O.; Bittner, M. L.; Meltzer, P. S. ; Ray, M.; Chen, Y. Use of a cDNA Microarray to Analyse Gene Expression Patterns in Human Cancer. Nat. Gen. 1996, 14, 457-460.
-
(1996)
Nat. Gen.
, vol.14
, pp. 457-460
-
-
DeRisi, U.J.1
Penland, L.2
Brown, P.O.3
Bittner, M.L.4
Meltzer, P.S.5
Ray, M.6
Chen, Y.7
-
138
-
-
0033044686
-
Fas-dependent Component in 5-flourouracil/leucovorin-induced Cytotoxicity in Colon Carcinoma cells
-
Tilman, D. M.; Petak L.; Houghton J. A. Fas-dependent Component in 5-flourouracil/leucovorin-induced Cytotoxicity in Colon Carcinoma cells. Clin. Cancer Res. 1999, 5, 425-430.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 425-430
-
-
Tilman, D.M.1
Petak, L.2
Houghton, J.A.3
|