Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testes

Journal of Veterinary Science

Volumn 8, Issue 3, 2007, Pages 213-218

  Baek, In Jeoung ^a   Yon, Jung Min ^a   Lee, Se Ra ^a   Jin, Yan ^a   Kim, Mi Ra ^a   Ahn, Byeongwoo ^a   Jin, Tae Hong ^a   Choo, Young Kug ^b   Beom, Jun Lee ^a   Young, Won Yun ^a   Nam, Sang Yoon ^a  

^a Chungbuk National University   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

Biomarker; Endocrine disrupting chemicals; Phospholipid hydroperoxide glutathione peroxidase; RT PCR; Testis

Indexed keywords

RATTUS;

EID: 34548580176     PISSN: 1229845X     EISSN: None     Source Type: Journal    
DOI: 10.4142/jvs.2007.8.3.213     Document Type: Article

References (35)

1. Albertson BD, Frederick KL, Maronian NC, Feuillan P, Schorer S, Dunn JF, Loriaux DL. The effect of ketoconazole on steroidogenesis: I. Leydig cell enzyme activity in vitro. Res Commun Chem Pathol Pharmacol 1988, 61, 17-26.
2. Barlow NJ, Phillips SL, Wallace DG, Sar M, Gaido KW, Foster PM. Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. Toxicol Sci 2003, 73, 431-441.
3. Baskin LS, Himes K, Colborn T. Hypospadias and endocrine disruption: is there a connection? Environ Health Perspect 2001, 109, 1175-1183.
4. Boockfor FR, Blake CA. Chronic administration of 4-tertoctylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities. Biol Reprod 1997, 57, 267-277.
5. Brigelius-Flohé R. Tissue-specific functions of individual glutathione peroxidases. Free Radic Biol Med 1999, 27, 951-965.
6. Brigelius-Flohé R, Aumann KD, Blöcker H, Gross G, Kiess M, Klöppel KD, Maiorino M, Roveri A, Schuckelt R, Ursini F, Wingender E, Flohé L. Phospholipid-hydroperoxide glutathione peroxidase. Genomic DNA, cDNA, and deduced amino acid sequence. J Biol Chem 1994, 269, 7342-7348.
7. Couse JF, Dixon D, Yates M, Moore AB, Ma L, Maas R, Korach KS. Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract. Dev Biol 2001, 238, 224-238.
8. Couse JF, Korach KS. Estrogen receptor-α mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology 2004, 205, 55-63.
9. Fisher JS. Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 2004, 127, 305-315.
10. Giger W, Brunner PH, Schaffner C. 4-Nonylphenol in sewage sludge: accumulation of toxic metabolites from nonionic surfactants. Science 1984, 225, 623-625.
11. Gray LE, Ostby JS, Kelce WR. Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicol Appl Pharmacol 1994, 129, 46-52.
12. Hotchkiss AK, Ostby JS, Vandenbergh JG, Gray LE. An environmental antiandrogen, vinclozolin, alters the organization of play behavior. Physiol Behav 2003, 79, 151-156.
13. Imai H, Nakagawa Y. Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic Biol Med 2003, 34, 145-169.
14. Kim HH, Kwak DH, Yon JM, Baek IJ, Lee SR, Lee JE, Nahm SS, Jeong JH, Lee BJ, Yun YW, Nam SY. Differential expression of 3 ß-hydroxysteroid dehydrogenase mRNA in rat testes exposed to endocrine disruptors. J Reprod Dev 2007, 53, 465-471.
15. Knopp EA, Arndt TL, Eng KL, Caldwell M, LeBoeuf RC, Deeb SS, O'Brien KD. Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping. Mamm Genome 1999, 10, 601-605.
16. Korach KS, Chae K, Gibson M, Curtis S. Estrogen receptor stereochemistry: ligand binding and hormonal responsiveness. Steroids 1991, 56, 263-270.
17. Lapointe J, Kimmins S, Maclaren LA, Bilodeau JF. Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts. Endocrinology 2005, 146, 2583-2592.
18. LeBlanc GA, Bain LJ, Wilson VS. Pesticides: multiple mechanisms of demasculinization. Mol Cell Endocrinol 1997, 126, 1-5.
19. Maiorino M, Wissing JB, Brigelius-Flohé R, Calabrese F, Roveri A, Steinert P, Ursini F, Flohé L. Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation. FASEB J 1998, 12, 1359-1370.
20. Majdic G, Sharpe RM, Saunders PT. Maternal oestrogen/ xenoestrogen exposure alters expression of steroidogenic factor-1 (SF-1/Ad4BP) in the fetal rat testis. Mol Cell Endocrinol 1997, 127, 91-98.
21. Miossec P, Archambeaud-Mouveroux F, Teissier MP. Inhibition of steroidogenesis by ketoconazole. Therapeutic uses. Ann Endocrinol (Paris) 1997, 58, 494-502.
22. Mylchreest E, Sar M, Cattley RC, Foster PM. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol 1999, 156, 81-95.
23. Nam SY, Baek IJ, Lee BJ, In CH, Jung EY, Yon JM, Ahn B, Kang JK, Yu WJ, Yun YW. Effects of 17β-estradiol and tamoxifen on the selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA expression in male reproductive organs of rats. J Reprod Dev 2003, 49, 389-396.
24. Nam SY, Fujisawa M, Kim JS, Kurohmaru M, Hayashi Y. Expression pattern of phospholipid hydroperoxide glutathione peroxidase messenger ribonucleic acid in mouse testis. Biol Reprod 1998, 58, 1272-1276.
25. Ohsako S, Kubota K, Kurosawa S, Takeda K, Qing W, Ishimura R, Tohyama C. Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide. J Reprod Dev 2003, 49, 275-290.
26. Parks LG, Ostby JS, Lambright CR, Abbott BD, Klinefelter GR, Barlow NJ, Gray LE. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci 2000, 58, 339-349.
27. Pelletier G, Labrie C, Labrie F. Localization of oestrogen receptor α, oestrogen receptor β and androgen receptors in the rat reproductive organs. J Endocrinol 2000, 165, 359-370.
28. Prins GS, Birch L, Couse JF, Choi I, Katzenellenbogen B, Korach KS. Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with αERKO and βERKO mice. Cancer Res 2001, 61, 6089-6097.
29. Roveri A, Casasco A, Maiorino M, Dalan P, Calligaro A, Ursini F. Phospholipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin dependence and immunocytochemical identification. J Biol Chem 1992, 267, 6142-6146.
30. Sharpe RM, Irvine DS. How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health? BMJ 2004, 328, 447-451.
31. Thomas JP, Maiorino M, Ursini F, Girotti AW. Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides. J Biol Chem 1990, 265, 454-461.
32. Thompson CJ, Ross SM, Gaido KW. Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. Endocrinology 2004, 145, 1227-1237.
33. Viguier-Martinez MC, Hochereau-de Reviers MT, Perreau C. Effects of flutamide or of supplementation with testosterone in prepubertal male rats prenatally treated with busulfan. Acta Endocrinol (Copenh) 1985, 109, 550-557.
34. White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 1994, 135, 175-182.
35. Yagi K, Komura S, Kojima H, Sun Q, Nagata N, Ohishi N, Nishikimi M. Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury. Biochem Biophys Res Commun 1996, 219, 486-491.