Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 20, 2007, Pages 5567-5572

  Larsen, Scott D ^a   Poel, Toni Jo ^a   Filipski, Kevin J ^a   Kohrt, Jeffrey T ^a   Pfefferkorn, Jeffrey A ^a   Sorenson, Roderick J ^a   Tait, Bradley D ^a   Askew, Valerie ^a   Dillon, Lisa ^a   Hanselman, Jeffrey C ^a   Lu, Gina H ^a   Robertson, Andrew ^a   Sekerke, Catherine ^a   Kowala, Mark C ^a   Auerbach, Bruce J ^a  

^a PFIZER INC   (United States)

Author keywords

Atherosclerosis; Cholesterol; HMG CoA reductase; Statin

Indexed keywords

DIHYDROXYHEPTANOIC ACID; HEPTANOIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; OXYPYRAZOLE; PYRAZOLE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; SYNTHESIS;

ANIMALS; CELL LINE; CRICETINAE; DRUG DESIGN; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; MOLECULAR STRUCTURE; MUSCLE CELLS; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548576831     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.004     Document Type: Article

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