A biochemical mechanism for resistance of intervertebral discs to metastatic cancer: Fas ligand produced by disc cells induces apoptotic cell death of cancer cells

European Spine Journal

Volumn 16, Issue 9, 2007, Pages 1319-1324

  Park, Jong Beom ^a   Lee, Jin Kyung ^b   Cho, Sung Tae ^a   Park, Eun Young ^a   Daniel Riew, K ^c  

^a The Catholic University of Korea   (South Korea)

^b Korea Cancer Center Hospital   (South Korea)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Fas and Fas ligand; Intervertebral disc; Metastatic cancer; Resistance

Indexed keywords

FAS LIGAND;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL DEATH; CELL INFILTRATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERVERTEBRAL DISK; NONHUMAN; PRIORITY JOURNAL; SPINE METASTASIS;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELLS, CULTURED; FAS LIGAND PROTEIN; HUMANS; IMMUNITY, NATURAL; INTERVERTEBRAL DISK; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NEOPLASMS;

EID: 34548569379     PISSN: 09406719     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00586-007-0463-2     Document Type: Article

References (32)

1. Asdourian PL, Weidenbaum M, DeWald RL, et al (1990) The pattern of vertebral involvement in metastatic vertebral breast cancer. Clin Orthop 250:164-170
2. Batson OV (1940) The function of the vertebral veins and their role ion the spread of metastases. Ann Surg 112:138-149
3. Berrettoni BA, Carter JR (1986) Current concepts review: mechanisms of cancer metastasis to bone. J Bone Joint Surg Am 68:308-312
4. Boland PJ, Lane JM, Sundaresan N (1982) Metastatic disease of the spine. Clin Orthop 169:95-102
5. Dunne AA, Grobe A, Sesterhenn AM, et al (2005) Influence of matrix metalloproteinase 9 (MMP-9) on the metastatic behavior of oropharyngeal cancer. Anticancer Res 25:4129-4134
6. Fujita T, Ueda Y, Kawahara N, et al (1997) Local spread of metastatic vertebral tumors: a histologic study. Spine 22:1905-1912
7. Griffith TS, Brunner T, Fletcher SM, et al (1995) Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270:1189-1192
8. Griffith TS, Ferguson TA (1997) The role of FasL-induced apoptosis in immune privilege. Immunol Today 18:240-244
9. Gruber HE, Ashraf N, Kilburn J, et al (2005) Vertebral endplate architecture and vascularization: application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat. Spine 30:2593-2600
10. Harrington KD (1986) Metastatic disease of the spine. J Bone Joint Surg Am 68:1110-1115
11. Kamat AA, Fletcher M, Gruman LM, et al (2006) The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer. Clin Cancer Res 12:1707-1714
12. Kauppila LI (1995) Ingrowth of blood vessels in disc degeneration. Angiographic and histological studies of Cadaveric spines. J Bone Joint Surg Am 77:26-31
13. Krishnamurthy GT, Tubis M, Hiss J, et al (1977) Distribution pattern of metastatic bone disease: a need for total body skeletal image. JAMA 237:2504-2506
14. Langer R, Brem H, Falterman K, et al (1976) Isolation of a cartilage factor that inhibits tumor neovascularization. Science 193:70-72
15. Müllauer L, Mosberger I, Grusch M, et al (2000) Fas ligand is expressed in normal breast epithelial cells and is frequently up-regulated in breast cancer. J Pathol 190:20-30
16. Muneta Y, Shimoji Y, Inumaru S, et al (2001) Molecular cloning, characterization, and expression of porcine Fas ligand (CD95 Ligand). J Interferon Cytokine Res 21:305-312
17. Nikkola J, Vihinen P, Vuoristo MS, et al (2005) High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanoma. Clin Cancer Res 11:5158-5166
18. Nishida K, Kang JD, Gilbertson LG, et al (1999) Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene. Spine 24:2419-2425
19. Park JB, Chang H, Kim KW (2001) Expression of Fas ligand and apoptosis of disc cells in herniated lumbar disc tissue. Spine 26:618-621
20. Reichmann E (2002) The biological role of the Fas/FasL system during tumor formation and progression. Cancer Biol 12:309-315
21. Roberts S, Evans H, Trivedi J, et al (2006) Histology and pathology of the human intervertebral disc. J Bone Joint Surg Am 88:S10-S14
22. Schneider P, Holler N, Bodmer JL, et al (1998) Conversion of membrane-bound Fas (CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med 187:1205-1213
23. Sprague JE, LI QP, Liang K, et al (2006) In vitro and in vivo investigation of matrix metalloproteinase expression in metastatic tumor models. Nucl Med Biol 33:227-237
24. Suda T, Nagata S (1994) Purification and characterization of the Fas-ligand that induces apoptosis. J Exp Med 179:873-879
25. Takada T, Nishida K, Doita M, et al (2002) Fas ligand expression on intervertebral disc cells: a potential molecular mechanism for immune privileged of the disc. Spine 27:1526-1530
26. Takahashi T, Tanaka M, Inazawa J, et al (1994) Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol 6:1567-1574
27. Tanaka M, Itai T, Adachi M, et al (1998) Downregulation of Fas ligand by shedding. Nat Med 4:31-36
28. Tsuyuki S, Kono M, Bloom ET (2002) Cloning and potential utility of porcine Fas ligand: overexpression in porcine endothelial cells protects them from attack by human cytolytic cells. Xenotransplantation 9:410-421
29. Urban JP, Smith S, Fairbank JC (2004) Nutrition of the intervertebral disc. Spine 29:2700-2709
30. Yasuma T, Yamauchi Y, Arai K, et al (1989) Histopathologic study on tumor infiltration into the intervertebral disc. Spine 14:1245-1248
31. Younes M, Schwartz MR, Ertan A, et al (2000) Fas ligand expression in esophageal carcinomas and their lymph node metastases. Cancer 88:524-528
32. Yuh WTC, Quets JP, Lee HJ, et al (1996) Anatomic distribution of metastases in the vertebral body and modes of hematogenous spread. Spine 21:2243-2250