Part 6: Synthesis of spiro 1,5-benzodiazepine attached with different heterocyclic moeities

Synthetic Communications

Volumn 37, Issue 18, 2007, Pages 3245-3258

  Khodairy, A ^a   El Sayed, A M ^a   Salah, H ^a   Abdel Ghany, H ^a  

^a Sohag University   (Egypt)

Author keywords

3 (p tolylazo) 4 phenyl 1(H)(1,5)benzodiazepin 2 one; 3 bromo 3 cyano 4 phenyl l(H)(1,5)benzodiazepin 2 one; 3 oxime 4 phenyl 1(H) (1,5)benzodiazepin 2 one; PTC

Indexed keywords

3 (4 TOLYLAZO) 4 PHENYL 1 (H) (1,5) BENZODIAZEPIN 2 ONE; 3 BROMO 3 CYANO 4 (4' BROMOPHENYL) 1(H) (1,5) BENZODIAZEPIN 2 ONE; 3 BROMO 3 CYANO 4 PHENYL 1(H) (1,5) BENZODIAZEPIN 2 ONE; 3 CYANO 4 PHENYL 1 (H) (1,5) BENZODIAZAPIN 2 ONE; 3 CYANO 4 PHENYL) 1(H) (1,5) BENZODIAZEPIN 2 ONE; 3 CYANO 4-PHENYL 1 (H) (1,5) BENZODIAZAPINE 3,2' (3' AMINO 1',5',6' TRIHYDRO (1'4') PIPRAZINE; 3 OXIME 4 PHENYL 1(H) (1,5) BENZODIAZEPIN 2 ONE; BENZODIAZEPINE DERIVATIVE; HETEROCYCLIC COMPOUND; SPIRO 1,5 BENZODIAZEPINE; SPIRO [2 OXO 4 (4 BROMOPHENYL) 1 (H) (L,5) BENZODIAZEPINE 3,3' (2 IMINO 4',5',6' TRIHYDROCYCLOPENTAFURAN)]; SPIRO [2 OXO 4 (4 BROMOPHENYL) 1 (H) (L,5) BENZODIAZEPINE 3,5' (4' AMINO 2 IMINO 1' (H) IMIDAZOLE)]; SPIRO [2 OXO 4 (4 BROMOPHENYL) 1 (H) (L,5) BENZODIAZEPINE 3,6' (2',5' DIAMINO (1',3',4') THIADIAZINE)]; SPIRO [2 OXO 4 (4 BROMOPHENYL) L (H) (1,5) BENZODIAZAPINE 3,2' (3' AMINO L'(H) QUINOXALINE)]; SPIRO [2 OXO 4 PHENYL 1 (H) (1,5) BENZODIAZEPINE 3,3' (5' AMINO CYANO 2'(H) ISOXAZOLE)]; SPIRO [2 OXO 4 PHENYL 1 (H) (L,5) BENZODIAZEPINE 3,2' (3' AMINO 5',6' DIHYRO (L',4') THIAZINE)]; SPIRO [2 OXO 4 PHENYL 1 (H)(1,5) BENZODIAZAPINE 3,2' (3' AMINO (1,4') BENZOTHIAZINE)]; SPIRO [2 OXO 4 PHENYL 1(H) (L,5) BENZODIAZEPINE 3,2' (4' (4 TOLYL) 3' (H) (1',3',4') THIADIAZOL 5' YLIDENEMALONONITRILE)]; SPIRO [2 OXO 4 PHENYL 1(H) (L,5) BENZODIAZEPINE 3,3' (1' (4 TOLYL) 2',4',5',6' TETRAPENTAPYRAZOLE)]; SPIRO [2 OXO 4 PHENYL 1(H) (L,5) BENZODIAZEPINE 3,3' (2',6' DIHYDRO 5' IMINO (4 TOLYL)PYRAZOLE[4',3' B]PYRAZOLE)]; SPIRO [2 OXO 4 PHENYL 1(H) (L,5) BENZODIAZEPINE 3,3' (4' CYANO 5' (4 METHOXYPHENYL) 2' (H) ISOXAZOLE)]; SPIRO [2 OXO 4 PHENYL 1(H) (L,5) BENZODIAZEPINE 3,3' (4' CYANO 5' (4 NITROPHENYL) 2' (H) ISOXAZOLE)]; SPIRO [2 OXO 4 PHENYL 1(H) (L,5) BENZODIAZEPINE 3,3' (5' AINO 4' CYANO 1' (4 TOLYL) 2' (H) PYRAZOLE)]; SPIRO [2 OXO 4 PHENYL 1(H) (L,5) BENZODIAZEPINE 3,3' (5' PHENYL 4 THIOCARBOXAMIDE) 2' (H) ISOXAZOLE)]; SPIRO [2 OXO 4 PHENYL L (H) (1,5) BENZODIAZEPINE 3,2' (3',4' DIHYDRO (L',3',4') BENZOTHIADIAZINE)]; SPIRO [2 OXO 4 PHENYL L (H) (1,5) BENZODIAZEPINE 3,2' (3',4',5',6' TETRAHYDRO (L',3',4') THIADIAZINE)]; SPIRO [2 OXO 4 PHENYL L (H) (1,5) BENZODIAZEPINE 3,3' (1',2',4' TRIHYDRO (L',2',4') BENZOTRIAZINE)]; SPIRO [2 OXO 4 PHENYL L (H) (1,5) BENZODIAZEPINE 3,3' (1',2',4', PENTAHYDRO (L',2',4') TRIAZINE)]; SPIRO [2 OXO 4 PHENYL L(H) (L,5) BENZODIAZAPINE 3,3' (4' CYANO 5' (4 CHLOROPHENYL) 2'(H) ISOXAZOLE)]; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BROMINATION; DRUG SYNTHESIS;

EID: 34548561595     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910601055214     Document Type: Article

References (11)

1. Zavala, F. Pharmacol Ther. 1997, 75, 199.
2. Fruscellaa, P.; Sottocornoa, M.; Di-Braccio, M.; Diomedea, L.; Piccardia, L.; Cagnottoa, A.; Grossib, G.; Romanoa, M.; Menninia, T.; Roma, G. Pharmacol. Res. 2001, 43, 445.
3. Benjaram, M. R.; Sreekanth, P. M. Tetrahedron Lett. 2003, 44, 4447.
4. Kling, A.; Backfisch, G.; Delzer, J.; Geneste, H.; Graef, C.; Hornberger, W.; Lange, U.; Lauterbach, A.; Seitz, W.; Subkowski, T. Bioorg. Med. Chem. 2002, 11, 1319.
5. Giancarlo, G.; Di-Braccio, M.; Roma, G.; Ballabeni, V.; Tognolini, M.; Calcina, F.; Barocelli, E. Eur J. Med. Chem. 2002, 37, 933.
6. Abdel-Ghany, H.; El-Sayed, A. M.; Sultan, A. A.; El-Shafei, A. K. Synth. Commun. 1990, 20 (6), 893.
7. El-Sayed, A. M.; Abdel-Ghany, H.; El-Saghier, A. M. M. Synth. Commun. 1999, 29 (20), 3561.
8. Abdel-Ghany, H.; El-Sayed, A. M.; Khodairy, A.; Salah, H. Synth. Commun. 2001, 31, 2523.
9. Khodairy, A.; El-Sayed, A. M.; Abdel-Ghany, H.; Salah, H. J. Chin. Chem. Soc. 2003, 50, 1195.
10. Khodairy, A. Phosphorous, Sulfur Silicon Relat. Elem. 2005, 180, 1893.
11. Reid, W.; Stahlofen, P. Chem. Ber. 1957, 90, 825.