Allium cepa chromosome aberration and micronucleus tests applied to study genotoxicity of extracts from pesticide-treated vegetables and grapes

Food Additives and Contaminants

Volumn 24, Issue 6, 2007, Pages 561-572

  Feretti, D ^a   Zerbini, I ^a   Zani, C ^a   Ceretti, E ^a   Moretti, M ^b   Monarca, S ^b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Allium cepa test; Genotoxicity; Pesticides; Vegetables

Indexed keywords

MUTAGENIC AGENT; PESTICIDE; PLANT EXTRACT;

ANAPHASE; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; FOOD ANALYSIS; FOOD CONTAMINATION; FOOD SAFETY; GAS CHROMATOGRAPHY; GENOTOXICITY; GRAPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ITALY; MICRONUCLEUS TEST; NONHUMAN; ONION; PLANT CELL; PLANT CHROMOSOME; PLANT ROOT; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TELOPHASE; TOXIN ANALYSIS; VEGETABLE;

CHROMOSOME ABERRATIONS; FOOD CONTAMINATION; MICRONUCLEUS TESTS; ONIONS; PESTICIDE RESIDUES; PESTICIDES; PLANT EXTRACTS; VEGETABLES; VITIS;

ALLIUM CEPA; ANIMALIA; VITACEAE;

EID: 34548559372     PISSN: 0265203X     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/02652030601113602     Document Type: Article

References (70)

1. Abdalla, MH, Gutierrez-Mohamed, ML and Farah, IO (2003) Association of pesticide exposure and risk of breast cancer mortality in Mississippi. Biomedical Sciences Instrumentation, 39, pp. 397-401.
2. Ahmed, M. and Grant, WF (1972) Cytological effects of pesticides Phosdrin and Bladex on Tradescantia and Vicia faba. Canadian Journal of Genetics and Cytology, 14, pp. 157-165.
3. Alavanja, MC, Hoppin, JA and Camel, F. (2004) Health effects of chronic pesticide exposure: Cancer and neurotoxicity. Annual Review of Public Health, 25, pp. 155-197.
4. Al-Saleh, IA (1994) Pesticide: A review article. Journal of Environmental Pathology, Toxicology and Oncology, 13, pp. 151-161.
5. Ambrus, A., Lantos, J., Visi, E., Csatlos, I. and Sarvari, L. (1981) General method for determination of pesticides residues in samples of plant origin, soil and water. I. Extraction and cleanup. Journal of Association of Official Analytical Chemists, 64, pp. 733-742.
6. Ames, BN, Magaw, R. and Gold, L Swirsky (1987) Ranking possible carcinogenic hazards. Science, 27, pp. 271-280.
7. Bianchi-Santamaria, A., Gobbi, M., Cembran, M. and Arnaboldi, A. (1997) Human lymphocyte micronucleus genotoxicity test with mixtures of phytochemicals in environmental concentrations. Mutation Research, 388, pp. 27-32.
8. Blair, A. and Zahm, SH (1991) Cancer among farmers. Occupational Medicine, 6, pp. 335-354.
9. Block, G., Patterson, B. and Subar, A. (1992) Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutrition and Cancer, 17, pp. 1-29.
10. Bonassi, S., Znaor, A., Ceppi, M., Lando, C., Chang, WP, Holland, N., Kirsch-Volders, M., Zeiger, E., Ban, S. and Barale, R. (2006) An increase micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans, Carcinogenesis, Advance Access published September 14 2006
11. Brown, LM, Blair, A., Gibson, R., Everett, GD, Cantor, KP, Schuman, LM, Burmeister, LF, Van Lier, SF and Dick, F. (1990) Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Research, 50, pp. 6585-6591.
12. Cabrera, GL and Rodriguez, DMG (1999) Genotoxicity of soil from farmland irrigated with wastewater using three plant bioassays. Mutation Research, 426, pp. 211-214.
13. Cerhan, JR, Cantor, KP, Williamson, K., Lynch, CF, Torner, JC and Burmeister, LF (1998) Cancer mortality among Iowa farmers: Recent results, time trends, and lifestyle factors. Cancer Causes and Control, 9, pp. 311-319.
14. Cueto Jr, C. (1980) Consideration of the possible carcinogenity of some pesticides. Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants and Agricultural Wastes, 15, pp. 949-975.
15. Curl, CL, Fenske, RA and Elgethun, K. (2003) Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environmental Health Perspectives, 111, pp. 377-382.
16. Dagna, L., Gasparini, G., Icardi, ML and Sesia, E. (1993) Metodo multiresiduo di estrazione su colonna per la determinazione di residui di fitofarmaci in matrici vegetali e liquide. (Multiresidue analysis method based on column extraction of residue of pesticide in vegetables and liquid samples). Bollettino dei Chimici Igienisti, 44, pp. 383-397.
17. De Bertoldi, M. (1996) Genotoxic effects of pesticides. European Journal of Cancer Prevention, 5, pp. 397-399.
18. De Kergommeaux, DJ, Grant, WF and Sandhu, SS (1983) Clastogenic and physiological response of chromosomes to nine pesticides in the Vicia faba in vivo root tip assay system. Mutation Research, 124, pp. 69-84.
19. De Marco, A., De Salvia, R., Polani, S., Ricordy, R., Sorrenti, F., Perticone, P., Cozzi, R., D'Ambrosio, C., De Simone, C. and Guidotti, M. (2000) Evaluation of genotoxic and cytotoxic properties of pesticides employed in Italian agricultural practices. Environmental Research, 83, pp. 311-321.
20. Dolara, P., Torricelli, F. and Antonelli, N. (1994) Cytogenetic effects on human lymphocytes of a mixture of fifteen pesticides commonly used in Italy. Mutation Research, 325, pp. 47-51.
21. Dolara, P., Vezzani, A., Caderni, G., Coppi, C. and Torricelli, F. (1993) Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet. Cell Biology and Toxicology, 9, pp. 333-343.
22. Doll, R. and Peto, R. (1981) The causes of cancer: Quantitative estimates of available risks of cancer in the United States today. Journal of the National Cancer Institute, 66, pp. 1191-1308.
23. Ennever, FK, Andreano, G. and Rosenkranz, HS (1988) The ability of plant assays to predict carcinogenicity. Mutation Research, 205, pp. 99-105.
24. Fiskesjö, G. (1985) The Allium test as a standard in environmental monitoring. Hereditas, 102, pp. 98-112.
25. Fiskesjö, G. (1995) Allium test. Methods in Molecular Biology, 43, pp. 119-127.
26. Fiskesjö, G., Lassen, C. and Renberg, L. (1981) Chlorinated phenoxyacetic acids and chlorophenols in the modified Allium test. Chemico-Biological Interactions, 34, pp. 333-344.
27. Garrett, NE, Stack, HF and Waters, MD (1986) Evaluation of the genetic activity profiles of 65 pesticides. Mutation Research, 168, pp. 301-325.
28. Grant, WF (1982) Chromosome aberration assay in Allium. A report of U.S. Environmental Protection Agency Gene-Tox Program. Mutation Research, 99, pp. 273-291.
29. Grant, WF (1994) The present status of higher plant bioassay for the detection of environmental mutagens. Mutation Research, 310, pp. 175-185.
30. Grant, WF (1999) Higher plant assays for the detection of chromosomal aberrations and gene mutations - a brief historical background on their use for screening and monitoring environmental chemicals. Mutation Research, 426, pp. 107-112.
31. Grant, WF, Sandhu, SS, De Serres, FJ, Gopalau, HN, Svendsgaard, D., Veleminsky, J. and Becking, GC (1994) Environmental monitoring for genotoxicity with plant system. Results and recommendations. Mutation Research, 310, pp. 257-263.
32. Grant, WF, Zinov'eva-Stahevitch, AE and Zura, KD (1981) Plant genetic test system for the detection of chemical mutagens. Short term test for chemical carcinogens, pp. 200-216. Springer, New York, NY
33. Grover, IS, Dhingra, AK, Neeta, A. and Ladhar, SS (1990) Genotoxicity of pesticides and plant systems. Mutation and the Environment, pp. 91-106. Wiley-Liss, New York, NY
34. Grover, IS and Kaur, S. (1999) Genotoxicity of wastewater samples from sewage and industrial effluent detected by the Allium root anaphase aberration and micronucleus assays. Mutation Research, 426, pp. 183-188.
35. Guzzella, L., De Paolis, A., Bartone, C., Pozzoni, F. and Giuliano, G. (1996) Migration of pesticides residues from agricultural soil to groundwater. International Journal of Environmental Analytical Chemistry, 65, pp. 261-275.
36. Hanna, PJ and Dyer, KF (1975) Mutagenicity of organophosphorus compounds in bacteria and Drosophila. Mutation Research, 28, pp. 405-420.
37. Heeren, GA, Tyler, J. and Mandeya, A. (2003) Agricultural chemical exposures and birth defects in Cape Province, South Africa. A case-control study. Environmental Health: A Global Access Science Source, 2, pp. 11-19.
38. Hour, TC, Chen, L. and Lin, JK (1998) Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames and lactam tests. Mutagenesis, 13, pp. 157-166.
39. IPCS (1990) Environmental Health Criteria 104: Principles for the toxicological assessment of pesticide residues in food. International Programme on Chemical Safety, WHO, Geneva
40. Jayakrishnan, S., Dikshit, AK, Singh, JP and Pachauri, DC (2005) Dissipation of Lambda-cyhalothrin on tomato (Lycopersicon esculentum Mill.) and removal of its residues by different washing processes and steaming. Bulletin of Environmental Contamination and Toxicology, 75, pp. 324-328.
41. Kaya, B., Creus, A., Yanikoglu, A., Cabre, O. and Marcos, R. (2000) Use of the Drosophila wing spot test in the genotoxicity testing of different herbicides. Environmental and Molecular Mutagenesis, 36, pp. 40-46.
42. Leiss, JK and Savitz, DA (1995) Home pesticide use and childhood cancer: A case-control study. American Journal of Public Health, 85, pp. 249-252.
43. Lenza-Rizos, C., Avramides, EJ and Kokkinaki, K. (2006) Residues of azoxystrobin from grapes to raisins. Journal of Agricultural and Food Chemistry, 54, pp. 138-141.
44. Ma, TH, Harris, MM, Anderson, VA, Ahmed, K., Mohammed, KB, Bare, JL and Lin, G. (1984) Tradescantia-micronucleus (Trad-MCN) tests on 140 health-related agents. Mutation Research, 138, pp. 157-167.
45. Ma, TH, McConnell, H., Rabago, E Vailterra, Arreola, AG and Zhang, H. (1995) The improved Allium/Vicia root tip micronucleous assay for clastogenicity of environmental pollutants. Mutation Research, 334, pp. 185-195.
46. Manninen, A., Kuitunen, ML and Julin, L. (1987) Gas chromatographic properties of the M series of universal retention index standards and their application to pesticide analysis. Journal of Chromatography, 394, pp. 465-471.
47. Mohammed, KB and Ma, TH (1999) Tradescantia-micronucleus and stamen hair mutation assays on genotoxicity of the gaseous and liquid forms of pesticides. Mutation Research, 426, pp. 193-199.
48. Monarca, S., Feretti, D., Collivignarelli, C., Guzzella, L., Zerbini, I., Bertanza, G. and Pedrazzani, R. (2000) The influence of different disinfectants on mutagenicity and toxicity of urban wastewater. Water Research, 34, pp. 4261-4269.
49. Monarca, S., Feretti, D., Zerbini, I., Alberti, A., Zani, C., Resola, S., Gelatti, U. and Nardi, G. (2002) Soil contamination detected using bacterial and plant mutagenicity tests and chemical analyses. Environmental Research, 88, pp. 64-69.
50. Monarca, S., Richardson, SD, Feretti, D., Grottolo, M., Thruston, AD, Zani, C., Navazio, G., Ragazzo, P., Zerbini, I. and Alberti, A. (2002) Mutagenicity and disinfection by-products in surface drinking water disinfected with peracetic acid. Environmental Toxicology and Chemistry, 21, pp. 309-318.
51. Monarca, S., Rizzoni, M., Gustavino, B., Zani, C., Alberti, A., Feretti, D. and Zerbini, I. (2003) Genotoxicity of surface water treated with different disinfectants using in situ plant tests. Environmental and Molecular Mutagenesis, 41, pp. 353-359.
52. Moriya, M., Ohta, T., Watanabe, K., Miyazawa, T., Kato, K. and Shirasu, Y. (1983) Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutation Research, 116, pp. 185-216.
53. Panneerselvam, N., Sinha, S. and Shanmugam, G. (1995) Genotoxicity of the herbicide fluchloralin on human lymphocytes in vitro: Chromosomal aberration and micronucleus tests. Mutation Research, 344, pp. 69-72.
54. Plewa, MJ, Wagner, ED, Gentile, GJ and Gentile, JM (1984) An evaluation of the genotoxic properties of herbicides following plant and animal activation. Mutation Research, 136, pp. 233-245.
55. Radwan, MA, Abu-Elamayem, MM, Shiboob, MH and Abdel-Aal, A. (2005) Residual behaviour of profenofos on some field-grown vegetables and its removal using various washing solutions and household processing. Food and Chemical Toxicology, 43, pp. 553-557.
56. Rank, J., Jensen, AG, Skov, B., Pedersen, LH and Jensen, K. (1993) Genotoxicity testing of the herbicide Roundup and its active ingredient glyphosate isopropylamine using the mouse bone marrow micronucleus test, Salmonella mutagenicity test, and Allium anaphase-telophase test. Mutation Research, 300, pp. 29-36.
57. Rank, J. and Nielsen, MH (1993) A modified Allium test as a tool in the screening of genotoxicity of complex mixtures. Hereditas, 118, pp. 49-53.
58. Rank, J. and Nielsen, MH (1997) Allium cepa anaphase-telophase root tip chromosome aberration assay on N-methyl-N-nitrosourea, maleic hydrazide, sodium azide, and ethyl methanesulfonate. Mutation Research, 390, pp. 121-127.
59. Ribas, G., Surralles, J., Carbonell, E., Xamena, N., Creus, A. and Marcos, R. (1996) Genotoxicity of the herbicides alachlor and maleic hydrazide in cultured human lymphocytes. Mutagenesis, 11, pp. 221-227.
60. Rodrigues, GS, Pimentel, D. and Weinstein, LH (1998) In situ assessment of pesticide genotoxicity in an integrated pest management program I - Tradescantia micronucleus assay. Mutation Research, 412, pp. 235-244.
61. Saftlas, AF, Blair, A., Cantor, KP, Hanrahan, L. and Anderson, HA (1987) Cancer and other causes of death among Wisconsin farmers. American Journal of Industrial Medicine, 11, pp. 119-129.
62. Saleh, MA (1980) Mutagenic and carcinogenic effects of pesticides. Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants and Agricultural Wastes, 15, pp. 907-927.
63. Settimi, L., Masina, A., Andrion, A. and Axelson, O. (2003) Prostate cancer and exposure to pesticides in agricultural settings. International Journal of Cancer, 104, pp. 458-461.
64. Smaka-Kincl, V., Stegnar, P., Lovka, M. and Toman, MJ (1996) The evaluation of waste, surface and ground water quality using the Allium test procedure. Mutation Research, 368, pp. 171-179.
65. Steinkellner, H., Mun-Sik, K., Helma, C., Ecker, S., Ma, TH, Horak, O., Kundi, M. and Knasmüller, S. (1998) Genotoxic effects of heavy metals: Comparative investigation with plant bioassay. Environmental Molecular and Mutagenesis, 31, pp. 183-191.
66. Gold, L Swirsky, Stern, BR, Slone, TH, Brown, JP, Manley, NB and Ames, BN (1997) Pesticide residues in food: Investigation of disparities in cancer risk estimates. Cancer Letters, 117, pp. 195-207.
67. Tezuka, H., Ando, N., Suzuki, R., Terahata, M., Moriya, M. and Shirasu, Y. (1980) Sister-chromatid exchanges and chromosomal aberrations in cultured Chinese hamster cells treated with pesticides positive in microbial reversion assays. Mutation Research, 78, pp. 177-191.
68. Vogel, JM (2005) Perils of paradigm: Complexity, policy design, and the endocrine disruptor screening program. Environmental Health: A Global Access Science Source, 4, pp. 2-13.
69. Waters, MD, Sandhu, SS, Simmon, VF, Mortelmans, KE, Mitchell, AD, Jorgenson, TA, Jones, DC, Valencia, R. and Garrett, NE (1982) Study of pesticide genotoxicity. Basic Life Sciences, 21, pp. 275-326.
70. Zang, Y., Zhong, Y., Luo, Y. and Kong, ZM (2000) Genotoxicity of two novel pesticides for the earthworm, Eisenia fetida. Environmental Pollution, 108, pp. 271-278.