Correlation of carboxylic acid pKa to protein binding and antibacterial activity of a novel class of bacterial translation inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 19, 2007, Pages 5479-5482

  Stiff, Cory M ^a   Zhong, Min ^a   Sarver, Ronald W ^a   Gao, Hua ^a   Ho, Andrea M ^a   Sweeney, Michael T ^a   Zurenko, Gary E ^a   Romero, Donna L ^a  

^a PFIZER INC   (United States)

Author keywords

Acidity; Antibacterial; Capillary electrophoresis; Protein binding; Translation inhibitors

Indexed keywords

ANTHRANILIC ACID DERIVATIVE; CARBOXYLIC ACID; PROTEIN INHIBITOR; TRANSLATION INHIBITOR; UNCLASSIFIED DRUG;

ACIDITY; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CORRELATION ANALYSIS; DRUG PROTEIN BINDING; PHYSICAL CHEMISTRY; PKA; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; CALORIMETRY; CAPILLARY ELECTROCHROMATOGRAPHY; CARBOXYLIC ACIDS; CATTLE; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; SERUM ALBUMIN, BOVINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 34548558676     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.006     Document Type: Article

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