Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4

Clinical and Experimental Immunology

Volumn 150, Issue 1, 2007, Pages 144-150

  Steel, H C ^a,b   Tintinger, G R ^a   Theron, A J ^a,b   Anderson, R ^a,b,c  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

^c Department of Immunology ^*  (South Africa)

Author keywords

5 lipoxygenase; Calcium; Itraconazole; Leukotriene B4; Neutrophils; Platelet activating factor

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 5 ETHYL 2 HYDROXY 4 [6 METHYL 6 (1H TETRAZOL 5 YL)HEPTYLOXY]ACETOPHENONE; 5' LIPOXYGENASE; ADENOSINE TRIPHOSPHATE; CALCIUM; ITRACONAZOLE; LEUKOTRIENE B4; LEUKOTRIENE B4 RECEPTOR; LIPOXYGENASE; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL; SPECTROFLUOROMETRY;

ADENOSINE TRIPHOSPHATE; ANTIFUNGAL AGENTS; CALCIUM; CELLS, CULTURED; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; ITRACONAZOLE; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENE B4; LIPOXYGENASE INHIBITORS; NEUTROPHIL ACTIVATION; NEUTROPHILS; PLATELET ACTIVATING FACTOR; SPECTROMETRY, FLUORESCENCE; TETRAZOLES;

EID: 34548531551     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03470.x     Document Type: Article

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