Optimization of imidazole 5-lipoxygenase inhibitors and selection and synthesis of a development candidate

Chemical and Pharmaceutical Bulletin

Volumn 53, Issue 8, 2005, Pages 965-973

  Mano, Takashi ^a   Stevens, Rodney W ^a   Ando, Kazuo ^a   Kawai, Makoto ^a   Kawamura, Kiyoshi ^a   Nakao, Kazunari ^a   Okumura, Yoshiyuki ^a   Okumura, Takako ^a   Sakakibara, Minoru ^a   Miyamoto, Kimitaka ^a   Tamura, Tetsuya ^a  

^a PFIZER INC   (United States)

Author keywords

Inhibitor; Leukotriene; Lipoxygenase; Structure activity relationship; Unsymmetric thioether

Indexed keywords

4 [3 [4 (2 METHYL 1H IMIDAZOL 1 YL)PHENYLTHIO]]PHENYL 3,4,5,5 TETRAHYDRO 2H PYRAN 4 CARBOXAMIDE; IMIDAZOLE 5 LIPOXYGENASE INHIBITOR; IMIDAZOLE DERIVATIVE; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CLINICAL FEATURE; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; EYE TOXICITY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; RAT; SAFETY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; FEMALE; IMIDAZOLES; LIPOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 24944500826     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.53.965     Document Type: Article

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