Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the determination of paeoniflorin in rat brain and its application to pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 857, Issue 1, 2007, Pages 32-39

  Xia, Su Mei ^a,b   Shen, Rong ^b   Sun, Xue Ying ^b   Shen, Li Li ^b   Yang, Yi Ming ^a   Ke, Ying ^b   Wang, Yun ^b   Chen, Dong Ying ^a   Han, Xing Mei ^b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b Central Research Institute of Shanghai Pharmaceutical Group   (China)

Author keywords

Brain distribution; LC MS MS; Matrix effects; Paeoniflorin; Pharmacokinetics

Indexed keywords

BRAIN; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEINS; RATS;

BRAIN DISTRIBUTION; MATRIX EFFECTS; PAEONIFLORIN; TANDEM MASS SPECTROMETRY;

PHARMACOKINETICS;

FORMIC ACID; GENIPOSIDE; METHANOL; PAEONIFLORIN; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOIC ACIDS; BRAIN; BRAIN CHEMISTRY; BRIDGED COMPOUNDS; CALIBRATION; CHROMATOGRAPHY, LIQUID; DRUGS, CHINESE HERBAL; GLUCOSIDES; INJECTIONS, SUBCUTANEOUS; IRIDOIDS; MALE; MOLECULAR STRUCTURE; PAEONIA; PLANT ROOTS; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

RATTUS;

EID: 34548446292     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.06.022     Document Type: Article

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