Determination of paeoniflorin in rat plasma by a liquid chromatography-tandem mass spectrometry method coupled with solid-phase extraction

Biomedical Chromatography

Volumn 20, Issue 2, 2006, Pages 173-179

  Wang, Qiao ^a,b,c   Yang, Hanyu ^d   Liu, Weina ^c   Feng, Xiaolong ^d   Zhang, Lantong ^c   Li, Yanling ^d   Bi, Kaishun ^b   Guo, Dean ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c HEBEI MEDICAL UNIVERSITY   (China)

^d Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd   (China)

Author keywords

HPLC MS MS; Paeoniflorin; Solid phase extraction

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RATS; STATISTICS;

HPLC-MS-MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY-TANDEM SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; PAEONIFLORIN; RAT PLASMA; RELATIVE ERRORS; RELATIVE STANDARDS DEVIATIONS; SELECTIVE LIQUID CHROMATOGRAPHY; SOLID-PHASE EXTRACTION;

PHASE SEPARATION;

ACETONITRILE; FORMIC ACID; GENIPOSIDE; PAEONIFLORIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; NONHUMAN; QUALITY CONTROL; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALIA;

EID: 32544436252     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.548     Document Type: Article

References (18)

1. Chen LC, Lee MH, Chou MH, Lin MF and Yang LL. Pharmacokinetic study of paeoniflorin in mice after oral administration of Paeoniae radix extract. Journal of Chromatography B 1999; 735: 33-40.
2. Chen LC, Chou MH, Lin MF and Yang LL. Pharmacokinetics of paeoniflorin after oral administration of Shao-yao Gan-chao Tang in mice. Japanese Journal of Pharmacology 2002; 88: 250-255.
3. 2+ mobilization in the nerve-stimulated skeletal muscle of mice. Japanese Journal of Pharmacology 1995; 69: 281-284.
4. Hsu FL, Lai CW and Cheng JT. Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora. Planta Medica 1997; 63: 323-325.
5. Ishida H, Takamatsu M, Tsuji K and Kosuge T. Studies on active substances in herbs used for Oketsu ('stagnant bloos') in Chinese medicine. VI. On the anticoagulative principle in Paeoniae radix. Chemical and Pharmaceutical Bulletin 1987; 35: 849-852.
6. 2+-aequorin luminescence transients with or without caffeine in directly stimulated-diaphragm muscle of mouse. Japanese Journal of Pharmacology 1985; 39: 387-390.
7. Kimura M, Kimura I and Nojima H. Depolarizing neuromuscular blocking action induced by eletropharmacological coupling in the combined effect of paeoniflorin and glycyrrhizin. Japanese Journal of Pharmacology 1985; 37: 395-399.
8. Ohta H, Matsumoto K, Watanabe H and Shimizu M. Involvement of beta-adrenergic systems in the antagonizing effect of paeoniflorin on the scopolamine-induced deficit in radial maze performance in rats. Japanese Journal of Pharmacology 1993; 62: 345-349.
9. Ohta H, Matsumoto K, Shimizu M and Watanabe H. Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task. Pharmacology Biochemistry Behavior 1994; 49: 213-217.
10. Sheng YX, Li L, Wang CS, Li YY and Guo DA. Solid-phase extraction-liquid chromatographic method for the determination and pharmacokinetic studies of albiflorin and paeoniflorin in rat serum after oral administration of Si-Wu decoction. Journal of Chromatography B 2004; 806: 127-132.
11. Shibata S, Nakahara M and Aimi N. Studies on the constituents of Japanese and Chinese crude drugs. VIII. Paeoniflorin; a glucoside of Chinese paeony root (1). Chemical and Pharmaceutical Bulletin 1963; 11: 372-378.
12. Takeda S, Isono T, Wakui Y, Mutsuzaki Y, Sasaki H, Amagaya S and Maruno M. Absorption and excretion of paeoniflorin in rats. Journal of Pharmacy and Pharmacology 1995; 47: 1036-1040.
13. Watanabe H. Candidates for cognitive enhancer extracted from medicinal plants, paeoniflorin and tetramethyipyrazine. Behavioural Brain Research 1997; 83: 135-141.
14. Xu S, Chen C and Chen G. The pharmacokinetics of paeoniflorin. European Journal of Pharmacology 1990; 183: 2390.
15. Yamasaki K, Kaneda M and Tanaka O. Carbon-13 NMR spectral assignments of paeoniflorin homologues with the aid of spin-lattice relaxation time. Tetrahedron Letters 1976; 44: 3965-3968.
16. Ye G, Li YZ, Li YY, Guo HZ and Guo DA. SPE-HPLC method for the determination and pharmacokinetic studies on paeoniflorin in rat serum after oral administration of traditional Chinese medicinal preparation Guan-Xin-Er-Hao decoction. Journal of Pharmaceutical and Biomedical Analysis 2003; 33: 521-527.
17. Zhang KR, Liu RX, Xu JB and Bi KS. Determination of three chemical constituents in Radix Paeoniae Rubra by RP-HPLC simultaneously. Chinese Pharmaceutical Journal 2003; 38: 793-795.
18. Zhang Z, Qin LM and Chen KJ. Study on the pharmacokinetic of paeoniflorin contained in xiongshao capsule in canine. Chinese Journal Experimental Traditional Medical Formulae 2000; 6: 21-24.