Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system

Journal of Receptor and Signal Transduction Research

Volumn 19, Issue 1-4, 1999, Pages 59-74

  Simmen, U ^a   Burkard, W ^a   Berger, K ^a   Schaffner, W ^a   Lundstrom, K ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DELTA OPIATE RECEPTOR; ESTROGEN RECEPTOR; GLUTAMATE RECEPTOR; HISTAMINE RECEPTOR; HYPERICIN; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; OPIATE RECEPTOR; PHLOROGLUCINOL; PLANT EXTRACT; PSEUDOHYPERICIN; SEROTONIN 6 RECEPTOR; SEROTONIN 7 RECEPTOR; TACHYKININ RECEPTOR;

ANIMAL CELL; CENTRAL NERVOUS SYSTEM; CHO CELL; CONFERENCE PAPER; DRUG ACTIVITY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ESTROGEN BINDING; HYPERICUM PERFORATUM; LIGAND BINDING; NONHUMAN; RECEPTOR DENSITY; SEMLIKI FOREST ALPHAVIRUS;

ALPHAVIRUS; ANIMALIA; HYPERICUM; HYPERICUM PERFORATUM; PASSIFLORA INCARNATA; SAINT JOHNS WORT; SEMLIKI FOREST VIRUS; VALERIANA OFFICINALIS;

EID: 0032998772     PISSN: 10799893     EISSN: None     Source Type: Journal    
DOI: 10.3109/10799899909036637     Document Type: Conference Paper

References (27)

1. Linde, K.; Ramirez, G.; Mulrow, C.D.; Pauls, A.; Weidenhammer, W. and Melchart, D. St John's wort for depression - an overview and meta-analysis of randomised clinical trials. Br. Med. J. 313, 253-258, 1996.
2. Sparenberg, B.; Demisch, L. and Hölzl, J. Untersuchungen über antidepressive Wirkstoffe von Johanniskraut. Pharm. Ztg. Wiss. 2(6), 50-54, 1993.
3. Thiede, H.M. and Walper, A. MAO- und COMT-Hemmung durch Hypericum-Extrakte und Hypericin. Nervenheilkunde 12, 346-348, 1993.
4. Perovic, S. and Müller, W.E.G. Pharmacological profile of Hypericum extract. Arzneim.-Forsch. 45, 1145-1148, 1995.
5. Müller, W.E. and Schäfer, C. Johanniskraut. Deutsche Apotheker Zeitung. 13, 17-24, 1996.
6. Müller, W.E.; Rolli, M.; Schäfer, C. and Hafner, U. Effects of Hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiat. 30 (Suppl.), 102-107, 1997.
7. 2A receptors. Pharmacopsychiat. 30 (Suppl.), 113-116, 1997.
8. Winterhoff, H.; Butterweck, V.; Nahrstedt, A.; Gumbinger, H.G.; Schulz, V.; Erping, S.; Bosshammer, F. and Wieligmann, A. Pharmakologische Untersuchungen zur antidepressiven Wirkung von Hypericum perforatum L. In: D. Loew and N. Riehbrock (Eds.), Phytopharmaka in Forschung und klinischer Anwendung. Steinkopf Verlag, Darmstadt, pp. 39-56, 1995.
9. Thiele, B.; Brink, I. and Ploch, M. Modulation of cytokine expression by Hypericum extract. J. Ger. Psych. Neurol. 7, Suppl. 60-62, 1993.
10. nd Internat. Congress on Phytomedicine, Munich, 1996.
11. Nielsen, M.; Frokjaer, S. and Braestrub. C. High affinity of the naturally-occurring biflavonoid, amentoflavon, to brain benzodiazepine receptors in vitro. Biochem. Pharmacol. 37, 3285-3287, 1988.
12. Baureithel, K.H.; Berger Büter, K.; Engesser, A.; Burkard, W. and Schaffner, W. Inhibition of benzodiazepine binding in vitro by amentoflavon, a constituent of various species of Hypericum. Pharmac. Acta Helvetiae 72, 153-157, 1997.
13. Cott, J.M. In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiat. 30 (Suppl.) 108-112, 1997.
14. Simmen, U.; Schweitzer, C; Burkard, W.; Schaffner, W. and Lundstrom, K. Hypericum perforatum inhibits the binding of μ- and κ-opioid receptors expressed with the Semliki Forest virus system. Pharmac. Acta Helvetiae. In press, 1998.
15. Pfeiffer, A.; Brantl, V.; Herz, A. and Emrich, H.M. Psychotomimesis mediated by κ opiate receptors. Science 233, 774-776, 1986.
16. Pasternak, G.W. Pharmacological mechanisms of opioid analgesics. Clin. Neuropharmacology 16, 1-18, 1993.
17. Bot, G.; Blake, A.D.; Li, S. and Reisine, T. Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells. Mol. Pharmacol. 52, 272-281, 1997.
18. 2A receptors in cerebral cortex and nucleus accumbens in the female rat. J. Steroid Biochem. Molec. Biol. 54, 15-20, 1995.
19. 7 receptors: Molecular biology, functional correlates and possible therapeutic indications. DN&P 10, 214-224, 1997.
20. Maggi, C.A.; Patacchini, R.; Rovero P. and Giachetti A. Tachykinin receptors and tachykinin receptor antagonists. J. Auton. Pharmacol. 13, 23-93, 1993.
21. Khawaja, A.M. and Rogers, D.F. Tachykinins: receptor to effector. Int. J. Biochem. Cell Biol. 28, 721-738, 1996.
22. Zhu, M., Phillipson, D., Greengrass, P.M., Bowery, N.B. and Cai, Y. Plant polyphenols: Biologically active compounds or non-selective binders to protein? Phytochemistry 44, 441-447 1997.
23. 1 receptor on antagonist affinity. Eur. J. Pharmacol. 337,73-81, 1997.
24. Berglund, P., Sjöberg, M., Garoff, H., Atkins, J.G., Sheahan, B.J. and Liljeström, P. Semliki Forest Virus expression system: Production of conditionally infectious recombinant particles. Bio/Technology 11, 916-920, 1993.
25. Lundstrom, K., Mills, A., Buell, G., Allet, E., Adami, N. and Liljestrom, P. High-level expression of the human neurokinin-1 receptor in mammalian cell lines using the Semliki Forest virus expression system. Eur. J. Biochem 224, 917-921, 1994.
26. Smith, P.K., Krohn, R.I., Hermanson, G.T., Mallia, A.K., Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J. and Klenk, D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85, 1985.
27. Miksicek, R.J. Estrogenic flavonoids: Structural requirements for biological activity. Proceed. Soc. Exp. Biol. Med. 208, 44-50, 1995.