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1
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33750087289
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▶ Arzimanoglou A, Rahbani A. Zonisamide for the treatment of epilepsy. Expert Rev Neurother 2006;6(9):1283-1292. A broad overview of zonisamide efficacy, tolerability, and safety.
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▶ Arzimanoglou A, Rahbani A. Zonisamide for the treatment of epilepsy. Expert Rev Neurother 2006;6(9):1283-1292. A broad overview of zonisamide efficacy, tolerability, and safety.
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2
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0242490778
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▶ Ben-Menachem E. Levetiracetam: treatment in epilepsy. Expert Opin Pharmacother 2003;4(11):2079-2088. A broad overview of levetiracetam efficacy, tolerability, and safety.
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▶ Ben-Menachem E. Levetiracetam: treatment in epilepsy. Expert Opin Pharmacother 2003;4(11):2079-2088. A broad overview of levetiracetam efficacy, tolerability, and safety.
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3
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0030694614
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▶ Beydoun A. Monotherapy trials of new antiepileptic drugs. Epilepsia 1997;38(suppl 9):21-31. A good review of all monotherapy trials of new antiepileptic drugs (AEDs), focusing on initial monotherapy.
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▶ Beydoun A. Monotherapy trials of new antiepileptic drugs. Epilepsia 1997;38(suppl 9):21-31. A good review of all monotherapy trials of new antiepileptic drugs (AEDs), focusing on initial monotherapy.
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4
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0036317763
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▶ Beydoun A, Kutluay E. Oxcarbazepine. Expert Opin Pharmacother 2002;3(1):59-71. A broad overview of oxcarbazepine efficacy, tolerability, and safety.
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▶ Beydoun A, Kutluay E. Oxcarbazepine. Expert Opin Pharmacother 2002;3(1):59-71. A broad overview of oxcarbazepine efficacy, tolerability, and safety.
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5
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0030975686
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▶ Brodie MJ, Yuen AW. Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. Epilepsy Res 1997;26(3):423-432.
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▶ Brodie MJ, Yuen AW. Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. Epilepsy Res 1997;26(3):423-432.
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6
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32944455269
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▶ Chaves J, Sander JW. Seizure aggravation in idiopathic generalized epilepsies. Epilepsia 2005;46;(suppl 9):133-139. Important review of drugs that exacerbate seizures, with clinical suggestions to avoid problematic drug choices.
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▶ Chaves J, Sander JW. Seizure aggravation in idiopathic generalized epilepsies. Epilepsia 2005;46;(suppl 9):133-139. Important review of drugs that exacerbate seizures, with clinical suggestions to avoid problematic drug choices.
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7
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0033549029
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▶ French J, Smith M, Faught E, Brown N. Neurology and the American Epilepsy Society epilepsy: Report of the Quality Standards Subcommittee of the American Academy of Neurology. Practice advisory: The use of felbamate in the treatment of patients with intractable epilepsy. Neurology 1999;52(8):1540-1545.
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▶ French J, Smith M, Faught E, Brown N. Neurology and the American Epilepsy Society epilepsy: Report of the Quality Standards Subcommittee of the American Academy of Neurology. Practice advisory: The use of felbamate in the treatment of patients with intractable epilepsy. Neurology 1999;52(8):1540-1545.
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8
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11144356543
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▶ French JA, Kanner AM, Bautista J, et al. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004a;62(8):1252-1260. An evidence-based report that reviews all the clinical trials of new AEDs in newly diagnosed patients and classifies them in terms of strength of the evidence for efficacy (Appendix C).
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▶ French JA, Kanner AM, Bautista J, et al. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004a;62(8):1252-1260. An evidence-based report that reviews all the clinical trials of new AEDs in newly diagnosed patients and classifies them in terms of strength of the evidence for efficacy (Appendix C).
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9
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11144353969
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▶ French JA, Kanner AM, Bautista J, et al. Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004b;62(8):1261-1273. Similar to above, for trials of new AEDs in refractory patients (Appendix D).
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▶ French JA, Kanner AM, Bautista J, et al. Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004b;62(8):1261-1273. Similar to above, for trials of new AEDs in refractory patients (Appendix D).
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10
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10744228775
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▶ Galindo PA, Borja J, Gomez E, et al. Anticonvulsant drug hypersensitivity. J Investig Allergol Clin Immunol 2002;12(4):299-304.
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▶ Galindo PA, Borja J, Gomez E, et al. Anticonvulsant drug hypersensitivity. J Investig Allergol Clin Immunol 2002;12(4):299-304.
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11
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33746124186
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▶ Glauser T, Ben-Menachem, Bourgeois B, et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006;47(7):1094-1120. These evidence-based guidelines focus on newly diagnosed patients, but unlike the AAN guidelines, they cover both older and newer AEDs.
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▶ Glauser T, Ben-Menachem, Bourgeois B, et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006;47(7):1094-1120. These evidence-based guidelines focus on newly diagnosed patients, but unlike the AAN guidelines, they cover both older and newer AEDs.
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12
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33645828611
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▶ Guerrini R, Parmeggiani, L. Topiramate and its clinical applications in epilepsy. Expert Opin Pharmacother 2006;7(6):811-823. A broad overview of topiramate efficacy, tolerability, and safety.
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▶ Guerrini R, Parmeggiani, L. Topiramate and its clinical applications in epilepsy. Expert Opin Pharmacother 2006;7(6):811-823. A broad overview of topiramate efficacy, tolerability, and safety.
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13
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0033759937
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▶ Harden CL. Therapeutic safety monitoring: what to look for and when to look for it. Epilepsia 2000;41(suppl 8):37-44. This review covers guidelines for monitoring laboratory values and clinical signs of adverse reactions in patients treated with AEDs.
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▶ Harden CL. Therapeutic safety monitoring: what to look for and when to look for it. Epilepsia 2000;41(suppl 8):37-44. This review covers guidelines for monitoring laboratory values and clinical signs of adverse reactions in patients treated with AEDs.
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14
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33845706134
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▶ Harden CL, Leppik I. Optimizing therapy of seizures in women who use oral contraceptives. Neurology 2006;67(12 suppl 4):56-58.
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▶ Harden CL, Leppik I. Optimizing therapy of seizures in women who use oral contraceptives. Neurology 2006;67(12 suppl 4):56-58.
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15
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34548445259
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▶ Holmes LB, Wyszynski DF, Baldwin EJ, et al. Increased risk for non-syndromic cleft palate among infants exposed to lamotrigine during pregnancy (abstract). Birth Defects Rese Part A: Clin Mol Teratol 2006;76(5):318.
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▶ Holmes LB, Wyszynski DF, Baldwin EJ, et al. Increased risk for non-syndromic cleft palate among infants exposed to lamotrigine during pregnancy (abstract). Birth Defects Rese Part A: Clin Mol Teratol 2006;76(5):318.
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16
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0038442675
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▶ Johannessen SI, Battino D, Berry DJ, et al. Therapeutic drug monitoring of the newer antiepileptic drugs. Ther Drug Monit 25(3):347-63. A useful review of evidence regarding utility of blood levels for the new AEDs.
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▶ Johannessen SI, Battino D, Berry DJ, et al. Therapeutic drug monitoring of the newer antiepileptic drugs. Ther Drug Monit 25(3):347-63. A useful review of evidence regarding utility of blood levels for the new AEDs.
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17
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30844450792
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▶ Kaddurah AK, Holmes GL. Possible precipitation of myoclonic seizures with oxcarbazepine. Epilepsy Behav 2006;8(1):289-293.
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▶ Kaddurah AK, Holmes GL. Possible precipitation of myoclonic seizures with oxcarbazepine. Epilepsy Behav 2006;8(1):289-293.
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18
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0034598762
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▶ Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342(5):314-319. This important study followed over 500 newly diagnosed epilepsy patients to see whether they would respond to AED therapy. Most responded to the first AED, but those who failed their first drug for efficacy reasons had a very low likelihood of responding to any subsequent drug trial.
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▶ Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342(5):314-319. This important study followed over 500 newly diagnosed epilepsy patients to see whether they would respond to AED therapy. Most responded to the first AED, but those who failed their first drug for efficacy reasons had a very low likelihood of responding to any subsequent drug trial.
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19
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33749513257
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▶ Leppik IE. Epilepsy in the elderly. Epilepsia 2006;47(suppl 1):65-70.
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▶ Leppik IE. Epilepsy in the elderly. Epilepsia 2006;47(suppl 1):65-70.
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20
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33846378108
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▶ Lofgren E, Mikkonen K, Tolonen U, et al. Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication. Epilepsy Behav 2007;10(1):77-83.
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▶ Lofgren E, Mikkonen K, Tolonen U, et al. Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication. Epilepsy Behav 2007;10(1):77-83.
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21
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3042748137
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▶ Lynch BA, Lambeng N, Nocka K, et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci USA 2004;101(26):9861-9866. Until this paper was published, the mechanism of action of levetiracetam was unknown. Now, several additional drugs that bind to SV2A are in development.
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▶ Lynch BA, Lambeng N, Nocka K, et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci USA 2004;101(26):9861-9866. Until this paper was published, the mechanism of action of levetiracetam was unknown. Now, several additional drugs that bind to SV2A are in development.
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22
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33845442442
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▶ Malik S, Arif H, Hirsch LJ. Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. Expert Rev Neurother 2006;6(11):1609-1627. A broad overview of lamotrigine efficacy, tolerability. and safety.
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▶ Malik S, Arif H, Hirsch LJ. Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. Expert Rev Neurother 2006;6(11):1609-1627. A broad overview of lamotrigine efficacy, tolerability. and safety.
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23
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0026794763
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▶ Mattson RH, Cramer JA, Collins JF. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. N Engl J Med 1992;327(11):765-771. One of several landmark Veterans Affairs studies that were among the first to compare two or more active drugs head to head. This was one of the few that demonstrated differences in efficacy: valproate and carbamazepine were equivalent in their ability to control generalized tonic-clonic seizures, but carbamazepine was superior in its ability to control complex partial seizures.
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▶ Mattson RH, Cramer JA, Collins JF. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. N Engl J Med 1992;327(11):765-771. One of several landmark Veterans Affairs studies that were among the first to compare two or more active drugs head to head. This was one of the few that demonstrated differences in efficacy: valproate and carbamazepine were equivalent in their ability to control generalized tonic-clonic seizures, but carbamazepine was superior in its ability to control complex partial seizures.
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24
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13144282677
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▶ Pack AM, Morrell MJ, Marcus R, et al. Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. Ann Neurol 2005;57(2):252-257. A scientifically strong study showing that both carbamazepine and valproate therapy lead to increased bone turnover and therefore may be associated with decreased bone density with chronic use.
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▶ Pack AM, Morrell MJ, Marcus R, et al. Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. Ann Neurol 2005;57(2):252-257. A scientifically strong study showing that both carbamazepine and valproate therapy lead to increased bone turnover and therefore may be associated with decreased bone density with chronic use.
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25
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0034992257
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▶ Panayiotopoulos CP. Treatment of typical absence seizures and related epileptic syndromes. Paediatr Drugs 2001;3(5):379-403.
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▶ Panayiotopoulos CP. Treatment of typical absence seizures and related epileptic syndromes. Paediatr Drugs 2001;3(5):379-403.
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26
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0038196961
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▶ Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs. Lancet Neurol 2003a;2(6):347-356. Comprehensive review of interactions between AEDs, both old and new.
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▶ Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs. Lancet Neurol 2003a;2(6):347-356. Comprehensive review of interactions between AEDs, both old and new.
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27
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0038714895
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▶ Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003b;2(8):473-481. Extremely useful and comprehensive review of potential interactions between all AEDs and concomitant medications including antihypertensives, psychiatric medications, chemotherapeutic agents, and others.
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▶ Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003b;2(8):473-481. Extremely useful and comprehensive review of potential interactions between all AEDs and concomitant medications including antihypertensives, psychiatric medications, chemotherapeutic agents, and others.
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28
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33748764381
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▶ Pellock JM, Faught E, Leppik IE, et al. Felbamate: consensus of current clinical experience. Epilepsy Res 2006;71(2-3):89-101. A broad overview of felbamate efficacy, tolerability, and safety, with specific emphasis and data regarding risk of idiosyncratic toxicities.
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▶ Pellock JM, Faught E, Leppik IE, et al. Felbamate: consensus of current clinical experience. Epilepsy Res 2006;71(2-3):89-101. A broad overview of felbamate efficacy, tolerability, and safety, with specific emphasis and data regarding risk of idiosyncratic toxicities.
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29
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33749518296
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▶ Pennell PB. 2005 AES annual course: evidence used to treat women with epilepsy. Epilepsia 2006;47(suppl 1):46-53.
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▶ Pennell PB. 2005 AES annual course: evidence used to treat women with epilepsy. Epilepsia 2006;47(suppl 1):46-53.
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30
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0842282467
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▶ Pennell PB, Newport DJ, Stowe ZN, et al. The impact of pregnancy and childbirth on the metabolism of lamotrigine. Neurology 2004;62(2):292-295. This study underscored the degree of change in serum lamotrigine levels and the variability between women during pregnancy.
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▶ Pennell PB, Newport DJ, Stowe ZN, et al. The impact of pregnancy and childbirth on the metabolism of lamotrigine. Neurology 2004;62(2):292-295. This study underscored the degree of change in serum lamotrigine levels and the variability between women during pregnancy.
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31
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0036401554
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▶ Perucca E. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 2002;16(10): 695-714. A broad overview of valproic acid efficacy, tolerability, and safety.
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▶ Perucca E. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 2002;16(10): 695-714. A broad overview of valproic acid efficacy, tolerability, and safety.
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32
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27744435940
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▶ Ryvlin P. Defining success in clinical trials - profiling pregabalin, the newest AED. Eur J Neurol 2005;12(suppl 4):12-21. A broad overview of pregabalin efficacy, tolerability, and safety.
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▶ Ryvlin P. Defining success in clinical trials - profiling pregabalin, the newest AED. Eur J Neurol 2005;12(suppl 4):12-21. A broad overview of pregabalin efficacy, tolerability, and safety.
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33
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▶ Taylor CP, Angelotti T, Fauman E. Pharmacology and mechanism of action of pregabalin: the calcium channel alpha(2)-delta (alpha(2)-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res 2007;73(2):137-150.
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▶ Taylor CP, Angelotti T, Fauman E. Pharmacology and mechanism of action of pregabalin: the calcium channel alpha(2)-delta (alpha(2)-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res 2007;73(2):137-150.
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▶ Tomson T, Battino D. Teratogenicity of antiepileptic drugs: state of the art. Curr Opin Neurol 2005;18(2):135-140. Up-to-date overview of results of pregnancy registries, and other information about teratogenicity of AEDs.
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▶ Tomson T, Battino D. Teratogenicity of antiepileptic drugs: state of the art. Curr Opin Neurol 2005;18(2):135-140. Up-to-date overview of results of pregnancy registries, and other information about teratogenicity of AEDs.
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35
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▶ Wheless JW, Clarke DF, Carpenter D. Treatment of pediatric epilepsy: expert opinion, 2005. J Child Neurol 2005;20(suppl 1):1-56.
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▶ Wheless JW, Clarke DF, Carpenter D. Treatment of pediatric epilepsy: expert opinion, 2005. J Child Neurol 2005;20(suppl 1):1-56.
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▶ Yagi K. Overview of Japanese experience-controlled and uncontrolled trials. Seizure 2004;13(suppl 1):11-15.
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▶ Yagi K. Overview of Japanese experience-controlled and uncontrolled trials. Seizure 2004;13(suppl 1):11-15.
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