Disruption of the Pfg27 locus by homologous recombination leads to loss of the sexual phenotype in P. falciparum

Molecular Cell

Volumn 3, Issue 6, 1999, Pages 793-798

  Lobo, Cheryl Ann ^a   Fujioka, Hisashi ^b   Aikawa, Masamichi ^c   Kumar, Nirbhay ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TOKAI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GAMETOCYTE; GAMETOGENESIS; GENE DISRUPTION; GENE EXPRESSION; GENE LOCUS; GENE LOSS; GENE TARGETING; MOLECULAR CLONING; NONHUMAN; PARASITE DEVELOPMENT; PHENOTYPE; PLASMODIUM FALCIPARUM; PROTEIN EXPRESSION;

EID: 0033152090     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)80011-3     Document Type: Article

References (28)

1. Aikawa, M., Carter, R., Ito, Y., and Nijhout, M.M. (1984). New observations of gametogenesis, fertilization and zygote transformation in plasmodium gallinaceum. J. Protozool. 31, 403-413.
2. Alano, P., and Carter, R.C. (1990). Sexual differentiation in malaria parasites. Annu. Rev. Microbiol. 44, 429-449.
3. Alano, P., Premawansa, S., Bruce, M.C., and Carter, R. (1991). A stage-specific gene expressed at the onset of gametocytogenesis in plasmodium falciparum. Mol. Biochem. Parasitol. 46, 81-88.
4. Alano, P., Roca, L., Smith, D., Read, D., Carter, R., and Day, K. (1995). Plasmodium falciparum: Parasites defective in early stages of gametocytogenesis. Exp. Parasitol. 81, 227-235.
5. Alano, P., Silvestrini, F., and Roca, L. (1996). Structure and polymorphism of the upstream region of the pfg27/25 gene, transcriptionally regulated in gametocytogenesis of plasmodium falciparum. Mol. Biochem. Parasitol. 79, 207-217.
6. Carter, R., Graves, P.M., Creasey, A., Byrne, K., Read, D., Alano, P., and Fenton, B. (1989). Plasmodium falciparum: An abundant stage- Specific protein expressed during early gametocyte development. Exp. Parasitol. 69, 140-149.
7. Crabb, B.S., Cooke, B.M., Reeder, J.C., Waller, R.F., Caruana, S.R., Davern, K.M., Wickham, M., Brown, G., Coppel, R., and Cowman, A.F. (1997). Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Cell 89, 287-296.
8. Day, K.P., Karamalis, F., Thompson, J., Barnes, D.A., Peterson, C., Brown, H., Brown, G.V., and Kemp, D.J. (1993). Genes necessary for expression of a virulence determinant and for transmission of plasmodium falciparum are located on a 0.3 megabase region of chromosome 9. Proc. Natl. Acad. Sci. USA 90, 8292-8296.
9. Guinet, F., Dvorak, J.A., Fujioka, H., Keister, D.B., Muratova, O., Kaslow, D.C., Aikawa, M., Vaidya, A.K., and Wellems, T.H. (1996). A development defect in plasmodium falciparum male gametogenesis. J. Cell. Biol. 135, 269-275.
10. Hawking, F., Wilson, M.E., and Gammage, K. (1971). Evidence for cyclic development and short lived maturity in the gametocytes of plasmodium falciparum. Trans. Roy. Soc. Trop. Med. Hyg. 65, 549-559.
11. Ifediba, T., and Vanderberg, J. (1981). Complete in vitro maturation of plasmodium falciparum gametocytes. Nature 294, 364-366.
12. Kumar, N. (1997). Protein phosphorylation during the sexual differentiation of the malaria parasite plasmodium falciparum. Mol. BioChem. Parasitol. 87, 205-210.
13. Kumar, N., and Carter, R. (1984). Biosynthesis of the target antigens of antibodies blocking transmission of plasmodium falciparum. Mol. Biochem. Parasitol. 13, 333-342.
14. Lobo, C.A., and Kumar, N. (1998). Sexual differentiation and development in the malaria parasite. Parasitol. Today 14, 146-150.
15. Lobo, C.A., Konings, R.N., and Kumar, N. (1994). Expression of early gametocyte-stage antigens pfg27 and pfs16 in synchronized gametocytes and non-gametocyte producing clones of plasmodium falciparum. Mol. Biochem. Parasitol. 68, 151-154.
16. Menard, R., Sultan, A.A., Cortes, C., Altszuler, R., van Dijk, M.R., Janse, C.J., Waters, A.P., Nussenzweig, R.S., and Nussenzweig, V. (1997). Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes. Nature 385, 336-340.
17. Pologe, L.G. (1994). Aberrant transcription and the failure of plasmodium falciparum to differentiate into gametocytes. Mol. Biochem. Parasitol. 68, 35-43.
18. Quakyi, I.A., Matsumoto, Y., Carter, R., Udomsangpetch, R., SjoLander, A., Berzins, K., Perlmann, P., Aikawa, M., and Miller, L.H. (1989). Movement of a falciparum malaria protein through the erythrocyte cytoplasm to the erythrocyte membrane is associated with lysis of the erythrocyte and release of gametes. Infect. Immun. 57, 833-839.
19. Sinden, R.E. (1982). Gametocytogenesis of plasmodium falciparum in vitro: An electron microscopic study. Parasitology 84, 1-11.
20. Sinden, R.E. (1985). Gametocytogenesis in plasmodium spp. And observations on the meiotic division. Ann. Soc. Belg. Med. Trop. 65, 21-33.
21. Sultan, A.A., Thathy, V., Frevert, U., Robson, K., Crisanti, A., NussenZweig, V., Nussenzweig, R., and Menard, R. (1997). TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites. Cell 90, 511-522.
22. Trager, W., and Jensen, J.B., (1976). Human malaria parasites in continuous culture. Science 193, 673-675.
23. Vaidya, A.B., Muratova, O., Guinet, F., Keister, D., Wellems, T.E., and Kaslow, D.C. (1995). A genetic locus on plasmodium falciparum chromosome 12 linked to a defect in mosquito-infectivity and male gametogenesis. Mol. Biochem. Parasitol. 69, 65-71.
24. Van Dijk, M.R., Waters, A.P., and Janse, C.J. (1995). Stable transfection of malaria parasite blood stages. Science 268, 1358-1362.
25. Vermeulen, A.N., van Deursen, J., Brakenhoff, R.H., Lensen, T.H.W., Ponnudurai, T., and Meuwissen, J.H. (1986). Characterization of plasmodium falciparum sexual stage antigens and their biosynthesis in synchronized gametocyte cultures. Mol. Biochem. Parasitol. 20, 155-163.
26. Walliker, D. (1989). Genetic recombination in malaria parasites. Exp. Parasitol. 69, 303-309.
27. Wellems, T.E., Walliker, D., Smith, C.L., de Rosario, V.E., Lee Maloy, W.L., Howard, R., Carter, R., and McCutchan, T.F. (1987). A histidine- Rich protein gene marks a linkage group favored strongly in a genetic cross of plasmodium falciparum. Cell 49, 633-642.
28. Wu, Y., Kirkman, L.A., and Wellems, T.E., (1996). Transformation of plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proc. Natl. Acad. Sci. USA 93, 1130-1134.