Efficacy of barriers and hypoxia-inducible factor inhibitors to prevent CO2 pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model

Journal of Minimally Invasive Gynecology

Volumn 14, Issue 5, 2007, Pages 591-599

  Binda, Maria Mercedes ^a   Molinas, Carlos Roger ^b   Bastidas, Adriana ^a   Jansen, Marc ^c   Koninckx, Philippe Robert ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b Centre for Gynaecological Endoscopy Cendogyn   (Paraguay)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Barriers; Flotation; HIF; Hypoxia; Intraperitoneal adhesion formation; Laparoscopy; Pneumoperitoneum; Prevention; Surfactant

Indexed keywords

17 DEMETHOXYGELDANAMYCIN; CARBON DIOXIDE; CARBOXYMETHYLCELLULOSE; DEXTRAN 70; GELDANAMYCIN; HYPOXIA INDUCIBLE FACTOR 1; PHOSPHOLIPID DERIVATIVE; RADICICOL; RAPAMYCIN; SURFACTANT; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; LAPAROSCOPIC SURGERY; LAPAROSCOPY; MATERIALS TESTING; MOUSE; NONHUMAN; PERITONEUM ADHESION; PNEUMOPERITONEUM; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; TREATMENT OUTCOME;

EID: 34548426955     PISSN: 15534650     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmig.2007.04.002     Document Type: Article

References (74)

1. Molinas C.R., Mynbaev O., Pauwels A., Novak P., and Koninckx P.R. Peritoneal mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation in a laparoscopic mouse model. Fertil Steril 76 (2001) 560-567
2. Molinas C.R., Elkelani O., Campo R., Luttun A., Carmeliet P., and Koninckx P.R. Role of the plasminogen system in basal adhesion formation and carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 80 (2003) 184-192
3. Molinas C.R., Campo R., Dewerchin M., Eriksson U., Carmeliet P., and Koninckx P.R. Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 80 Suppl 2 (2003) 803-811
4. Molinas C.R., Campo R., Elkelani O.A., Binda M.M., Carmeliet P., and Koninckx P.R. Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 80 Suppl 2 (2003) 795-802
5. Salceda S., and Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272 (1997) 22642-22647
6. Maloney A., and Workman P. HSP90 as a new therapeutic target for cancer therapy: the story unfolds. Expert Opin Biol Ther 2 (2002) 3-24
7. Jiang B.H., Jiang G., Zheng J.Z., Lu Z., Hunter T., and Vogt P.K. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 12 (2001) 363-369
8. Wang G.L., Jiang B.H., and Semenza G.L. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem Biophys Res Commun 216 (1995) 669-675
9. Molinas C.R., Binda M.M., Carmeliet P., and Koninckx P.R. Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice. Fertil Steril 82 Suppl 3 (2004) 1149-1153
10. Elkelani O.A., Molinas C.R., Mynbaev O., and Koninckx P.R. Prevention of adhesions with crystalloids during laparoscopic surgery in mice. J Am Assoc Gynecol Laparosc 9 (2002) 447-452
11. Roman H., Canis M., Kamble M., Botchorishvili R., Pouly J.L., and Mage G. Efficacy of three adhesion-preventing agents in reducing severe peritoneal trauma induced by bipolar coagulation in a laparoscopic rat model. Fertil Steril 83 Suppl 1 (2005) 1113-1118
12. Detchev R., Bazot M., Soriano D., and Darai E. Prevention of de novo adhesion by ferric hyaluronate gel after laparoscopic surgery in an animal model. JSLS 8 (2004) 263-268
13. De Iaco P.A., Stefanetti M., Pressato D., et al. A novel hyaluronan-based gel in laparoscopic adhesion prevention: preclinical evaluation in an animal model. Fertil Steril 69 (1998) 318-323
14. Ozmen M.M., Aslar A.K., Terzi M.C., Albayrak L., and Berberoglu M. Prevention of adhesions by bioresorbable tissue barrier following laparoscopic intraabdominal mesh insertion. Surg Laparosc Endosc Percutan Tech 12 (2002) 342-346
15. De Iaco P., Costa A., Mazzoleni G., Pasquinelli G., Bassein L., and Marabini A. Fibrin sealant in laparoscopic adhesion prevention in the rabbit uterine horn model. Fertil Steril 62 (1994) 400-404
16. Kramer K., Senninger N., Herbst H., and Probst W. Effective prevention of adhesions with hyaluronate. Arch Surg 137 (2002) 278-282
17. Binda M.M., Molinas C.R., Mailova K., and Koninckx P.R. Effect of temperature upon adhesion formation in a laparoscopic mouse model. Hum Reprod 19 (2004) 2626-2632
18. Binda M.M., Molinas C.R., Hansen P., and Koninckx P.R. Effect of desiccation and temperature during laparoscopy on adhesion formation in mice. Fertil Steril 86 (2006) 166-175
19. Elkelani O.A., Binda M.M., Molinas C.R., and Koninckx P.R. Effect of adding more than 3% oxygen to carbon dioxide pneumoperitoneum on adhesion formation in a laparoscopic mouse model. Fertil Steril 82 (2004) 1616-1622
20. Lindberg V. Uncertainties and Error Propagation, Part I of a manual on Uncertainties, Graphing, and the Vernier Caliper (2000). http://www.rit.edu/~uphysics/uncertainties/Uncertaintiespart1.html www.rit.edu/∼uphysics/uncertainties/Uncertaintiespart1.html;
21. Kahan B.D., Chang J.Y., and Sehgal S.N. Preclinical evaluation of a new potent immunosuppressive agent, rapamycin. Transplantation 52 (1991) 185-191
22. Stepkowski S.M., Chen H., Daloze P., and Kahan B.D. Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat. Transplantation 51 (1991) 22-26
23. Schultz R.M., Merriman R.L., Andis S.L., et al. In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin. Anticancer Res 15 (1995) 1135-1139
24. Bagatell R., Khan O., Paine-Murrieta G., Taylor C.W., Akinaga S., and Whitesell L. Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer. Clin Cancer Res 7 (2001) 2076-2084
25. Kelland L.R., Sharp S.Y., Rogers P.M., Myers T.G., and Workman P. DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. J Natl Cancer Inst 91 (1999) 1940-1949
26. Soga S., Neckers L.M., Schulte T.W., et al. KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. Cancer Res 59 (1999) 2931-2938
27. Molinas C.R., Binda M.M., Campo R., and Koninckx P.R. Adhesion formation and interanimal variability in a laparoscopic mouse model varies with strains. Fertil Steril 83 (2005) 1871-1874
28. Bland J.M., and Altman D.G. Multiple significance tests: the Bonferroni method. BMJ 310 (1995) 170
29. Brader S., and Eccles S.A. Phosphoinositide 3-kinase signaling pathways in tumor progression, invasion and angiogenesis. Tumori 90 (2004) 2-8
30. Giuliani N., Lunghi P., Morandi F., et al. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Leukemia 18 (2004) 628-635
31. Sliva D. Signaling pathways responsible for cancer cell invasion as targets for cancer therapy. Curr Cancer Drug Targets 4 (2004) 327-336
32. Kietzmann T., Samoylenko A., Roth U., and Jungermann K. Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes. Blood 101 (2003) 907-914
33. Puri K.D., Doggett T.A., Douangpanya J., et al. Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue. Blood 103 (2004) 3448-3456
34. Roach T.I., Slater S.E., White L.S., et al. The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages. Curr Biol 8 (1998) 1035-1038
35. Zhou J., Schmid T., Frank R., and Brune B. PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J Biol Chem 279 (2004) 13506-13513
36. Sue-A-Quan A.K., Fialkow L., Vlahos C.J., et al. Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases. J Cell Physiol 172 (1997) 94-108
37. Young L.H., Ikeda Y., Scalia R., and Lefer A.M. Wortmannin, a potent antineutrophil agent, exerts cardioprotective effects in myocardial ischemia/reperfusion. J Pharmacol Exp Ther 295 (2000) 37-43
38. De Iaco P.A., Muzzupapa G., Bigon E., et al. Efficacy of a hyaluronan derivative gel in postsurgical adhesion prevention in the presence of inadequate hemostasis. Surgery 130 (2001) 60-64
39. Belluco C., Meggiolaro F., Pressato D., et al. Prevention of postsurgical adhesions with an autocrosslinked hyaluronan derivative gel. J Surg Res 100 (2001) 217-221
40. Kocak I., Unlu C., Akcan Y., and Yakin K. Reduction of adhesion formation with cross-linked hyaluronic acid after peritoneal surgery in rats. Fertil Steril 72 (1999) 873-878
41. Pellicano M., Bramante S., Cirillo D., et al. Effectiveness of autocrosslinked hyaluronic acid gel after laparoscopic myomectomy in infertile patients: a prospective, randomized, controlled study. Fertil Steril 80 (2003) 441-444
42. Pellicano M., Guida M., Bramante S., et al. Reproductive outcome after autocrosslinked hyaluronic acid gel application in infertile patients who underwent laparoscopic myomectomy. Fertil Steril 83 (2005) 498-500
43. Acunzo G., Guida M., Pellicano M., et al. Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study. Hum Reprod 18 (2003) 1918-1921
44. Guida M., Acunzo G., Di Spiezio Sardo A., et al. Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study. Hum Reprod 19 (2004) 1461-1464
45. Hiro D., Ito A., Matsuta K., and Mori Y. Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages. Biochem Biophys Res Commun 140 (1986) 715-722
46. Kobayashi H., and Terao T. Hyaluronic acid-specific regulation of cytokines by human uterine fibroblasts. Am J Physiol 273 (1997) C1151-C1159
47. Haslinger B., Mandl-Weber S., Sellmayer A., and Sitter T. Hyaluronan fragments induce the synthesis of MCP-1 and IL-8 in cultured human peritoneal mesothelial cells. Cell Tissue Res 305 (2001) 79-86
48. Hodge-DuFour J., Noble P.W., Horton M.R., et al. Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages. J Immunol 159 (1997) 2492-2500
49. Foschi D., Castoldi L., Radaelli E., et al. Hyaluronic acid prevents oxygen free-radical damage to granulation tissue: a study in rats. Int J Tissue React 12 (1990) 333-339
50. Lym H.S., Suh Y., and Park C.K. Effects of hyaluronic acid on the polymorphonuclear leukocyte (PMN) release of active oxygen and protection of bovine corneal endothelial cells from activated PMNs. Korean J Ophthalmol 18 (2004) 23-28
51. Kvam C., Granese D., Flaibani A., Pollesello P., and Paoletti S. Hyaluronan can be protected from free-radical depolymerisation by 2,6-diisopropylphenol, a novel radical scavenger. Biochem Biophys Res Commun 193 (1993) 927-933
52. Reijnen M.M., Falk P., van Goor H., and Holmdahl L. The antiadhesive agent sodium hyaluronate increases the proliferation rate of human peritoneal mesothelial cells. Fertil Steril 74 (2000) 146-151
53. Reijnen M.M., van Goor H., Falk P., Hedgren M., and Holmdahl L. Sodium hyaluronate increases the fibrinolytic response of human peritoneal mesothelial cells exposed to tumor necrosis factor alpha. Arch Surg 136 (2001) 291-296
54. Reijnen M.M., Skrabut E.M., Postma V.A., Burns J.W., and van Goor H. Polyanionic polysaccharides reduce intra-abdominal adhesion and abscess formation in a rat peritonitis model. J Surg Res 101 (2001) 248-253
55. Harris E.S., Morgan R.F., and Rodeheaver G.T. Analysis of the kinetics of peritoneal adhesion formation in the rat and evaluation of potential antiadhesive agents. Surgery 117 (1995) 663-669
56. Buckenmaier III C.C., Pusateri A.E., Harris R.A., and Hetz S.P. Comparison of antiadhesive treatments using an objective rat model. Am Surg 65 (1999) 274-282
57. Diamond M.P., DeCherney A.H., Linsky C.B., Cunningham T., and Constantine B. Adhesion re-formation in the rabbit uterine horn model: I. Reduction with carboxymethylcellulose. Int J Fertil 33 (1988) 372-375
58. Ortega-Moreno J. Effects of TC7 associated to 32% dextran 70, heparin and carboxymethylcellulose in adhesion prevention in the rat. Arch Gynecol Obstet 253 (1993) 27-32
59. Gehlbach D.L., O'Hair K.C., Parks A.L., and Rosa C. Combined effects of tissue plasminogen activator and carboxymethylcellulose on adhesion reformation in rabbits. Int J Fertil Menopausal Stud 39 (1994) 172-176
60. Heidrick G.W., Pippitt Jr. C.H., Morgan M.A., and Thurnau G.R. Efficacy of intraperitoneal sodium carboxymethylcellulose in preventing postoperative adhesion formation. J Reprod Med 39 (1994) 575-578
61. Neuwirth R.S., and Khalaf S.M. Effect of thirty-two per cent dextran 70 on peritoneal adhesion formation. Am J Obstet Gynecol 121 (1975) 420-422
62. Diamond M.P., DeCherney A.H., Linsky C.B., Cunningham T., and Constantine B. Assessment of carboxymethylcellulose and 32% dextran 70 for prevention of adhesions in a rabbit uterine horn model. Int J Fertil 33 (1988) 278-282
63. Frishman G.N., Peluso J.J., Kratka S.A., Maier D.B., and Luciano A.A. Preoperative versus postoperative dextran 70 for preventing adhesion formation. J Reprod Med 36 (1991) 707-710
64. Best C.L., Rittenhouse D., and Sueldo C.E. A comparison of TC7 and 32% dextran 70 for prevention of postoperative adhesions in hamsters. Obstet Gynecol 78 (1991) 858-860
65. Dunn R., Lyman M.D., Edelman P.G., and Campbell P.K. Evaluation of the SprayGel adhesion barrier in the rat cecum abrasion and rabbit uterine horn adhesion models. Fertil Steril 75 (2001) 411-416
66. Ferland R., Mulani D., and Campbell P.K. Evaluation of a sprayable polyethylene glycol adhesion barrier in a porcine efficacy model. Hum Reprod 16 (2001) 2718-2723
67. Johns D.A., Ferland R., and Dunn R. Initial feasibility study of a sprayable hydrogel adhesion barrier system in patients undergoing laparoscopic ovarian surgery. J Am Assoc Gynecol Laparosc 10 (2003) 334-338
68. Mettler L., Audebert A., Lehmann-Willenbrock E., Schive-Peterhansl K., and Jacobs V.R. A randomized, prospective, controlled, multicenter clinical trial of a sprayable, site-specific adhesion barrier system in patients undergoing myomectomy. Fertil Steril 82 (2004) 398-404
69. Muller S.A., Treutner K.H., Tietze L., et al. Efficacy of adhesion prevention and impact on wound healing of intraperitoneal phospholipids. J Surg Res 96 (2001) 68-74
70. Muller S.A., Treutner K.H., Jorn H., Anurov M., Oettinger A.P., and Schumpelick V. Adhesion prevention comparing liquid and solid barriers in the rabbit uterine horn model. Eur J Obstet Gynecol Reprod Biol 120 (2005) 222-226
71. Falk K., Lindman B., Bengmark S., Larsson K., and Holmdahl L. Prevention of adhesions by surfactants and cellulose derivatives in mice. Eur J Surg 167 (2001) 136-141
72. Jansen M., Treutner K.H., Jansen P.L., et al. Phospholipids reduce the intraperitoneal adhesion of colonic tumor cells in rats and adhesion on extracellular matrix in vitro. Int J Colorectal Dis 19 (2004) 525-532
73. Chen Y., Hills B.A., and Hills Y.C. Unsaturated phosphatidylcholine and its application in surgical adhesion. ANZ J Surg 75 (2005) 1111-1114
74. Hills B.A. Role of surfactant in peritoneal dialysis. Perit Dial Int 20 (2000) 503-515