Immunomodulatory properties of maxadilan, the vasodilator peptide from sand fly salivary gland extracts

American Journal of Tropical Medicine and Hygiene

Volumn 54, Issue 6, 1996, Pages 665-671

  Qureshi, Abrar A ^a   Asahina, Akihiko ^a   Ohnuma, Manami ^b   Tajima, Masahiro ^b   Granstein, Richard D ^a   Lerner, Ethan A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b SHISEIDO RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; FEMALE; FLY; HEMOSTASIS; IMMUNOMODULATION; INSECT BITE; MOUSE; NONHUMAN; SALIVARY GLAND;

ANIMALIA; ARTHROPODA; INSECTA; MURINAE; PHLEBOTOMINAE;

EID: 0029940290     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1996.54.665     Document Type: Article

References (21)

1. Champagne DE, 1994. The role of salivary vasodilators in blood feeding and parasite transmission. Parasitol Today 10: 430-433.
2. Lerner EA, Ribiero JMC, Nelson RJ, Lerner MR, 1991. Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis. J Biol Chem 266: 11234-11236.
3. Lerner EA, Shoemaker CB, 1992. Maxadilan: cloning and functional expression of the gene encoding this potent vasodilator peptide. J Biol Chem 267: 1062-1066.
4. Grevelink SA, Osborne J, Loscalzo J, Lerner EA, 1995. Vasorelaxant and second messenger effects of maxadilan. J Pharm Exp Ther 272: 33-37.
5. Ribeiro JMC, Vachereau A, Modi GB, Tesh RB, 1989. A novel vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis. Science 243: 212-214.
6. Ribiero JMC, 1987. Role of saliva in blood-feeding by arthropods. Annu Rev Entomol 32: 463-478.
7. Titus RG, Ribeiro JMC, 1990. The role of vector saliva in transmission of arthropod-borne diseases. Parasitol Today 6: 157-160.
8. Theodos CM, Ribiero JMC, Titus RG, 1991. Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice. Infect Immun 59: 1592-1598.
9. Titus RG, Ribeiro JMC, 1988. Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity. Science 239: 1306-1308.
10. Samuelson J, Lerner EA, Tesh R, Titus RG, 1991. A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva. J Exp Med 173: 49-54.
11. Theodos CM, Titus RG, 1993. Salivary gland material from the sand fly Lutzomyia longipalpis has an inhibitory effect on macrophage function in vitro. Parasite Immunol 15: 481-487.
12. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, Granstein RD, 1993. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 363: 159-163.
13. Boudard F, Bastide M, 1991. Inhibition of mouse T-cell proliferation by CGRP and VIP: effects of these neuropeptides on IL-2 production and cAMP synthesis. J Neurosci Res 29: 29-41.
14. Coligan JE, Kiuisbeek AM, Margulies DH, Shevach EM, Strober W, 1992. Current Protocols in Immunology. N.I.H. Health, ed. New York: Wiley Interscience, 3.11.1-10.
15. Umeda Y, Takamiya M, Voshizaki H, Arisawa M, 1988. Inhibition of mitogen-stimulated T lymphocyte proliferation by calcitonin gene-related peptide. Biochem Biophys Res Common 154: 227-235.
16. +) T cell subsets by the anti-receptor antibody. J Immunol 144: 16-22.
17. Strong DM, Ahmed AA, Thurman GB, Sell KW, 1973. In vitro stimulation of murine spleen cells using a microculture system and a multiple automated sample harvester. J Immunol Methods 2: 279-287.
18. Grabbe S, Bruvers S, Gallo RL, Knisely TL, Nazareno R, Granstein RD, 1991. Tumor antigen presentation by murine epidermal cells. J Immunol 146: 3656-3661.
19. Moll H, 1993. Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis. Immunol Today 14: 383-387.
20. Moro O, Tsomides TJ, Tajima M, Lerner EA, 1995. Maxadilan binds to membrane fractions of brain tissue. Biochem Biophys Res Comm 216: 234-241.
21. Warburg A, Saraiva E, Lanzaro GC, Titus RG, Neva F, 1994. Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis. Phil Trans R Soc Lond B 345: 223-230.