Conditional targeting in the kidney

Nephron - Physiology

Volumn 107, Issue 1, 2007, Pages

  Wu, Fiona ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SOUTHMEAD HOSPITAL   (United Kingdom)

Author keywords

Cre loxP; Inducible targeting; Kidney specific targeting

Indexed keywords

AQUAPORIN 2; CRE RECOMBINASE; HU ANTIGEN; MINERAL; VITAMIN;

BLOOD PRESSURE; CELL TYPE; FLUID BALANCE; GENE CONTROL; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; HOMEOSTASIS; HUMAN; KIDNEY; KIDNEY DISEASE; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUMOR; KNOCKOUT GENE; LOXP SITE; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY;

ANIMALS; GENE TARGETING; GENETIC ENGINEERING; HUMANS; INTEGRASES; KIDNEY;

EID: 34548394967     PISSN: 16602137     EISSN: None     Source Type: Journal    
DOI: 10.1159/000106483     Document Type: Short Survey

References (22)

1. Capecchi MR: Altering the genome by homologous recombination. Science 1989;244:1288-1292.
2. Lantinga-van Leeuwen IS, Leonhard WN, van de Wal A, Breuning MH, Verbeek S, de Heer E, Peters DJM: Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells. Genesis 2006;44:225-232.
3. Ge Y, Ahn D, Stricklett PK, Hughes AK, Yanagisawa M, Verbalis JG, Kohan DE: Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol 2005;288:F912-F920.
4. Ge Y, Strickett PK, Hughes AK, Yanagisawa M, Kohan DE: Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. Am J Physiol Renal Physiol 2005;289:F692-F698.
5. Rojek A, Füchtbauer E-M, Kwon T-H, Frokiaer J, Nielsen S: Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci USA 2006;103: 6307-6342.
6. Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T, McMahon A, Hummler E, Rossier BC: Collecting duct-specific gene inactivation of alpha-ENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest 2003;112:554-565.
7. Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD: Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med 2005;11: 861-866.
8. Willnow TE, Hilpert J, Armstrong S, Rohlmann A, Hammer RE, Burns DK, Herz J: Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci USA 1996;93:8460-8464.
9. Leheste JR, Melsen F, Wellner M, Jansen P, Schlichting U, Renner-Müller I, Andreassen TT, Wolf E, Bachmann S, Nykjaer A, Willnow TE: Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J 2003;17:247-249.
10. Raila J, Willnow TE, Schweigert FJ: Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasis. J Nutr 2005;135: 2512-2516.
11. Bachmann S, Schlichting U, Geist B, Mutig K, Petsch T, Bacic D, Wagner CA, Kaissling B, Biber J, Murer H, Willnow TE: Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa). J Am Soc Nephrol 2004;15:892-900.
12. Lin F, Hiesberger T, Cordes K, Sinclair AM, Goldstein LSB, Somlo S, Igarashi P: Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci USA 2003;100:5286-5291.
13. Gresh L, Fischer E, Reimann A, Tanguy M, Garbay S, Shao X, Hiesberger T, Fiette L, Igarashi P, Yaniv M, Pontoglio M: A transcriptional network in polycystic kidney disease. EMBO J 2004;23:1657-1668.
14. Piontek KB, Huso DL, Grinberg A, Liu L, Bedja D, Zhao H, Gabrielson K, Qian F, Mei C, Westphal H, Germino GG: A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol 2004;15:3035-3043.
15. Rankin EB, Tomaszewski JE, Haase VH: Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res 2006;66:2576-2583.
16. Qian CN, Knol J, Igarashi P, Lin F, Zylstra U, Teh BT, Williams BO: Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem 2005;280:3938-3945.
17. Sansom OJ, Griffiths DFR, Reed KR, Winton DJ, Clarke AR: Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene 2005;24:8205-8210.
18. Oxburgh L, Chu GC, Michael SK, Robertson EJ: TGFβ superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 2004;131:4593-4605.
19. Yu J, Carroll TJ, McMahon AP: Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 2002;129:5301-5312.
20. Eremina V, Sood M, Haigh J, Nagy A, Lajoie G, Ferrara N, Gerber H-P, Kikkawa Y, Miner JH, Quaggin SE: Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003;111:707-716.
21. Yang B, Zhao D, Qian L, Verkman AS: Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol 2006;291:F465-F472.
22. Wagner K-D, Wagner N, Guo J-K, Elger M, Dallman MJ, Bugeon L, Schedl A: An inducible mouse model for PAX2-dependent glomerular disease: insights into a complex pathogenesis. Curr Biol 2006;16:793-800.