Vaccination with Brucella recombinant DnaK and SurA proteins induces protection against Brucella abortus infection in BALB/c mice

Vaccine

Volumn 25, Issue 37-38, 2007, Pages 6721-6729

  Delpino, Maria Victoria ^a   Estein, Silvia Marcela ^b   Fossati, Carlos Alberto ^a   Baldi, Pablo César ^a   Cassataro, Juliana ^a,c  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSIDAD NACIONAL DEL CENTRO DE LA PROVINCIA DE BUENOS AIRES   (Argentina)

^c HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

Author keywords

Brucella spp.; Heat shock protein; Recombinant protein; Vaccine

Indexed keywords

FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; PROTEIN DNAK; PROTEIN SURA; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUCELLA ABORTUS; BRUCELLOSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SPLEEN CELL; TH1 CELL; TH2 CELL; VACCINATION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTIBODY FORMATION; BRUCELLA ABORTUS; BRUCELLA VACCINE; BRUCELLOSIS; CARRIER PROTEINS; FEMALE; MICE; MICE, INBRED BALB C; PEPTIDYLPROLYL ISOMERASE; RECOMBINANT PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TH2 CELLS;

EID: 34548321638     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.07.002     Document Type: Article

References (43)

1. Young E.J. An overview of human brucellosis. Clin Infect Dis 21 2 (1995) 283-289 quiz 290
2. Nicoletti P. Vaccination against Brucella. Adv Biotechnol Processes 13 (1990) 147-168
3. Baldi P.C., Giambartolomei G.H., Goldbaum F.A., Abdon L.F., Velikovsky C.A., Kittelberger R., et al. Humoral immune response against lipopolysaccharide and cytoplasmic proteins of Brucella abortus in cattle vaccinated with B. abortus S19 or experimentally infected with Yersinia enterocolitica serotype 0:9. Clin Diagn Lab Immunol 3 4 (1996) 472-476
4. Moriyon I., Grillo M.J., Monreal D., Gonzalez D., Marin C., Lopez-Goni I., et al. Rough vaccines in animal brucellosis: structural and genetic basis and present status. Vet Res 35 1 (2004) 1-38
5. Ashford D.A., di Pietra J., Lingappa J., Woods C., Noll H., Neville B., et al. Adverse events in humans associated with accidental exposure to the livestock brucellosis vaccine RB51. Vaccine 22 25-26 (2004) 3435-3439
6. Joint FAO/WHO Expert Committee on Brucellosis. World Health Organ Tech. Rep. Ser. 740 (1986) pp. 1-132
7. Oliveira S.C., and Splitter G.A. Immunization of mice with recombinant L7/L12 ribosomal protein confers protection against Brucella abortus infection. Vaccine 14 10 (1996) 959-962
8. Tabatabai L.B., and Pugh Jr. G.W. Modulation of immune responses in Balb/c mice vaccinated with Brucella abortus Cu-Zn superoxide dismutase synthetic peptide vaccine. Vaccine 12 10 (1994) 919-924
9. Cespedes S., Andrews E., Folch H., and Onate A. Identification and partial characterisation of a new protective antigen of Brucella abortus. J Med Microbiol 49 2 (2000) 165-170
10. Al-Mariri A., Tibor A., Mertens P., De Bolle X., Michel P., Godefroid J., et al. Protection of BALB/c mice against Brucella abortus 544 challenge by vaccination with bacterioferritin or P39 recombinant proteins with CpG oligodeoxynucleotides as adjuvant. Infect Immun 69 8 (2001) 4816-4822
11. Velikovsky C.A., Goldbaum F.A., Cassataro J., Estein S.M., Bowden R.A., Bruno L., et al. Brucella lumazine synthase elicits a mixed Th1-Th2 immune response and reduces infection in mice challenged with Brucella abortus 544 independently of the adjuvant formulation used. Infect Immun 71 10 (2003) 5750-5755
12. Cassataro J., Estein S.M., Pasquevich K.A., Velikovsky C.A., de la Barrera S., Bowden R., et al. Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection. Infect Immun 73 12 (2005) 8079-8088
13. Yang X., Hudson M., Walters N., Bargatze R.F., and Pascual D.W. Selection of protective epitopes for Brucella melitensis by DNA vaccination. Infect Immun 73 11 (2005) 7297-7303
14. Luo D., Ni B., Li P., Shi W., Zhang S., Han Y., et al. Protective immunity elicited by a divalent DNA vaccine encoding both the L7/L12 and Omp16 genes of Brucella abortus in BALB/c mice. Infect Immun 74 5 (2006) 2734-2741
15. Commander N.J., Spencer S.A., Wren B.W., and MacMillan A.P. The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16 M genes. Vaccine 25 1 (2007) 43-54
16. Cassataro J., Pasquevich K.A., Estein S.M., Laplagne D.A., Velikovsky C.A., de la Barrera S., et al. A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination. Vaccine 25 22 (2007) 4437-4446
17. Kohler S., Teyssier J., Cloeckaert A., Rouot B., and Liautard J.P. Participation of the molecular chaperone DnaK in intracellular growth of Brucella suis within U937-derived phagocytes. Mol Microbiol 20 4 (1996) 701-712
18. Mogensen J.E., and Otzen D.E. Interactions between folding factors and bacterial outer membrane proteins. Mol Microbiol 57 2 (2005) 326-346
19. Lazar S.W., and Kolter R. SurA assists the folding of Escherichia coli outer membrane proteins. J Bacteriol 178 6 (1996) 1770-1773
20. Justice S.S., Hunstad D.A., Harper J.R., Duguay A.R., Pinkner J.S., Bann J., et al. Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli. J Bacteriol 187 22 (2005) 7680-7686
21. Rhodius V.A., Suh W.C., Nonaka G., West J., and Gross C.A. Conserved and variable functions of the sigmaE stress response in related genomes. PLoS Biol 4 1 (2006) e2
22. Rollenhagen C., Sorensen M., Rizos K., Hurvitz R., and Bumann D. Antigen selection based on expression levels during infection facilitates vaccine development for an intracellular pathogen. Proc Natl Acad Sci U S A 101 23 (2004) 8739-8744
23. Skovierova H., Rowley G., Rezuchova B., Homerova D., Lewis C., Roberts M., et al. Identification of the sigmaE regulon of Salmonella enterica serovar Typhimurium. Microbiology 152 Pt 5 (2006) 1347-1359
24. Young D., Lathigra R., Hendrix R., Sweetser D., and Young R.A. Stress proteins are immune targets in leprosy and tuberculosis. Proc Natl Acad Sci U S A 85 12 (1988) 4267-4270
25. Mertz A.K., Ugrinovic S., Lauster R., Wu P., Grolms M., Bottcher U., et al. Characterization of the synovial T cell response to various recombinant Yersinia antigens in Yersinia enterocolitica-triggered reactive arthritis. Heat-shock protein 60 drives a major immune response. Arthritis Rheum 41 2 (1998) 315-326
26. Wang Y., Whittall T., McGowan E., Younson J., Kelly C., Bergmeier L.A., et al. Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells. J Immunol 174 6 (2005) 3306-3316
27. Panjwani N.N., Popova L., and Srivastava P.K. Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs. J Immunol 168 6 (2002) 2997-3003
28. Noll A., and Autenrieth I.B. Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12. Infect Immun 64 8 (1996) 2955-2961
29. Penttila T., Vuola J.M., Puurula V., Anttila M., Sarvas M., Rautonen N., et al. Immunity to Chlamydia pneumoniae induced by vaccination with DNA vectors expressing a cytoplasmic protein (Hsp60) or outer membrane proteins (MOMP and Omp2). Vaccine 19 9-10 (2000) 1256-1265
30. Tascon R.E., Colston M.J., Ragno S., Stavropoulos E., Gregory D., and Lowrie D.B. Vaccination against tuberculosis by DNA injection. Nat Med 2 8 (1996) 888-892
31. Suzue K., and Young R.A. Heat shock proteins as immunological carriers and vaccines. Exs 77 (1996) 451-465
32. Bosseray N., and Plommet M. A laboratory reference vaccine to titrate immunogenic activity of antibrucella vaccines in mice. Ann Rech Vet 14 2 (1983) 163-168
33. Cassataro J., Pasquevich K., Bruno L., Wallach J.C., Fossati C.A., and Baldi P.C. Antibody reactivity to Omp31 from Brucella melitensis in human and animal infections by smooth and rough Brucellae. Clin Diagn Lab Immunol 11 1 (2004) 111-114
34. Cassataro J., Velikovsky C.A., de la Barrera S., Estein S.M., Bruno L., Bowden R., et al. A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response. Infect Immun 73 10 (2005) 6537-6546
35. Zhan Y., and Cheers C. Endogenous gamma interferon mediates resistance to Brucella abortus infection. Infect Immun 61 11 (1993) 4899-4901
36. Teixeira-Gomes A.P., Cloeckaert A., and Zygmunt M.S. Characterization of heat, oxidative, and acid stress responses in Brucella melitensis. Infect Immun 68 5 (2000) 2954-2961
37. Celli J., and Gorvel J.P. Organelle robbery: Brucella interactions with the endoplasmic reticulum. Curr Opin Microbiol 7 1 (2004) 93-97
38. Bardwell J.C., and Craig E.A. Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous. Proc Natl Acad Sci U S A 81 3 (1984) 848-852
39. Harmala L.A., Ingulli E.G., Curtsinger J.M., Lucido M.M., Schmidt C.S., Weigel B.J., et al. The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivo. J Immunol 169 10 (2002) 5622-5629
40. Cassataro J., Pasquevich K.A., Estein S.M., Laplagne D.A., Zwerdling A., de la Barrera S., et al. A DNA vaccine coding for the chimera BLSOmp31 induced a better degree of protection against B. ovis and a similar degree of protection against B. melitensis than Rev.1 vaccination. Vaccine 25 32 (2007) 5958-5967
41. Dagan R., Eskola J., Leclerc C., and Leroy O. Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants. Infect Immun 66 5 (1998) 2093-2098
42. Singh R.A., Rodgers J.R., and Barry M.A. The role of T cell antagonism and original antigenic sin in genetic immunization. J Immunol 169 12 (2002) 6779-6786
43. Igietseme J.U., Eko F.O., and Black C.M. Contemporary approaches to designing and evaluating vaccines against Chlamydia. Expert Rev Vaccines 2 1 (2003) 129-146