Protection of BALB/c mice against Brucella abortus 544 challenge by vaccination with bacterioferritin or P39 recombinant proteins with CpG oligodeoxynucleotides as adjuvant

Infection and Immunity

Volumn 69, Issue 8, 2001, Pages 4816-4822

  Al Mariri, A ^a   Tibor, A ^a   Mertens, P ^a   De Bolle, X ^a   Michel, P ^a   Godefroid, J ^a   Walravens, K ^a   Letesson, J J ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOFERRITIN; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOLOGICAL ADJUVANT; OLIGODEOXYNUCLEOTIDE; RECOMBINANT ANTIGEN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTERIAL INFECTION; BRUCELLA ABORTUS; BRUCELLA MELITENSIS; CONTROLLED STUDY; CPG ISLAND; DELAYED HYPERSENSITIVITY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; INTERFERON PRODUCTION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BRUCELLA ABORTUS; BRUCELLA VACCINE; BRUCELLOSIS; CARRIER PROTEINS; CELL DIVISION; CELLS, CULTURED; CHICKENS; CYTOCHROME B GROUP; DNA; FEMALE; FERRITINS; GENE EXPRESSION; INTERFERON TYPE II; INTERLEUKIN-5; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PERIPLASMIC BINDING PROTEINS; RECOMBINANT FUSION PROTEINS; SPLEEN; VACCINATION; VACCINES, SYNTHETIC;

EID: 0034927083     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.8.4816-4822.2001     Document Type: Article

References (59)

1. Temporal development of protective cell-mediated and humoral immunity, in BALB/c mice infected with Brucella abortus
2. Humoral immune response of BALB/c mice to a vaccinia virus recombinant expressing Brucella abortus GroEL does not correlate with protection against a B. abortus challenge
3. An evaluation of the delayed-type hypersensitivity test for diagnosing brucellosis in individual cattle: A field study
4. Oligonucleotide adjuvants for T helper 1 (Th1)-specific vaccination
5. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism
6. CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance antipolysaccharide immunoglobulin G2a (IgG2a) and IgG3 antibodies
7. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
8. Recent advances in brucellosis
9. Persistence of Brucella abortus strain 19 infection in adult cattle vaccinated with reduced doses
10. Structure and function prediction of the Brucella abortus P39 protein by comparative modeling with marginal sequence similarities
11. Characterization, occurrence, and molecular cloning of a 39-kilodalton Brucella abortus cytoplasmic protein immunodominant in cattle
12. Identification of the major T-cell antigens present in the Brucella melitensis B115 protein preparation, Brucellergene OCB
13. Cloning and sequencing of the bacterioferritin gene of Brucella melitensis 16M strain
14. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
15. Vaccination against bovine brucellosis with a low dose of strain 19 administered by the conjunctival route. IV. Comparison between two methods of vaccination
16. Genetic organisation of the lipopolysaccharide O-antigen biosynthesis region of Brucella melitensis 16M (wbk)
17. Induction and regulation of Th1-inducing cytokines by bacterial DNA, lipopolysaccharide, and heat-inactivated bacteria
18. Protection conferred on mice by combinations of monoclonal antibodies directed against outer-membrane proteins or smooth lipopolysaccharide of Brucella
19. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
20. Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: Implications for the augmentation of Th1 responses
21. + T cells: Specificity and function
22. Characterization of allergens prepared from smooth and rough strains of Brucella melitensis
23. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
24. CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
25. CpG DNA: A novel immunomodulator
26. The role of CpG motifs in innate immunity
27. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
28. Humoral immune responses of Brucella-infected cattle, sheep, and goats to eight purified recombinant Brucella proteins in an indirect enzyme-linked immunosorbent assay
29. Humoral immunity in mice mediated by monoclonal antibodies against the A and M antigens of Brucella
30. Immunological response to the Brucella abortus GroEL homolog
31. Protection against Brucella abortus in mice with O-polysaccharide-specific monoclonal antibodies
32. Enzyme-linked immunosorbent assay for differentiation of the antibody response of cattle naturally infected with Brucella abortus or vaccinated with strain 19
33. Role of cytokines in determining T-lymphocyte function
34. + T cells from Brucella -vaccinated mice and delayed-type hypersensitivity in sensitized guinea pigs
35. 10 T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I- and class II-deficient mice
36. Immunization of mice with recombinant L7/L12 ribosomal protein confers protection against Brucella abortus infection
37. + T cells
38. Vaccination with live Escherichia coli expressing Brucella abortus Cu/Zn superoxide dismutase protects mice against virulent B. abortus
39. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
40. Identification of an immunoreactive Brucella abortus HtrA stress response protein homolog
41. Vaccines against intracellular infections requiring cellular immunity
42. Pathogenesis of Brucella
43. Inhibition of growth by erythritol catabolism in Brucella abortus
44. T lymphocyte mediated protection against facultative intracellular bacteria
45. Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major
46. Immune and pathologic responses in mice infected with Brucella abortus 19, RB51, or 2308
47. Modulation of immune responses in BALB/c mice vaccinated with Brucella abortus Cu-Zn superoxide dismutase synthetic peptide vaccine
48. Molecular cloning, nucleotide sequence, and occurrence of a 16.5-kilodalton outer membrane protein of Brucella abortus with similarity to PAL lipoproteins
49. Selective humoral immune response of BALB/c mice to Brucella abortus proteins expressed by vaccinia virus recombinants
50. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma)
51. Structure and function of human and murine receptors for IgG
52. Characterization of specific immune responses of mice inoculated with recombinant vaccinia virus expressing an 18-kilodalton outer membrane protein of Brucella abortus
53. Cloning and sequencing of yajC and secD homologs of Brucella abortus and demonstration of immune responses to YajC in mice vaccinated with B. abortus RB51
54. Overexpression of protective antigen as a novel approach to enhance vaccine efficacy of Brucella abortus strain RB51
55. Protection and suppression of the humoral immune response in mice mediated by a monoclonal antibody against the M epitope of Brucella
56. Endogenous gamma interferon mediates resistance to Brucella abortus infection
57. Endogenous interleukin-12 is involved in resistance to Brucella abortus infection
58. Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms
59. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis