Neuroprotective effect of topically applied brimonidine tartrate 0.2% in endothelin-1-induced optic nerve ischaemia model

Clinical and Experimental Ophthalmology

Volumn 35, Issue 6, 2007, Pages 527-534

  Aktaş, Zeynep ^a,b   Gürelik, Gökhan ^a   Akyürek, Nalan ^a   Önol, Merih ^a   Hasanreisoglu, Berati ^a  

^a GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

^b Mustafa Kemal Mah 54/17   (Turkey)

Author keywords

Brimonidine tartrate 0.2 ; Endothelin 1; Neuroprotection; Optic nerve ischaemia

Indexed keywords

BRIMONIDINE; ENDOTHELIN 1; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL SPECIFICITY; CELL SURVIVAL; CONTROLLED STUDY; HISTOPATHOLOGY; ISCHEMIC OPTIC NEUROPATHY; NEUROPROTECTION; NONHUMAN; OSMOTIC MINIPUMP; RABBIT; RETINA BIPOLAR GANGLION CELL; RETINA GANGLION CELL;

ADMINISTRATION, TOPICAL; ADRENERGIC ALPHA-AGONISTS; ANIMALS; APOPTOSIS; CELL COUNT; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; INFUSION PUMPS, IMPLANTABLE; NEUROPROTECTIVE AGENTS; OPTIC NEUROPATHY, ISCHEMIC; QUINOXALINES; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-2; RETINA; RETINAL GANGLION CELLS;

EID: 34548303845     PISSN: 14426404     EISSN: 14429071     Source Type: Journal    
DOI: 10.1111/j.1442-9071.2007.01533.x     Document Type: Article

References (35)

1. Sommer A. Intraocular pressure and glaucoma. Am J Ophthalmol 1989; 107: 186-8.
2. Flammer J, Orgül S, Costa VP et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 2002; 21: 359-93.
3. Nicolela MT, Drance SM, Rankin SJ, Buckley AR, Walman BE. Color Doppler imaging in patients with asymmetric glaucoma and unilateral visual field loss. Am J Ophthalmol 1996; 121: 502-10.
4. Haefliger IO, Meyer P, Flammer J, Lüscher TF. The vascular endothelium as a regulator of the ocular circulation: A new concept in ophthalmology. Surv Ophthalmol 1994; 39: 123-32.
5. La M, Reid JJ. Endothelin-1 and the regulation of vascular tone. Clin Exp Pharmacol Physiol 1995; 22: 315-23.
6. Reel B, Ozkal S, Islekel H et al. The role of endothelin receptor antagonism in collar-induced intimal thickening and vascular reactivity changes in rabbits. J Pharm Pharmacol 2005; 57: 1599-608.
7. Kaur S, Frishman WH, Singh I, Tamirisa P, Kumar A. Endothelin as a therapeutic target in the treatment of cardiovascular disease. Review. Heart Dis 2001; 3: 176-88.
8. Yorio T, Krishnamoorthy R, Prasanna G. Endothelin: Is it a contributor to glaucoma pathophysiology? J Glaucoma 2002; 11: 259-70.
9. Cellini M, Posatti GL, Profazio V, Sbrocca M, Caramazza N, Caramazza R. Color Doppler imaging and plasma levels of endothelin-1 in low tension glaucoma. Acta Ophthalmol Scand Suppl 1997; 224: 11-3.
10. Sugiyama T, Moriya S, Oku H, Azuma I. Association of endothelin-1 with normal tension glaucoma: Clinical and fundamental studies. Surv Ophthalmol 1995; 39: S49-56.
11. Oku H, Sugiyma T, Kojima S, Watanabe T, Azuma I. Experimental optic cup enlargement caused by endothelin-1 induced chronic optic nerve head ischemia. Surv Ophthalmol 1999; 44: 74-84.
12. Orgul S, Cioffi GA, Wilson DJ, Bacon DR, Van Buskirk EM. An endothelin-1 induced model of optic nerve ischemia in the rabbit. Invest Ophthalmol Vis Sci 1996; 37: 1860-9,.
13. Vidal-Sanz M, Lafuente MP, Sobrado-Calvo P. Death and neuroprotection of retinal ganglion cells after different types of injury. Neurotox Res 2000; 2: 215-27.
14. Yoles E, Wheeler L, Schwartz M. Alpha-2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration. Invest Ophthalmol Vis Sci 1999; 40: 65-73.
15. Woldemussie E, Ruiz G, Wijono M, Wheeler LA. Neuroprotection of retinal ganglion cells by brimonidine in rats with laser induced chronic ocular hypertension. Invest Ophthalmol Vis Sci 2001; 42: 2849-55.
16. Vidal-Sanz M, Lafuente MP, Mayor S, Miralles de Imperial J, Villegas-Perez MP. Retinal ganglion cell death induced by retinal ischemia: Neuroprotective effects of two alpha-2 agonists. Surv Ophthalmol 2001; 45: 261-7.
17. Wen R, Cheng T, Li Y, Cao W, Steinberg R. Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage. J Neurosci 1996; 16: 5986-92.
18. Cioffi GA, Van Buskirk EM. Microvasculature of the anterior optic nerve. Surv Ophthalmol 1994; 38: S107-S117.
19. Cioffi GA, Orgul S, Onda E, Bacon DR, Van Buskirk EM. An in vivo model of chronic optic nerve ischemia: The dose-dependent effects of endothelin-1 on the optic nerve microvasculature. Curr Eye Res 1995; 14: 1147-53.
20. Pang IH, Yorio T. Ocular actions of endothelins. Proc Soc Exp Biol Med 1997; 215: 21-34.
21. Yorio T, Krishnamoorthy R, Prasanna G. Endothelin: Is it a contributor glaucoma pathophysiology? J Glaucoma 2002; 11: 259-70.
22. Oz O, Gurelik G, Akyurek N, Cinel L, Hondur A. Short duration transient ischemia induces apoptosis in retinal layers: An experimental study in rabbits. Eur J Ophthalmol 2005; 15: 233-8.
23. Kim TW, Kim DM, Park KH, Kim H. Neuroprotective effect of memantine in a rabbit model of optic nerve ischemia. Korean J Ophthalmol 2002; 16: 1-7.
24. Goto W, Oku H, Okuno T, Sugiyama T, Ikeda T. Amelioration of endothelin-1-induced optic nerve head ischemia by topical bunazosin. Curr Eye Res 2005; 30: 81-91.
25. Prasanna G, Krishnamoorthy R, Clark AF, Wordinger RJ, Yorio T. Human optic nerve head astrocytes as a target for endothelin-1. Invest Ophthalmol Vis Sci 2002; 43: 2704-13.
26. Stokely ME, Brady ST, Yorio T. Effects of ET-1 on components of anterograde axonal transport in optic nerve. Invest Ophthalmol Vis Sci 2002; 43: 3223-30.
27. Osborne NN, Cazevieielle C, Pergande G, Wood JPM. Induction of apoptosis in cultured human retina pigment epithelial cells is counteracted by flupirtine. Invest Ophthalmol Vis Sci 1997; 38: 1390-400.
28. Lam TT, Fu J, Hrynewycz M, Tso MO. The effect of aurintricarboxylicacid, an endonuclease inhibitor, on ischemia/reperfusion damage in rat retina. J Ocul Pharmacol Ther 1995; 11: 253-9.
29. Achheampong AA, Shackleton M, Tang-Liu DD. Comperative ocular pharmacokinetics of brimonidine after a single dose application to the eyes of albino and pigmented rabbits. Drug Metab Dispos 1995; 23: 708-12.
30. Wheeler LA, Gil DW, WoldeMussie E. Role of alpha-2 adrenergic receptors in neuroprotection and glaucoma. Surv Ophthalmol 2001; 45: 290-4.
31. Acheampong AA, Shackleton M, John B, Burke J, Wheeler L, Tang-Liu D. Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes. Drug Metab Dispos 2002; 30: 421-9.
32. 2-agonist pathway is neuroprotective in models of retinal and optic nerve injury. Eur J Ophthalmol 1999; 9: S27-37.
33. Stadelmann C, Lassmann H. Detection of apoptosis in tissue sections. Cell Tissue Res 2000; 301: 19-31.
34. Mangili F, Cigala C, Santambrogio G. Staining apoptosis in paraffin sections. Advantages and limits. Anal Quant Cytol Histol 1999; 21: 273-6.
35. Mayordomo R, Valenciano AI, de la Rosa EJ, Hallbook F. Generation of retinal ganglion cells is modulated by caspase-dependent programmed cell death. Eur J Neurosci 2003; 18: 1744-50.