A short duration transient ischemia induces apoptosis in retinal layers: An experimental study in rabbits

European Journal of Ophthalmology

Volumn 15, Issue 2, 2005, Pages 233-238

  Öz, Özay ^a   Gurelik G ^a   Akyurek N ^b   Cinel, L ^a   Hondur, A ^a  

^a MERSIN UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

Author keywords

Arterial occlusion; Retinal cell apoptosis; Transient ischemia

Indexed keywords

EOSIN; HEMATOXYLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CILIARY DISK; CONTROLLED STUDY; INTRAOCULAR HEMORRHAGE; INTRAOCULAR PRESSURE; MICROSCOPY; NERVE CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RABBIT; RETINA ARTERY OCCLUSION; RETINA CELL; RETINA INJURY; RETINA ISCHEMIA; VITRECTOMY;

EID: 18744394950     PISSN: 11206721     EISSN: None     Source Type: Journal    
DOI: 10.1177/112067210501500210     Document Type: Article

References (19)

1. Buchi ER, Suivaizdis I, Fu J. Pressure-induced retinal ischemia in rats: an experimental model for quantitative study. Ophthalmologica 1991; 203: 138-47.
2. Buchi ER. Cell death in the rat retina after a pressure-induced ischemia-reperfusion insult: an electron microscopic study: I: Ganglion cell layer and inner nuclear layer. Exp Eye Res 1992; 55: 573-82.
3. Selles-Navarro I, Villegas-Peres MP, Salvador-Silva M, Ruiz-Gomez JM, Vidal-Sanz M. Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals: a quantitative in vivo study. Invest Ophthalmol Vis Sci 1996; 37: 2002-14.
4. Takahashi K, Lam TT, Edward DP, Buchi ER, Tso MOM. Protective effects of flunarizine on ischemic injury in the rat retina. Arch Ophthalmol 1992; 110: 862-70.
5. Vidal-Sanz M, Lafuente MP, Selles-Navarro I, Rodriguez ME, Mayor-Torroglosa S, Villegas-Peres MP. Retinal ischemia. In: Levin L, Di Polo A, eds. Ocular neuroprotection. New York: Marcel Dekker; 2003: 129-52.
6. Hayreh SS, Weingeist TA. Experimental occlusion of the central retinal artery of the retina: IV: retinal tolerance time to acute ischemia. Br J Ophthalmol 1980; 64: 818-25.
7. Szabo ME, Droy-Lefaix MT, Doly M, Carre C, Braquet P. Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical mediated mechanism. Invest Ophthalmol Vis Sci 1991; 32: 1471-8.
8. Hughes WF. Quantitation of ischemic damage in the rat retina. Exp Eye Res 1991; 53: 573-82.
9. Adachi M, Takahashi K, Nishikawa M, Miki H, Vyoma M. High intraocular pressure-induced ischemia and reperfusion injury in the optic nerve and retina in rats. Graefes Arch Clin Exp Ophthalmol 1996; 234: 445-51.
10. Daugeliene L, Niwa M, Hara A, et al. Transient ischemic injury in the rat retina caused by thrombotic occlusion-thrombolytic reperfusion. Invest Ophthalmol Vis Sci 2000; 41: 2743-7.
11. Lafuente MP, Villegas-Peres MP, Sobrado-Calvo P, Garcia-Aviles A, Miralles de Imperial J, Vidal-Sanz M. Neuroprotective effects of alpha-2 selective adrenergic agonists against ischemia-induced retinal ganglion cell death. Invest Ophthalmol Vis Sci 2001; 42: 2074-84.
12. Lafuente MP, Villegas-Perez MP, Selles-Navarro I, Mayor-Toroglosa S, Imperial J, Vidal-Sanz M. Retinal ganglion cell death after acute retinal ischemia is an ongoing process whose severity and duration depends on the duration of the insult. Neuroscience 2002; 109: 157-68.
13. Rosenbaum DM, Rosenbaum PS, Gupta A, Michaelson MD, Hall DH, Kessler JA. Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. Vision Res 1997; 37: 3445-51.
14. Joo CK, Choi JS, Ko HW, et al. Necrosis and apoptosis after retinal ischemia: involvement of NMDA-mediated excitotoxicity and p53. Invest Ophthalmol Vis Sci 1999; 40: 713-20.
15. Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997; 326: 1-16.
16. Li B, Pang LH, Barnes G, McLaughlin M, Holt W. A new method and device to induce transient retinal ischemia in the rat. Curr Eye Res 2002; 24: 458-64.
17. Rosenbaum DM, Rosenbaum PS, Gupta H, et al. The role of the p53 protein in the selective vulnerability of the inner retina to transient ischemia. Invest Ophthalmol Vis Sci 1998; 39: 2132-9.
18. Attanasio A, Schiffer D. Ultrastructural detection of DNA strand breaks by in situ end-labeling techniques. J Pathol 1995; 176: 27-35.
19. Chapman RS, Chresta CM, Herberg AA, et al. Further characterization of the in situ terminal deoxynucleotidyl transferase (TdT) assay for the flow cytometric analysis of apoptosis in drug resistant and drug sensitive leukemia cells. Cytometry 1995; 20: 245-56.