The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcγRIIa) mediated signaling

Molecular Immunology

Volumn 45, Issue 1, 2008, Pages 253-258

  Alvarez, Yelina ^a   Tang, Xiaobin ^a   Coligan, John E ^a   Borrego, Francisco ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

CD300a; Inflammation; Inhibitory receptor; ITAM; ITIM; Neutrophils; Reactive oxygen species

Indexed keywords

CD32 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INHIBITOR PROTEIN; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; PROTEIN CD300A; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL STIMULATION; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UPREGULATION;

ANTIGENS, CD; CYCLOHEXIMIDE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INFLAMMATION MEDIATORS; NEUTROPHILS; RECEPTORS, IGG; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 34548293761     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.05.006     Document Type: Article

References (28)

1. Atzeni F., Schena M., Ongari A.M., Carrabba M., Bonara P., Minonzio F., and Capsoni F. Induction of CD69 activation molecule on human neutrophils by GM-CSF, IFN-gamma, and IFN-alpha. Cell Immunol. 220 (2002) 20-29
2. Bachelet I., Munitz A., and Levi-Schaffer F. Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a. J. Allergy Clin. Immunol. 117 (2006) 1314-1320
3. Bachelet I., Munitz A., Moretta A., Moretta L., and Levi-Schaffer F. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. J. Immunol. 175 (2005) 7989-7995
4. Breitman T.R., Selonick S.E., and Collins S.J. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc. Natl. Acad. Sci. U.S.A. 77 (1980) 2936-2940
5. Bustamante C.D., Fledel-Alon A., Williamson S., Nielsen R., Hubisz M.T., Glanowski S., Tanenbaum D.M., White T.J., Sninsky J.J., Hernandez R.D., Civello D., Adams M.D., Cargill M., and Clark A.G. Natural selection on protein-coding genes in the human genome. Nature 437 (2005) 1153-1157
6. Cantoni C., Bottino C., Augugliaro R., Morelli L., Marcenaro E., Castriconi R., Vitale M., Pende D., Sivori S., Millo R., Biassoni R., Moretta L., and Moretta A. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. Eur. J. Immunol. 29 (1999) 3148-3159
7. + transients. J. Biol. Chem. 273 (1998) 8071-8079
8. Fitzgerald K.A., and Chen Z.J. Sorting out toll signals. Cell 125 (2006) 834-836
9. Ghazizadeh S., Bolen J.B., and Fleit H.B. Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells. J. Biol. Chem. 269 (1994) 8878-8884
10. Liu Y., Buhring H.J., Zen K., Burst S.L., Schnell F.J., Williams I.R., and Parkos C.A. Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration. J. Biol. Chem. 277 (2002) 10028-10036
11. Maasho K., Masilamani M., Valas R., Basu S., Coligan J.E., and Borrego F. The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation. Mol. Immunol. 42 (2005) 1521-1530
12. Mingari M.C., Vitale C., Romagnani C., Falco M., and Moretta L. p75/AIRM1 and CD33, two sialoadhesin receptors that regulate the proliferation or the survival of normal and leukemic myeloid cells. Immunol. Rev. 181 (2001) 260-268
13. Munitz A., Bachelet I., Eliashar R., Moretta A., Moretta L., and Levi-Schaffer F. The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils. Blood 107 (2006) 1996-2003
14. Munitz A., Bachelet I., and Levi-Schaffer F. Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a. J. Allergy Clin. Immunol. 118 (2006) 1082-1089
15. Nathan C. Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 6 (2006) 173-182
16. Nielsen R., Bustamante C., Clark A.G., Glanowski S., Sackton T.B., Hubisz M.J., Fledel-Alon A., Tanenbaum D.M., Civello D., White T.J.J.J.S., Adams M.D., and Cargill M. A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol 3 (2005) e170
17. Quesada J.M., Lopez L.G., Buron M.I., Alcain F.J., Borrego F., Velde J.P., Blanco I., Bouillon R., and Navas P. Ascorbate increases the 1.25 dihydroxyvitamin D3-induced monocytic differentiation of HL-60 cells. Calcif. Tissue Int. 59 (1996) 277-282
18. Ravetch J.V., and Bolland S. IgG Fc receptors. Annu. Rev. Immunol. 19 (2001) 275-290
19. Richard M., Thibault N., Veilleux P., Breton R., and Beaulieu A.D. The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents. Biochem. Biophys. Res. Commun. 310 (2003) 767-773
20. Richard M., Veilleux P., Rouleau M., Paquin R., and Beaulieu A.D. The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. J. Leukoc. Biol. 71 (2002) 871-880
21. Selvaraj P., Fifadara N., Nagarajan S., Cimino A., and Wang G. Functional regulation of human neutrophil Fc gamma receptors. Immunol. Res. 29 (2004) 219-230
22. +]i flux in Fc gamma RIIA signaling. J. Immunol. 152 (1994) 3017-3023
23. Skubitz K.M., Campbell K.D., and Skubitz A.P. Synthetic peptides of CD66a stimulate neutrophil adhesion to endothelial cells. J. Immunol. 164 (2000) 4257-4264
24. Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L., Taillon-Miller P., Kwok P.Y., Menter A., and Bowcock A.M. Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility. Hum. Genet. 112 (2003) 34-41
25. Thompson C.B., and Allison J.P. The emerging role of CTLA-4 as an immune attenuator. Immunity 7 (1997) 445-450
26. Tivol E.A., Borriello F., Schweitzer A.N., Lynch W.P., Bluestone J.A., and Sharpe A.H. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3 (1995) 541-547
27. Verbrugge A., de Ruiter T., Geest C., Coffer P.J., and Meyaard L. Differential expression of leukocyte-associated Ig-like receptor-1 during neutrophil differentiation and activation. J. Leukoc. Biol. 79 (2006) 828-836
28. Wu Y., Stabach P., Michaud M., and Madri J.A. Neutrophils lacking platelet-endothelial cell adhesion molecule-1 exhibit loss of directionality and motility in CXCR2-mediated chemotaxis. J. Immunol. 175 (2005) 3484-3491