Synthetic peptides of CD66a stimulate neutrophil adhesion to endothelial cells

Journal of Immunology

Volumn 164, Issue 8, 2000, Pages 4257-4264

  Skubitz, Keith M ^a,b   Campbell, Kenneth D ^b   Skubitz, Amy P N ^b  

^a UNIVERSITY OF MINNESOTA MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIBODY; CARCINOEMBRYONIC ANTIGEN; MONOCLONAL ANTIBODY; SYNTHETIC PEPTIDE;

ANTIGEN EXPRESSION; ARTICLE; DOWN REGULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; NEUTROPHIL; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034655154     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.8.4257     Document Type: Article

References (89)

1. Thompson, J. A., F. Grunert, and W. Zimmerman. 1991. Carcinoembryonic antigen gene family: molecular biology and clinical prespectives. J. Clin. Lab. Anal. 5:344.
2. Shively, J. E., Y. Hinoda, L. J. F. Hefta, M. Neumaier, S. A. Hefta, L. Shively, R. J. Paxton, and A. D. Riggs. 1989. Molecular Cloning of Members of the Carcinoembryonic Antigen Gene Family. Elsevier Science Publishers, Amsterdam.
3. Obrink, B. 1997. CEA adhesion molecules - multifunctional proteins with signal-regulatory properties. Curr. Opin. Cell Biol. 95:616.
4. Skubitz, K. M., T. P. Ducker, and S. A. Goueli. 1992. CD66 monoclonal antibodies recognize a phosphotyrosine-containing protein bearing a carcinoembryonic antigen cross-reacting antigen on the surface of human neutrophils. J. Immunol. 148:852.
5. Mayne, K. M., K. Pulford, M. Jones, K. Micklem, G. Nagel, and E. C. van der Schoot. 1993. Antibody By114 is selective for the 90 kD P1-linked component of tre CD66 antigen: a new reagent for the study of paroxysmal nocturnal haemoglobinuria. Br. J. Haematol. 83:30.
6. Nagel, G., F. Grunert, T. W. Kuijpers, S. M. Watt, J. Thompson, and W. Zimmerman. 1993. Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family. FEBS Lett. 214:27.
7. Daniel, S., G. Nagel, J. P. Johnson, F. M. Lobo, M. Hirn, P. Jantscheff, M. Kuroki, S. von Kleist, and F. Grunert. 1993. Determination of the specificities of monoclonal antibodies recognizing members of the CEA family using a panel of transfectants. Int. J. Cancer 55:303.
8. Watt, S. M., G. Sala-Newby, T. Hoang, D. J. Gilmore, F. Grunert, G. Nagel, S. J. Murdoch, E. Tchilian, E. S. Lennox, and H. Waldmann. 1991. CD66 identifies a neutrophil-specific epitope within the hematopoietic system that is expressed by members of the carcinoembryonic antigen family of adhesion molecules. Blood 78:63.
9. Kuroki, M., Y. Matsuo, T. Kinugasa, and Y. Matsuoka. 1992. Three different NCA species, CGM6/CD67, NCA-95, and NCA-90, and comprised in the major 90 to 100-KDa band of granulocyte NCA detectable upon SDS-polyacrylamide gel electrophoresis. Biochem. Biophys. Res. Commun. 182:501.
10. Skubitz, K. M., K. Micklem, and C. E. van der Schoot. 1995. Summary of CD66 and CD67 Cluster Report. Oxford University Press, Oxford, U.K.
11. Stoffel, A., M. Neumaier, F.-J. Gaida, U. Fenger, Z. Drzeniek, H.-D. Haubeck, and C. Wagener. 1993. Monoclonal, anti-domain and anti-peptide antibodies assign the molecular weight 160,000 granulocyte membrane antigen of the CD66 cluster to a mRNA species encoded by the biliary glycoprotein gene, a member of the carcinoembryonic antigen gene family. J. Immunol. 150:4978.
12. Watt, S. M., J. Fawcett, S. J. Murdoch, A. M. Teixeira, S. E. Gschmeissner, N. M. Hajibagheri, and D. L. Simmons. 1994. CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression and adhesion functions of the BGPc splice variant. Blood 84:200.
13. Skubitz, K. M., F. Grunert, P. Jantscheff, M. Kuroki, and A. P. N. Skubitz. 1997. Summary of the CD66 Cluster Workshop. In Leukocyte Typing VI. T. Kisimoto, H. Kikutaui, A. van der Borne, S. Goyert, D. Mason, M. Miyasaka, L. Moretta, K. Okumura, S. Shaw, T. Springer, et al., eds. Garland Publishing, New York and London, pp. 992-1000.
14. Beauchemin, N., P. Draber, G. Dveksler, P. Gold, S. Gray-Owen, F. Grunert, S. Hammarstrom, K. Holmes, K. Karlsson, M. Kuroki, et al. 2000. Redefined nomenclature or members of the carcinoembryonic antigen family. Exp. Cell Res. 252:243.
15. Khan, W. N., L. Frangsmyr, S. Teglund, A. Israelsson, K. Bremer, and S. Hammarstrom. 1992. Identification of three new genes and estimation of the carcinoembryonic antigen family. Genomics 14:384.
16. Bates, P. A., J. Lou, and M. J. E. Sternberg. 1992. A predicted three-dimensional structure for the carcinoembryonic antigen (CEA). FEBS Lett. 301:207.
17. Oikawa, S., C. Inuzuka, M. Kuroki, Y. Matsuoka, G. Kosaki, and H. Nakazato. 1989. Cell adhesion activity of non-specific cross reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on cho cell surface: hemophilic and heterophilic adhesion. Biochem. Biophys. Res. Commun. 164:39.
18. Benchimol, S., A. Fuks, S. Jothy, N. Beauchemin, K. Shirota, and C. P. Stanners. 1989. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57:327.
19. 2+-dependent intercellular adhesion molecule. Cell Growth Differ. 1:527.
20. Pignatelli, M., H. Durbin, and W. F. Bodmer. 1990. Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell-collagen interactions. Proc. Natl. Acad. Sci. USA 87:1541.
21. Oikawa, S., C. Inuzuka, M. Kuroki, F. Arakawa, Y. Matsuoka, G. Kosaki, and H. Nakazato. 1991. A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. J. Biol. Chem. 266:7995.
22. ++-independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell surface. Biochem. Biophys. Res. Commun. 186:881.
23. Zhou, H., A. Fuks, G. Alcaraz, T. J. Boiling, and C. P. Stanners. 1993. Homophilic adhesion between Ig superfamily carcinoembryonic antigen molecules involves double reciprocal bonds. J. Cell Biol. 122:951.
24. Zhou, H., C. P. Stanners, and A. Fuks. 1993. Specificity of anti-carcinoembryonic antigen monoclonal antibodies and their effects on CEA-mediated adhesion. Cancer Res. 53:3817.
25. Teixeira, A. M., J. Fawcett, D. L. Simmons, and S. M. Watt. 1994. The N-domain of the biliary glycoprotein (BGP) adhesion molecule mediates homotypic binding: domain interactions and epitope analysis of BGPc. Blood 84:211.
26. Kuijpers, T., M. Hoogerwerf, L. van der Laan, G. Nagel, C. E. van der Schoot, F. Grunert, and D. Roos. 1992. CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. J. Cell Biol. 118:457.
27. Kuijpers, T. W., C. E. van der Schoot, M. Hoogerwerf, and D. Roos. 1993. Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation. J. Immunol. 151:4934.
28. Stocks, S. C., M. A. Kerr, C. Haslett, and I. Dransfield. 1995. CD66-dependent neutrophil activation: a possible mechanism for vascular selectin-mediated regulation of neutrophil adhesion. J. Leukocyte Biol. 58:40.
29. Stocks, S. C., and M. A. Kerr. 1992. Stimulation of neutrophil adhesion of antibodies recognizing CD15 (Lex(X)) and CD15-expressing carcinoembryonic antigen-related glycoprotein NCA-160. Biochem. J. 288:23.
30. Lund-Johansen, F., J. Olweus, F. W. Symington, A. Arli, J. S. Thompson, R. Vilella, K. M. Skubitz, and V. Horejsi. 1993. Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens. Eur. J. Immunol. 23:2782.
31. Yamanaka, T., M. Kuroki, Y. Matsuo, and Y. Matsuoka. 1996. Analysis of heterophilic cell adhesion mediated by CD66b and CD66c using their soluble recombinant proteins. Biochem. Biophys. Res. Commun. 219:842.
32. Wikstrom, K., G. Kjellstrom, and B. Obrink. 1996. Homophilic intercellular adhesion mediated by C-CAM is due to a domain 1-domain 1 reciprocal binding. Exp. Cell Res. 227:360.
33. Tetteroo, P. A. T., M. J. E. Bos, F. J. Visser, and A. E. G. Kr. von dem Borne. 1986. Neutrophil activation detected by monoclonal antibodies. J. Immunol. 136: 3427.
34. von Kleist, S., and P. Burtin. 1966. Cancerologie. Mise en evidence dans les tumeurs coliques humaines d'antigenes non presents dans la muqueuse colique de l'adulte normal. Compte Rendus De L Academie Des Sciences 263:1543.
35. Neumaier, M., S. Paululat, A. Chan, P. Matthaes, and C. Wagener. 1993. Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc. Natl. Acad. Sci. USA 90:10744.
36. Riethdorf, L., B. W. Lisboa, U. Henkel, M. Naumann, C. Wagener, and T. Loning. 1997. Differential expression of CD66a (BGP), a cell adhesion molecule of the carcinoembryonic antigen family, in benign, premalignant, and malignant lesions of the human mammary gland. J. Histochem. Cytochem. 45:957.
37. Nollau, P., H. Scheller, M. Kona-Horstmann, S. Rohde, F. Hagenmuller, C. Wagener, and M. Neumaier. 1997. Expression of CD66a (human C-CAM) and other members of the carcinoembryonic antigen gene family of adhesion molecules in human colorectal adenomas. Cancer Res. 57:2354.
38. Nollau, P., F. Prall, U. Helmchen, C. Wagener, and M. Neumaier. 1997. Dysregulation of carcinoembryonic antigen group members CGM2, CD66a (biliary glycoprotein), and nonspecific cross-reacting antigen in colorectal carcinomas. Am. J. Pathol. 151:521.
39. Tanaka, K., Y. Hinoda, H. Takahashi, H. Sakamoto, Y. Nakajima, and K. Imai. 1997. Decreased expression of biliary glycoprotein in hepatocellular carcinomas. Int. J. Cancer 74:15.
40. Kunath, T., C. Ordonez-Garcia, C. Turbide, and N. Beauchemin. 1995. Inhibition of colonic tumor cell growth by biliary glycoprotein. Oncogene 11:2375.
41. Hsieh, J.-R., W. Luo, W. Song, Y. Wang, D. I. Kleinerman, N. T. Van, and S.-H. Lin. 1995. Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches. Cancer Res. 55:190.
42. Kleinerman, D. I., P. Troncosco, S.-H. Lin, L. L. Pisters, E. R. Sherwood, T. Brooks, A. C. von Eschenbach, and J.-T. Hsieh. 1995. Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: Implication as a tumor suppressor. Cancer Res. 55:1215.
43. Luo, W., C. G. Wood, K. Earley, M.-C. Hung, and S.-H. Lin. 1997. Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains. Oncogene 14:1697.
44. Kleinerman, D. I., C. P. N. Dinney, W.-W. Zhang, S.-H. Lin, N. T. Van, and J.-T. Hsieh. 1996. Suppression of human bladder cancer growth by increased expression of C-CAM1 gene in an orthotopic model. Cancer Res. 56:3431.
45. Virji, M., S. M. Watt, S. Barker, K. Makepeace, and R. Doyonnis. 1996. The N-domain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae. Mol. Microbiol. 22:929.
46. Virji, M., K. Makepeace. D. J. P. Ferguson, and S. M. Watt. 1996. Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neissenae. Mol. Microbiol. 22:941.
47. Gray-Owen, S., C. Dehio, A. Haude, F. Grunert, and T. F. Meyer. 1997. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes. EMBO J. 16:3435.
48. Chen, T., and E. C. Gotschlich. 1996. CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins. Proc. Natl. Acad. Sci. USA 93:14851.
49. Bos, M. P., F. Grunert, and R. J. Belland. 1997. Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae. Infect. Immun 65:2353.
50. Bos, M. P., M. Kuroki, A. Krop-Watorek, D. Hogan, and J. Belland. 1998. CD66 receptor specificity exhibited by neisserial Opa variants is controlled by protein determinants in CD66 N-domains. Proc. Natl. Acad. Sci. USA 95:9584.
51. Dveksler, G. S., M. N. Pensiero, C. B. Cardellichio, R. K. Williams, G.-S. Jiang, K. V. Holmes, and C. W. Dieffenbach. 1991. Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV. J. Virol. 65:6881.
52. Pensiero, M. N., G. S. Dveksler, C. B. Cardellichio, G.-S. Jiang, P. E. Elia, C. W. Dieffenbach, and K. V. Holmes. 1992. Binding of the coronavirus mouse hepatitis virus A59 to its receptor expressed from a recombinant vaccinia virus depends on posttranslational processing of the receptor glycoprotein. J. Virol. 66:4028.
53. Williams, R. K., G.-S. Jiang, and K. V. Holmes. 1991. Receptor for mouse hepatitis virus is a member of the carcijojembryonic antigen family of glycoproteins. Proc. Natl. Acad. Sci. USA 88:5533.
54. Holmes, K. V., G. Dveksler, S. Gagneten, C. Yeager, S.-H. Lin, N. Beauchemin, A. T. Look, R. Ashumn, and C. Dieffenbach. 1994, Coronavirus receptor specificity. In Cornaviruses. H. Laude and J. F. Vautherot, eds. Plenum Press, New York, p. 261-266.
55. Yokomori, K., and M. M. C. Lai. 1992. Mouse hepatitis virus utilizes two carcinoembryonic antigens as alternative receptors. J. Virol. 66:6194.
56. Prall, F., P. Nollau, M. Neumaier, H.-D. Haubeck, Z. Drzeniek, U. Helmchen, T. Loning, and C. Wagener. 1996. CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues. J. Histochem. Cytochem. 44:31.
57. Sippel, C. J., R. J. Fallon, and D. Perlmutter. 1994. Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation. J. Biol. Chem. 269:19539.
58. Sippel, C. J., T. Shen, and D. H. Perlmutter. 1996. Site-directed mutagenesis within an ectoplasmic ATPase consensus sequence abrogates the cell aggregating properties of the rat liver canalicular bile acid transporter/ecto-ATPase/cell CAM 105 and carcinoembryonic antigen. J. Biol. Chem 271:33095.
59. Skubitz, K. M., K. D. Campbell, K. Ahmed, and A. P. N. Skubitz. 1995. CD66 family members are associated with tyrosine kinase activity in human neutrophils. J. Immunol. 155:5382.
60. Afar, D. E., C. P. Stanners, and J. C. Bell. 1992. Tyrosine phosphorylation of biliary glycoprotein, a cell adhesion molecule related to carcinoembryonic antigen. Biochim. Biophys. Acta 1134:46.
61. Skubitz, K. M., T. P. Ducker, A. P. N. Skubitz, and S. A. Goueli. 1993. Antiserum to carcinoembryonic antigen recognizes a phosphotyrosine-containing protein in human colon cancer cell lines. FEBS Lett. 318:200.
62. c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas. Oncogene 11:1649.
63. Beauchemin, N., T. Kunath, J. Robitaille, B. Chow, C. Turbide, E. Daniels, and A. Veillette. 1997. Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malingnant colon epithelial cells. Oncogene 14:783.
64. Skubitz, K. M., and R. W. Snook. II. 1987 Monoclonal antibodies that recognize lacto-N-fucopenatose 111 (CD15) react with adhesion-promoting glycoprotein family (LFA-1/HMAC-1/GP 150, 95) and CR1 on human neutrophils. J. Immunol. 139:1631.
65. Vaporciyan, A. A., M. L. Jones, and P. A. Ward. 1993. Rapid analysis of leukocyte-endothelial adhesion. J. Immunol. Methods 159:93.
66. Skubitz, K. M., K. D. Campbell, and A. P. N. Skubitz. 1996. CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. J. Leukocyte Biol. 60:106.
67. Skubitz, K. M., K. D. Cambell, J. Iida, and A. P. N. Skubitz. 1996. CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils. J. Immunol. 157:3617.
68. Skubitz, K. M., K. D. Campbell, and A. P. N. Skubitz. 1997. CD50 monoclonal antibodies inhibit neutrophil activation. J. Immunol. 159:820.
69. Wertheimer, A. J., C. L. Myers, R. W. Wallace, and T. P. Parks. 1992. Intercellular adhesion molecule-1 gene expression in human endothelial cells. J. Biol. Chem. 267:12030.
70. Carlos, T. M., and J. M. Haran. 1994. Leukocyte-endothelial adhesion molecules. Blood 84:2068.
71. Wright, S. D., and B. C. Meyer. 1986. Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes. J. Immunol. 136:1759.
72. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
73. Boehm, M. K., M. O. Mayans, J. D. Thornton, R. H. J. Begent, P. A. Keep, and S. J. Perkens. 1996. Extended glycoprotein structure of the seven domains in human carcinoembryonic antigen by X-ray and neutron solution scattering and an automated curve fitting procedure: implications for cellular adhesion. J. Mol. Biol. 259:718.
74. Stocks, S. C., M.-H. Ruchaud-Sparagano, M. A. Kerr, F. Grunert, C. Haslett, and I. Dransfield. 1996. CD66: role in the regulation of neutrophil effector function. Eur. J. Immunol. 26:2924.
75. Jantscheff, P., G. Nagel, J. Thompson, S. V. Kleist, M. J. Embleton, M. R. Price, and F. Grunert. 1996. A CD66a-specific, activation-dependent epitope detected by recombinant human signal chain fragments (scFvs) on CHO transfectants and activated granulocytes. J. Leukocyte Biol. 59:891.
76. Hunter, I., H. Sawa, M. Edlund, and B. Obrink. 1996. Evidence for regulated dimerization of cell-cell adhesion molecule (C-CAM) in epithelial cells. Biochem. J. 320:847.
77. Lisowska, E., A. Krop-Watorek, and P. Sedlaczek. 1983. The dimeric structure of carcinoembryonic antigen (CEA). Biochem. Biophys. Res. Commun. 115:206.
78. Blechman, J. M., S. Lev, J. Barg, M. Eisenstein, B. Vaks, Z. Vogel, D. Givol, and Y. Yarden. 1995. The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction. Cell 80:103.
79. Yarden, Y., and J. Schlessinger. 1987. Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. Biochemistry 26:1443.
80. Bishayee, S., S. Majumdar, J. Khire, and M. Das. 1989. Ligand-induced dimerization of the plalelet-derived growth factor receptor. J. Biol. Chem. 264:11699.
81. Cochet, C., O. Kashles, E. M. Chambaz, I. Borrello, C. R. King, and J. Schlessinger. 1988. Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking antigen. J. Biol. Chem. 263:3290.
82. Edlund, M., I. Blikstad, and B. Obrink. 1996. Calmodulin binds to specific sequences in the cytoplasmic domain of C-CAM and down-regulates C-CAM self-association. J. Biol. Chem. 271:1393.
83. Zachary, C. B., D. Kist, and K. M. Skubitz. 1995. Reactivity of the CD66 Panel of Antibodies with Regenerating Epidermis Near Basal Cell Carcinoma. Oxford University Press, Oxford, U.K.
84. Metze, D., R. Bhardwaj, G. Kolde, S. Daniel, and F. Grunert. 1992. Distribution and ultrastructural localization of the carcinoembryonic antigen (CEA) family in normal skin and cutaneous tumors. J. Invest. Dermatol. 98:543.
85. Leusch, H. G., Z. Drezeniek, Z. Markos-Pusztai, and C. Wagener. 1991. Binding of Escherichia coli and Salmonella strains to members of the carcinoembryonic antigen family: differential binding inhibition by aromatic a-glycosides of mannose. Infect. Immun. 59:2051.
86. Sauter, S. L., S. M. Rutherfurd, C. Wagener, J. E. Shively, and S. A. Hefta. 1991. Binding of nonspecific cross-reacting antigen, a granulocyte membrane glycoprotein, to Escherichia coli expressing type 1 finbriae. Infect. Immun. 59:2485.
87. Moller, M. J., R. Kammerer, F. Grunert, and S. von Kleist. 1996. Biliary glycoprotein (BGP) expression on T cells and on a natural-killer-cell sub-population. Int. J. Cancer 65:740.
88. Kammerer, R., and S. von Kleist. 1994. CEA expression of colorectal adenocarcinomas is correlated with their resistance against LAK-cell lysis. Int. J. Cancer 57:341.
89. Prado, I. B., A. A. Laudanna, and C. R. W. Carneiro. 1995. Susceptibility of colorectal carcinoma cells to natural-killer-mediated lysis: relationship to CEA expression and degree of differentiation. Int. J. Cancer 61:854.