Evaluation of the safety and relative bioavailability of a new dihydroartemisinin tablet formulation in healthy Thai volunteers

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 101, Issue 10, 2007, Pages 972-979

  Kongpatanakul, Supornchai ^a   Chatsiricharoenkul, Somruedee ^a   Sathirakul, Korbtham ^b   Suputtamongkol, Yupin ^a   Atipas, Suvajana ^a   Watnasirichaikul, Suchat ^c   Pongnarin, Piyapat ^a   Sangvanich, Polkit ^d  

^a MAHIDOL UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c Thailand Government Pharmaceutical Organization   (Thailand)

^d Faculty of Science   (Thailand)

Author keywords

Bioavailability; Dihydroartemisinin; Drug formulation; Drug toxicity; Malaria; Pharmacokinetics

Indexed keywords

DIHYDROARTEMISININ;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ANEMIA; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG SOLUBILITY; DRUG TOLERABILITY; DRUG USE; EOSINOPHIL COUNT; FEMALE; FEVER; HEARING LOSS; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALARIA; MALE; NORMAL HUMAN; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; TABLET FORMULATION; TANDEM MASS SPECTROMETRY; THAILAND; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; UREA NITROGEN BLOOD LEVEL; VESTIBULAR FUNCTION; VOLUNTEER;

ADMINISTRATION, ORAL; ADULT; ANTIMALARIALS; ARTEMISININS; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; FEMALE; HUMANS; MALE; SESQUITERPENES; TABLETS; THAILAND; TREATMENT OUTCOME;

EID: 34548289920     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2007.05.010     Document Type: Article

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