Elucidation of substrate specificity in the cobalamin (vitamin B 12) biosynthetic methyltransferases: Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicus

Journal of Biological Chemistry

Volumn 282, Issue 33, 2007, Pages 23957-23969

  Frank, Stefanie ^a   Deery, Evelyne ^a   Brindley, Amanda A ^a   Leech, Helen K ^a   Lawrence, Andrew ^a   Heathcote, Peter ^b   Schubert, Heidi L ^c   Brocklehurst, Keith ^b   Rigby, Steve E J ^b   Warren, Martin J ^a   Pickersgill, Richard W ^b  

^a UNIVERSITY OF KENT   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; METHYLATION; OXIDATION; PARAMAGNETIC RESONANCE; PROTEINS; REACTION KINETICS;

BIOSYNTHETIC METHYLTRANSFERASES; COBALAMIN;

VITAMINS;

CYANOCOBALAMIN; METAL ION; METHYLTRANSFERASE; TETRAPYRROLE DERIVATIVE;

ARTICLE; BACTERIAL STRAIN; BIOSYNTHESIS; CALORIMETRY; CATALYSIS; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGAND BINDING; MASS SPECTROMETRY; METHYLATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TITRIMETRY; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ELECTRON SPIN RESONANCE SPECTROSCOPY; LIGANDS; METHANOBACTERIACEAE; METHYLATION; METHYLTRANSFERASES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; VITAMIN B 12;

METHANOTHERMOBACTER THERMAUTOTROPHICUS;

EID: 34548276563     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703827200     Document Type: Article

References (34)

1. Blanche, F., Cameron, B., Crouzet, J., Debussche, L., Thibaut, D., Vuilhorgne, M., Leeper, F. J., and Battersby, A. R. (1995) Angew. Chem. Int. Ed. Engl. 34, 383-411
2. Roessner, C. A., and Scott, A. I. (2006) J. Bacteriol. 188, 7331-7334
3. Roth, J. R., Lawrence, J. G., and Bobik, T. A. (1996) Annu. Rev. Microbiol. 50, 137-181
4. Warren, M. J., Raux, E., Schubert, H. L., and Escalante-Semerena, J. C. (2002) Nat. Prod. Rep. 19, 390-412
5. Blanche, F., Thibaut, D., Debussche, L., Hertle, R., Zipfel, F., and Müller, G. (1993) Angew. Chem. Int. Ed. Engl. 32, 1651-1653
6. Roth, J. R., Lawrence, J. G., Rubenfield, M., Kieffer-Higgins, S., and Church, G. M. (1993) J. Bacteriol. 175, 3303-3316
7. Raux, E., Schubert, H. L., Roper, J. M., Wilson, S. W., and Warren, M. J. (1999) Bioorganic Chem. 27, 100-118
8. Eschenmoser, A. (1988) Angew. Chem. Int. Ed. Engl. 27, 5-39
9. Roessner, C. A., Spencer, J. B., Ozaki, S., Min, C., Atshaves, B. P., Nayar, P., Anousis, N., Stolowich, N. J., Holderman, M. T., and Scott, A. I. (1995) Protein Expression Purif. 6, 155-163
10. Spencer, P., Stolowich, N. J., Sumner, L. W., and Scott, A. I. (1998) Biochemistry 37, 14917-14927
11. Santander, P. J., Kajiwara, Y., Williams, H. J., and Scott, A. I. (2006) Bioorg. Med. Chem. 14, 724-731
12. Wada, K., Harada, J., Yaeda, Y., Tamiaki, H., Oh-Oka, H., and Fukuyama, K. (2007) FEBS J. 274, 563-573
13. Raux, E., Leech, H. K., Beck, R., Schubert, H. L., Santander, P. J., Roessner, C. A., Scott, A. I., Martens, J. H., Jahn, D., Thermes, C., Rambach, A., and Warren, M. J. (2003) Biochem. J. 370, 505-516
14. Raux, E., Lanois, A., Levillayer, F., Warren, M. J., Brody, E., Rambach, A., and Thermes, C. (1996) J. Bacteriol. 178, 753-767
15. Leslie, A. G. W. (1992) Joint CCP4 + ESF-EAMCB Newsletter Protein Crystallogr. 26
16. Collaborative Computational Project, N. (1994) Acta Crystallogr. Sect. D 50, 760-763
17. Vagin, A., and Teplyakov, A. (1997) J. Appl. Crystallogr. 30, 1022-1025
18. Otwinowski, Z. (1991) in Isomorphous Replacement and Anomalous Scattering (Wolf, W., and Leslie, A.G.W. eds) pp. 80-86, Daresbury, CCP4 Study Weekend Proceedings, SERC, Daresbury Laboratory, Warrington, U.K.
19. Cowtan, K. D., and Zhang, K. Y. (1999) Prog. Biophys. Mol. Biol. 72, 245-270
20. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect. D Biol. Crystallogr. 53, 240-255
21. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
22. Laskowski, R. A., Macarthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
23. Wiseman, T., Williston, S., Brandts, J. F., and Lin, L. N. (1989) Anal. Biochem. 179, 131-137
24. Smith, D. R., Doucette-Stamm, L. A., Deloughery, C., Lee, H., Dubois, J., Aldredge, T., Bashirzadeh, R., Blakely, D., Cook, R., Gilbert, K., Harrison, D., Hoang, L., Keagle, P., Lumm, W., Pothier, B., Qiu, D., Spadafora, R., Vicaire, R., Wang, Y., Wierzbowski, J., Gibson, R., Jiwani, N., Caruso, A., Bush, D., Reeve, J. N., et al. (1997) J. Bacteriol. 179, 7135-7155
25. Scott, A. I. (1994) Heterocycles 39, 471-476
26. Schubert, H. L., Wilson, K. S., Raux, E., Woodcock, S. C., and Warren, M. J. (1998) Nat. Struct. Biol. 5, 585-592
27. Schubert, H. L., Blumenthal, R. M., and Cheng, X. (2003) Trends Biochem. Sci. 28, 329-335
28. Stroupe, M. E., Leech, H. K., Daniels, D. S., Warren, M. J., and Getzoff, E. D. (2003) Nat. Struct. Biol. 10, 1064-1073
29. Vevodova, J., Graham, R. M., Raux, E., Schubert, H. L., Roper, D. I., Brindley, A. A., Ian Scott, A., Roessner, C. A., Stamford, N. P., Elizabeth Stroupe, M., Getzoff, E. D., Warren, M. J., and Wilson, K. S. (2004) J. Mol. Biol. 344, 419-433
30. Bayston, J. H., Looney, F. D., Pilbrow, J. R., and Winfield, M. E. (1970) Biochemistry 9, 2164-2172
31. Kajiwara, Y., Santander, P. J., Roessner, C. A., Perez, L. M., and Scott, A. I. (2006) J. Am. Chem. Soc. 128, 9971-9978
32. Santander, P. J., Roessner, C. A., Stolowich, N. J., Holderman, M. T., and Scott, A. I. (1997) Chem. Biol. 4, 659-666
33. Brindley, A. A., Raux, E., Leech, H. K., Schubert, H. L., and Warren, M. J. (2003) J. Biol. Chem. 278, 22388-22395
34. Raux, E., McVeigh, T., Peters, S. E., Leustek, T., and Warren, M. J. (1999) Biochem. J. 338, 701-708