Bin1 interacts with and restrains the DNA end-binding protein complex Ku

Cell Cycle

Volumn 6, Issue 15, 2007, Pages 1914-1918

  Ramalingam, Arivudainambi ^a   Farmer, George E ^b,d   Stamato, Thomas D ^a,c   Prendergast, George C ^a,c  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b DuPont Pharmaceuticals Company   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d Wachovia Securities   (United States)

Author keywords

Amphiphysin II; Cancer; DNA damage response; DNA repair; hob1; NHEJ; pku70; pku80; Rad6; Rvs167; Telomere maintenance

Indexed keywords

KU ANTIGEN; PHLEOMYCIN; PROTEIN BIN1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; HUMAN; HUMAN CELL; MOUSE; MUTATION; NONHUMAN; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TELOMERE;

MURINAE; SCHIZOSACCHAROMYCETACEAE;

EID: 34548270102     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.15.4514     Document Type: Article

References (37)

1. Ren G, Vajjhala P, Lee JS, Winsor B, Munn AL. The BAR domain proteins: Molding membranes in fission, fusion, and phagy. Microbiol Mol Biol Rev 2006; 70:37-120.
2. Sakamuro D, Elliott K, Wechsler-Reya R, Prendergast GC. BIN1 is a novel MYC-interacting protein with features of a tumor suppressor. Nature Genet 1996; 14:69-77.
3. Elliott K, Sakamuro D, Basu A, Du W, Wunner W, Staller P, Gaubatz S, Zhang H, Prochownik E, Eilers M, Prendergast GC. Bin1 functionally interacts with Myc in cells and inhibits cell proliferation by multiple mechanisms. Oncogene 1999; 18:3564-73.
4. Elliott K, Ge K, Du W, Prendergast GC. The c-Myc-interacting adapter protein Bin1 activates a caspase-independent cell death program. Oncogene 2000; 19:4669-84.
5. Ge K, DuHadaway J, Sakamuro D, Wechsler-Reya R, Reynolds C, Prendergast GC. Losses of the tumor suppressor Bin1 in breast carcinoma are frequent and reflect deficits in a programmed cell death capacity. Int J Cancer 2000; 85:376-83.
6. Ge K, Minhas F, DuHadaway J, Mao NC, Wilson D, Sakamuro D, Buccafusca R, Nelson P, Malkowicz SB, Tomaszewski JT, Prendergast GC. Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma. Int J Cancer 2000; 86:155-61.
7. Ge K, DuHadaway J, Du W, Herlyn M, Rodeck U, Prendergast GC. Mechanism for elimination of a tumor suppressor: Aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma. Proc Natl Acad Sci USA 1999; 96:9689-94.
8. Chang M, Boulden J, Sutanto-Ward E, Duhadaway JB, Soler AP, Muller AJ, Prendergast GC. Bin1 mosaic null mice exhibit increased reproductive fecundity and cancer incidence during aging. Cancer Res 2007; In press.
9. Chang M, Boulden J, Sutanto-Ward E, Duhadaway JB, Soler AP, Muller AJ, Prendergast GC. Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression. Cancer Res 2007; 67:100-7.
10. Ghaneie A, Zemba-Palko V, Itoh H, Itoh K, Sakamuro D, Nakamura S, Soler AP, Prendergast GC. Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival. Cancer Biol Ther 2007; 6.
11. Muller AJ, DuHadaway JB, Sutanto-Ward E, Donover PS, Prendergast GC. Inhibition of indoleamine 2,3-dioxygenase, an immunomodulatory target of the tumor suppressor gene Bin1, potentiates cancer chemotherapy. Nature Med 2005; 11:312-9.
12. Routhier EL, Donover PS, Prendergast GC. hob1+, the homolog of Bin1 in fission yeast, is dispensable for endocytosis but required for the response to starvation or genotoxic stress. Oncogene 2003; 22:637-48.
13. Bahler J, Wu, Jq, Longtime MS, Shah NG, McKenzie A, Steever AB, Wach A, Philippsen P, Pringle JR. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 1998; 14:943-51.
14. Moreno S, Klar A, Nurse P. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol 1991; 194:795-823.
15. +. Genetics 1999; 152:1501-12.
16. Wechsler-Reya R, Elliott K, Prendergast GC. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Mol Cell Biol 1998; 18:566-75.
17. Grelle G, Kostka S, Otto A, Kersten B, Genser KF, Muller EC, Walter S, Boddrich A, Stelzl U, Hanig C, Volkmer-Engert R, Landgraf C, Alberti S, Hohfeld J, Strodicke M, Wanker EE. Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics 2006; 5:234-44.
18. Ramalingam A, Prendergast GC. Bin1 homolog Hob1 supports a Rad6-Set1 pathway of transcriptional repression in fission yeast. Cell Cycle 2007; 6:1655-62.
19. Baumann P, Cech TR. Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell 2000; 11:3265-75.
20. Miyoshi T, Sadaie M, Kanoh J, Ishikawa F. Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast. J Biol Chem 2003; 278:1924-31.
21. Mishra K, Shore D. Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins. Curr Biol 1999; 9:1123-6.
22. Sun ZW, Allis CD. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 2002; 418:104-8.
23. Kanoh J, Francesconi S, Collura A, Schramke V, Ishikawa F, Baldacci G, Geli V. The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway. J Mol Biol 2003; 326:1081-94.
24. Roguev A, Schaft D, Shevchenko A, Aasland R, Stewart AF. High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts. J Biol Chem 2003; 278:8487-93.
25. Shahbazian MD, Zhang K, Grunstein M. Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1. Mol Cell 2005; 19:271-7.
26. Gullo C, Au M, Feng G, Teoh G. The biology of Ku and its potential oncogenic role in cancer. Biochim Biophys Acta 2006; 1765:223-34.
27. Sawada M, Sun W, Hayes P, Leskov K, Boothman DA, Matsuyama S. Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nat Cell Biol 2003; 5:320-9.
28. Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell 2004; 13:627-38.
29. Park SJ, Ciccone SL, Freie B, Kurimasa A, Chen DJ, Li GC, Clapp DW, Lee SH. A positive role for the Ku complex in DNA replication following strand break damage in mammals. J Biol Chem 2004; 279:6046-55.
30. Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 2002; 419:135-41.
31. Haracska L, Unk I, Prakash L, Prakash S. Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis. Proc Natl Acad Sci USA 2006; 103:6477-82.
32. Sleigh MJ, Grigg GW. The mechanism of sensitivity to phleomycin in growing Escherichia coli cells. Biochem J 1976; 155:87-99.
33. Cabal GG, Genovesio A, Rodriguez-Navarro S, Zimmer C, Gadal O, Lesne A, Buc H, Feuerbach-Fournier F, Olivo-Marin JC, Hurt EC, Nehrbass U. SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope. Nature 2006; 441:770-3.
34. Taddei A, Van Houwe G, Hediger F, Kalck V, Cubizolles F, Schober H, Gasser SM. Nuclear pore association confers optimal expression levels for an inducible yeast gene. Nature 2006; 441:774-8.
35. Therizols P, Fairhead C, Cabal GG, Genovesio A, Olivo-Marin JC, Dujon B, Fabre E. Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J Cell Biol 2006; 172:189-99.
36. Mauldin SK, Getts RC, Liu W, Stamato TD. DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: Evidence for assembly of a repair complex. Nucleic Acids Res 2002; 30:4075-87.
37. Yu E, Song K, Moon H, Maul GG, Lee I. Characteristic immunolocalization of Ku protein nuclear matrix. Hybridoma 1998; 17:413-20.