HLA-DRB1 alleles control allergic bronchopulmonary aspergillosis-like pulmonary responses in humanized transgenic mice

Journal of Allergy and Clinical Immunology

Volumn 120, Issue 3, 2007, Pages 570-577

  Koehm, Sherri ^a   Slavin, Raymond G ^a   Hutcheson, Patricia S ^a   Trejo, Theodore ^b   David, Chella S ^b   Bellone, Clifford J ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Allergic bronchopulmonary aspergillosis; Aspergillus fumigatus; asthma; cystic fibrosis; eosinophilia; HLA DR; MHC; pulmonary immunity; TH2; transgenic

Indexed keywords

FUNGUS ANTIGEN; HLA DR ANTIGEN; HLA DR2 ANTIGEN; MUCIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLUS; ASTHMA; BRONCHOPULMONARY ASPERGILLOMA; CELL INFILTRATION; CELL PROLIFERATION; COMPARATIVE STUDY; CONIDIUM; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE COURSE; DISEASE RESISTANCE; EOSINOPHIL; EXPOSURE; LUNG; LUNG PARENCHYMA; MOUSE; NONHUMAN; ORGANISM; PNEUMONIA; PRIORITY JOURNAL; R FACTOR; RISK; SPECIES; T LYMPHOCYTE; TH1 CELL; TRANSGENIC MOUSE;

ALLELES; ANIMALS; ASPERGILLOSIS, ALLERGIC BRONCHOPULMONARY; GENETIC PREDISPOSITION TO DISEASE; HLA-DR ANTIGENS; HUMANS; IMMUNOGLOBULIN E; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUNG; MICE; MICE, TRANSGENIC; POLYMORPHISM, GENETIC;

EID: 34548261376     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.04.037     Document Type: Article

References (40)

1. Nepom G.T., and Erlich H. MHC class-II molecules and autoimmunity. Annu Rev Immunol 9 (1991) 493-525
2. Thomson G. HLA disease associations: models for the study of complex human genetic disorders. Crit Rev Clin Lab Sci 32 (1995) 183-219
3. Marsh D.G., and Huang S.K. Molecular genetics of human immune responsiveness to pollen allergens. Clin Exp Allergy 21 suppl 1 (1991) 168-172
4. Curik I., Fraser D., Eder C., Achmann R., Swinburne J., Crameri R., et al. Association between the MHC gene region and variation of serum IgE levels against specific mould allergens in the horse. Genet Sel Evol 35 suppl 1 (2003) S177-S190
5. *0501 genotype with Artemisia vulgaris allergic asthma. Hum Immunol 64 (2003) 811-815
6. Stephan V., Kuehr J., Seibt A., Saueressig H., Zingsem S., Dinh T.D., et al. Genetic linkage of HLA-class II locus to mite-specific IgE immune responsiveness. Clin Exp Allergy 29 (1999) 1049-1054
7. *0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population. Clin Exp Allergy 29 (1999) 60-71
8. Chauhan B., Hutcheson P.S., Slavin R.G., and Bellone C.J. MHC restriction in allergic bronchopulmonary aspergillosis. Front Biosci 8 suppl (2003) s140-s148
9. Senechal H., Geny S., Desvaux F.X., Busson M., Mayer C., Aron Y., et al. Genetics and specific immune response in allergy to birch pollen and food: evidence of a strong, positive association between atopy and the HLA class II allele HLA-DR7. J Allergy Clin Immunol 104 (1999) 395-401
10. Huang S.K., Zwollo P., and Marsh D.G. Class II major histocompatibility complex restriction of human T cell responses to short ragweed allergen, Amb a V. Eur J Immunol 21 (1991) 1469-1473
11. Evavold B.D., Sloan-Lancaster J., and Allen P.M. Tickling the TCR: selective T-cell functions stimulated by altered peptide ligand. Immunol Today 14 (1993) 602-609
12. Evavold B.D., and Allen P.M. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252 (1991) 1308-1310
13. Brogdon J.L., Leitenberg D., and Bottomly K. The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells. J Immunol 168 (2002) 3825-3832
14. Rogers P.R., and Croft M. Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance. J Immunol 163 (1999) 1205-1213
15. Schountz T., Kasselman J.P., Martinson F.A., Brown L., and Murray J.S. MHC genotype controls the capacity of ligand density to switch T helper (Th)-1/Th-2 priming in vivo. J Immunol 157 (1996) 3893-3901
16. Pfeiffer C., Murray J., Madri J., and Bottomly K. Selective activation of Th1- and Th2-like cells in vivo-response to human collagen IV. Immunol Rev 123 (1991) 65-84
17. Knutsen A.P., Mueller K.R., Levine A.D., Chauhan B., Hutcheson P.S., and Slavin R.G. Characterization of Asp f1 CD4+ T cell lines in allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 94 (1994) 215-221
18. Chauhan B., Knutsen A.P., Hutcheson P.S., Slavin R.G., and Bellone C.J. T cell subsets, epitope mapping, and HLA-restriction in patients with allergic bronchopulmonary aspergillosis. J Clin Invest 97 (1996) 2324-2331
19. Chauhan B., Santiago L., Kirschman D.A., Hauptfeld V., Knutsen A.P., Hutcheson P.S., et al. The association of HLA-DR alleles and T-cell activation with allergic bronchopulmonary aspergillosis. J Immunol 159 (1997) 4072-4076
20. Chauhan B., Santiago L., Hutcheson P.S., Schwartz H.J., Spitznagel E., Castro M., et al. Evidence for the involvement of two different MHC class II regions in susceptibility or protection in allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 106 (2000) 723-729
21. *1502 (DR2Dw12) transgene reduces incidence and severity of arthritis in mice. Hum Immunol 50 (1996) 54-60
22. Yoshitake S., Kimura A., Okada M., Yao T., and Sasazuki T. HLA class II alleles in Japanese patients with inflammatory bowel disease. Tissue Antigens 53 (1999) 350-358
23. Bellone C.J., Koehm S., Hembrador E., Hutcheson P.S., Trejo T., David C.S., et al. The role of HLA genes in allergic bronchopulmonary aspergillosis using a humanized transgenic mouse model. J Allergy Clin Immunol 115 suppl (2005) S234
24. Cosgrove D., Gray D., Dierich A., Kaufman J., Lemeur M., Benoist C., et al. Mice lacking MHC class II molecules. Cell 66 (1991) 1051-1066
25. Svensson A.C., Setterblad N., Pihlgren U., Rask L., and Andersson G. Evolutionary relationship between human major histocompatibility complex HLA-DR haplotypes. Immunogenetics 43 (1996) 304-314
26. Nabozny G.H., Baisch J.M., Cheng S., Cosgrove D., Griffiths M.M., Luthra H.S., et al. HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J Exp Med 183 (1996) 27-37
27. Hogaboam C.M., Blease K., Mehrad B., Steinhauser M.L., Standiford T.J., Kunkel S.L., et al. Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus. Am J Pathol 156 (2000) 723-732
28. Kurup V.P., Mauze S., Choi H., Seymour B.W., and Coffman R.L. A murine model of allergic bronchopulmonary aspergillosis with elevated eosinophils and IgE. J Immunol 148 (1992) 3783-3788
29. Slavin R.G., Gleich G.J., Hutcheson P.S., Kephart G.M., Knutsen A.P., and Tsai C.C. Localization of IgE to lung germinal lymphoid follicles in a patient with allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 90 (1992) 1006-1008
30. Cohn L., Herrick C., Niu N., Homer R., and Bottomly K. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol 166 (2001) 2760-2767
31. Hsieh C.-S., Heimberger A.B., Gold J.S., O'Garra A., and Murphy K.M. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an ab T-cell receptor transgenic system. Proc Natl Acad Sci U S A 89 (1992) 6065-6069
32. Seder R.A., Paul W.E., Davis M.M., and Fazekas De St Groth B. The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med 176 (1992) 1091-1098
33. Gajewski T.F., Pinnas M., Wong T., and Fitch F.W. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J Immunol 146 (1991) 1750-1758
34. Trincheiri G. Interleukin-12 and its role in the generation of Th1 cells. Immunol Today 14 (1993) 335-338
35. Murray J.S., Madri J., Tite J., Carding S.R., and Bottomly K. MHC control of CD4+ T cell subset activation. J Exp Med 170 (1989) 2135-2140
36. Murray J.S., Madri J., Pasqualini T., and Bottomly K. Functional CD4 T cell subset interplay in an intact immune system. J Immunol 150 (1993) 4270-4276
37. Soloway P., Fish S., Passmore H., Gefter M.L., Coffee R., and Manser T.J. Regulation of the immune response to peptide antigens: differential induction of immediate type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype. J Exp Med 174 (1991) 847-858
38. Gebe J.A., Novak E.J., Kwok W.W., Farr A.G., Nepom G.T., and Buckner J.H. T cell selection and differential activation on structurally related HLA-DR4 ligands. J Immunol 167 (2001) 3250-3256
39. Mycko M.P., Waldner H., Anderson D.E., Bourcier K.D., Wucherpfennig K.W., Kuchroo V.K., et al. Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol 173 (2004) 1689-1698
40. Murray J.S., Pfeiffer C., Madri J., and Bottomly K. Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell-mediated responses in mice of distinct MHC genotype. Eur J Immunol 22 (1992) 559-565