Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery

Molecular Brain Research

Volumn 43, Issue 1-2, 1996, Pages 57-64

  Lin, Yuzhong J ^a   Bovetto, Sylvie ^b   Carver, Jeffrey M ^a   Giordano, Tony ^a  

^a Symphony Pharmaceuticals   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Cloning; Distribution; Human; in situ; NMDA receptors; NR2C

Indexed keywords

COMPLEMENTARY DNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

AMINO ACID SEQUENCE; AMYGDALOID NUCLEUS; ANIMAL TISSUE; ARTICLE; BRAIN; CAUDATE NUCLEUS; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CORPUS CALLOSUM; DNA LIBRARY; GENE EXPRESSION; GENE ISOLATION; HEART; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MOLECULAR CLONING; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OLFACTORY BULB; PANCREAS; PRIORITY JOURNAL; RAT; RECEPTOR GENE; SEQUENCE HOMOLOGY; SKELETAL MUSCLE; SUBTHALAMIC NUCLEUS; THALAMUS; TISSUE DISTRIBUTION; VESTIBULAR NUCLEUS;

ANIMALIA;

EID: 0030608485     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(96)00146-5     Document Type: Article

References (41)

1. Anegawa, N.J., Lynch, D.R., Verdoorn, T.A. and Pritchett, D.B., Transfection of NMDA receptors in a nonneuronal cell line leads to cell death, J. Neurochem., 64 (1995) 2004-2012.
2. Bennett, J.A. and Dingledine, R., Topology profile for a glutamate receptor: three transmembrane domains and a channel-lining reentrant membrane loop, Neuron, 14 (1995) 373-384.
3. Carter, A.J., Glycine antagonists: regulation of the NMDA receptor-channel complex by the strychnine-insensitive glycine site, Drug Future, 17 (1992) 595-613.
4. Chazot, P.L., Coleman, S.K., Cik, M. and Stephenson, A., Molecular characterization of NMDA receptors expressed in mammalian cells yields evidence for the coexistence of 3 subunit types within a discrete receptor molecule, J. Biol. Chem., 269 (1994) 24403- 24409.
5. Choi, D.W., Glutamate neurotoxicity and diseases of the CNS, Neuron, 1 (1988) 623-634.
6. Collingridge, G.L., Long term potentiation in the hippocampus: mechanisms of initiation and modulation by neurotransmitters, Trends Pharmacol. Sci., 6 (1985) 407-411.
7. Collingridge, G.L. and Bliss, T.V.P., NMDA receptors - their role in long term potentiation, Trends Neurosci., 10 (1987) 288-293.
8. Collingridge, G.L. and Singer, W., Excitatory amino acid receptors and synaptic plasticity, Trends Pharmacol. Sci., 11 (1990) 290-296.
9. Foldes, R.L., Rampersad, V. and Kamboj, R.K., Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing, Gene, 131 (1993) 293-298.
10. Fonnum, F., Glutamate: a neurotransmitter in mammalian brain, J. Neurochem., 42 (1984) 1-11.
11. Gonoi, T., Mizuno, N., Inagaki, N., Kuromi, H., Seino, Y., Miyazaki, J. and Seino, S., Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6, J. Biol. Chem., 269 (1994) 16989-16992.
12. Hollmann, M. and Heinemann, S., Cloned glutamate receptors, Annu. Rev. Neurosci., 17 (1994) 31-108.
13. Hollman, M., Maron, C. and Heinemann, S., N-Glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1, Neuron, 13 (1994) 1331-1343.
14. Ikeda, K., Nagasawa, M., Mori, H., Araki, K., Sakimura, K., Watanabe, M., Inoue, Y. and Mishina, M., Cloning and expression of the e4 subunit of the NMDA receptor channel, FEBS Lett., 313 (1992) 34-38.
15. Ikeda, K., Araki, K., Takayama, C., Inoue, Y., Yagi, T., Aizawa, S. and Mishina, M., Reduced spontaneous activity of mice defective in the ε4 subunit of the NMDA receptor channel, Mol. Brain Res., 33 (1995) 61-71.
16. Ishii, T., Moriyoshi, K., Sugihara, H., Sakurada, K., Kadotani, H., Yokoi, M., Akazawa, C., Shigemoto, R., Masu, M. and Nakashini, S., Molecular characterization of the family of the NMDA receptor subtypes, J. Biol. Chem., 268 (1993) 2836-2843.
17. Karp, S.J., Masu, M., Eki, T., Ozawa, K. and Nakanishi, S., Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor, J. Biol. Chem., 268 (1993) 3728-3733.
18. Kutsuwada, T., Kashiwabushi, N., Mori, H., Sakimura, K., Kushiya, E., Araki, K., Meguro, H., Masaki, H., Kumanishi, T., Arakawa, M. and Mishina, M., Molecular diversity of the NMDA receptor channel, Nature, 358 (1992) 36-41.
19. Kirkwood, A., Dudek, S.M., Gold, J.T., Aizenman, C.D. and Bear, M.F., Common forms of synaptic plasticity in the hippocampus and neocortex in vitro, Science, 260 (1993) 1518-1521.
20. Kyte, J. and Doolitle, R.F., A simple method for displaying the hydropathic character of a protein, J. Mol. Biol., 157 (1982) 105-132.
21. Le Bourdelles, B., Wafford, K.A., Kemp, J.A., Marshall, G., Bain, C., Wilcox, A.S., Sikela, J.M. and Whiting, P.J., Cloning, functional coexpression, and pharmacological characterization of human cDNAs encoding NMDA receptor NR1 and NR2A subunits, J. Neurochem., 62 (1994) 2091-2098.
22. Lynch, D., Anegawa, N.J, Verdoorn, T. and Pritchett, D.B., NMDA receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonist and channel blocking agents, Mol. Pharmacol., 45 (1994) 540-545.
23. Maragos, W.F., Greenamyre, T., Penney, Jr., J.B. and Young, A.B., Glutamate dysfunction in Alzheimer's disease: a hypothesis, Trends Neurol. Sci., 10 (1987) 65-68.
24. Meguro, H., Mori, H., Araki, K., Kushiya, E., Kutsuwada, T., Yamazaki, M., Kumanishi, T., Akazawa, C., Sakimura, K. and Mishina, M., Functional characterization of a heterodimeric NMDA receptor channel expressed from cloned cDNAs, Nature, 357 (1992) 70-74.
25. Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B. and Seeburg, P.H., Heterodimeric NMDA receptors: molecular and functional distinction of subtypes, Science, 256 (1992) 1217-1221.
26. Monyer, H., Burnashev, N., Laurie, D.J., Sakmann, B. and Seeburg, P.H., Developmental and regional expression in the rat brain and functional properties of four NMDA receptors, Neuron, 12 (1994) 529-540.
27. Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N. and Nakanishi, S., Molecular cloning and characterization of the rat NMDA receptor, Nature, 354 (1991) 31-37.
28. Morris, R.G.M., Anderson, E., Lynch, G. and Baudry, M., Selective impairment of learning and blockade of long term potentiation by an N-methyl-D-aspartate receptor antagonist, AP-5, Nature, 319 (1986) 774-776.
29. Nakanishi, S., Molecular diversity of glutamate receptors and implications for brain function, Science, 258 (1992) 597-603.
30. Nakanishi, N., Axel, R. and Shneider, N.A., Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors, Proc. Natl. Acad. Sci. USA, 89 (1992) 8552-8556.
31. Nicoll, R.A., Kauer, J.A. and Malenka, R.C., The current excitement in long-term potentiation, Neuron, 1 (1988) 97-103.
32. Planells-Cases, R., Sun, W., Ferrer-Montiel, A.V. and Montal, M., Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain, Proc. Natl. Acad. Sci. USA, 90 (1993) 5057-5061.
33. Robinson, M. and Coyle, J., Glutamate and related excitatory amino neurotransmitters: from basic science to clinical application, FASEB J., 1 (1987) 446-455.
34. Simmons, D.M., Arriza, J.L. and Swanson, L.W., A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radio-labeled single-stranded RNA probes, J. Histotechnol., 12 (1989) 169-181.
35. Standaert, D.G., Testa, C.M., Young, A.B. and Penney Jr., J.B., Organization of N-methyl-D-aspartate glutamate receptor gene expression in the basal ganglia of the rat, J. Comp. Neurol., 343 (1994) 1-16.
36. Stern, P., Behe, P., Scoepfer, R. and Colquhoun, D., Single-channel conductance of NMDA receptors expressed from cloned cDNAs: comparison with native receptors, Proc. Roy. Soc. Lond. B, 250 (1992) 271-277.
37. Sugihara, H., Moriyoshi, K., Ishii, T., Masu, M. and Nakanishi, S., Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing, Biochem. Biophys. Res. Commun., 185 (1992) 826-832.
38. Tingley, W.G., Roche, K.W., Thompson, A.K. and Huganir, R.L., Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain, Nature, 364 (1993) 70-73.
39. Wafford, K.A., Bain, C.J., Le Bourdelles, B., Whiting, P.J. and Kemp, J.A., Preferential co-assembly of recombinant NMDA receptors composed of three different subunits, NeuroReport, 4 (1993) 1247-1349.
40. Watanabe, M., Mishina, M. and Inoue, Y., Distinct distribution of five NMDA receptor channel subunit mRNAs in the brainstem, J. Comp. Neurol., 343 (1994) 520-531.
41. Zhang, L., Zheng, X., Paupard, M.-C., Wang, A.P., Santchi, L., Friedman, L.K., Zukin, R.S. and Bennett, M.V.L., Spermine potentiation of recombinant NMDA receptors is affected by subunit composition, Proc. Natl. Acad. Sci. USA, 91 (1994) 10883-10887.