Cathelicidin-derived Trp/Pro-rich antimicrobial peptides with lysine peptoid residue (Nlys): Therapeutic index and plausible mode of action

Journal of Peptide Science

Volumn 13, Issue 8, 2007, Pages 529-535

  Zhu, Wan Long ^a   Hahm, Kyung Soo ^a,b   Shin, Song Yub ^a,b  

^a Chosun University   (South Korea)

^b Chosun University College of Medicine   (South Korea)

Author keywords

Cathelicidin derived Trp Pro rich antimicrobial peptide; Cell selectivity; Indolicidin; Lysine peptoid residue (Nlys); Therapeutic index; Tritrpticin

Indexed keywords

CATHELICIDIN; INDOLICIDIN; LYSINE; LYSYLLYSYLPHENYLALANYLPROLYLTRYPTOPHYLTRYPTOPHYLTRYPTOPHYLPROLYLPHENYLALANYLLYSYLLYSYLAMIDE; POLYPEPTIDE ANTIBIOTIC AGENT; PROLINE; TRITRPTICIN AMIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SYNTHESIS; HEMOLYSIS; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; ERYTHROCYTES; HEMOLYSIS; HEMOLYTIC AGENTS; HUMANS; MEMBRANE POTENTIALS; MICROBIAL SENSITIVITY TESTS; PEPTOIDS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 34548236882     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.882     Document Type: Article

References (31)

1. Boman HG. Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol. 1995; 13: 61-92.
2. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002; 415: 389-395.
3. Brogden KA. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 2005; 3: 238-250.
4. Beisswenger C, Bals R. Functions of antimicrobial peptides in host defense and immunity. Curr. Protein Pept. Sci. 2005; 6: 255-264.
5. Hancock RE, Lehrer R. Cationic peptides: a new source of antibiotics. Trends Biotechnol. 1998; 16: 82-88.
6. Neu HC. The crisis in antibiotic resistance. Science 1992; 257: 1064-1073.
7. Travis J. Reviving the antibiotic miracle? Science 1994; 264: 360-362.
8. Murakami M, Ohtake T, Dorschner RA, Gallo RL. Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva. J. Dent. Res. 2002; 81: 845-850.
9. Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity. J. Leukoc. Biol. 2004; 75: 39-48.
10. Lehrer RI, Ganz T. Cathelicidins: a family of endogenous antimicrobial peptides. Curr. Opin. Hematol. 2002; 9: 18-22.
11. Chen C, Brock R, Luh F, Chou PJ, Larrick JW, Huang RF, Huang TH. The solution structure of the active domain of CAP18 - a lipopolysaccharide binding protein from rabbit leukocytes. FEBS Lett. 1995; 370: 46-52.
12. Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J. Biol. Chem. 1997; 272: 13088-13093.
13. Shin SY, Park EJ, Yang ST, Jung HJ, Eom SH, Song WK, Kim Y, Habra KS, Kim JI. Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide. Biochem. Biophys. Res. Commun. 2001; 285: 1046-1051.
14. Roumestand C, Louis V, Aumelas A, Grassy G, Calas B, Chavanieu A. Oligomerization of protegrin-1 in the presence of DPC micelles. A proton high-resolution NMR study. FEBS Lett. 1998; 421: 263-267.
15. Boman H, Agerberth B, Boman A. Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect. Immun. 1993; 61: 2978-2984.
16. Frank RW, Gennaro R, Schneider K, Przybylski M, Romeo D. Amino acid sequences of two proline-rich bactenecins. Antimicrobial peptides of bovine neutrophils. J. Biol. Chem. 1990: 265: 18871-18874.
17. Huttner KM, Lambeth MR, Burkin HR, Burkin DJ, Broad TE. Localisation and genomic organisation of sheep antimicrobial peptide genes. Gene 1998; 206: 85-91.
18. Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K. Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides. FEBS Lett. 1996; 390: 95-98.
19. Selsted ME, Novotny MJ, Morris WL, Tang YQ, Smith W, Cullor JS. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J. Biol. Chem. 1992; 267: 4292-4295.
20. Yang ST, Shin SY, Kim YC, Kim Y, Hahm KS, Kim JI. Conformation -dependent antibiotic activity of tritrpticin, a cathelicidinderived antimicrobial peptide. Biochem. Biophys. Res. Commun. 2002; 296: 1044-1050.
21. Falla TJ, Karunaratne DN, Hancock RE. Mode of action of the antimicrobial peptide indolicidin. J. Biol. Chem. 1996; 271: 19298-19303.
22. Yang ST, Shin SY, Lee CW, Kim YC, Hahm, KS, Kim JI. Selective cytotoxicity following Arg-to-Lys substitution in tritrpticin adopting a unique amphipathic turn structure. FEBS Lett. 2003; 540: 229-233.
23. Yang ST, Shin SY, Hahm KS, Kim JI. Design of perfectly symmetric Trp-rich peptides with potent and broadspectrum antimicrobial activities. Int. J. Antimicrob. Agents 2006; 27: 325-330.
24. Ryge TS, Dolsy X, Ifrah D, Olsen JE, Hansen PR. New indolicidin analogues with potent antibacterial activity. J. Pept. Res. 2004; 64: 171-185.
25. Subbalakshmi C, Bikshapathy E, Sitaram N, Nagaraj R. Antibacterial and hemolytic activities of single tryptophan analogs of indolicidin. Biochem. Biophys. Res. Commun. 2000; 274: 714-716.
26. Zhu WL, Lan H, Park Y, Yang ST, Kim JI, Park IS, You HJ, Lee JS, Park YS, Kim Y, Hahm KS, Shin SY. Effects of Pro → peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. Biochemistry 2006; 45: 13007-13017.
27. Tang YC, Deber CM. Hydrophobicity and helicity of membrane-interactive peptides containing peptoid residues. Biopolymers 2002; 65: 254-262.
28. Mao D, Wallace BA. Differential light scattering and absorption flattening optical effects are minimal in the circular dichroism spectra of small unilamellar vesicles. Biochemistry 1984; 23: 2667-2673.
29. Shai Y, Bach D, Yanovsky A. Channel formation properties of synthetic pardaxin and analogues. J. Biol. Chem. 1990; 265: 20202-20209.
30. Friedrich CL, Moyles D, Beveridge TJ, Hancock RE. Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria. Antimicrob. Agents Chemother. 2000; 44: 2086-2092.
31. Yang ST, Shin SY, Kim JI. Interaction mode of a symmetric Trp-rich undeca peptide PST11-RK with lipid bilayers. FEBS Lett. 2007; 581: 157-163.