Ferriporphyrins and endothelium: A 2-edged sword - Promotion of oxidation and induction of cytoprotectants

Blood

Volumn 95, Issue 11, 2000, Pages 3442-3450

  Balla, József ^a   Balla, György ^a   Jeney, Viktoria ^a   Kakuk, György ^a   Jacob, Harry S ^a   Vercellotti, Gregory M ^a  

^a Box 293 ^*

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEMATIN; HEME; HEME ARGINATE; HEME OXYGENASE;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; OXIDATION; PORPHYRIA; PRIORITY JOURNAL; UMBILICAL VEIN;

EID: 0034210202     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.11.3442.011k51_3442_3450     Document Type: Article

References (71)

1. Bloomer JR, Bonkowsky HL. The porphyrias. Dis Mon. 1989;35:1-54.
2. Moore MR, McColl KE, Filzsimons EJ, Goldberg SA. The porphyrias. Blood Rev. 1990;4:88-96.
3. Kappas A, Sassa S, Galbraith RA, Nordmann Y. The porphyrias. In: Scriver CR, Beaudet AL, Sly WS, et al, eds. The Metabolic and Molecular Basis of Inherited Diseases. Vol 11. New York, NY: McGraw-Hill; 1995:2103-2134.
4. Jeans JB, Savik K, Gross CR, et al. Mortality in patients with acute intermittent porphyria requiring hospitalization: a United States case series. Am J Med Genet. 1996;65:269-273.
5. Bonkowsky HL, Tschudy DP, Collins A, et al. Repression of the overproduction of porphyrin precursors in acute intermittent porphyria by intravenous infusion of hematin. Proc Natl Acad Sci USA. 1971;68:2725-2729.
6. Watson CJ, Pierach CA, Bossenmaier I, Cardinal R. Postulated deficiency of hepatic heme and repair by hematin infusions in the "inducible" hepatic porphyrias. Proc Natl Acad Sci U S A. 1977; 77:2118-2120.
7. Lamon JM, Frykholm BC, Bennett M, Tschudy DP. Prevention of acute porphyric attacks by intravenous haematin. Lancet. 1978;2:492-494.
8. McColl KE, Moore MR, Thompson GG, Goldberg A. Treatment with haematin in acute hepatic porphyria. Q J Med. 1981;50:161-174.
9. Bissell DM. Treatment of acute hepatic porphyria with hematin. J Hepatol 1988;6:1-7.
10. Dhar GJ, Bossenmaier I, Cardinal R, Petryka ZJ, Watson CJ. Transitory renel failure following rapid administration of a relatively large amount of hematin in a patient with acute intermittent porphyria in clinical remission. Acta Med Scand. 1978;203:437-443.
11. Morris DL, Dudley MD, Pearson RD. Coagulopathy associated with hematin treatment for acute intermittent porphyria. Ann Intern Med. 1981;95: 700-701.
12. Glueck R, Green D, Cohen I, Ts'ao CH. Hematin: unique effects of hemostasis. Blood. 1983;61: 243-249.
13. Peterson JM, Pierach CA. Hematin-induced hemolysis in acute porphyria. Ann Intern Med. 1984; 101:877-878.
14. Khanderia U. Circulatory collapse associated with hemin therapy for acute intermittent porphyria. Clin Pharm. 1986;5:690-692.
15. Goetsch CA, Bissell DM. Instability of hematin used in the treatment of acute hepatic porphyria. N Engl J Med. 1986;315:235-238.
16. Pierach CA. Porphyrins and porphyrias. In: Nordmann Y, ed. Proceedings of the Second International Congress on Porphyrins and Porphyrias. London, England: John Libbey; 1986:217-224.
17. Simionatto DS, Cabal R, Jones RL, Galbraith RA. Thrombophlebitis and disturbed hemostasis following administration of intravenous hematin in normal volunteers. Am J Med. 1988;85:538-540.
18. Tenhunen R. A new drug for porphyria. Nord Med. 1986;101:132-133.
19. Tokola O, Linden IB, Tenhunen R. The effects of haem arginate and haematin upon the allylisopropylacetamide induced experimental porphyria in rats. Pharmacol Toxicol. 1987;61:75-78.
20. Mustajoki P, Tenhunen R, Tokola O, Gothoni G. Haem arginate in the treatment of acute hepatic porphyrias. Br Med J. 1986;293:538-539.
21. Herrick AL, McColl KE, Moore MR, Cook A, Goldberg A. Controlled trial of haem arginate in acute hepatic porphyria. Lancet 1989;1:1295-1297.
22. Nordmann Y, Deybach JC. Acute attacks of hepatic porphyria: specific treatment with heme arginate. Ann Med Interne (Paris). 1993;144:165-167.
23. Tenhunen R, Mustajoki P. Acute porphyria: treatment with heme. Semin Liver Dis. 1998;18:53-55.
24. Varani J, Fligiel SEG, Till GO, Kunkel RG, Ryen US, Ward PA. Pulmonary endothelial cell killing by human neutrophils: possible involvement of hydroxyl radical. Lab Invest. 1985;53:656-663.
25. Ward PA. Mechanism of endothelial cell injury. J Lab Clin Med. 1991;118:421-426.
26. Van Lenten BJ, Prieve J, Navab M, Hama S. Lusis AJ, Fogelman AM. Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo. J Clin Invest. 1995;95:2104-2110.
27. Balla G, Vercellotti GM, Eaton JW, Jacob HS. Iron loading of endothelial cells augments oxidant damage. J Lab Clin Med. 1990;116:546-554.
28. Balla G, Vercellotti GM, Muller-Eberhard U, Eaton J, Jacob HS. Exposure of endothelial cells to free heme potentiates damage mediated by granulocyte and toxic oxygen species. Lab Invest. 1991; 64:648-655.
29. Gutteridge JM, Smith A. Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation. Biochem J. 1988;256:861-865.
30. Eskew JD, Vanacore RM, Sung L, Morales PJ, Smith A. Cellular protection mechanisms against extracellular heme: heme-hemopexin, but not free heme, activates the N-terminal c-jun kinase. J Biol Chem. 1999;274:638-648.
31. Balla G, Jacob HS, Eaton JW, Belcher JD, Vercellotti GM. Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial cell injury. Arterioscler Thromb. 1991;11: 1700-1711.
32. Balla G, Jacob HS, Balla J, et al. Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem. 1992;267:18,148-18,153.
33. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci U S A. 1968;61:748-755.
34. Maines MD, Kappas A. Cobalt induction of hepatic heme oxygenase: with evidence that cytochrome P-450 in not essential for this enzyme activity. Proc Natl Acad Sci U S A. 1974;71:4293-4297.
35. McCoubrey WK, Huang TJ, Maines MD. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem. 1997;247:725-732.
36. Keyse SM, Tyrell RM. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblast by UVA radiation, hydrogen peroxide, and sodium arsenate. Proc Natl Acad Sci U S A. 1989;86:99-103.
37. Choi AMK, Alam J. Heme oxygenase-1 : function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol. 1996;15:9-19.
38. Shibahara S, Yoshida T, Kikuchi G. Induction of heme oxygenase by hemin in cultured pig alveolar macrophages. Arch Biochem Biophys. 1978; 188:243-250.
39. Cantoni L, Rossi C, Rizzardini M, Gadina M, Ghezzi P. Interleukin-1 and tumor necrosis factor induce hepatic haem oxygenase: feedback regulation by glucocorticoids. Biochem J. 1991;279: 891-894.
40. Taylor JL, Carraway MS, Piantadosi CA. Lung-specific induction of heme oxygenase-1 and hyperoxic lung injury. Am J Physiol. 1998;274:L582-L590.
41. Agarwal A, Balla J, Balla G, Croatt AJ, Vercellotti GM, Nath KA. Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL. Am J Physiol. 1996;271:F814-F823.
42. Theil EC. The ferritin family of iron storage proteins. Adv Enzymol Relat Areas Mol Biol. 1990; 63:421-449.
43. Harrison PM, Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1996;1275:161-203.
44. Broxmeyer HE, Cooper S, Levi S, Arosio P. Mutated recombinant human heavy-chain ferritins and myelosuppression in vitro and in vivo: a link between ferritin ferroxidase activity and biological function. Proc Natl Acad Sci U S A. 1991;88:770-774.
45. Balla J, Jacob HS, Balla G, Nath K, Eaton JW, Vercellotti GM. Endotheliat-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci U S A. 1993;90:9285-9289.
46. Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal Biochem. 1992;202:384-389.
47. Ujhelyi L, Balla J, Muszbek L. A microassay to assess the oxidative resistance of low-density lipoproteins. Clin Chem. 1998;44:1762-1764.
48. Eisenstein RS, Garcia-Mayol D, Pettingell W, Munro HN. Regulation of ferritin and heme oxygenase synthesis in rat fibroblast by different forms of iron. Proc Natl Acad Sci U S A. 1991;88: 688-692.
49. Tenhunen R, Tokola O, Linden IB. Haem arginate: a new stable haem compound. J Pharm Pharmacol. 1987;39:780-786.
50. Lin JJ, Daniels-McQueen S, Patino MM, Gaffield L, Walden WE, Thach RE. Derepression of ferritin messenger RNA translation by hemin in vitro. Science. 1990;247:74-77.
51. Rouault TA, Tang CK, Kaptain S. Cloning of the cDNA encoding an RNA regulatory protein - the human iron-responsive element-binding protein. Proc Natl Acad Sci U S A. 1990;87:7958-7962.
52. Balla J, Nath K, Balla G, Juckett MB, Jacob HS, Vercellotti GM. Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo. Am J Physiol. 1995;268:L321-L327.
53. Lin F, Girotti AW. Hemin-enhanced resistance of human leukemia cells to oxidative killing: antisense determination of ferritin involvement. Arch Biochem Biophys. 1998;352:51-58.
54. Juckett MB, Balla J, Balla G, Jessurun J, Jacob HS, Vercellotti GM. Ferritin protects endothelial cells from oxidized low density lipoprotein in vitro. Am J Pathol. 1995;147:782-789.
55. Wang L, Lee T, Lee F, Pai R, Chau L. Expression of heme oxygenase-1 in atherosclerotic lesions. Am J Pathol. 1998;152:711-720.
56. Nath KA, Balla G, Vercellotti GM, et al. Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Invest. 1992;90:267-270.
57. Soares MP, Lin Y, Anrather J, et al. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med. 1998;4:1073-1077.
58. Dennery PA, Spitz DR, Yang G, et al. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. J Clin Invest. 1998; 101:1001-1011.
59. Yachie A, Niida Y, Wada T. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999;103:129-135.
60. Ewing JF, Haber SN, Maines MD. Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: hyperthermia causes rapid induction of mRNA and protein. J Neurochem. 1992;58:1140-1149.
61. Dore S, Takahashi M, Ferris CD, Hester LD, Guastella D, Snyder SH. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci U S A. 1999;96:2445-2450.
62. Ishikawa K, Navab M, Leitinger N, Fogelman AM, Lusis AJ. Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL. J Clin Invest. 1997;100:1209-1216.
63. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science. 1987; 235:1043-1046.
64. Vile GF, Basu-Modak S, Waltner C, Tyrell RM. Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblast. Proc Natl Acad Sci U S A. 1994;91:2607-2610.
65. Abraham NG, Lavrovsky Y, Schwartzman ML, et al. Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc Natl Acad Sci U S A. 1995;92: 6798-6802.
66. Morita T, Kourembanas S. Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J Clin Invest. 1995;96:2676-2682.
67. Ponka P. Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. Blood. 1997; 89:1-25.
68. Kappas A, Drummond GS, Simionatto CS, Anderson KE. Control of heme oxygenase and plasma levels of bilirubin by a synthetic heme analogue, tin protoporphyrin. Hepatology. 1984;4:336-341.
69. Dover SB, Moore MR, Fitzsimmons EJ, Graham A, McColl KEL. Tin protoporphyrin prolongs the biochemical remission produced by heme arginate in acute hepatic porphyria. Gastroenterology. 1993;105:500-506.
70. Mustajoki P, Tenhunen R, Pierach C, Volin L. Heme in the treatment of porphyrias and hematological disorders. Semin Hematol. 1989;26:1-9.
71. Volin L, Rasi V, Vahtera E, Tenhunen R. Heme arginate: effects on hemostasis. Blood. 1988;71: 625-628.