Imaging hypoxia in vivo by controlling the electrochemistry of copper radionuclide complexes

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 50, Issue 5-6, 2007, Pages 354-359

  Blower, Philip J ^a   Went, Michael J ^b   Martin, Kath E ^b   Smith, Gareth E ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

Author keywords

Copper; Hypoxia; Imaging; PET

Indexed keywords

COPPER COMPOUNDS; DISEASES; KETONES;

DIKETONES; HEART DISEASE; HYPOXIA; HYPOXIC CELLS; IMAGING AGENT; IN-VITRO; IN-VIVO; PROPERTY; TISSUE HYPOXIA; VITRO AND IN VIVO;

PHARMACOKINETICS;

2,3 BUTANEDIONE BIS(N METHYL)THIOSEMICARBAZONE CU 60; 2,3 BUTANEDIONE BIS(N METHYL)THIOSEMICARBAZONE CU 62; 2,3 BUTANEDIONE BIS(N METHYL)THIOSEMICARBAZONE CU 64; RADIOISOTOPE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; COMBINATORIAL CHEMISTRY; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROCHEMISTRY; HYPOXIA; IN VIVO STUDY; NONHUMAN; RAT;

EID: 34548170952     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1195     Document Type: Conference Paper

References (24)

1. Martin GV, Caldwell JH, Graham MM, Grierson JR, Kroll K, Cowan MJ, Lewellen TK, Rasey JS, Casciari JJ, Krohn KA. J Nucl Med 1992; 33: 2202.
2. Lewis JS, Welch MJ. Quart J Nucl Med 2001; 45: 183.
3. Fujibayashi Y, Wada K, Taniuchi H, Yonekura Y, Konishi J, Yokoyama A. Biol Pharm Bull 1993; 16: 146.
4. Fujibayashi Y, Taniuchi H, Yonekura Y, Ohtani H, Konishi J, Yokoyama A. J Nucl Med 1997; 38: 1155.
5. Dearling JLJ, Lewis JS, McCarthy DW, Welch MJ, Blower PJ. Chem Commun 1998: 2531;
6. Dearling JLJ, Lewis JS, Mullen GED, Rae MT, Zweit J, Blower PJ. Eur J Nucl Med 1998; 25: 788.
7. Dearling JLJ, Lewis JS, Mullen GED, Welch MJ, Blower PJ. J Biol Inorg Chem 2002; 7: 249.
8. Jones CJ, McCleverty JA. J Chem Soc A 1970: 2829.
9. Takahashi N, Fujibayashi Y, Yonekura Y, Welch MJ, Waki A, Tsuchida T, Sadato N, Sugimoto K, Itoh H. Ann Nucl Med 2000; 14: 323.
10. Takahashi N, Fujibayashi Y, Yonekura Y, Welch MJ, Waki A, Tsuchida T, Sadato N, Sugimoto K, Nakano A, Lee JD, Itoh H. Ann Nucl Med 2001; 15: 293;
11. Lewis JS, Herrero P, Sharp TL, Engelbach JA, Fujibayashi Y, Laforest R, Kovacs A, Gropler RJ, Welch MJ. J Nucl Med 2002; 43: 1557.
12. Laforest R, Dehdashti F, Lewis JS, Schwarz SW. Eur J Nucl Med Mol Imaging 2005; 32: 764;
13. Dehdashti F, Mintun MA, Lewis JS, Bradley J, Govindan R, Laforest R, Welch MJ, Siegel BA. Eur J Nucl Med Mol Imaging 2003; 30: 844;
14. Dehdashti F, Grigsby PW, Mintun MA, Lewis JS, Siegel BA, Welch MJ. Int J Radiat Oncol Biol Phys 2003; 55: 1233.
15. Obata A, Fujibayashi Y, Miono Y, Waki A, Yonekura Y, Welch MJ. J Label Compd Radiopharm 1999; 42: S273;
16. Obata A, Yoshimi E, Waki A, Lewis JS, Oyama N, Welch MJ, Saji H, Yonekura Y, Fujibayashi Y. Ann Nucl Med 2001; 15: 499;
17. Cowley AR, Davis J, Dilworth JR, Donnelly PS, Dobson R, Nightingale A, Peach JM, Shore B, Kerr D, Seymour L. Chem Commun 2005; 845.
18. Maurer RI, Blower PJ, Dilworth JR, Reynolds CA, Zheng YF, Mullen GED J Med Chem 2002; 45: 1420.
19. Blower PJ, Castle TC, Cowley AR, Dilworth JR, Donnelly PS, Labisbal E, Sowrey FE, Teat SJ, Went MJ, Dalton Trans 2003: 4416.
20. Castle TC, Maurer RI, Sowrey FE, Went MJ, Reynolds CA, McInnes EJL, Blower PJ. J Am Chem Soc 2003; 125: 4416.
21. Dearling JL, Mullen GD, Lewis JS, Welch MJ, Blower PJ. J Label Compd Radiopharm 1999; 42 (suppl 1): S276.
22. McQuade P, Martin KE, Castle TC, Went MJ, Blower PJ, Welch MJ, Lewis JS. Nucl Med Biol 2005; 32: 147.
23. Lim JK, Mathias CJ, Green MA. J Med Chem 1997; 40: 132.
24. Burgman P, O'Donoghue JA, Lewis JS, Welch MJ, Humm JL, Ling CC. Nucl Med Biol 2005; 32: 623.