Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis

Journal of Lipid Research

Volumn 48, Issue 6, 2007, Pages 1362-1370

  De Juan, Susana Cuesta ^a   Monte, Maria J ^a   Macias, Rocio I R ^a   Wauthier, Valérie ^b   Calderon, Pedro Buc ^b   Marin, Jose J G ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Cholesterol; CYP7A1; CYP8B1; Cytochrome P450 enzymes; Fetus; Intestine; Liver; Nuclear receptor; Senescence; Synthesis; Transport; Weaning

Indexed keywords

ALPHA MURICHOLIC ACID; BILE ACID; CELL NUCLEUS RECEPTOR; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 27; CYTOCHROME P450 3A11; CYTOCHROME P450 8 B 1; FARNESOID X RECEPTOR; FETOPROTEIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; STEROID 5ALPHA REDUCTASE; STEROID 5BETA REDUCTASE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FETUS; GAS CHROMATOGRAPHY; GENE EXPRESSION; HOMEOSTASIS; LIVER WEIGHT; MALE; MASS SPECTROMETRY; NONHUMAN; ONTOGENY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; WEANING;

AGE FACTORS; ANIMALS; BILE ACIDS AND SALTS; CHENODEOXYCHOLIC ACID; CHOLIC ACID; CHOLIC ACIDS; CYTOCHROME P-450 ENZYME SYSTEM; DEOXYCHOLIC ACID; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEPATOCYTE NUCLEAR FACTOR 4; HOMEOSTASIS; OXIDOREDUCTASES; PREGNANCY; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSCRIPTION FACTORS; WEANING;

EID: 34548157280     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700034-JLR200     Document Type: Article

References (35)

1. El-Mir, M. Y., M. D. Badia, N. Luengo, M. J. Monte, and J. J. G. Marin. 2001. Increased levels of typically fetal bile acid species in patients with hepatocellular carcinoma. Clin. Sci. 100: 499-508.
2. Monte, M. J., M. C. Martinez-Diez, M. Y. El-Mir, M. E. Mendoza, P. Bravo, O. Bachs, and J. J. G. Marin. 2002. Changes in the pool of bile acids in hepatocyte nuclei during rat liver regeneration. J. Hepatol. 36: 534-542.
3. Mendoza, M. E., M. J. Monte, M. Y. El-Mir, M. D. Badia, and J. J. G. Marin. 2002. Changes in the pattern of bile acids in the nuclei of rat liver cells during hapatocarcinogenesis. Clin. Sci. 102: 143-150.
4. Monte, M. J., M. Fernandez-Tagarro, and J. J. G. Marin. 2005. Transient changes in the expression pattern of key enzymes for bile acid synthesis during rat liver regeneration. Biochim. Biophys. Acta. 1734: 127-135.
5. Monte, M. J., M. Fernandez-Tagarro, R. I. Macias, F. Jimenez, F. Gonzalez-San Martin, and J. J. G. Marin. 2005. Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis. Clin. Sci. 109: 199-207.
6. Massimi, M., S. R. Lear, S. L. Huling, A. L. Jones, and S. K. Erickson. 1998. Cholesterol 7α-hydroxylase (CYP7A): patterns of messenger RNA expression during rat liver development. Hepatology. 28: 1064-1072.
7. Hardikar, W., M. Ananthanarayanan, and F. J. Suchy. 1995. Differential ontogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver. J. Biol. Chem. 270: 20841-20846.
8. Tomer, G., M. Ananthanarayanan, A. Weymann, N. Balasubramanian, and F. J. Suchy. 2003. Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2. Pediatr. Res. 53: 288-294.
9. Monte, M. J., A. I. Morales, M. Arevalo, I. Alvaro, R. I. R. Macias, and J. J. G. Marin. 1996. Reversible impairment of neonatal hepatobiliary function by maternal cholestasis. Hepatology. 23: 1208-1217.
10. Balasubramaniyan, N., M. Shahid, F. J. Suchy, and M. Ananthanarayanan. 2005. Multiple mechanisms of ontogenic regulation of nuclear receptors during rat liver development. Am. J. Physiol. 288: G251-G260.
11. Vicens, M., R. I. R. Macias, O. Briz, A. Rodriguez, M. Y. El-Mir, M. Medarde, and J. J. G. Marin. 2007. Inhibition of the intestinal absorption of bile acids using cationic derivatives. Mechanism and repercussions. Biochem. Pharmacol. 73: 394-404.
12. Macias, R. I. R., M. A. Serrano, M. J. Monte, S. Jimenez, B. Hernandez, and J. J. G. Marin. 2005. Long-term effect of treating pregnant rats with ursodeoxycholic acid on the congenital impairment of bile secretion induced in the pups by maternal cholestasis. J. Pharmacol. Exp. Ther. 312: 751-758.
13. Mashige, U., K. Imai, and T. Osuga. 1976. Simple and sensitive assay of serum total bile acids. Clin. Chim. Acta. 70: 79-86.
14. Malavolti, M., H. Fromm, E. Nsien, K. D. R. Setchell, M. B. Albert, B. Cohen, and S. Ceryak. 1993. Formation, absorption, and biotransformation of delta6-lithocholenic acid in humans. Am. J. Physiol. 264: G163-G171.
15. Shoda, J., T. Osuga, K. Matsuura, R. Mahara, M. Tohma, N. Tanaka, Y. Matsuzaki, and H. Miyazaki. 1989. Concurrent occurrence of 3-beta,12-alpha- dihydroxy-5-cholenoic acid associated with 3-betahydroxy-5-cholenoic acid and their preferential urinary excretion in liver diseases. J. Lipid Res. 30: 1233-1242.
16. Alme, B., A. Bremmelgaard, J. Sjovall, and P. Thomassen. 1977. Analysis of metabolic profiles of bile acids in urine using a lipophilic anion exchanger and computerized gas-liquid chromatographymass spectrometry. J. Lipid Res. 18: 339-362.
17. Sainz, G. R., M. J. Monte, E. R. Barbero, M. C. Herrera, and J. J. G. Marin. 1997. Bile secretion by the rat liver during synchronized regeneration. Int. J. Exp. Pathol. 78: 109-116.
18. Vandesompele, J., K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, A. De Paepe, and F. Speleman. 2002. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3: RESEARCH0034.
19. Monte, M. J., T. Rodriguez-Bravo, R. I. R. Macias, P. Bravo, M. Y. El-Mir, M. A. Serrano, A. Lopez-Salva, and J. J. G. Marin. 1995. Relationship between bile acid transplacental gradients and transport across the fetal-facing plasma membrane of the human trophoblast. Pediatr. Res. 38: 156-163.
20. Marin, J. J. G., M. A. Serrano, M. Y. El-Mir, N. Eleno, and C. A. R. Boyd. 1990. Bile acid transport by basal membrane vesicles of human term placental trophoblast. Gastroenterology. 99: 1431-1438.
21. El-Mir, M. Y., N. Eleno, M. A. Serrano, P. Bravo, and J. J. G. Marin. 1991. Bicarbonate-induced activation of taurocholate transport across the basal plasma membrane of the human term trophoblast. Am. J. Physiol. 260: G887-G894.
22. Serrano, M. A., P. Bravo, M. Y. A. El-Mir, and J. J. G. Marin. 1993. Influence of hydroxylation and conjugation in bile acid-induced inhibition of taurocholate binding and transport across the basal membrane of human trophoblast. Biochim. Biophys. Acta. 1151: 28-34.
23. Pandak, W. M., P. Bohdan, C. Franklund, D. H. Mallonee, G. Eggertsen, I. Bjorkhem, G. Gil, Z. R. Vlahcevic, and P. B. Hylemon. 2001. Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo. Gastroenterology. 120: 1801-1809.
24. Bodin, K., U. Lindbom, and U. Diczfalusy. 2005. Novel pathways of bile acid metabolism involving CYP3A4. Biochim. Biophys. Acta. 1687: 84-93.
25. Xie, W., A. Radominska-Pandya, Y. Shi, C. M. Simon, M. C. Nelson, E. S. Ong, D. J. Waxman, and R. M. Evans. 2001. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc. Natl. Acad. Sci. USA. 98: 3375-3380.
26. Zollner, G., M. Wagner, T. Moustafa, P. Fickert, D. Silbert, J. Gumhold, A. Fuchsbichler, E. Halilbasic, H. Denk, H. U. Marschall, et al. 2006. Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids. Am. J. Physiol. 290: G923-G932.
27. Setchell, K. D., F. J. Suchy, M. B. Welsh, L. Zimmer-Nechemias, J. Heubi, and W. F. Balistreri. 1988. Delta 4-3-oxosteroid 5 beta-reductase deficiency described in identical twins with neonatal hepatitis. A new inborn error in bile acid synthesis. J. Clin. Invest. 82: 2148-2157.
28. Bjorkhem, I., and K. Einarsson. 1970. Formation and metabolism of 7alpha-hydroxy-5-alpha-cholestan-3-one and 7alpha,12alpha-dihydroxy-5-alpha- cholestan-3-one in rat liver. Eur. J. Biochem. 13: 174-179.
29. Torres, J. M., and E. Ortega. 2003. Precise quantitation of 5α-reductase type 1 mRNA by RT-PCR in rat liver and its positive regulation by testosterone and dihydrotestosterone. Biochem. Biophys. Res. Commun. 308: 469-473.
30. Kamiya, A., Y. Inoue, and F. J. Gonzalez. 2003. Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. Hepatology. 37: 1375-1384.
31. Henning, S. J. 1981. Postnatal development: coordination of feeding, digestion, and metabolism. Am. J. Physiol. 241: G199-G214.
32. Suchy, F. J., S. M. Courchene, and W. F. Balistreri. 1985. Ontogeny of hepatic bile acid conjugation in the rat. Pediatr. Res. 19: 97-101.
33. Schneider, B. L., P. A. Dawson, D. M. Christie, W. Hardikar, M. H. Wong, and F. J. Suchy. 1995. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. J. Clin. Invest. 95: 745-754.
34. Hwang, S. T., and S. J. Henning. 2000. Hormonal regulation of expression of ileal bile acid binding protein in suckling rats. Am. J. Physiol. 278: R1555-R1563.
35. Suchy, F. J., J. C. Bucuvalas, and D. A. Novak. 1987. Determinants of bile formation during development: ontogeny of hepatic bile acid metabolism and transport. Semin. Liver Dis. 7: 77-84.