메뉴 건너뛰기




Volumn 18, Issue 9, 2007, Pages 1157-1175

Searching for genes underlying susceptibility to osteoporotic fracture: Current progress and future prospect

Author keywords

Association study; Candidate genes; Genetic determination; Osteoporotic fracture; Risk of osteoporotic fracture

Indexed keywords

DISEASE PREDISPOSITION; FRAGILITY FRACTURE; GENE; GENETIC REGULATION; HUMAN; MOLECULAR GENETICS; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

EID: 34548130773     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-007-0402-4     Document Type: Review
Times cited : (24)

References (89)
  • 1
    • 26944458929 scopus 로고    scopus 로고
    • Epidemiology of osteoporotic fractures
    • Suppl 2
    • Johnell O, Kanis J (2005) Epidemiology of osteoporotic fractures. Osteoporos Int 16 Suppl 2:S3-S7
    • (2005) Osteoporos Int , vol.16
    • Johnell, O.1    Kanis, J.2
  • 4
    • 0026446492 scopus 로고
    • Hip fractures in the elderly: A world-wide projection
    • Cooper C, Campion G, Melton LJ, III (1992) Hip fractures in the elderly: a world-wide projection. Osteoporos Int 2:285-289
    • (1992) Osteoporos Int , vol.2 , pp. 285-289
    • Cooper, C.1    Campion, G.2    Melton III, L.J.3
  • 6
    • 0036136714 scopus 로고    scopus 로고
    • Relevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human diseases
    • Deng HW, Mahaney MC, Williams JT, Li J, Conway T, Davies KM, Li JL, Deng H, Recker RR (2002) Relevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human diseases. Genet Epidemiol 22:12-25
    • (2002) Genet Epidemiol , vol.22 , pp. 12-25
    • Deng, H.W.1    Mahaney, M.C.2    Williams, J.T.3    Li, J.4    Conway, T.5    Davies, K.M.6    Li, J.L.7    Deng, H.8    Recker, R.R.9
  • 7
    • 21644444684 scopus 로고    scopus 로고
    • Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD
    • Andrew T, Antioniades L, Scurrah KJ, Macgregor AJ, Spector TD (2005) Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD. J Bone Miner Res 20:67-74
    • (2005) J Bone Miner Res , vol.20 , pp. 67-74
    • Andrew, T.1    Antioniades, L.2    Scurrah, K.J.3    MacGregor, A.J.4    Spector, T.D.5
  • 8
    • 23844452335 scopus 로고    scopus 로고
    • Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density
    • Garnero P, Munoz F, Borel O, Sornay-Rendu E, Delmas PD (2005) Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density. J Clin Endocrinol Metab 90:4829-4835
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4829-4835
    • Garnero, P.1    Munoz, F.2    Borel, O.3    Sornay-Rendu, E.4    Delmas, P.D.5
  • 11
    • 0032862644 scopus 로고    scopus 로고
    • Family history of appendicular fracture and risk of osteoporosis: A population-based study
    • Keen RW, Hart DJ, Arden NK, Doyle DV, Spector TD (1999) Family history of appendicular fracture and risk of osteoporosis: a population-based study. Osteoporos Int 10:161-166
    • (1999) Osteoporos Int , vol.10 , pp. 161-166
    • Keen, R.W.1    Hart, D.J.2    Arden, N.K.3    Doyle, D.V.4    Spector, T.D.5
  • 12
    • 0031672985 scopus 로고    scopus 로고
    • Family history and risk of osteoporotic fracture. Study of Osteoporotic Fractures Research Group
    • Fox KM, Cummings SR, Powell-Threets K, Stone K (1998) Family history and risk of osteoporotic fracture. Study of Osteoporotic Fractures Research Group. Osteoporos Int 8:557-562
    • (1998) Osteoporos Int , vol.8 , pp. 557-562
    • Fox, K.M.1    Cummings, S.R.2    Powell-Threets, K.3    Stone, K.4
  • 13
    • 0034834403 scopus 로고    scopus 로고
    • Risk factors for osteoporosis related to their outcome: Fractures
    • van der Voort DJ, Geusens PP, Dinant GJ (2001) Risk factors for osteoporosis related to their outcome: fractures. Osteoporos Int 12:630-638
    • (2001) Osteoporos Int , vol.12 , pp. 630-638
    • Van Der Voort, D.J.1    Geusens, P.P.2    Dinant, G.J.3
  • 14
    • 0035852034 scopus 로고    scopus 로고
    • Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: Results from the National Osteoporosis Risk Assessment
    • Siris ES, Miller PD, Barrett-Connor E, Faulkner KG, Wehren LE, Abbott TA, Berger ML, Santora AC, Sherwood LM (2001) Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA 286:2815-2822
    • (2001) JAMA , vol.286 , pp. 2815-2822
    • Siris, E.S.1    Miller, P.D.2    Barrett-Connor, E.3    Faulkner, K.G.4    Wehren, L.E.5    Abbott, T.A.6    Berger, M.L.7    Santora, A.C.8    Sherwood, L.M.9
  • 15
  • 17
    • 0030023989 scopus 로고    scopus 로고
    • Axial bone mass in older women. Study of Osteoporotic Fractures Research Group
    • Orwoll ES, Bauer DC, Vogt TM, Fox KM (1996) Axial bone mass in older women. Study of Osteoporotic Fractures Research Group. Ann Intern Med 124:187-196
    • (1996) Ann Intern Med , vol.124 , pp. 187-196
    • Orwoll, E.S.1    Bauer, D.C.2    Vogt, T.M.3    Fox, K.M.4
  • 18
    • 0031444111 scopus 로고    scopus 로고
    • Bone mass and risk factors for bone loss in perimenopausal Danish women
    • Brot C, Jensen LB, Sorensen OH (1997) Bone mass and risk factors for bone loss in perimenopausal Danish women. J Intern Med 242:505-511
    • (1997) J Intern Med , vol.242 , pp. 505-511
    • Brot, C.1    Jensen, L.B.2    Sorensen, O.H.3
  • 21
    • 85007664256 scopus 로고    scopus 로고
    • Genetic factors and osteoporotic fractures in elderly people. Twin data support genetic contribution to risk of fracture
    • MacGregor A, Snieder H, Spector TD (2000) Genetic factors and osteoporotic fractures in elderly people. Twin data support genetic contribution to risk of fracture. BMJ 320:1669-1670
    • (2000) BMJ , vol.320 , pp. 1669-1670
    • MacGregor, A.1    Snieder, H.2    Spector, T.D.3
  • 23
    • 0030015906 scopus 로고    scopus 로고
    • Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in a high-endemic area of osteoporosis
    • Berg JP, Falch JA, Haug E (1996) Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in a high-endemic area of osteoporosis. Eur J Endocrinol 135:96-100
    • (1996) Eur J Endocrinol , vol.135 , pp. 96-100
    • Berg, J.P.1    Falch, J.A.2    Haug, E.3
  • 25
    • 0037559781 scopus 로고    scopus 로고
    • Do the COL1A1 and Taq 1 vitamin D receptor polymorphisms have a role in identifying individuals at risk of developing osteoporosis?
    • McClean E, Archbold GP, Taggart HM (2003) Do the COL1A1 and Taq 1 vitamin D receptor polymorphisms have a role in identifying individuals at risk of developing osteoporosis? Ulster Med J 72:26-33
    • (2003) Ulster Med J , vol.72 , pp. 26-33
    • McClean, E.1    Archbold, G.P.2    Taggart, H.M.3
  • 32
    • 0033790774 scopus 로고    scopus 로고
    • A TA repeat polymorphism in the estrogen receptor gene is associated with osteoporotic fractures but polymorphisms in the first exon and intron are not
    • Langdahl BL, Lokke E, Carstens M, Stenkjaer LL, Eriksen EF (2000) A TA repeat polymorphism in the estrogen receptor gene is associated with osteoporotic fractures but polymorphisms in the first exon and intron are not. J Bone Miner Res 15:2222-2230
    • (2000) J Bone Miner Res , vol.15 , pp. 2222-2230
    • Langdahl, B.L.1    Lokke, E.2    Carstens, M.3    Stenkjaer, L.L.4    Eriksen, E.F.5
  • 33
    • 0034641607 scopus 로고    scopus 로고
    • Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women
    • Becherini L, Gennari L, Masi L, Mansani R, Massart F, Morelli A, Falchetti A, Gonnelli S, Fiorelli G, Tanini A, Brandi ML (2000) Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women. Hum Mol Genet 9:2043-2050
    • (2000) Hum Mol Genet , vol.9 , pp. 2043-2050
    • Becherini, L.1    Gennari, L.2    Masi, L.3    Mansani, R.4    Massart, F.5    Morelli, A.6    Falchetti, A.7    Gonnelli, S.8    Fiorelli, G.9    Tanini, A.10    Brandi, M.L.11
  • 34
    • 0042164749 scopus 로고    scopus 로고
    • Mutational and polymorphic analysis of the estradiol receptor-alpha gene in men with symptomatic vertebral fractures
    • Allcroft LC, Varanasi SS, Dimopoulos D, Francis RM, Datta HK (2002) Mutational and polymorphic analysis of the estradiol receptor-alpha gene in men with symptomatic vertebral fractures. Calcif Tissue Int 71:400-405
    • (2002) Calcif Tissue Int , vol.71 , pp. 400-405
    • Allcroft, L.C.1    Varanasi, S.S.2    Dimopoulos, D.3    Francis, R.M.4    Datta, H.K.5
  • 36
    • 0030789557 scopus 로고    scopus 로고
    • The human type I collagen mutation database
    • Dalgleish R (1997) The human type I collagen mutation database. Nucleic Acids Res 25:181-187
    • (1997) Nucleic Acids Res , vol.25 , pp. 181-187
    • Dalgleish, R.1
  • 39
    • 0031703736 scopus 로고    scopus 로고
    • An Sp1 binding site polymorphism in the COLIA1 gene predicts osteoporotic fractures in both men and women
    • Langdahl BL, Ralston SH, Grant SF, Eriksen EF (1998) An Sp1 binding site polymorphism in the COLIA1 gene predicts osteoporotic fractures in both men and women. J Bone Miner Res 13:1384-1389
    • (1998) J Bone Miner Res , vol.13 , pp. 1384-1389
    • Langdahl, B.L.1    Ralston, S.H.2    Grant, S.F.3    Eriksen, E.F.4
  • 40
    • 1542720317 scopus 로고    scopus 로고
    • Association of the collagen type 1 (COL1A 1) Sp1 binding site polymorphism to femoral neck bone mineral density and wrist fracture in 1044 elderly Swedish women
    • Gerdhem P, Brandstrom H, Stiger F, Obrant K, Melhus H, Ljunggren O, Kindmark A, Akesson K (2004) Association of the collagen type 1 (COL1A 1) Sp1 binding site polymorphism to femoral neck bone mineral density and wrist fracture in 1044 elderly Swedish women. Calcif Tissue Int 74:264-269
    • (2004) Calcif Tissue Int , vol.74 , pp. 264-269
    • Gerdhem, P.1    Brandstrom, H.2    Stiger, F.3    Obrant, K.4    Melhus, H.5    Ljunggren, O.6    Kindmark, A.7    Akesson, K.8
  • 41
    • 0034043309 scopus 로고    scopus 로고
    • Susceptibility to osteoporotic fracture is determined by allelic variation at the Sp1 site, rather than other polymorphic sites at the COL1A1 locus
    • McGuigan FE, Reid DM, Ralston SH (2000) Susceptibility to osteoporotic fracture is determined by allelic variation at the Sp1 site, rather than other polymorphic sites at the COL1A1 locus. Osteoporos Int 11:338-343
    • (2000) Osteoporos Int , vol.11 , pp. 338-343
    • McGuigan, F.E.1    Reid, D.M.2    Ralston, S.H.3
  • 42
    • 0034741919 scopus 로고    scopus 로고
    • Association of collagen Ialpha 1 Sp1 polymorphism with the risk of prevalent fractures: A meta-analysis
    • Efstathiadou Z, Tsatsoulis A, Ioannidis JP (2001) Association of collagen Ialpha 1 Sp1 polymorphism with the risk of prevalent fractures: a meta-analysis. J Bone Miner Res 16:1586-1592
    • (2001) J Bone Miner Res , vol.16 , pp. 1586-1592
    • Efstathiadou, Z.1    Tsatsoulis, A.2    Ioannidis, J.P.3
  • 43
    • 0142124733 scopus 로고    scopus 로고
    • Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture
    • Mann V, Ralston SH (2003) Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture. Bone 32:711-717
    • (2003) Bone , vol.32 , pp. 711-717
    • Mann, V.1    Ralston, S.H.2
  • 44
    • 2942683420 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern Chinese women
    • Lau HH, Ho AY, Luk KD, Kung AW (2004) Transforming growth factor-beta1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern Chinese women. Calcif Tissue Int 74:516-521
    • (2004) Calcif Tissue Int , vol.74 , pp. 516-521
    • Lau, H.H.1    Ho, A.Y.2    Luk, K.D.3    Kung, A.W.4
  • 45
    • 0041832354 scopus 로고    scopus 로고
    • The T869C TGF beta polymorphism is associated with fracture, bone mineral density, and calcaneal quantitative ultrasound in elderly women
    • Dick IM, Devine A, Li S, Dhaliwal SS, Prince RL (2003) The T869C TGF beta polymorphism is associated with fracture, bone mineral density, and calcaneal quantitative ultrasound in elderly women. Bone 33:335-341
    • (2003) Bone , vol.33 , pp. 335-341
    • Dick, I.M.1    Devine, A.2    Li, S.3    Dhaliwal, S.S.4    Prince, R.L.5
  • 46
    • 16844371643 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD
    • Villadsen MM, Bunger MH, Carstens M, Stenkjaer L, Langdahl BL (2005) Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. Osteoporos Int 16:411-416
    • (2005) Osteoporos Int , vol.16 , pp. 411-416
    • Villadsen, M.M.1    Bunger, M.H.2    Carstens, M.3    Stenkjaer, L.4    Langdahl, B.L.5
  • 48
    • 0035992658 scopus 로고    scopus 로고
    • Alleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fracture
    • Vaughan T, Pasco JA, Kotowicz MA, Nicholson GC, Morrison NA (2002) Alleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fracture. J Bone Miner Res 17:1527-1534
    • (2002) J Bone Miner Res , vol.17 , pp. 1527-1534
    • Vaughan, T.1    Pasco, J.A.2    Kotowicz, M.A.3    Nicholson, G.C.4    Morrison, N.A.5
  • 49
    • 0034006946 scopus 로고    scopus 로고
    • Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1-receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene
    • Langdahl BL, Lokke E, Carstens M, Stenkjaer LL, Eriksen EF (2000) Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1-receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene. J Bone Miner Res 15:402-414
    • (2000) J Bone Miner Res , vol.15 , pp. 402-414
    • Langdahl, B.L.1    Lokke, E.2    Carstens, M.3    Stenkjaer, L.L.4    Eriksen, E.F.5
  • 50
    • 0042733421 scopus 로고    scopus 로고
    • Association between polymorphisms of apolipoprotein E, bone mineral density of the lower forearm, quantitative ultrasound of the calcaneus and osteoporotic fractures in postmenopausal women with hip or lower forearm fracture
    • Sennels HP, Sand JC, Madsen B, Lauritzen JB, Fenger M, Jorgensen HL (2003) Association between polymorphisms of apolipoprotein E, bone mineral density of the lower forearm, quantitative ultrasound of the calcaneus and osteoporotic fractures in postmenopausal women with hip or lower forearm fracture. Scand J Clin Lab Invest 63:247-258
    • (2003) Scand J Clin Lab Invest , vol.63 , pp. 247-258
    • Sennels, H.P.1    Sand, J.C.2    Madsen, B.3    Lauritzen, J.B.4    Fenger, M.5    Jorgensen, H.L.6
  • 52
    • 0035991255 scopus 로고    scopus 로고
    • Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures
    • Langdahl BL, Carstens M, Stenkjaer L, Eriksen EF (2002) Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures. J Bone Miner Res 17:1245-1255
    • (2002) J Bone Miner Res , vol.17 , pp. 1245-1255
    • Langdahl, B.L.1    Carstens, M.2    Stenkjaer, L.3    Eriksen, E.F.4
  • 53
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33:177-182
    • (2003) Nat Genet , vol.33 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3    Lander, E.S.4    Hirschhorn, J.N.5
  • 54
    • 0036255811 scopus 로고    scopus 로고
    • Candidate-gene approaches for studying complex genetic traits: Practical considerations
    • Tabor HK, Risch NJ, Myers RM (2002) Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat Rev Genet 3:391-397
    • (2002) Nat Rev Genet , vol.3 , pp. 391-397
    • Tabor, H.K.1    Risch, N.J.2    Myers, R.M.3
  • 55
    • 14344259508 scopus 로고    scopus 로고
    • Nonreplication in genetic studies of complex diseases-lessons learned from studies of osteoporosis and tentative remedies
    • Shen H, Liu Y, Liu P, Recker RR, Deng HW (2005) Nonreplication in genetic studies of complex diseases-lessons learned from studies of osteoporosis and tentative remedies. J Bone Miner Res 20:365-376
    • (2005) J Bone Miner Res , vol.20 , pp. 365-376
    • Shen, H.1    Liu, Y.2    Liu, P.3    Recker, R.R.4    Deng, H.W.5
  • 57
    • 0035679875 scopus 로고    scopus 로고
    • Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits
    • Deng HW (2001) Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits. Genetics 159:1319-1323
    • (2001) Genetics , vol.159 , pp. 1319-1323
    • Deng, H.W.1
  • 58
    • 0031028361 scopus 로고    scopus 로고
    • Transmission-disequilibrium tests for quantitative traits
    • Allison DB (1997) Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet 60:676-690
    • (1997) Am J Hum Genet , vol.60 , pp. 676-690
    • Allison, D.B.1
  • 59
    • 0036223601 scopus 로고    scopus 로고
    • Role of genetics in osteoporosis
    • Recker RR, Deng HW (2002) Role of genetics in osteoporosis. Endocrine 17:55-66
    • (2002) Endocrine , vol.17 , pp. 55-66
    • Recker, R.R.1    Deng, H.W.2
  • 62
    • 0031658699 scopus 로고    scopus 로고
    • Quality assurance and quality control in longitudinal studies
    • Whitney CW, Lind BK, Wahl PW (1998) Quality assurance and quality control in longitudinal studies. Epidemiol Rev 20:71-80
    • (1998) Epidemiol Rev , vol.20 , pp. 71-80
    • Whitney, C.W.1    Lind, B.K.2    Wahl, P.W.3
  • 63
    • 0035131982 scopus 로고    scopus 로고
    • The impact of genotyping error on family-based analysis of quantitative traits
    • Abecasis GR, Cherny SS, Cardon LR (2001) The impact of genotyping error on family-based analysis of quantitative traits. Eur J Hum Genet 9:130-134
    • (2001) Eur J Hum Genet , vol.9 , pp. 130-134
    • Abecasis, G.R.1    Cherny, S.S.2    Cardon, L.R.3
  • 64
    • 1842859051 scopus 로고    scopus 로고
    • Power and sample size calculations for case-control genetic association tests when errors are present: Application to single nucleotide polymorphisms
    • Gordon D, Finch SJ, Nothnagel M, Ott J (2002) Power and sample size calculations for case-control genetic association tests when errors are present: application to single nucleotide polymorphisms. Hum Hered 54:22-33
    • (2002) Hum Hered , vol.54 , pp. 22-33
    • Gordon, D.1    Finch, S.J.2    Nothnagel, M.3    Ott, J.4
  • 66
    • 0032714352 scopus 로고    scopus 로고
    • Genomic control for association studies
    • Devlin B, Roeder K (1999) Genomic control for association studies. Biometrics 55:997-1004
    • (1999) Biometrics , vol.55 , pp. 997-1004
    • Devlin, B.1    Roeder, K.2
  • 69
    • 0036682217 scopus 로고    scopus 로고
    • International Meta-analysis of HIV Host Genetics. Commentary: Meta-analysis of individual participants' data in genetic epidemiology
    • Ioannidis JP, Rosenberg PS, Goedert JJ, O'Brien TR (2002) International Meta-analysis of HIV Host Genetics. Commentary: meta-analysis of individual participants' data in genetic epidemiology. Am J Epidemiol 156:204-210
    • (2002) Am J Epidemiol , vol.156 , pp. 204-210
    • Ioannidis, J.P.1    Rosenberg, P.S.2    Goedert, J.J.3    O'Brien, T.R.4
  • 70
    • 29944445973 scopus 로고    scopus 로고
    • Two strategies to identify genes underlying complex diseases
    • Lei SF, Wu S, Li LM, Deng HW (2005) Two strategies to identify genes underlying complex diseases. Current Genomics 6:551-561
    • (2005) Current Genomics , vol.6 , pp. 551-561
    • Lei, S.F.1    Wu, S.2    Li, L.M.3    Deng, H.W.4
  • 71
    • 0032835425 scopus 로고    scopus 로고
    • Vitamin D receptor gene polymorphisms and the risk of fractures in older women. for the Study of Osteoporotic Fractures Research Group
    • Ensrud KE, Stone K, Cauley JA, White C, Zmuda JM, Nguyen TV, Eisman JA, Cummings SR (1999) Vitamin D receptor gene polymorphisms and the risk of fractures in older women. For the Study of Osteoporotic Fractures Research Group. J Bone Miner Res 14:1637-1645
    • (1999) J Bone Miner Res , vol.14 , pp. 1637-1645
    • Ensrud, K.E.1    Stone, K.2    Cauley, J.A.3    White, C.4    Zmuda, J.M.5    Nguyen, T.V.6    Eisman, J.A.7    Cummings, S.R.8
  • 72
    • 0032812623 scopus 로고    scopus 로고
    • FokI polymorphism at translation initiation site of the vitamin D receptor gene predicts bone mineral density and vertebral fractures in postmenopausal Italian women
    • Gennari L, Becherini L, Mansani R, Masi L, Falchetti A, Morelli A, Colli E, Gonnelli S, Cepollaro C, Brandi ML (1999) FokI polymorphism at translation initiation site of the vitamin D receptor gene predicts bone mineral density and vertebral fractures in postmenopausal Italian women. J Bone Miner Res 14:1379-1386
    • (1999) J Bone Miner Res , vol.14 , pp. 1379-1386
    • Gennari, L.1    Becherini, L.2    Mansani, R.3    Masi, L.4    Falchetti, A.5    Morelli, A.6    Colli, E.7    Gonnelli, S.8    Cepollaro, C.9    Brandi, M.L.10
  • 73
    • 0033945139 scopus 로고    scopus 로고
    • Polymorphisms in the vitamin D receptor gene and bone mass, bone turnover and osteoporotic fractures
    • Langdahl BL, Gravholt CH, Brixen K, Eriksen EF (2000) Polymorphisms in the vitamin D receptor gene and bone mass, bone turnover and osteoporotic fractures. Eur J Clin Invest 30:608-617
    • (2000) Eur J Clin Invest , vol.30 , pp. 608-617
    • Langdahl, B.L.1    Gravholt, C.H.2    Brixen, K.3    Eriksen, E.F.4
  • 74
    • 0033797802 scopus 로고    scopus 로고
    • Polymorphisms of the VDR, ER and COLIA1 genes and osteoporotic hip fracture in elderly postmenopausal women
    • Aerssens J, Dequeker J, Peeters J, Breemans S, Broos P, Boonen S (2000) Polymorphisms of the VDR, ER and COLIA1 genes and osteoporotic hip fracture in elderly postmenopausal women. Osteoporos Int 11:583-591
    • (2000) Osteoporos Int , vol.11 , pp. 583-591
    • Aerssens, J.1    Dequeker, J.2    Peeters, J.3    Breemans, S.4    Broos, P.5    Boonen, S.6
  • 75
    • 0035147604 scopus 로고    scopus 로고
    • Relation of collagen type I alpha 1 (COLIA 1) and vitamin D receptor genotypes to bone mass, turnover, and fractures in early postmenopausal women and to hip fractures in elderly people
    • Valimaki S, Tahtela R, Kainulainen K, Laitinen K, Loyttyniemi E, Sulkava R, Valimaki M, Kontula K (2001) Relation of collagen type I alpha 1 (COLIA 1) and vitamin D receptor genotypes to bone mass, turnover, and fractures in early postmenopausal women and to hip fractures in elderly people. Eur J Intern Med 12:48-56
    • (2001) Eur J Intern Med , vol.12 , pp. 48-56
    • Valimaki, S.1    Tahtela, R.2    Kainulainen, K.3    Laitinen, K.4    Loyttyniemi, E.5    Sulkava, R.6    Valimaki, M.7    Kontula, K.8
  • 76
    • 0037170846 scopus 로고    scopus 로고
    • Estrogen receptor alpha polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogen
    • Kobayashi N, Fujino T, Shirogane T, Furuta I, Kobamatsu Y, Yaegashi M, Sakuragi N, Fujimoto S (2002) Estrogen receptor alpha polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogen. Maturitas 41:193-201
    • (2002) Maturitas , vol.41 , pp. 193-201
    • Kobayashi, N.1    Fujino, T.2    Shirogane, T.3    Furuta, I.4    Kobamatsu, Y.5    Yaegashi, M.6    Sakuragi, N.7    Fujimoto, S.8
  • 78
    • 0031666593 scopus 로고    scopus 로고
    • Polymorphism at the Sp 1 binding site in the collagen type I alpha 1 gene does not predict bone mineral density in postmenopausal women in sweden
    • Liden M, Wilen B, Ljunghall S, Melhus H (1998) Polymorphism at the Sp 1 binding site in the collagen type I alpha 1 gene does not predict bone mineral density in postmenopausal women in sweden. Calcif Tissue Int 63:293-295
    • (1998) Calcif Tissue Int , vol.63 , pp. 293-295
    • Liden, M.1    Wilen, B.2    Ljunghall, S.3    Melhus, H.4
  • 79
    • 0033005248 scopus 로고    scopus 로고
    • Association of polymorphism at the type I collagen (COL1A1) locus with reduced bone mineral density, increased fracture risk, and increased collagen turnover
    • Keen RW, Woodford-Richens KL, Grant SF, Ralston SH, Lanchbury JS, Spector TD (1999) Association of polymorphism at the type I collagen (COL1A1) locus with reduced bone mineral density, increased fracture risk, and increased collagen turnover. Arthritis Rheum 42:285-290
    • (1999) Arthritis Rheum , vol.42 , pp. 285-290
    • Keen, R.W.1    Woodford-Richens, K.L.2    Grant, S.F.3    Ralston, S.H.4    Lanchbury, J.S.5    Spector, T.D.6
  • 80
    • 0032955104 scopus 로고    scopus 로고
    • Polymorphism at an Sp1 binding site of COL1A1 and bone mineral density in premenopausal female twins and elderly fracture patients
    • Hustmyer FG, Liu G, Johnston CC, Christian J, Peacock M (1999) Polymorphism at an Sp1 binding site of COL1A1 and bone mineral density in premenopausal female twins and elderly fracture patients. Osteoporos Int 9:346-350
    • (1999) Osteoporos Int , vol.9 , pp. 346-350
    • Hustmyer, F.G.1    Liu, G.2    Johnston, C.C.3    Christian, J.4    Peacock, M.5
  • 81
    • 0343986447 scopus 로고    scopus 로고
    • COLIA1 polymorphism contributes to bone mineral density to assess prevalent wrist fractures
    • Weichetova M, Stepan JJ, Michalska D, Haas T, Pols HA, Uitterlinden AG (2000) COLIA1 polymorphism contributes to bone mineral density to assess prevalent wrist fractures. Bone 26:287-290
    • (2000) Bone , vol.26 , pp. 287-290
    • Weichetova, M.1    Stepan, J.J.2    Michalska, D.3    Haas, T.4    Pols, H.A.5    Uitterlinden, A.G.6
  • 83
    • 0030999773 scopus 로고    scopus 로고
    • A sequence variation: 713-8delC in the transforming growth factor-beta 1 gene has higher prevalence in osteoporotic women than in normal women and is associated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women
    • Langdahl BL, Knudsen JY, Jensen HK, Gregersen N, Eriksen EF (1997) A sequence variation: 713-8delC in the transforming growth factor-beta 1 gene has higher prevalence in osteoporotic women than in normal women and is associated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women. Bone 20:289-294
    • (1997) Bone , vol.20 , pp. 289-294
    • Langdahl, B.L.1    Knudsen, J.Y.2    Jensen, H.K.3    Gregersen, N.4    Eriksen, E.F.5
  • 84
    • 0038099459 scopus 로고    scopus 로고
    • Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. a case control study in Danish postmenopausal women
    • Jorgensen HL, Madsen JS, Madsen B, Saleh MM, Abrahamsen B, Fenger M, Lauritzen JB (2002) Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women. Calcif Tissue Int 71:386-392
    • (2002) Calcif Tissue Int , vol.71 , pp. 386-392
    • Jorgensen, H.L.1    Madsen, J.S.2    Madsen, B.3    Saleh, M.M.4    Abrahamsen, B.5    Fenger, M.6    Lauritzen, J.B.7
  • 85
    • 33846214713 scopus 로고    scopus 로고
    • The Effect of Interleukin-1alpha Polymorphisms on Bone Mineral Density and the Risk of Vertebral Fractures
    • Knudsen S, Harslof T, Husted LB, Carstens M, Stenkjaer L, Langdahl BL. (2007) The Effect of Interleukin-1alpha Polymorphisms on Bone Mineral Density and the Risk of Vertebral Fractures. Calcif Tissue Int 80:21-30
    • (2007) Calcif Tissue Int , vol.80 , pp. 21-30
    • Knudsen, S.1    Harslof, T.2    Husted, L.B.3    Carstens, M.4    Stenkjaer, L.5    Langdahl, B.L.6
  • 89
    • 33748659273 scopus 로고    scopus 로고
    • Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: The Dubbo Osteoporosis Epidemiology Study (DOES)
    • Wang CY, Nguyen ND, Morrison NA, Eisman JA, Center JR, Nguyen TV (2006) Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). BMC Med Genet 5:57
    • (2006) BMC Med Genet , vol.5 , pp. 57
    • Wang, C.Y.1    Nguyen, N.D.2    Morrison, N.A.3    Eisman, J.A.4    Center, J.R.5    Nguyen, T.V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.