Increased urinary cystatin C reflects structural and functional renal tubular impairment independent of glomerular filtration rate

Clinical Biochemistry

Volumn 40, Issue 13-14, 2007, Pages 946-951

  Herget Rosenthal, Stefan ^a   van Wijk, Joanna A E ^a   Bröcker Preuss, Martina ^a   Bökenkamp, Arend ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Chronic kidney disease; Creatinine; Cystatin C; Glomerular filtration rate; ROC; Sensitivity and specificity

Indexed keywords

BIOLOGICAL MARKER; CREATINE; CREATININE; CYSTATIN C; PROTEIN;

ADOLESCENT; ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CHILD; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; GLOMERULOPATHY; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEINURIA; ROC CURVE; TUBULAR DYSFUNCTION;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CREATININE; CYSTATINS; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY DISEASES; KIDNEY TUBULES; MALE; MIDDLE AGED; ROC CURVE;

EID: 34548120847     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2007.04.013     Document Type: Article

References (35)

1. El Nahas A.M., and Bello A.K. Chronic kidney disease: the global challenge. Lancet 365 (2005) 331-340
2. Levey A.S., Eckardt K.U., Tsukamoto Y., et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 67 (2005) 2089-2100
3. Go A.S., Chertow G.M., Fan D., McCulloch C.E., and Hsu C.Y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Engl. J. Med. 351 (2004) 1296-1305
4. Vanholder R., Massry Z., Argiles A., Spasovski G., Verbeke F., and Lameire N. Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol. Dial. Transplant. 20 (2005) 1048-1056
5. De Nicola L., Minutolo R., Chiodini P., et al. Global approach to cardiovascular risk in chronic kidney disease: reality and opportunities for intervention. Kidney Int. 69 (2006) 538-545
6. Perrone R.D., Madias N.E., and Levey A.S. Serum creatinine as an index of renal function: new insights into old concepts. Clin. Chem. 38 (1992) 1933-1953
7. Herget-Rosenthal S., Bokenkamp A., and Hofmann W. How to estimate GFR - serum creatinine serum cystatin C or equations?. Clin. Biochem. 40 (2007) 153-161
8. Hellerstein S., Berenbom M., Erwin P., Wilson N., and DiMaggio S. The ratio of urinary cystatin C to urinary creatinine for detecting decreased GFR. Pediatr. Nephrol. 19 (2004) 521-525
9. Abrahamson M., Olafsson I., Palsdottir A., Ulvsbaeck M., Lundwall A., and Grubb A. Structure and expression of the human cystatin C gene. Biochem. J. 268 (1990) 287-294
10. Tenstad O., Roald A.B., Grubb A., and Aukland K. Renal handling of radiolabelled human cystatin C in the rat. Scand. J. Clin. Lab. Invest. 56 (1996) 409-414
11. Herget-Rosenthal S., Feldkamp T., Volbracht L., and Kribben A. Measurement of urinary cystatin C by particle enhanced nephelometric immunoassay: precision, interferences, stability and reference range. Ann. Clin. Biochem. 41 (2004) 111-118
12. Tian S., Kusano E., Ohara T., et al. Cystatin C measurement and its practical use in patients with various renal diseases. Clin. Nephrol. 48 (1997) 104-108
13. Maack T., Johnson V., Kau S.T., Figueiredo J., and Sigulem D. Renal filtration, transportation, and metabolism of low-molecular-weight proteins: a review. Kidney Int. 16 (1979) 251-270
14. Tomlinson P.A., Dalton R.N., Hartley B., Haycock G.B., and Chantler C. Low molecular weight protein excretion in glomerular disease: a comparative analysis. Pediatr. Nephrol. 11 (1997) 285-290
15. Thielemans N., Lauwerys R., and Bernard A. Competition between albumin and low-molecular-weight proteins for renal tubular uptake in experimental nephropathies. Nephron 66 (1994) 453-458
16. Tkaczyk M., Nowicki M., and Lukamowicz J. Increased cystatin C concentration in urine of nephrotic children. Pediatr. Nephrol. 19 (2004) 1278-1280
17. Risch L., Herklotz R., Blumberg A., and Huber A.R. Effects of glucocorticoid immunosuppression on serum cystatin C concentrations in renal transplant patients. Clin. Chem. 47 (2001) 2055-2059
18. Fricker M., Wiesli P., Brandle M., Schwegler B., and Schmid C. Impact of thyroid dysfunction on serum cystatin C. Kidney Int. 63 (2003) 1944-1947
19. Klasen I.S., Reichert L.J.M., De Kat Angelino C.M., and Wetzels J.F.M. Quantitative determination of low and high molecular proteins in human urine. Influence of temperature and storage time. Clin. Chem. 45 (1999) 430-432
20. Finney H., Newman D.J., Gruber W., Merle P., and Price C.P. Initial evaluation of cystatin C measurement by particle-enhanced immunonephelometry on the Behring nephelometer systems (BNA, BN II). Clin. Chem. 43 (1997) 1016-1022
21. Levey A.S., Coresh J., Greene T., et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann. Intern. Med. 145 (2006) 247-254
22. Newman D.J., Pugia M.J., Lott J.A., Wallace J.F., and Hiar A.M. Urinary protein and albumin excretion corrected by creatinine and specific gravity. Clin. Chim. Acta 294 (2000) 139-155
23. Ivandic M., Hofmann W., and Guder W.G. Development and evaluation of a urine protein expert system. Clin. Chem. 42 (1996) 1214-1222
24. Schwartz G.J., Haycock G.B., Edelmann C.B., and Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58 (1976) 259-263
25. Filler G., and Lepage N. Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula?. Pediatr. Nephrol. 18 (2003) 981-985
26. Hoek F.J., Kemperman F.A., and Krediet R.T. A comparison between cystatin, C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate. Nephrol. Dial. Transplant. 18 (2003) 2024-2031
27. Kabanda A., Jadoul M., Lauwerys R., Bernard A., and Van Ypersele de Strihou C. Low molecular weight proteinuria in Chinese herbs nephropathy. Kidney Int. 48 (1995) 1571-1576
28. Uchida K., and Gotoh A. Measurement of cystatin C and creatinine in urine. Clin. Chim. Acta 323 (2002) 121-128
29. Kubota R., Machii R., Hiratsuka N., et al. Cellulose acetate membrane electrophoresis in the analysis of urinary proteins in patients with tubulointerstitial nephritis. J. Clin. Lab. Anal. 17 (2003) 44-51
30. Herget-Rosenthal S., Poppen D., Husing J., et al. Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis. Clin. Chem. 50 (2004) 552-558
31. Conti M., Moutereau S., Zater M., et al. Urinary cystatin C as a specific marker of tubular dysfunction. Clin. Chem. Lab. Med. 44 (2006) 288-291
32. Nath K.A. The tubulointerstitium in progressive renal disease. Kidney Int. 54 (1998) 992-994
33. Dharnidharka V.R., Kwon C., and Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am. J. Kidney Dis. 40 (2002) 221-226
34. Poge U., Gerhardt T., Palmedo H., Klehr H.U., Sauerbruch T., and Woitas R.P. MDRD equations for estimation of GFR in renal transplant recipients. Am. J. Transplant. 5 (2005) 1306-1311
35. Poge U., Gerhardt T., Stoffel-Wagner B., et al. Cystatin C-based calculation of glomerular filtration rate in kidney transplant recipients. Kidney Int. 70 (2006) 204-210