How to estimate GFR-serum creatinine, serum cystatin C or equations?

Clinical Biochemistry

Volumn 40, Issue 3-4, 2007, Pages 153-161

  Herget Rosenthal, Stefan ^a   Bökenkamp, Arend ^b   Hofmann, Walter ^c  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Institute of Clinical Chemistry and Immunology   (Germany)

Author keywords

Chronic kidney disease; Creatinine; Cystatin C; Glomerular filtration rate; MDRD equation

Indexed keywords

CREATININE; CYSTATIN C;

ANTHROPOMETRIC PARAMETERS; CARDIOVASCULAR DISEASE; CLINICAL DECISION MAKING; CREATININE BLOOD LEVEL; DIAGNOSTIC VALUE; GLOMERULUS FILTRATION RATE; HUMAN; MATHEMATICAL ANALYSIS; MOLECULAR WEIGHT; PRIORITY JOURNAL; REVIEW; SENSITIVITY ANALYSIS; THYROID DISEASE;

EID: 33846242959     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2006.10.014     Document Type: Review

References (101)

1. Gilbertson D.T., Liu J., Xue J.L., et al. Projecting the number of patients with end-stage renal disease in the United States to the year 2015. J. Am. Soc. Nephrol. 16 (2005) 3736-3741
2. Levey A.S., Eckardt K.U., Tsukamoto Y., et al. Definition and classification of chronic kidney disease: a position statement from kidney disease: Improving Global Outcomes (KDIGO). Kidney Int. 67 (2005) 2089-2100
3. Perrone R.D., Madias N.E., and Levey A.S. Serum creatinine as an index of renal function: new insights into old concepts. Clin. Chem. 38 (1992) 1933-1953
4. Rahn K.H., Heidenreich S., and Bruckner D. How to assess glomerular function and damage in humans. J. Hypertens 17 (1999) 309-317
5. Blaufox M.D., Aurell M., Bubeck B., et al. Report of the radionuclides in nephrology committee on renal clearance. J. Nucl. Med. 37 (1996) 1883-1890
6. Fleming J.S., Zivanovic M.A., Blake G.M., Burniston M., and Cosgriff P.S. Guidelines for the measurement of glomerular filtration rate using plasma sampling. Nucl. Med. Commun. 25 (2004) 759-769
7. Keevil B.G., Kilpatrick E.S., Nichols S.P., and Maylor P.W. Biological variation of cystatin C: implications for the assessment of glomerular filtration rate. Clin. Chem. 44 (1998) 1535-1539
8. Owen J.A., Iggo B., Scandrett F.J., and Stewart C.P. The determination of creatinine in plasma or serum, and urine, a critical examination. Biochem. J. 58 (1954) 426-437
9. Wahlefeld A.W., Herz G., and Bergmeyer H.U. A completely enzymatic determination of creatinine in human sera or urine. Scand. J. Clin. Lab. Invest., Suppl. 29 (1972) 126
10. Lamb E.J., Wood J., Stowe H.J., O'Riordan E., Webb M., and Dalton R.N. Susceptibility of glomerular filtration rate estimations to variations in creatinine methodology: a study in older patients. Ann. Clin. Biochem. 42 (2005) 11-18
11. Myers G.L., Miller W.G., Coresh J., et al. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney disease Education Program. Clin. Chem. 52 (2006) 5-18
12. Levey A.S., Coresh J., Balk E., et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann. Intern. Med. 139 (2003) 137-147
13. Bauer J.H., Brooks C.S., and Burch R.N. Clinical appraisal of creatinine clearance as a measurement of glomerular filtration rate. Am. J. Kidney Dis. 2 (1982) 337-346
14. Van Acker B.A., Koomen G.C., Koopman M.G., de Waart D.R., and Arisz L. Creatinine clearance during cimetidine administration for measurement of glomerular filtration rate. Lancet 340 (1992) 1326-1329
15. Hellerstein S., Berenbom M., Alon U.S., and Warady B.A. Creatinine clearance following cimetidine for estimation of glomerular filtration rate. Pediatr. Nephrol. 12 (1998) 49-54
16. Schwartz G.J., Haycock G.B., Edelmann C.M., and Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58 (1976) 259-263
17. Cockcroft D.W., and Gault M.H. Prediction of creatinine clearance from serum creatinine. Nephron 16 (1976) 31-41
18. Levey A.S., Bosch J.P., Lewis J.B., Greene T., Rogers N., and Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann. Intern. Med. 130 (1999) 461-470
19. Schwartz G.J., Brion L.P., and Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr. Clin. North Am. 34 (1987) 571-590
20. Levey A.S., Greene T., Kusek J.W., Beck G.J., and Group M.S. A simplified equation to predict glomerular filtration rate from serum creatinine [Abstract]. J. Am. Soc. Nephrol. 11 (2000) A0828
21. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am. J. Kidney Dis. 39 Suppl. 2 (2002) S1-S266
22. Van Biesen W., Vanholder R., Veys N., et al. The importance of standardization of creatinine in the implementation of guidelines and recommendations for CKD: implications for CKD management programmes. Nephrol. Dial. Transplant. 21 (2006) 77-83
23. Murthy K., Stevens L.A., Strak P.C., and Levey A.S. Variation in the serum creatinine assay calibration: a practical application to glomerular filtration rate estimation. Kidney Int. 68 (2005) 1884-1887
24. Levey A.S., Coresh J., Greene T., et al. Using standardize serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann. Intern. Med. 145 (2006) 247-254
25. Bostom A.G., Kronenberg F., and Ritz E. Predictive performance of renal function equations for patients with chronic kidney disease and normal serum creatinine levels. J. Am. Soc. Nephrol. 13 (2002) 2140-2144
26. Rule A.D., Larson T.S., Bergstralh E.J., Slezak J.M., Jacobsen S.J., and Cosio F.G. Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease. Ann. Intern. Med. 141 (2004) 929-937
27. Poggio E.D., Nef P.C., Wang X., Greene T., Van Lente F., Dennis V.W., et al. Performance of the Cockcroft-Gault and modification of diet in renal disease equations in estimating GFR in ill hospitalized patients. Am. J. Kidney Dis. 46 (2005) 242-252
28. Branten A.J., Vervoort G., and Wetzels J.F. Serum creatinine is a poor marker of GFR in nephrotic syndrome. Nephrol. Dial. Transplant. 20 (2005) 707-711
29. Rule A.D., Gussak H.M., Pond G.R., et al. Measured and estimated GFR in healthy potential kidney donors. Am. J. Kidney Dis. 43 (2004) 112-119
30. Jafar T.H., Schmid C.H., and Levey A.S. Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan. J. Am. Soc. Nephrol. 16 (2005) 1413-1419
31. Zuo L., Ma Y.C., Zhou Y.H., Wang M., Xu G.B., and Wang H.Y. Application of GFR-estimating equations in Chinese patients with chronic kidney disease. Am. J. Kidney Dis. 45 (2005) 463-472
32. Perkins B.A., Nelson R.G., Ostrander B.E., et al. Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up study. J. Am. Soc. Nephrol. 16 (2005) 1404-1412
33. Cirillo M., Anastasio P., and De Santo N.G. Relationship of gender, age, and body mass index to errors in predicted kidney function. Nephrol. Dial. Transplant. 20 (2005) 1791-1798
34. Stevens L.A., and Levey A.S. Clinical implications of estimating equations for glomerular filtration. Ann. Intern. Med. 141 (2004) 959-961
35. Rule A.D., Bergstralh E.J., Slezak J.M., Bergert J., and Larson T.S. Glomerular filtration rate estimated by cystatin C among different clinical presentations. Kidney Int. 69 (2006) 399-405
36. Grubb A.O. Cystatin C-properties and use as diagnostic marker. Adv. Clin. Chem. 35 (2000) 63-99
37. Tenstad O., Roald A.B., Grubb A., and Aukland K. Renal handling of radiolabelled human cystatin C in the rat. Scand. J. Clin Lab. Invest. 56 (1996) 409-414
38. Filler G., Bökenkamp A., Hofmann W., LeBricon T., Martinez-Bru C., and Grubb A. Cystatin C as a marker of GFR-history, indications, and future research. Clin. Biochem. 38 (2005) 1-8
39. Bokenkamp A., Domanetzki M., Zinck R., Schumann G., Byrd D., and Brodehl J. Cystatin C-A new marker of glomerular filtration rate in children independent of age and height. Pediatrics 101 (1998) 875-881
40. Tan G.D., Lewis A.V., James T.J., Altmann P., Taylor R.P., and Levy J.C. Clinical usefulness of cystatin C for the estimation of glomerular filtration rate in type 1 diabetes. Diabetes Care 25 (2002) 2004-2009
41. Christensson A., Ekberg J., Grubb A., Ekberg H., Lindstrom V., and Lilja H. Serum cystatin C is a more sensitive and more accurate marker of glomerular filtration rate than enzymatic measurements of creatinine in renal transplantation. Nephron. Physiol. 94 (2003) p19-p27
42. Orlando R., Mussap M., Plebani M., et al. Diagnostic value of plasma cystatin C as a glomerular filtration marker in decompensated liver cirrhosis. Clin. Chem. 48 (2002) 850-858
43. Stabuc B., Vrhovec L., Stabuc-Silih M., and Cizej T.E. Improved prediction of decreased creatinine clearance by serum cystatin C: use in cancer patients before and during chemotherapy. Clin. Chem. 46 (2000) 193-197
44. Lamb E.J., Stowe H., Simpson D.E., Coakley A.J., Newmann D.J., and Leahy M. Diagnostic accuracy of cystatin C as a marker of kidney disease in patients with multiple myeloma: calculated glomerular filtration rate formulas are equally useful. Clin. Chem. 50 (2005) 1848-1851
45. Strevens H., Wide-Swennsson D., Torffvit O., and Grubb A. Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate. Scand. J. Clin. Lab. Invest. 61 (2001) 575-580
46. Thomassen S.A., Johannesen I.L., Erlandsen E.J., Abrahamsen J., and Randers E. Serum cystatin C as a marker of the renal function in patients with spinal cord injury. Spinal Cord 40 (2002) 524-528
47. Newman D.J., Thakker H., Edwards R.G., et al. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int. 47 (1995) 312-318
48. Mussap M., DallaVestra M., Fioretto P., et al. Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients. Kidney Int. 61 (2002) 1453-1461
49. Hoek F.J., Kemperman F.A., and Krediet R.T. A comparison between cystatin C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate. Nephrol. Dial. Transplant. 18 (2003) 2024-2031
50. Kocak H., Oner-Iyidogan Y., Gurdol F., Kocak T., and Esin D. The relationship between serum MDA and cystatin C levels in chronic spinal cord injury patients. Clin. Biochem. 38 (2005) 1034-1037
51. Herget-Rosenthal S., Marggraf G., Husing J., et al. Early detection of acute renal failure by serum cystatin C. Kidney Int. 66 (2004) 1115-1122
52. Biancofiore G., Pucci L., Cerutti E., et al. Cystatin C as a marker of renal function immediately after liver transplantation. Liver Transplant. 12 (2006) 285-291
53. Zhu J., Yin R., Wu H., et al. Cystatin C as a reliable marker or renal function following heart valve replacement surgery with cardiopulmonary bypass. Clin. Chim. Acta 374 (2006) 116-121
54. Benohr P., Grenz A., Hartmann J.T., Muller G.A., and Blaschke S. Cystatin C-A marker for assessment of the glomerular filtration rate in patients with cisplatin chemotherapy. Kidney Blood Press. Res. 29 (2006) 32-35
55. Rickli H., Benou K., Ammann P., et al. Time course of serial cystatin C levels in comparison with serum creatinine after application of radiocontrast media. Clin. Nephrol. 61 (2004) 98-102
56. Artunc F.H., Fischer I.U., Risler T., and Erley C.M. Improved estimation of GFR by serum cystatin C in patients undergoing cardiac catheterization. Int. J. Cardiol. 102 (2005) 173-178
57. Herget-Rosenthal S., Pietruck F., Volbracht L., Philipp T., and Kribben A. Serum cystatin C-a superior marker of rapidly reduced glomerular filtration after uninephrectomy in kidney donors compared to creatinine. Clin. Nephrol. 64 (2005) 41-46
58. Filler G., Priem F., Lepage N., et al. β-Trace protein, cystatin C, β2-microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children. Clin. Chem. 48 (2002) 729-736
59. Kobata M., Shimizu A., Rinno H., et al. Beta-trace protein, a marker of GFR, may predict the early prognostic stages of patients with type 2 diabetic nephropathy. J. Clin. Lab. Anal. 18 (2004) 237-239
60. Poge U., Gerhardt T.M., Stoffel-Wagner B., et al. β-Trace protein is an alternative marker for glomerular filtration rate in renal transplantation patients. Clin. Chem. 51 (2005) 1531-1533
61. Kyhse-Andersen J., Schmidt C., Nordin G., et al. Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate. Clin. Chem. 40 (1994) 1921-1926
62. Erlandsen E.J., Randers E., and Kristensen J.H. Evaluation of the Dade Behring N Latex cystatin C assay on the Dade Behring nephelometer II system. Scand. J. Clin. Lab. Invest. 59 (1999) 1-8
63. Lamb E., and Stowe H. Rheumatoid factor can interfere with cystatin C measurement. Ann. Clin. Biochem. 40 (2003) 195-196
64. Bokenkamp A., Domanetzki M., Zinck R., Schumann G., and Brodehl J. Reference values for cystatin C serum concentrations in children. Pediatr. Nephrol. 12 (1998) 125-129
65. Fliser D., and Ritz E. Serum cystatin C concentration as a marker of renal dysfunction in the elderly. Am. J. Kidney Dis. 37 (2001) 79-83
66. Oddoze C., Morange S., Portugal H., Berland Y., and Dussol B. Cystatin C is not more sensitive than creatinine for detecting early renal impairment in patients with diabetes. Am. J. Kidney Dis. 38 (2001) 310-316
67. Wasen E., Isoaho R., Mattila K., Vahlberg T., Kivela S.L., and Irjala K. Renal impairment associated with diabetes in the elderly. Diabetes Care 27 (2004) 2648-2653
68. Poge U., Gerhardt T., Stoffel-Wagner B., Klehr H.U., Sauerbruch T., and Woitas R.P. Calculation of glomerular filtration rate based on cystatin C in cirrhotic patients. Nephrol. Dial. Transplant. 21 (2006) 660-664
69. Finney H., Bates C.J., and Price C.P. Plasma cystatin C determinations in a healthy elderly population. Arch. Gerontol. Geriatr. 29 (1999) 75-94
70. Wasen E., Suominen P., Isoaho R., et al. Serum cystatin C as a marker of kidney dysfunction in an elderly population. Clin. Chem. 48 (2002) 1138-1141
71. Hojs R., Bevc S., Ekart R., Gorenjak M., and Puklavec L. Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function. Nephrol. Dial. Transplant. 21 (2006) 1855-1862
72. Poge U., Gerhardt T., Stoffel-Wagner B., et al. Prediction of glomerular filtration rate in renal transplant recipients: cystatin C or modification of diet in renal disease equation. Clin. Transplant. 20 (2006) 200-2005
73. Newman D.J. Cystatin C. Ann. Clin. Biochem. 39 (2002) 89-104
74. Buysschaert M., Joudi I., Wallemacq P., and Hermans M.P. Comparative performance of serum cystatin C versus serum creatinine in diabetic subjects. Diabetes Metab. 29 (2003) 377-383
75. Podracka L., Feber J., Lepage N., and Filler G. Intra-individual variation of cystatin C and creatinine in pediatric solid organ transplant recipients. Pediatr. Transplant. 9 (2005) 28-32
76. Sjostrom P., Tidman M., and Jones I. The shorter T1/2 of cystatin C explains the earlier change of its serum level compared to serum creatinine. Clin. Nephrol. 62 (2004) 241-242
77. Fehr T., and Rickli H. Cystatin C and creatinine for assessment of kidney function: differences in pharmacokinetics-and more!. Clin. Nephrol. 62 (2004) 327-328
78. Dharnidharka V.R., Kwon C., and Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am. J. Kidney Dis. 40 (2002) 221-226
79. Coll E., Botey A., Alvarez L., et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am. J. Kidney Dis. 36 (2000) 29-34
80. Van Den Noortgate N.J., Janssens W.H., Delanghe J.R., Afschrift M.B., and Lameire N.H. Serum cystatin C concentration compared with other markers of glomerular filtration rate in the old old. J. Am. Geriatr. Soc. 50 (2002) 1278-1282
81. Fricker M., Wiesli P., Brandle M., Schwegler B., and Schmid C. Impact of thyroid dysfunction on serum cystatin C. Kidney Int. 63 (2003) 1944-1947
82. Risch L., Herklotz R., Blumberg A., and Huber A.R. Effects of glucocorticoid immunosuppression on serum cystatin C concentrations in renal transplant patients. Clin. Chem. 47 (2001) 2055-2059
83. Poge U., Gerhardt T., and Bokenkamp A. Time course of low molecular weight proteins in the early kidney transplantation period-Influence of corticosteroids. Nephrol. Dial. Transplant. 19 (2004) 2858-2863
84. Sarnak M.J., Katz R., Stehman-Breen C.O., et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann. Intern. Med. 142 (2005) 497-505
85. Shlipak M.G., Sarnak M.J., Katz R., et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N. Engl. J. Med. 352 (2005) 2049-2060
86. Shlipak M.G., Fyr C.L., Chertow G.M., et al. Cystatin C and mortality risk in the elderly: the health, aging, and body composition study. J. Am. Soc. Nephrol. 17 (2006) 254-261
87. Koenig W., Twardella D., Brenner H., and Rothenbacher D. Plasma concentration of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate. Clin. Chem. 51 (2005) 321-327
88. Bokenkamp A., Herget-Rosenthal S., and Bokenkamp R. Cystatin C, kidney function and cardiovascular disease. Pediatr. Nephrol. 21 (2006) 1223-1230
89. Knight E.L., Verhave J.C., Spiegelmann D., et al. Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int. 65 (2004) 1416-1421
90. Curhan G. Cystatin C: a marker of renal function or something more?. Clin. Chem. 51 (2005) 293-294
91. Filler G., and Lepage N. Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula?. Pediatr. Nephrol. 18 (2003) 981-985
92. Grubb A., Bjork J., Lindstrom V., Sterner G., Bondesson P., and Nyman U. A cystatin C-based formula without anthropometric variables estimates glomerular filtration rate better than creatinine clearance using Cockcroft-Gault formula. Scand. J. Clin. Lab. Invest. 65 (2005) 153-162
93. Larsson A., Malm J., Grubb A., and Hansson L.O. Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L. Scand. J. Clin. Lab. Invest. 64 (2004) 25-30
94. Grubb A., Nyman U., Bjork J., et al. Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. Clin. Chem. 51 (2005) 1420-1431
95. LeBricon T., Thervet E., Froissart M., et al. Plasma cystatin C is superior to 24-h creatinine clearance and plasma creatinine for estimation of glomerular filtration rate 3 months after kidney transplantation. Clin. Chem. 46 (2000) 1206-1207
96. MacIsaac R.J., Tsalamandris C., Thomas M.C., et al. Estimating glomerular filtration rate in diabetes: a comparison or cystatin C- and creatinine-based methods. Diabetologia 49 (2006) 1686-1689
97. Zappitelli M., Parvex P., Joseph L., et al. Derivation and validation of cystatin C based prediction for GFR in children. Am. J. Kidney Dis. 48 (2006) 221-230
98. White C., Akbari A., Hussain N., et al. Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methods. J. Am. Soc. Nephrol. 16 (2005) 3763-3770
99. Risch L., and Huber A.R. Assessing glomerular filtration rate in renal transplant recipients by estimates derived from serum measurements of creatinine and cystatin C. Clin. Chim. Acta 356 (2005) 204-211
100. Poge U., Gerhardt T., Stoffel-Wagner B., et al. Cystatin C-based calculation of glomerular filtration rate in kidney transplant recipients. Kidney Int. 70 (2006) 204-210
101. Bouvet Y., Bouissou F., Coulais Y., et al. GFR is better estimated considering both serum cystatin C and creatinine levels. Pediatr. Nephrol. 21 (2006) 1299-1306