Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3

Carcinogenesis

Volumn 28, Issue 8, 2007, Pages 1653-1658

  Lee, Kuk Wha ^a   Cobb, Laura J ^a   Paharkova Vatchkova, Vladislava ^a   Liu, Bingrong ^a   Milbrandt, Jeffrey ^b   Cohen, Pinchas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR RECEPTOR NUR77; PROTEIN KINASE B; RETINOID X RECEPTOR ALPHA; SOMATOMEDIN BINDING PROTEIN 3; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENZYME PHOSPHORYLATION; FIBROBLAST; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; FIBROBLASTS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTORS;

EID: 34548069891     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm088     Document Type: Article

References (41)

1. Chan,J.M. et al. (1998) Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study. Science 279, 563-566.
2. Ali,O. et al. (2003) Epidemiology and biology of insulin-like growth factor binding protein-3 (IGFBP-3) as an anti-cancer molecule. Horm. Metab. Res., 35, 726-733.
3. Liu,B. et al. (2005) Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo. Clin. Cancer Res., 11, 4851-4856.
4. Silha,J.V. et al. (2006) Insulin-like growth factor binding protein-3 attenuates prostate tumor growth by IGF-dependent and IGF-independent mechanisms. Endocrinology, 147, 2112-2121.
5. Lee,K.W. et al. (2005) Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. J. Biol. Chem., 280, 16942-16948.
6. Lin,B. et al. (2004) Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell, 116, 527-540.
7. Moll,U.M. et al. (2006) p53 and Nur77/TR3-transcription factors that directly target mitochondria for cell death induction. Oncogene 25, 4725-4743.
8. Craft,N. et al. (1999) A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat. Med., 5, 280-285.
9. Sell,C. et al. (1993) Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc. Natl. Acad. Sci. USA, 90, 11217-11221.
10. Liu,B. et al. (2000) Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis. J. Biol. Chem., 275, 33607-33613.
11. Schedlich,L.J. et al. (2004) Insulin-like growth factor binding protein-3 prevents retinoid receptor heterodimerization: Implications for retinoic acid-sensitivity in human breast cancer cells. Biochem. Biophys. Res. Commun., 314, 83-88.
12. Lee,K.W. et al. (2004) Cellular internalization of insulin-like growth factor binding protein-3: Distinct endocytic pathways facilitate re-uptake and nuclear localization. J. Biol. Chem., 279, 469-476.
13. Weih,F. et al. (1996) Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway. Proc. Natl Acad. Sci. USA, 93, 5533-5538.
14. Cheng,L.E. et al. (1997) Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J., 16 1865-1875.
15. Kolluri,S.K. et al. (2003) Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. Mol. Cell. Biol. 23, 8651-8667.
16. Masuyama,N. et al. (2001) Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. J. Biol. Chem., 276, 32799-32805.
17. Pekarsky,Y. et al. (2001) Akt phosphorylates and regulates the orphan nuclear receptor Nur77. Proc. Natl Acad. Sci. USA, 98 3690-3694.
18. Han,Y.H. et al. (2006) Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. Oncogene, 25, 2974-2986.
19. Oufattole,M. et al. (2006) et al. (2006) Rna polymerase II binding subunit 3 (rpb3), a potential nuclear target of IGFBP-3. Endocrinology, 147, 2138-2146.
20. Ikezoe,T. et al. (2004) Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells. Blood, 104, 237-242.
21. Schedlich,L.J. et al. (1998) Insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 share a common nuclear transport pathway in T47D human breast carcinoma cells. J. Biol. Chem., 273, 18347-18352.
22. Silha,J.V. et al. (2002) Impaired glucose homeostasis in insulin-like growth factor-binding protein-3-transgenic mice. Am. J. Physiol. Endocrinol. Metab., 283, E937-E945.
23. Chan,S.S. et al. (2005) Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes. J. Clin. Endocrinol. Metab., 90, 6588-6595.
24. Bhattacharyya,N. et al. (2006) Nonsecreted insulin-like growth factor binding protein-3 (IGFBP-3) can induce apoptosis in human prostate cancer cells by IGF-independent mechanisms without being concentrated in the nucleus. J. Biol. Chem., 281, 24588-24601.
25. Huang,S.S. et al. (2003) Cellular growth inhibition by IGFBP-3 and TGF-beta1 requires LRP-1. FASEB J., 17, 2068-2081.
26. Spagnoli,A. et al. (2002) Identification of STAT-1 as a molecular target of insulin-like growth factor binding protein-3 (IGFBP-3) in the process of chondrogenesis. J. Biol. Chem., 277, 18860-18867.
27. Fanayan,S. et al. (2002) Signaling through the Smad pathway by insulin-like growth factor-binding protein-3 in breast cancer cells. Relationship to transforming growth factor-beta 1 signaling. J. Biol. Chem., 277, 7255-7261.
28. Ricort,J.M. et al. (2002) Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. Effects on the insulin-like growth factor signaling pathway. J. Biol. Chem., 277, 19448-19454.
29. Ricort,J.M. et al. (2002) Insulin-like growth factor binding protein-3 increases intracellular calcium concentrations in MCF-7 breast carcinoma cells. FEBS Lett., 527, 293-297.
30. Li,H. et al. (2000) Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science, 289, 1159-1164.
31. Dawson,M.I. et al. (2001) Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity. Cancer Res. 61, 4723-4730.
32. Kawauchi,K. et al. (2003) Involvement of Akt kinase in the action of STI571 on chronic myelogenous leukemia cells. Blood Cells Mol. Dis., 31, 11-17.
33. Sordella,R. et al. (2004) Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science, 305, 1163-1167.
34. Jin,S. (2007) Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. Cancer Biol. Ther., 6, 261-268.
35. Yu,C. et al. (2006) Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Mol. Cancer Ther., 5, 2378-2387.
36. Katagiri,Y. et al. (2000) Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B. Nat. Cell Biol., 2, 435-440.
37. Wingate,A.D. et al. (2006) Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. Biochem. J., 393, 715-724.
38. Cobb,L.J. et al. (2006) Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. Cancer Res., 66, 10878-10884.
39. Schedlich,L.J. et al. (2003) Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation. Endocrinology, 144, 1984-1993.
40. Coverley,J.A. et al. (2000) The effect of phosphorylation by casein kinase 2 on the activity of insulin-like growth factor-binding protein-3. Endocrinology, 141, 564-570.
41. Cao,X. et al. (2004) Retinoid X receptor regulates Nur77/ TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting. Mol. Cell. Biol., 24, 9705-9725.