Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 12, 2005, Pages 6588-6595

  Chan, Sophie S Y ^a,c   Twigg, Stephen M ^a   Firth, Sue M ^b   Baxter, Robert C ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 4; INSULIN; MUTANT PROTEIN; PROTEIN KINASE B; RETINOID X RECEPTOR ALPHA; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C RECEPTOR; THREONINE;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; EXPLANT; GLUCOSE TRANSPORT; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; DEOXYGLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MICE; OMENTUM; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; SUBCUTANEOUS TISSUE;

ANIMALIA; MUS MUSCULUS;

EID: 28744437575     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-0595     Document Type: Article

References (32)

1. De Mellow JS, Baxter RC 1988 Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts. Biochem Biophys Res Commun 156:199-204
2. Oh Y, Muller HL, Lamson G, Rosenfeld RG 1993 Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition. J Biol Chem 268:14964-14971
3. Valentinis B, Bhala A, DeAngelis T, Baserga R, Cohen P 1995 The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene. Mol Endocrinol 9:361-367
4. Rajah R, Valentinis B, Cohen P 1997 Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-β1 on programmed cell death through a p53- and IGF-independent mechanism. J Biol Chem 272:12181-12188
5. Schedlich LJ, Young TF, Firth SM, Baxter RC 1998 Insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 share a common nuclear transport pathway in T47D human breast carcinoma cells. J Biol Chem 273:18347-18352
6. Wraight CJ, Liepe IJ, White PJ, Hibbs AR, Werther GA 1998 Intranuclear localization of insulin-like growth factor binding protein-3 (IGFBP-3) during cell division in human keratinocytes. J Invest Dermatol 111:239-242
7. Jaques G, Noll K, Wegmann B, Witten S, Kogan E, Radulescu RT, Havemann K 1997 Nuclear localization of insulin-like growth factor binding protein 3 in a lung cancer cell line. Endocrinology 138:1767-1770
8. Liu B, Lee HY, Weinzimer SA, Powell DR, Clifford JL, Kurie JM, Cohen P 2000 Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor- regulate transcriptional signaling and apoptosis. J Biol Chem 275:33607-33613
9. Boney CM, Moats-Staats BM, Stiles AD, D'Ercole AJ 1994 Expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins during adipogenesis. Endocrinology 135:1863-1868
10. Wabitsch M, Heinze E, Debatin KM, Blum WF 2000 IGF-I- and IGFBP-3-expression in cultured human preadipocytes and adipocytes. Horm Metab Res 32:555-559
11. Silha JV, Gui Y, Murphy LJ 2002 Impaired glucose homeostasis in insulin-like growth factor-binding protein-3-transgenic mice. Am J Physiol Endocrinol Metab 283:E937-E945
12. Shim L, Liu B, Ramirez E, Lee HY, Kurie JM, Law RE, Cohen P IGFBP-3 inhibits glucose transport and blocks nuclear PPAR signaling. Program of the 82nd Annual Meeting of The Endocrine Society, Toronto, Canada, 2000, p 74 (Abstract 271)
13. Schedlich LJ, Le Page SL, Firth SM, Briggs LJ, Jans DA, Baxter RC 2000 Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin β-subunit. J Biol Chem 275:23462-23470
14. Stolic M, Russell A, Hutley L, Fielding G, Hay J, MacDonald G, Whitehead J, Prins J 2002 Glucose uptake and insulin action in human adipose tissue-influence of BMI, anatomical depot and body fat distribution. Int J Obes Relat Metab Disord 26:17-23
15. Firth SM, Ganeshprasad U, Poronnik P, Cook DI, Baxter RC 1999 Adenoviral-mediated expression of human insulin-like growth factor-binding protein-3. Protein Expr Purif 16:202-211
16. Yan X, Forbes BE, McNeil KA, Baxter RC, Firth SM 2004 Role of N- and C-terminal residues of insulin-like growth factor (IGF)-binding protein-3 in regulating IGF complex formation and receptor activation. J Biol Chem 279:53232-53240
17. Baxter RC, Martin JL, Wood MH 1987 Two immunoreactive binding proteins for insulin-like growth factors in human amniotic fluid: relationship to fetal maturity. J Clin Endocrinol Metab 65:423-431
18. Robinson LJ, Pang S, Harris DS, Heuser J, James DE 1992 Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP-γS and localization of GLUT4 to clathrin lattices. J Cell Biol 117:1181-1196
19. 2+ in insulin-stimulated glucose transport in 3T3-L1 cells. J Biol Chem 276:27816-27824
20. Gunton JE, Delhanty PJ, Takahashi S, Baxter RC 2003 Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2. J Clin Endocrinol Metab 88:1323-1332
21. Payet LD, Wang XH, Baxter RC, Firth SM 2003 Amino- and carboxyl-terminal fragments of insulin-like growth factor (IGF) binding protein-3 cooperate to bind IGFs with high affinity and inhibit IGF receptor interactions. Endocrinology 144:2797-2806
22. Lundgren M, Buren J, Ruge T, Myrnas T, Eriksson JW 2004 Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes. J Clin Endocrinol Metab 89:2989-2997
23. Firth SM, Baxter RC 2002 Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 23:824-854
24. Singh B, Charkowicz D, Mascarenhas D 2004 Insulin-like growth factor-independent effects mediated by a C-terminal metal-binding domain of insulin-like growth factor binding protein-3. J Biol Chem 279:477-487
25. Lee KW, Liu B, Ma L, Li H, Bang P, Koeffler HP, Cohen P 2004 Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. J Biol Chem 279:469-476
26. Butt AJ, Fraley KA, Firth SM, Baxter RC 2002 IGF-binding protein-3-induced growth inhibition and apoptosis do not require cell surface binding and nuclear translocation in human breast cancer cells. Endocrinology 143:2693-2699
27. Worrall DS, Olefsky JM 2002 The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Mol Endocrinol 16:378-389
28. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P 1997 Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7:261-269
29. Huang SS, Leal SM, Chen CL, Liu IH, Huang JS 2004 Identification of insulin receptor substrate proteins as key molecules for the TβR-V/LRP-1-mediated growth inhibitory signaling cascade in epithelial and myeloid cells. FASEB J 18:1719-1721
30. Siddals KW, Westwood M, Gibson JM, White A 2002 IGF-binding protein-1 inhibits IGF effects on adipocyte function: implications for insulin-like actions at the adipocyte. J Endocrinol 174:289-297
31. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S 1987 Contribution of intraabdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 36:54-59
32. Zierath JR, Livingston JN, Thorne A, Bolinder J, Reynisdottir S, Lonnqvist F, Arner P 1998 Regional difference in insulin inhibition of nonesterified fatty acid release from human adipocytes: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway. Diabetologia 41:1343-1354