Solubility of E2050 at various pH: A case in which apparent solubility is affected by the amount of excess solid

Journal of Pharmaceutical Sciences

Volumn 91, Issue 6, 2002, Pages 1445-1455

  Wang, Zeren ^a,b   Burrell, Lana S ^a   Lambert, William J ^a  

^a EISAI INC   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Common ion effect; Parenteral formulation; Solubility determination; Solubility pH profile

Indexed keywords

1 [(4 CYANO 5 DIMETHYL 4 PHENYL)HEXYL] 4 [2 (4 FLUOROPHENOXY)ETHYL]PIPERAZINE; E 2050; HYDROCHLORIC ACID; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; AQUEOUS SOLUTION; ARTICLE; DRUG SOLUBILITY; HYDROPHOBICITY; PH; PKA; PREDICTION; SOLID;

EID: 0036282656     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10107     Document Type: Article

References (11)

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