The skin as a mirror of the aging process in the human organism - State of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2)

Experimental Gerontology

Volumn 42, Issue 9, 2007, Pages 879-886

  Makrantonaki, Evgenia ^a,b   Zouboulis, Christos C ^a,b  

^a DESSAU MEDICAL CENTER   (Germany)

^b Dermato Pharmacology and Dermato Endocrinology   (Germany)

Author keywords

Skin aging

Indexed keywords

GROWTH FACTOR; SEX HORMONE; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; BREAST CANCER; CARCINOGENESIS; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DEGENERATIVE DISEASE; DENTATORUBROPALLIDOLUYSIAN ATROPHY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; INTESTINE CANCER; LONGEVITY; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; SHORT SURVEY; UTERUS CANCER;

AGING; GENE EXPRESSION PROFILING; GENOME, HUMAN; HORMONES; HUMANS; MODELS, BIOLOGICAL; SEBACEOUS GLANDS; SKIN AGING;

EID: 34547950096     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2007.07.002     Document Type: Short Survey

References (74)

1. Aleksandrova S., and Velkova A. Population ageing in the Balkan countries. Folia Med. (Plovdiv) 45 (2003) 5-10
2. Bachmann G., Bancroft J., Braunstein G., Burger H., Davis S., Dennerstein L., Goldstein I., Guay A., Leiblum S., Lobo R., Notelovitz M., Rosen R., Sarrel P., Sherwin B., Simon J., Simpson E., Shifren J., Spark R., and Traish A. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil. Steril. 77 (2002) 660-665
3. Badawi A.F., Liu Y., Eldeen M.B., Morrow W., Razak Z.R., Maradeo M., and Badr M.Z. Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate. Carcinogenesis 25 (2004) 1681-1688
4. Barja G. Free radicals and aging. Trends Neurosci. 27 (2004) 595-600
5. Bateman A., and Chothia C. Fibronectin type III domains in yeast detected by a hidden Markov model. Curr. Biol. 6 (1996) 1544-1547
6. Bennett A.E., Wahner H.W., Riggs B.L., and Hintz R.L. Insulin-like growth factors I and II: aging and bone density in women. J. Clin. Endocrinol. Metab. 59 (1984) 701-704
7. Birg H. Ursachen und Folgen des Fertilitätsrückgangs in Deutschland. Zentralbl. Gynakol. 126 (2004) 101-111
8. Braverman I.M., and Fonferko E. Studies in cutaneous aging: I. The elastic fiber network. J. Invest. Dermatol. 78 (1982) 434-443
9. Bruckner-Tuderman L. Die dermo-epidermale Junktionszone. Hautarzt 44 (1993) 1-4
10. Burger H.G., Dudley E.C., Cui J., Dennerstein L., and Hopper J.L. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J. Clin. Endocrinol. Metab. 85 (2000) 2832-2838
11. Burgeson R.E., Chiquet M., Deutzmann R., Ekblom P., Engel J., Kleinman H., Martin G.R., Meneguzzi G., Paulsson M., Sanes J., et al. A new nomenclature for the laminins. Matrix Biol. 14 (1994) 209-211
12. Castelo-Branco C., Rovira M., Pons F., Duran M., Sierra J., Vives A., Balasch J., Fortuny A., and Vanrell J. The effect of hormone replacement therapy on bone mass in patients with ovarian failure due to bone marrow transplantation. Maturitas 23 (1996) 307-312
13. Chakraborty T.R., and Gore A.C. Aging-related changes in ovarian hormones, their receptors, and neuroendocrine function. Exp. Biol. Med. (Maywood) 22 (2004) 977-987
14. Corpas E., Harman S.M., and Blackman M.R. Human growth hormone and human aging. Endocr. Rev. 14 (1993) 20-39
15. Cuervo A.M., and Dice J.F. How do intracellular proteolytic systems change with age?. Front. Biosci. 3 (1998) d25-d43
16. Diczfalusy E. The third age, the Third World and the third millennium. Contraception 53 (1996) 1-7
17. Diepgen T.L. Aktuelle Bevölkerungsentwicklung in Deutschland. Hautarzt 54 (2003) 804-808
18. Downing D.T., Stewart M.E., Wertz P.W., Colton S.W., Abraham W., and Strauss J.S. Skin lipids: an update. J. Invest. Dermatol. 88 (1987) 2s-6s
19. Dunn L.B., Damesyn M., Moore A.A., Reuben D.B., and Greendale G.A. Does estrogen prevent skin aging? Results from the First National Health and Nutrition Examination Survey (NHANES I). Arch. Dermatol. 133 (1997) 339-342
20. Eastell R., and Lambert H. Strategies for skeletal health in the elderly. Proc. Nutr. Soc. 61 (2002) 173-180
21. Elias P.M., and Ghadially R. The aged epidermal permeability barrier: basis for functional abnormalities. Clin. Geriatr. Med. 18 (2002) 103-120 vii
22. Engelke M., Jensen J.M., Ekanayake-Mudiyanselage S., and Proksch E. Effects of xerosis and ageing on epidermal proliferation and differentiation. Br. J. Dermatol. 137 (1997) 219-225
23. Fain J.N., Kovacev V.P., and Scow R.O. Effect of growth hormone and dexamethasone on lipolysis and metabolism in isolated fat cells of the rat. J. Biol. Chem. 240 (1965) 3522-3529
24. Fisher G.J., Kang S., Varani J., Bata-Csorgo Z., Wan Y., Datta S., and Voorhees J.J. Mechanisms of photoaging and chronological skin aging. Arch. Dermatol. 138 (2002) 1462-1470
25. Flood J.F., and Roberts E. Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res. 448 (1988) 178-181
26. Fritsch M., Orfanos C.E., and Zouboulis C.C. Sebocytes are the key regulators of androgen homeostasis in human skin. J. Invest. Dermatol. 116 (2001) 793-800
27. Gambacciani M., Ciaponi M., Cappagli B., and Genazzani A.R. Effects of low-dose continuous combined conjugated estrogens and medroxyprogesterone acetate on menopausal symptoms, body weight, bone density, and metabolism in postmenopausal women. Am. J. Obstet. Gynecol. 185 (2001) 1180-1185
28. Ghadially R., Brown B.E., Sequeira-Martin S.M., Feingold K.R., and Elias P.M. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J. Clin. Invest. 95 (1995) 2281-2290
29. Gray A., Feldman H.A., McKinlay J.B., and Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J. Clin. Endocrinol. Metab. 73 (1991) 1016-1025
30. Hasty P., Campisi J., Hoeijmakers J., van Steeg H., and Vijg J. Aging and genome maintenance: lessons from the mouse?. Science 299 (2003) 1355-1359
31. Hijazi R.A., and Cunningham G.R. Andropause: is androgen replacement therapy indicated for the aging male?. Annu. Rev. Med. 56 (2005) 117-137
32. Holbrook K.A., Byers P.H., and Pinnell S.R. The structure and function of dermal connective tissue in normal individuals and patients with inherited connective tissue disorders. Scan. Electron Microsc. (1982) 1731-1744
33. Hollo I., Feher T., and Szucs J. Serum dehydroepiandrosterone, androsterone and cortisol level in primary postmenopausal and other type osteoporosis. Acta Med. Acad. Sci. Hung. 27 (1970) 155-160
34. Hu H.L., Forsey R.J., Blades T.J., Barratt M.E., Parmar P., and Powell J.R. Antioxidants may contribute in the fight against ageing: an in vitro model. Mech. Ageing Dev. 121 (2000) 217-230
35. Ishihara F., Hiramatsu K., Shigematsu S., Aizawa T., Niwa A., Takasu N., Yamada T., and Matsuo K. Role of adrenal androgens in the development of arteriosclerosis as judged by pulse wave velocity and calcification of the aorta. Cardiology 80 (1992) 332-338
36. Jiang Y.M., Yamamoto M., Kobayashi Y., Yoshihara T., Liang Y., Terao S., Takeuchi H., Ishigaki S., Katsuno M., Adachi H., Niwa J., Tanaka F., Doyu M., Yoshida M., Hashizume Y., and Sobue G. Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann. Neurol. 57 (2005) 236-251
37. Kanitakis J. Anatomy, histology and immunohistochemistry of normal human skin. Eur. J. Dermatol. 12 (2002) 390-399 quiz 400-1
38. Kielty C.M., and Shuttleworth C.A. Microfibrillar elements of the dermal matrix. Microsc. Res. Tech. 38 (1997) 413-427
39. Kohen R. Skin antioxidants: their role in aging and in oxidative stress -new approaches for their evaluation. Biomed. Pharmacother. 53 (1999) 181-192
40. Kostyo J.L., Hotchkiss J., and Knobil E. Stimulation of amino acid transport in isolated diaphragm by growth hormone added in vitro. Science 130 (1959) 1653-1654
41. Kovaiou R.D., Herndler-Brandstetter D., and Grubeck-Loebenstein B. Age-related changes in immunity: implications for vaccination in the elderly. Expert Rev. Mol. Med. 9 (2007) 1-17
42. Labat-Robert J. Age-dependent remodeling of connective tissue: role of fibronectin and laminin. Pathol. Biol. (Paris) 51 (2003) 563-568
43. Labrie F., Belanger A., Luu-The V., Labrie C., Simard J., Cusan L., Gomez J.L., and Candas B. DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: its role during aging. Steroids 63 (1998) 322-328
44. Levy L., and Hill C.S. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev. 17 (2006) 41-58
45. Lieber M.R., and Karanjawala Z.E. Ageing, repetitive genomes and DNA damage. Nat. Rev. Mol. Cell Biol. 5 (2004) 69-75
46. Lucas J.A., Ahmed S.A., Casey M.L., and MacDonald P.C. Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone. J. Clin. Invest. 75 (1985) 2091-2093
47. Luthi-Carter R., Strand A.D., Hanson S.A., Kooperberg C., Schilling G., La Spada A.R., Merry D.E., Young A.B., Ross C.A., Borchelt D.R., and Olson J.M. Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects. Hum. Mol. Genet. 11 (2002) 1927-1937
48. Makrantonaki E., and Zouboulis C.C. William J. Cunliffe Scientific Awards. Characteristics and pathomechanisms of endogenously aged skin. Dermatology 214 (2007) 352-360
49. Makrantonaki E., Adjaye J., Herwig R., Brink T.C., Groth D., Hultschig C., Lehrach H., and Zouboulis C.C. Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro. Aging Cell 5 (2006) 331-344
50. Massague J. TGF-beta signal transduction. Annu. Rev. Biochem. 67 (1998) 753-791
51. Massague J., Freidenberg G.F., Olefsky J.M., and Czech M.P. Parallel decreases in the expression of receptors for insulin and insulin-like growth factor I in a mutant human fibroblast line. Diabetes 32 (1983) 541-544
52. Moragas A., Castells C., and Sans M. Mathematical morphologic analysis of aging-related epidermal changes. Anal. Quant. Cytol. Histol. 15 (1993) 75-82
53. Nikkari T., Schreibman P.H., and Ahrens Jr. E.H. In vivo studies of sterol and squalene secretion by human skin. J. Lipid Res. 15 (1974) 563-573
54. Oeppen J., and Vaupel J.W. Demography. Broken limits to life expectancy. Science 296 (2002) 1029-1031
55. Orentreich N., Brind J.L., Rizer R.L., and Vogelman J.H. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J. Clin. Endocrinol. Metab. 59 (1984) 551-555
56. Parker Jr. C.R., Slayden S.M., Azziz R., Crabbe S.L., Hines G.A., Boots L.R., and Bae S. Effects of aging on adrenal function in the human: responsiveness and sensitivity of adrenal androgens and cortisol to adrenocorticotropin in premenopausal and postmenopausal women. J. Clin. Endocrinol. Metab. 85 (2000) 48-54
57. Pochi P.E., Strauss J.S., and Downing D.T. Age-related changes in sebaceous gland activity. J. Invest. Dermatol. 73 (1979) 108-111
58. Raine-Fenning N.J., Brincat M.P., and Muscat-Baron Y. Skin aging and menopause: implications for treatment. Am. J. Clin. Dermatol. 4 (2003) 371-378
59. Ramasastry P., Downing D.T., Pochi P.E., and Strauss J.S. Chemical composition of human skin surface lipids from birth to puberty. J. Invest. Dermatol. 54 (1970) 139-144
60. Rossouw J.E., Anderson G.L., Prentice R.L., LaCroix A.Z., Kooperberg C., Stefanick M.L., Jackson R.D., Beresford S.A., Howard B.V., Johnson K.C., Kotchen J.M., and Ockeue J. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA 288 (2002) 321-333
61. Salomon F., Cuneo R.C., Hesp R., and Sonksen P.H. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N. Engl. J. Med. 321 (1989) 1797-1803
62. Sipione S., Rigamonti D., Valenza M., Zuccato C., Conti L., Pritchard J., Kooperberg C., Olson J.M., and Cattaneo E. Early transcriptional profiles in huntington-inducible striatal cells by microarray analyses. Hum. Mol. Genet. 11 (2002) 1953-1965
63. Smyth C.D., Gosden R.G., McNeilly A.S., and Hillier S.G. Effect of inhibin immunoneutralization on steroidogenesis in rat ovarian follicles in vitro. J. Endocrinol. 140 (1994) 437-443
64. Thody A.J., and Shuster S. Control and function of sebaceous glands. Physiol. Rev. 69 (1989) 383-416
65. Uitto J. Connective tissue biochemistry of the aging dermis. Age-Related alterations in collagen and elastin. Dermatol. Clin. 4 (1986) 433-446
66. Weaver J.U., Monson J.P., Noonan K., John W.G., Edwards A., Evans K.A., and Cunningham J. The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. J. Clin. Endocrinol. Metab. 80 (1995) 153-159
67. Wulf H.C., Sandby-Moller J., Kobayasi T., and Gniadecki R. Skin aging and natural photoprotection. Micron 35 (2004) 185-191
68. Zouboulis C.C. Intrinsische Hautalterung - Eine kritische Bewertung der Rolle der Hormone. Hautarzt 54 (2003) 825-832
69. Zouboulis C.C. Acne and sebaceous gland function. Clin. Dermatol. 22 (2004) 360-366
70. Zouboulis C.C. The human skin as a hormone target and an endocrine gland. Hormones 3 (2004) 9-26
71. Zouboulis C.C., and Boschnakow A. Chronological ageing and photoageing of the human sebaceous gland. Clin. Exp. Dermatol. 26 (2001) 600-607
72. Zouboulis C.C., Chen W., Thornton M.J., Qin K., and Rosenfield R.L. Sexual hormones in human skin. Horm. Metab. Res. 39 (2007) 85-95
73. Zouboulis C.C., Fimmel S., Ortmann J., Turnbull J.R., and Boschnakow A. Sebaceous glands. In: Hoath S.B., and Maibach H.I. (Eds). Neonatal Skin - Structure and Function. second ed. (2003), Marcel Dekker, New York, Basel 59-88
74. Zouboulis C.C., Seltmann H., Neitzel H., and Orfanos C.E. Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J. Invest. Dermatol. 113 (1999) 1011-1020